Abstract:
:As a noninvasive and "task-free" technique, resting-state functional magnetic resonance imaging (rs-fMRI) has been gradually applied to pre-surgical functional mapping. Independent component analysis (ICA)-based mapping has shown advantage, as no a priori information is required. We developed an automated method for identifying language network in brain tumor subjects using ICA on rs-fMRI. In addition to standard processing strategies, we applied a discriminability-index-based component identification algorithm to identify language networks in three different groups. The results from the training group were validated in an independent group of healthy human subjects. For the testing group, ICA and seed-based correlation were separately computed and the detected language networks were assessed by intra-operative stimulation mapping to verify reliability of application in the clinical setting. Individualized language network mapping could be automatically achieved for all subjects from the two healthy groups except one (19/20, success rate = 95.0%). In the testing group (brain tumor patients), the sensitivity of the language mapping result was 60.9%, which increased to 87.0% (superior to that of conventional seed-based correlation [47.8%]) after extending to a radius of 1 cm. We established an automatic and practical component identification method for rs-fMRI-based pre-surgical mapping and successfully applied it to brain tumor patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lu J,Zhang H,Hameed NUF,Zhang J,Yuan S,Qiu T,Shen D,Wu Jdoi
10.1038/s41598-017-14248-5subject
Has Abstractpub_date
2017-10-23 00:00:00pages
13769issue
1issn
2045-2322pii
10.1038/s41598-017-14248-5journal_volume
7pub_type
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