Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.

Abstract:

:A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones were synthesized and evaluated for anticonvulsant activity in DBA/2 mice against sound-induced seizures and in rats against maximal electroshock-induced seizures. Most of the derivatives showed an anticonvulsant effect better than that of valproate, a commonly used anticonvulsant drug. Compound 3 possessed an anticonvulsant activity comparable to that of diphenylhydantoin in both tests and was selected for further studies. Structure-activity relationships are discussed.

journal_name

J Med Chem

authors

Chimirri A,De Sarro A,De Sarro G,Grasso S,Trimarchi GR,Zappalà M

doi

10.1021/jm00121a019

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

93-5

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

32

pub_type

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