Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence.

abstract：:Neurite formation involves coordinated changes between the actin cytoskeleton and the microtubule network. Rho GTPases are clearly implicated in several aspects of neuronal development and function. Indeed, RhoA is a negative regulator of neurite outgrowth and its effector Rho-kinase mediates the Rho-driven neurite re...

journal_title：Journal of neurochemistry

authors： Talens-Visconti R,Peris B,Guerri C,Guasch RM

更新日期：2010-02-01 00:00:00

abstract：:The protein anosmin-1, coded by the KAL1 gene responsible for the X-linked form of Kallmann syndrome (KS), exerts its biological effects mainly through the interaction with and signal modulation of fibroblast growth factor receptor 1 (FGFR1). We have previously shown the interaction of the third fibronectin-like type ...

journal_title：Journal of neurochemistry

authors： Esteban PF,Murcia-Belmonte V,García-González D,de Castro F

更新日期：2013-03-01 00:00:00

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:Oligodendrocytes are glial cells responsible for the synthesis and maintenance of myelin in the central nervous system (CNS). Oligodendrocytes are vulnerable to damage occurring in a variety of neurological diseases. Understanding oligodendrocyte biology is crucial for the dissemination of de- and remyelination mechan...

journal_title：Journal of neurochemistry

authors： Dumont D,Noben JP,Moreels M,Vanderlocht J,Hellings N,Vandenabeele F,Lambrichts I,Stinissen P,Robben J

更新日期：2007-07-01 00:00:00

abstract：:Preincubation of murine neuroblastoma cells (clone N1E-115) with terbium chloride resulted in a significant potentiation of carbachol-mediated increase in cyclic GMP formation. This effect was accompanied by a shift of the peak response from 30 s to 120 s and a 6-fold decrease in carbachol concentration producing half...

journal_title：Journal of neurochemistry

authors： El-Fakahany EE,Pfenning M,Richelson E

更新日期：1984-03-01 00:00:00

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures. PMA inhibited GPDH induction in both logarithmic- and stationary-phase cells. These eve...

journal_title：Journal of neurochemistry

authors： Bressler JP,Weingarten D,Kornblith PL

更新日期：1985-10-01 00:00:00

abstract：:Release-regulating heterocarriers exist on brain nerve endings. We have investigated in this study the mechanisms involved in the neurotransmitter release evoked by GABA heterocarrier activation. GABA increased the basal release of [3H]acetylcholine and [3H]noradrenaline from rat hippocampal synaptosomes and of [3H]do...

journal_title：Journal of neurochemistry

authors： Fassio A,Bonanno G,Fontana G,Usai C,Marchi M,Raiteri M

更新日期：1996-04-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:Converging lines of evidence implicate the beta-amyloid peptide (Ass) as causative in Alzheimer's disease. We describe a novel class of compounds that reduce A beta production by functionally inhibiting gamma-secretase, the activity responsible for the carboxy-terminal cleavage required for A beta production. These mo...

journal_title：Journal of neurochemistry

authors： Dovey HF,John V,Anderson JP,Chen LZ,de Saint Andrieu P,Fang LY,Freedman SB,Folmer B,Goldbach E,Holsztynska EJ,Hu KL,Johnson-Wood KL,Kennedy SL,Kholodenko D,Knops JE,Latimer LH,Lee M,Liao Z,Lieberburg IM,Motter RN,

更新日期：2001-01-01 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified...

journal_title：Journal of neurochemistry

authors： Nicholson AM,Finch NA,Wojtas A,Baker MC,Perkerson RB 3rd,Castanedes-Casey M,Rousseau L,Benussi L,Binetti G,Ghidoni R,Hsiung GY,Mackenzie IR,Finger E,Boeve BF,Ertekin-Taner N,Graff-Radford NR,Dickson DW,Rademakers R

更新日期：2013-09-01 00:00:00

abstract：:Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF recepto...

journal_title：Journal of neurochemistry

authors： Maher PA,Schubert D

更新日期：1995-10-01 00:00:00

abstract：:The proposed structural protein of peripheral nerve myelin, P0, has been shown to have several covalent modifications. In addition to being glycosylated, sulfated, and acylated, P0 is phosphorylated, with the intracellular site of this latter addition being in question. By employing nerve injury models that exhibit di...

journal_title：Journal of neurochemistry

authors： Brunden KR,Poduslo JF

更新日期：1987-12-01 00:00:00

abstract：:By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H...

journal_title：Journal of neurochemistry

authors： Wang Y,Jia J,Ao G,Hu L,Liu H,Xiao Y,Du H,Alkayed NJ,Liu CF,Cheng J

更新日期：2014-06-01 00:00:00

abstract：:Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intracellular M(1) -mAChRs using both biochemical and pharmacolog...

journal_title：Journal of neurochemistry

authors： Uwada J,Anisuzzaman AS,Nishimune A,Yoshiki H,Muramatsu I

更新日期：2011-09-01 00:00:00

abstract：:High-affinity binding sites for [3H]PK 11195 and [3H]Ro 5-4864 with the properties of the peripheral-type benzodiazepine receptor were detected in primary cultures of both mouse neocortical and cerebellar astrocytes. The binding sites were enriched in mitochondrial fractions on differential centrifugation. An 18-kDa p...

journal_title：Journal of neurochemistry

authors： Moynagh PN,Schousboe A,Williams DC

更新日期：1994-02-01 00:00:00

abstract：:The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding ...

