Dental pulp regeneration via cell homing.

Abstract:

:The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. This systematic review examines cell homing for dental pulp regeneration, selecting articles on in vitro experiments, in vivo ectopic transplantation models and in situ pulp revascularization. MEDLINE/PubMed and Scopus databases were electronically searched for articles without limits in publication date. Two reviewers independently screened and included papers according to the predefined selection criteria. The electronic searches identified 46 studies. After title, abstract and full-text examination, 10 articles met the inclusion criteria. In vitro data highlighted that multiple cytokines have the capacity to induce migration, proliferation and differentiation of dental pulp stem/progenitor cells. The majority of the in vivo studies obtained regenerated connective pulp-like tissues with neovascularization. In some cases, the samples showed new innervation and new dentine deposition. The in situ pulp revascularization regenerated intracanal pulp-like tissues with neovascularization, innervation and dentine formation. Cell homing strategies for pulp regeneration need further understanding and improvement if they are to become a reliable and effective approach in endodontics. Nevertheless, cell homing currently represents the most clinically viable pathway for dental pulp regeneration.

journal_name

Int Endod J

authors

Eramo S,Natali A,Pinna R,Milia E

doi

10.1111/iej.12868

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

405-419

issue

4

eissn

0143-2885

issn

1365-2591

journal_volume

51

pub_type

杂志文章,评审
  • Endodontic retreatment behaviour: the influence of disease concepts and personal values.

    abstract::To explain dentists' variation in endodontic retreatment decision making a praxis concept (PC) has been generated. PC assumes that practitioners operate along a health continuum. Various periapical conditions are then perceived as different stages on a continuous health scale, based on their radiographic appearance. P...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.1998.00170.x

    authors: Reit C,Kvist T

    更新日期:1998-09-01 00:00:00

  • The use of cone beam computed tomography in the management of dens invaginatus affecting a strategic tooth in a patient affected by hypodontia: a case report.

    abstract:AIM:To report on the use of cone beam computed tomography (CBCT) in the diagnosis and management of dens invaginatus. SUMMARY:Chronic apical periodontitis of an invaginated maxillary lateral incisor was diagnosed in a patient suffering from hypodontia and awaiting active orthodontic therapy. Loss of the tooth would ha...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01866.x

    authors: Durack C,Patel S

    更新日期:2011-05-01 00:00:00

  • Pattern of transmission of laser light through carious molar teeth.

    abstract:AIMS:The aims of this study were to investigate the pattern of transmission of laser light through carious human molar teeth, and to examine the effect on light transmission of reactions to caries in the dentine. METHODOLOGY:Sectioned carious human molars were examined whilst illuminated from their external surfaces b...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2001.00428.x

    authors: Chandler NP,Pitt Ford TR,Watson TF

    更新日期:2001-10-01 00:00:00

  • Examination on Candida spp. in refractory periapical granulomas.

    abstract:AIM:To examine the occurrence of Candida spp. in refractory periapical granulomas. METHODOLOGY:One hundred and three surgically removed periapical granulomas were subjected to molecular analysis for the occurrence of Candida albicans. DNA was extracted from the samples using a modified phenol/chloroform/isoamyl alcoho...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2003.00707.x

    authors: Waltimo T,Kuusinen M,Järvensivu A,Nyberg P,Väänänen A,Richardson M,Salo T,Tjäderhane L

    更新日期:2003-09-01 00:00:00

  • An in vitro investigation into the effects of retained coronal dentine on the strength of a tooth restored with a cemented post and partial core restoration.

    abstract:AIM:This study aimed to examine the fracture resistance of teeth restored with cast post and partial cores supported by different heights of coronal tooth structure. METHODOLOGY:Four specimen groups were prepared. Group A was the control and consisted of 10 single-rooted teeth restored with post and cores cemented in ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00596.x

    authors: Al-Wahadni A,Gutteridge DL

    更新日期:2002-11-01 00:00:00

  • Apical plug technique using mineral trioxide aggregate: results from a case series.

    abstract:AIM:To examine the clinical and radiographic appearance of teeth that suffered premature interruption of root development and were treated by an mineral trioxide aggregate (MTA) apical plug technique. SUMMARY:Eleven teeth with immature root apices in 11 patients were treated nonsurgically by the manual application of ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2007.01240.x

    authors: Pace R,Giuliani V,Pini Prato L,Baccetti T,Pagavino G

    更新日期:2007-06-01 00:00:00

  • Curved molar root canal preparations using Hero 642 rotary nickel-titanium instruments.

