Abstract:
:A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones were synthesized and evaluated for anticonvulsant activity in DBA/2 mice against sound-induced seizures and in rats against maximal electroshock-induced seizures. Most of the derivatives showed an anticonvulsant effect better than that of valproate, a commonly used anticonvulsant drug. Compound 3 possessed an anticonvulsant activity comparable to that of diphenylhydantoin in both tests and was selected for further studies. Structure-activity relationships are discussed.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Chimirri A,De Sarro A,De Sarro G,Grasso S,Trimarchi GR,Zappalà Mdoi
10.1021/jm00121a019subject
Has Abstractpub_date
1989-01-01 00:00:00pages
93-5issue
1eissn
0022-2623issn
1520-4804journal_volume
32pub_type
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