journal_title：Journal of neurochemistry

authors： Sato M,Mori Y,Matsui T,Aoki R,Oya M,Yanagihara Y,Fukuda M,Tsuboi T

更新日期：2010-07-01 00:00:00

abstract：:When synaptosomes from rat brain were incubated with S-adenosylmethionine (10(-3) M), noradrenaline uptake and KCl-stimulated release were decreased. These effects were dependent on MgCl2, temperature, and incubation time. We have investigated the enzymatic methylation of phosphatidylethanolamine to give phosphatidylc...

journal_title：Journal of neurochemistry

authors： Fonlupt P,Rey C,Pacheco H

更新日期：1982-06-01 00:00:00

abstract：:Mutations in Parkin, an E3 ligase, which participates in the ubiquitin-proteasome system (UPS), cause juvenile onset Parkinson's disease (PD). Some mutants aggregate upon over-expression, but the effects of such aggregation on the UPS and neuronal survival have not been characterized. We show in this study that transi...

journal_title：Journal of neurochemistry

authors： Kyratzi E,Pavlaki M,Kontostavlaki D,Rideout HJ,Stefanis L

更新日期：2007-08-01 00:00:00

abstract：:Previous studies from this laboratory have shown that synthesis of GT3, the precursor of c series gangliosides, occurs in proximal Golgi compartments, as has been shown for the synthesis of GM3 and GD3, the precursors of a and b series gangliosides, respectively. In this work we studied whether the synthesis of GM3, G...

journal_title：Journal of neurochemistry

authors： Rosales Fritz VM,Maxzúd MK,Maccioni HJ

更新日期：1996-10-01 00:00:00

abstract：:In this work, we have studied (a) the contents of gangliosides, glycoproteins, and phospholipids of the vesicle and plasma membrane fractions from brains of anesthetized and control rats and chickens and (b) the labeling of gangliosides and glycoproteins in the retina ganglion cell layer and optic tectum of urethane-a...

journal_title：Journal of neurochemistry

authors： Domowicz MS,Kivatinitz SC,Caputto BL,Caputto R

更新日期：1988-05-01 00:00:00

abstract：:The extracellular regulated kinases (ERK) 1 and ERK2 are members of mitogen-activated protein (MAP) kinase family that play an important role in transducing extracellular signals to the nucleus and have been implicated in a broad spectrum of biological responses. To test the hypothesis that MAP kinases may be involved...

journal_title：Journal of neurochemistry

authors： Dwivedi Y,Rizavi HS,Roberts RC,Conley RC,Tamminga CA,Pandey GN

更新日期：2001-05-01 00:00:00

abstract：:The prescribed drugs for treatment of cognitive deficits in Alzheimer's disease (AD) patients are regarded as symptomatic drugs. Effective disease modifying therapies are not yet prescribed in AD patients. Three major hallmarks of AD (e.g. cholinergic hypofunction, Aβ and tau neuropathologies) are closely linked raisi...

journal_title：Journal of neurochemistry

authors： Fisher A

更新日期：2012-01-01 00:00:00

abstract：:Copper/zinc-superoxide dismutase (CuZn-SOD) transgenic mice overexpress the gene for human CuZn-SOD. To assess the effects of the overexpression of CuZn-SOD on the brain scavenging systems, we have measured the activities of manganese-SOD (Mn-SOD), catalase, and glutathione peroxidase (GSH-Px) in various regions of th...

journal_title：Journal of neurochemistry

authors： Przedborski S,Jackson-Lewis V,Kostic V,Carlson E,Epstein CJ,Cadet JL

更新日期：1992-05-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:The binding of [3H]5-hydroxytryptamine (5-HT, serotonin) to cerebellar membranes was examined after preincubation of [3H]5-HT in the presence or absence of ascorbate. The tissue preparation was identical in all experiments and consisted of rat cerebellar homogenates in Tris-HCl buffer with 0.1% ascorbate. Cerebellar m...

journal_title：Journal of neurochemistry

authors： Peroutka SJ,Ison PJ,Liu DU,Barrett RW

更新日期：1986-07-01 00:00:00

abstract：:Although the excitatory action of GABA has been shown to activate the expression of brain-derived neurotrophic factor (BDNF), its molecular mechanisms remain unclear. Using cultured rat cortical cells, we here demonstrated that GABA induced Bdnf mRNA expression mainly via L-type voltage-dependent Ca(2+) channels (L-VD...

journal_title：Journal of neurochemistry

authors： Fukuchi M,Kirikoshi Y,Mori A,Eda R,Ihara D,Takasaki I,Tabuchi A,Tsuda M

更新日期：2014-10-01 00:00:00

abstract：:Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brai...

journal_title：Journal of neurochemistry

authors： Sumners C,Watkins LL,Raizada MK

更新日期：1986-10-01 00:00:00

abstract：:Despite considerable efforts to unravel the role of cellular prion protein (PrP(C)) in neuronal functions, the mechanisms by which PrP(C) takes part in the homeostasis of a defined neuronal phenotype remain poorly characterized. By taking advantage of a neuroectodermal cell line (1C11) endowed with the capacity to dif...

journal_title：Journal of neurochemistry

authors： Pradines E,Loubet D,Mouillet-Richard S,Manivet P,Launay JM,Kellermann O,Schneider B

更新日期：2009-08-01 00:00:00

abstract：:We investigated the molecular events triggered by NMDA and 3,5-dihydroxyphenylglycine (DHPG) preconditioning, that lead to neuroprotection against excitotoxic insults (AMPA or oxygen and glucose deprivation) in rat organotypic hippocampal slices, with particular attention on glutamate receptors and on cannabinoid syst...

journal_title：Journal of neurochemistry

authors： Gerace E,Zianni E,Landucci E,Scartabelli T,Berlinguer Palmini R,Iezzi D,Moroni F,Di Luca M,Mannaioni G,Gardoni F,Pellegrini-Giampietro DE

更新日期：2020-04-28 00:00:00