    abstract:AIM:The Bramante method was used to study how the natural curvature of root canals was modified when using the Hero 642 nickel-titanium rotary system. METHODOLOGY:Twenty-four canals were selected in freshly extracted human mandibular molars. Every root canal had an angle of curvature greater than 20 degrees. Roots wer...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2001.00440.x

    authors: Bertrand MF,Lupi-Pégurier L,Médioni E,Muller M,Bolla M

    更新日期:2001-12-01 00:00:00

  • Relationship between unintentional canal overfilling and the long-term outcome of primary root canal treatments and nonsurgical retreatments: a retrospective radiographic assessment.

    abstract:AIM:To determine retrospectively the long-term radiographic outcome of root canal treatments and root canal retreatments with unintentional root canal overfilling. METHODOLOGY:A total of 220 root canal treatments (143 primary/77 retreatments) with postoperative unintentional canal overfilling and performed by two endo...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13209

    authors: Goldberg F,Cantarini C,Alfie D,Macchi RL,Arias A

    更新日期:2020-01-01 00:00:00

  • Canal and isthmus debridement efficacies of two irrigant agitation techniques in a closed system.

    abstract:AIM:To compare canal and isthmus debris debridement efficacies of the manual dynamic irrigation (MDI) and apical negative pressure (ANP) techniques in the mesial root of mandibular first molars with narrow isthmi, using a closed canal design. METHODOLOGY:Micro-computed tomography was employed to select 20 teeth, each ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2010.01778.x

    authors: Susin L,Liu Y,Yoon JC,Parente JM,Loushine RJ,Ricucci D,Bryan T,Weller RN,Pashley DH,Tay FR

    更新日期:2010-12-01 00:00:00

  • A prospective clinical study of Mineral Trioxide Aggregate and IRM when used as root-end filling materials in endodontic surgery.

    abstract:AIM:To assess the success rate of the root-end filling material, Mineral Trioxide Aggregate (MTA). METHODOLOGY:Referred adult patients were recruited using strict entry criteria and randomly allocated to receive MTA or IRM. A standardized surgical technique was employed: the root end was resected perpendicularly and a...

    journal_title:International endodontic journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2591.2003.00682.x

    authors: Chong BS,Pitt Ford TR,Hudson MB

    更新日期:2003-08-01 00:00:00

  • Ex vivo evaluation of the accuracy of two electronic apex locators during root canal length determination in primary teeth.

    abstract:AIM:To evaluate ex vivo the accuracy of two electronic apex locators during root canal length determination in primary incisor and molar teeth with different stages of physiological root resorption. METHODOLOGY:One calibrated examiner determined the root canal length in 17 primary incisors and 16 primary molars (total...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2007.01366.x

    authors: Leonardo MR,Silva LA,Nelson-Filho P,Silva RA,Raffaini MS

    更新日期:2008-04-01 00:00:00

  • Dynamic torque and apical forces of ProFile.04 rotary instruments during preparation of curved canals.

    abstract:AIM:To analyse torque and force generated whilst shaping curved canals using rotary instruments. METHODOLOGY:A specially designed computer-controlled testing platform was used to record events during the shaping of straight and curved canals in plastic blocks and in extracted human teeth using ProFile.04 instruments. ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.0143-2885.2001.00494.x

    authors: Peters OA,Barbakow F

    更新日期:2002-04-01 00:00:00

  • Short- and long-term sealing ability of Gutta-flow and AH-Plus using an ex vivo fluid transport model.

    abstract:AIM:To use the fluid transport model to evaluate the ex vivo short- and long-term microleakage along root canals filled with Gutta-flow or AH-Plus using the cold lateral compaction technique. METHODOLOGY:A total of 38 single-rooted human teeth were used for the assessment of microleakage. The crowns of the teeth were ...

    journal_title:International endodontic journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2591.2010.01689.x

    authors: Vasiliadis L,Kodonas K,Economides N,Gogos C,Stavrianos C

    更新日期:2010-05-01 00:00:00

  • Bacterial localization and viability assessment in human ex vivo dentinal tubules by fluorescence confocal laser scanning microscopy.

    abstract:AIM:To develop a convenient method for the localization and quantification of live and dead bacteria in human ex vivo mineralized dentinal tubules. METHODOLOGY:The roots from human single-rooted teeth (n = 12) were infected with Enterococcus faecalis V583 and either treated with calcium hydroxide paste or left untreat...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01867.x

    authors: Parmar D,Hauman CH,Leichter JW,McNaughton A,Tompkins GR

    更新日期:2011-07-01 00:00:00

  • Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions.

