Abstract：
PURPOSE:Previous studies suggest that exercise and heat stress improve cutaneous endothelial function, caused by increases in shear stress. However, as vasodilatation in the skin is primarily a thermogenic phenomenon, we investigated if shear stress alone without increases in skin temperature that occur with exercise and heat stress increases endothelial function. We examined the hypothesis that repeated bouts of brief occlusion would improve cutaneous endothelial function via shear stress-dependent mechanisms. METHODS:Eleven males underwent a shear stress intervention (forearm occlusion 5 s rest 10 s) for 30 min, five times·week-1 for 6 weeks on one arm, the other was an untreated control. Skin blood flow was measured using laser-Doppler flowmetry, and endothelial function was assessed with and without NOS-inhibition with L-NAME in response to three levels of local heating (39, 42, and 44 °C), ACh administration, and reactive hyperaemia. Data are cutaneous vascular conductance (CVC, laser-Doppler/blood pressure). RESULTS:There were no changes in the control arm (all d ≤ 0.2, p > 0.05). In the experimental arm, CVC to 39 °C was increased after 3 and 6 weeks (d = 0.6; p ≤ 0.01). Nitric oxide contribution was increased after 6 weeks compared to baseline (d = 0.85, p < 0.001). Following skin heating to 42 °C and 44 °C, CVC was not different at weeks 3 or 6 (d ≤ 0.8, p > 0.05). For both 42 and 44 °C, nitric oxide contribution was increased after weeks 3 and 6 (d ≥ 0.4, p < 0.03). Peak and area-under-the-curve responses to ACh increased following 6 weeks (p < 0.001). CONCLUSIONS:Episodic increases in shear stress, without changes in skin or core temperature, elicit an increase in cutaneous microvascular reactivity and endothelial function.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Hodges GJ,Stewart DG,Davison PJ,Cheung SSdoi
10.1007/s00421-017-3732-8subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2457-2468issue
12eissn
1439-6319issn
1439-6327pii
10.1007/s00421-017-3732-8journal_volume
117pub_type
杂志文章abstract：:This investigation was undertaken to examine the influence of intensity fluctuation on metabolic responses during and after exercise. Twenty-four males and 24 females were randomly assigned into one of the four groups consisting of 12 subjects of equal gender. Each group performed one of four 30-min exercise protocols...
journal_title：European journal of applied physiology
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