Abstract：
Purpose:To evaluate the response of intravitreal aflibercept injection (IAI) in eyes with detachment of retinal pigment epithelium (DEP) secondary to nAMD refractory to monthly ranibizumab. Patients and Methods:This is a retrospective, multicenter study. All patients received 3 IAI then treated as needed every 4 weeks for 12 months. During the second year, the eyes were treated with a treat- and-extend regimen. Results:Forty-four eyes were included. Best-corrected visual acuity improved significantly after the loading phase (3.1 ± 6.4 letters) and at 6 months (2.8 ± 6.4 letters), but change was not significant at 1 year and 2 years. The height of the DEP was significantly decreased at 3 months and 6 months, but the difference did not reach statistical difference at 1 and 2 years. Rate of eyes with complete resolution of exudation was 59% after the loading phase and 34.3% at 2 years. Mean interval of anti-VEGF injection was extended from 31 ± 2.6 days to 61 ± 5 days after conversion. Conclusions:Aflibercept intravitreal injection in patients with fibrovascular DEP due to nAMD who respond poorly to monthly ranibizumab led to short-term functional and anatomical improvement. Reduction of intravitreal injection frequency was obtained until 2 years of follow-up.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Tran THC,Dumas S,Coscas Fdoi
10.1155/2017/8984313subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8984313eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract：:The aim of this study was to assess the oxidative stress status in eyes affected by synchysis scintillans and to compare it to vitreoretinal disorders without synchysis scintillans. Human aqueous and vitreous humors were obtained during vitrectomy from thirty-seven otherwise healthy patients that were randomly chosen ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/7231015
更新日期：2019-10-30 00:00:00
abstract：Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/2670153
更新日期：2020-07-25 00:00:00
abstract：:Objective. The purpose of this study was to examine how patient, physician, and situational factors are associated with the extent to which providers educate patients about glaucoma and glaucoma medications, and which patient and provider characteristics are associated with whether providers educate patients about gla...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/238939
更新日期：2014-01-01 00:00:00
abstract：Purpose:To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients. Methods:From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 200...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/8629429
更新日期：2018-09-09 00:00:00
abstract：:Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identifie...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/1621640
更新日期：2017-01-01 00:00:00
abstract：Purpose:To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods:Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. Changes i...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/6185919
更新日期：2018-12-23 00:00:00
abstract：:Purpose. To compare near, intermediate, and distance vision and quality of vision, when refractive rotational multifocal intraocular lenses with 3.0 diopters or diffractive multifocal intraocular lenses with 2.5 diopters near addition are implanted. Methods. 41 eyes of 41 patients in whom rotational +3.0 diopters near...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/1395302
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/923941
更新日期：2015-01-01 00:00:00
abstract：Purpose:To analyze the "in vitro" aberrometric pattern of a refractive IOL and two extended depth of focus IOLs. Methods:A special optical bench with a Shack-Hartmann wavefront sensor (SH) was designed for the measurement. Three presbyopia correction IOLs were analyzed: Mini WELL (MW), TECNIS Symfony ZXR00 (SYM), and ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/7095734
更新日期：2017-01-01 00:00:00
abstract：Purpose:To determine the effectiveness and safety of selective laser trabeculoplasty (SLT) in young patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Methods:This was a retrospective clinical study. Fifty-six eyes from 56 young (age ≤ 40 y) patients with POAG or OHT treated with SLT were ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/5742832
更新日期：2020-06-09 00:00:00
abstract：Purpose:The purpose of this study was to evaluate 2-year visual outcomes in patients with diabetic macular edema (DME) treated with anti-VEGF agents in a routine clinical setting. Methods:The medical records of patients treated with ranibizumab or aflibercept due to DME at the Eye Hospital, University Medical Centre L...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/6979758
更新日期：2020-03-16 00:00:00
abstract：:Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to investigate whether combination of lutein and zeaxanthin, two carotenoid p...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/862806
更新日期：2013-01-01 00:00:00
abstract：:Introduction. Retinoblastoma is the most common primary intraocular neoplasm in children. With the advances in medicine, the armamentarium of available treatment modalities has grown. Intraarterial chemotherapy is a relatively new treatment method with promising outcomes. The purpose of this literature review is to ev...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2020/3638410
更新日期：2020-01-24 00:00:00
abstract：:Purpose. To present a series of retinal disease cases that were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality. Methods. The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD)...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2011/764183
更新日期：2011-01-01 00:00:00
abstract：Purpose:To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China. Methods:A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 ki...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/5205946
更新日期：2018-03-05 00:00:00
abstract：:LASIK eye surgery has become a very common practice for myopic people, especially those in the military. Sometimes undertaken by people who need to keep a specific medical aptitude, this surgery could be performed in secret from the hierarchy and from the institute medical staff. However, even though the eyes have bee...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/762364
更新日期：2014-01-01 00:00:00
abstract：:Background. The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or no...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2010/106384
更新日期：2010-01-01 00:00:00
abstract：:SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness m...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/692574
更新日期：2011-01-01 00:00:00
abstract：:Background. We aimed to evaluate the association between maternal smoking and the occurrence of childhood refractive error and amblyopia. Methods. Relevant articles were identified from PubMed and EMBASE up to May 2015. Combined odds ratio (OR) corresponding with its 95% confidence interval (CI) was calculated to eval...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8263832
更新日期：2016-01-01 00:00:00
abstract：Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/9476749
更新日期：2020-12-17 00:00:00
abstract：Purpose:To compare the outcomes of Ex-PRESS glaucoma filtration device and transscleral cyclophotocoagulation (TSCP) in the management of neovascular glaucoma (NVG). Patients and Methods. A total of 30 eyes (12 express shunts and 18 TSCP) of 28 patients were included. The eyes had NVG with intraocular pressure (IOP) mo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/3781249
更新日期：2020-05-17 00:00:00
abstract：:Purpose. To compare the surgically induced astigmatism from clear corneal and square posterior limbal incisions at the time of cataract surgery. Methods. Surgically induced astigmatism was calculated for a set of eyes after cataract surgery using a temporal 2.2 mm square posterior limbal incision. Results were compare...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/243170
更新日期：2011-01-01 00:00:00
abstract：Purpose:This study aims to assess scleral and conjunctival thickness using optical coherence tomography after ultrasound ciliary plasty (UCP) procedure with reference to scleral marks appearing in the area where the ultrasound energy was applied. Materials and Methods:Seventy-eight patients with primary and secondary ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/9659014
更新日期：2020-09-24 00:00:00
abstract：:Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirr...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2011/285296
更新日期：2011-01-01 00:00:00
abstract：Purpose:To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods:We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in bo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/7936205
更新日期：2020-07-04 00:00:00
abstract：:Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages. Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divi...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/1549318
更新日期：2016-01-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evalua...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2013/895147
更新日期：2013-01-01 00:00:00
abstract：Background:The advantage of using an autostereoscopic smartphone is that it can achieve 3D effects without the need for glasses. The purpose of this study was to evaluate whether this technology could be utilized to detect stereoacuity. Methods:An autostereoscopic smartphone was used to imitate Lang stereotest I & II,...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1570309
更新日期：2019-10-31 00:00:00
abstract：:Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/397495
更新日期：2015-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2016/3690140.]. ...
journal_title：Journal of ophthalmology
pub_type： 已发布勘误
doi：10.1155/2019/6212745
更新日期：2019-06-11 00:00:00