    abstract:AIM:To investigate melatonin (MEL) levels in human dental pulp tissue (hDP) in type 2 diabetic (T2D) participants and the underlying molecular mechanisms of its effects in human dental pulp cells (hDPCs) under hyperglycaemia. METHODOLOGY:The study included 16 healthy and 16 T2D participants who underwent vital pulp ex...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12934

    authors: Milosavljević A,DJukić L,Toljić B,Milašin J,DŽeletović B,Brković B,Roganović J

    更新日期:2018-10-01 00:00:00

  • Atomic force microscopic evaluation of nanostructure alterations of rotary NiTi instruments after immersion in irrigating solutions.

    abstract:AIM:To compare the effect of 5.25% NaOCl or 17% EDTA solutions on the surface topography and roughness of GTX, TF, RaCe and Hero Shaper instruments using atomic force microscopy (AFM) analysis. METHODOLOGY:Four new files of each brand were subjected to AMF analysis; then each group was subdivided into two subgroups (n...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12189

    authors: Fayyad DM,Mahran AH

    更新日期:2014-06-01 00:00:00

  • Histological healing following surgical endodontics and its implications in case assessment: a case report.

    abstract::Following extraction of a symptomatic mandibular premolar which had been subjected to two periradicular surgical procedures, significant apical healing was identified histologically. The implications of these findings are discussed in relation to contemporary advocated treatment regimens, case assessment, and interpre...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.1994.tb00280.x

    authors: Meyers JP,Gutmann JL

    更新日期:1994-11-01 00:00:00

  • A quantitative method for determining the antiwashout characteristics of cement-based dental materials including mineral trioxide aggregate.

    abstract:AIM:To introduce and assess a novel method for measuring washout resistance of cement-based dental materials, including mineral trioxide aggregate (MTA), to qualitatively verify the results with a clinical simulation and to evaluate the washout resistance of a new root-end filling material. METHODOLOGY:A method for as...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2012.02108.x

    authors: Formosa LM,Mallia B,Camilleri J

    更新日期:2013-02-01 00:00:00

  • Periapical changes following root-canal treatment observed 20-27 years postoperatively.

    abstract:AIM:The aim of the present study was to identify periapical changes 20-27 years after root-canal treatment. METHODOLOGY:The periapical condition of 265 roots filled by undergraduate students was evaluated in two series of intraoral radiographs taken 10-17 and 20-27 years after treatment. Roots (72) not recorded with a...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00568.x

    authors: Molven O,Halse A,Fristad I,MacDonald-Jankowski D

    更新日期:2002-09-01 00:00:00

  • Detectability of residual Epiphany and gutta-percha after root canal retreatment using a dental operating microscope and radiographs--an ex vivo study.

    abstract:AIM:To compare the detectability of residual Epiphany and gutta-percha after root canal retreatment using a dental operating microscope and radiographic examination with the residual area measured after rendering the roots transparent. METHODOLOGY:Sixty extracted single-rooted maxillary central incisor teeth were enla...

    journal_title:International endodontic journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2591.2006.01126.x

    authors: Schirrmeister JF,Hermanns P,Meyer KM,Goetz F,Hellwig E

    更新日期:2006-07-01 00:00:00

  • European Society of Endodontology position statement: Management of deep caries and the exposed pulp.

    abstract::This position statement on the management of deep caries and the exposed pulp represents the consensus of an expert committee, convened by the European Society of Endodontology (ESE). Preserving the pulp in a healthy state with sustained vitality, preventing apical periodontitis and developing minimally invasive biolo...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13080

    authors: European Society of Endodontology (ESE) developed by:.,Duncan HF,Galler KM,Tomson PL,Simon S,El-Karim I,Kundzina R,Krastl G,Dammaschke T,Fransson H,Markvart M,Zehnder M,Bjørndal L

    更新日期:2019-07-01 00:00:00

  • Wear profile of canal wall surfaces and bond strength of endodontic sealers after in situ acid challenge.

    abstract:AIM:To evaluate the wear of root wall surfaces, the bond strength of sealers to dentine and the demineralization around root filling materials after canals were exposed to acid challenge in situ. METHODOLOGY:Eighty-seven roots of mandibular incisors were selected. Thirty-two were used in the laboratory bond strength s...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12858

    authors: Silva-Neto RD,Sousa-Neto MD,Pécora JD,Palma-Dibb RG,Souza-Gabriel AE

    更新日期:2018-03-01 00:00:00

  • Effect of EDTA conditioning upon the retention of fibre posts luted with resin cements.

