Abstract:
:Radiotherapy is ubiquitous in the treatment of patients with both primary brain tumors as well as disease which is metastatic to the brain. This therapy is not without cost, however, as cognitive decline is frequently associated with cranial radiation, particularly with whole brain radiotherapy (WBRT). The precise mechanisms responsible for radiation-induced morbidity remain incompletely understood and continue to be an active area of ongoing research. In this article, we review the hypothetical means by which cranial radiation induces cognitive decline as well as potential therapeutic approaches to prevent, minimize, or reverse treatment-induced cognitive deterioration. We additionally review advances in imaging modalities that can potentially be used to identify site-specific radiation-induced anatomic or functional changes in the brain and their correlation with clinical outcomes.
journal_name
Neuro Oncoljournal_title
Neuro-oncologyauthors
Wilke C,Grosshans D,Duman J,Brown P,Li Jdoi
10.1093/neuonc/nox195subject
Has Abstractpub_date
2018-04-09 00:00:00pages
597-607issue
5eissn
1522-8517issn
1523-5866pii
4554374journal_volume
20pub_type
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