    abstract:AIM:To determine if a final rinse with EDTA improves the short-term in-tooth retentive strength of adhesively luted fibre-reinforced composite posts. METHODOLOGY:Six different commercial fibre post systems were tested. Post spaces in extracted human anterior teeth were irrigated with either 6% NaOCl or 6% NaOCl follow...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2008.01482.x

    authors: Rasimick BJ,Shah RP,Musikant BL,Deutsch AS

    更新日期:2008-12-01 00:00:00

  • Stem/progenitor cell-mediated pulpal tissue regeneration: a systematic review and meta-analysis.

    abstract:BACKGROUND:Stem/progenitor cell-mediated pulpal regeneration could represent a promising therapeutic alternative in the field of clinical endodontics. AIM:The present study aimed to systematically assess and meta-analyse dental pulpal tissue regeneration, pulpal vitality and apical healing after the transplantation of...

    journal_title:International endodontic journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iej.13177

    authors: Fawzy El-Sayed KM,Ahmed GM,Abouauf EA,Schwendicke F

    更新日期:2019-11-01 00:00:00

  • Osteogenic cell response to calcium aluminate-based cement.

    abstract:AIM:To evaluate the effect of a calcium aluminate-based cement (CAC+) on the development of the osteogenic phenotype in vitro. METHODOLOGY:Rat calvaria-derived cells were grown on Thermanox® coverslips for 24 h and then exposed to either samples (4-h set) of CAC+ or mineral trioxide aggregate (MTA) placed on Transwell...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12682

    authors: Castro-Raucci LMS,Teixeira LN,Oliveira IR,Raucci-Neto W,Jacobovitz M,Rosa AL,de Oliveira PT

    更新日期:2017-08-01 00:00:00

  • A maxillary lateral incisor with four root canals.

    abstract:AIM:To describe the successful non-surgical endodontic management of a permanent maxillary lateral incisor tooth with four root canals. SUMMARY:Aberrant morphology of root canals can occur in any tooth, including maxillary lateral incisors. In the presented case, clinical examination and radiographs clearly depicted t...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01984.x

    authors: Kottoor J,Murugesan R,Albuquerque DV

    更新日期:2012-04-01 00:00:00

  • Effect of bleaching agents on bonding to pulp chamber dentine.

    abstract:AIM:To determine the effect of intracoronal bleaching agents on adhesion of bonding agents to pulp chamber dentine. METHODOLOGY:Forty extracted human maxillary anterior teeth were randomly divided into four groups of 10 teeth each. Bleaching agents were sealed in pulp chambers for 7 days, as in clinical use. Group 1 (...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2004.00931.x

    authors: Timpawat S,Nipattamanon C,Kijsamanmith K,Messer HH

    更新日期:2005-04-01 00:00:00

  • Cytotoxicity of resin-, zinc oxide-eugenol-, and calcium hydroxide-based root canal sealers on human periodontal ligament cells and permanent V79 cells.

    abstract:AIM:The purpose of this study was to determine the cytotoxicity of three different types of root canal sealer on human periodontal ligament (PDL) cells and a permanent hamster cell line (V79 cells). METHODOLOGY:Set specimens from two resin based sealers (AH26 and AHPlus), three zinc oxide-eugenol-based sealers (Canals...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00459.x

    authors: Huang FM,Tai KW,Chou MY,Chang YC

    更新日期:2002-02-01 00:00:00

  • Improvement of the fatigue resistance of NiTi endodontic files by surface and bulk modifications.

    abstract:AIM:To assess the failure mechanism of rotary NiTi instruments by chemical, structural and morphological analyses to provide a rational explanation of the effects of surface and bulk treatments on their resistance to fatigue fracture. METHODOLOGY:Thermal treatment (350-500 °C) was performed on electropolished (EP) and...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2010.01759.x

    authors: Condorelli GG,Bonaccorso A,Smecca E,Schäfer E,Cantatore G,Tripi TR

    更新日期:2010-10-01 00:00:00

  • Nitric oxide induces apoptosis in human gingival fibroblast through mitochondria-dependent pathway and JNK activation.

    abstract:AIM:To investigate the molecular mechanisms of nitric oxide (NO)-induced cytotoxic effect in human gingival fibroblast (HGF) cells. METHODOLOGY:After sodium nitroprusside (SNP), as NO donor, was treated to HGF, viability was measured by MTT assay and apoptosis was determined by TUNEL and DNA fragmentation assay. Mitoc...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12314

    authors: Baek MW,Seong KJ,Jeong YJ,Kim GM,Park HJ,Kim SH,Chung HJ,Kim WJ,Jung JY

    更新日期:2015-03-01 00:00:00