Study roadmap for high-throughput development of easy to use and affordable biomarkers as diagnostics for tropical diseases: a focus on malaria and schistosomiasis.

Abstract:

BACKGROUND:Interventions are currently being used against 'infectious diseases of poverty', which remain highly debilitating and deadly in most endemic countries, especially malaria, schistosomiasis, echinococcosis and African sleeping sickness. However, major limitations of current 'traditional' methods for diagnosis are neither simple nor convenient for population surveillance, and showed low sensitivity and specificity. Access to novel technologies for the development of adequate and reliable tools are expressly needed. A collaborative project between African Network for Drugs and Diagnostics Innovation and partner institutions in Africa and China aims to screen suitable serological biomarkers for diagnostic pipelines against these 'diseases of the poor'. METHODS:Parasite-specific exposed versus unexposed individuals were screened and sera or urine/stools were collected through case-control studies in China and African countries. Target genes/open reading frames were selected, then will be cloned and cell-free expressed, quantified and immuno-detected. Target antigens/epitopes will be probed and screened with sera from exposed or unexposed individuals using a high-throughput antigen screening platform as the study progresses. The specificity and sensitivity of highly immunoreactive biomarkers will be evaluated as well, using enzyme-linked immunosorbent assays or dipsticks. DISCUSSION:This roadmap explicitly unfolds the integrated operating procedures with focus on malaria and schistosomiasis, for the identification of suitable biomarkers that will aid the prioritization of diagnostics for population use. However, there is need to further validate any new diagnostic through comparison with standard methods in field deployable tests for each region. Our expectations for the future are to seek regulatory approval and promote the use of diagnostics in endemic areas.

journal_name

Infect Dis Poverty

authors

Kassegne K,Zhang T,Chen SB,Xu B,Dang ZS,Deng WP,Abe EM,Shen HM,Hu W,Guyo TG,Nwaka S,Chen JH,Zhou XN

doi

10.1186/s40249-017-0344-9

subject

Has Abstract

pub_date

2017-10-02 00:00:00

pages

130

issue

1

eissn

2095-5162

issn

2049-9957

pii

10.1186/s40249-017-0344-9

journal_volume

6

pub_type

杂志文章
  • Report of the first international workshop on onchocerciasis-associated epilepsy.

    abstract:BACKGROUND:Recently, several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy (OAE) may constitute an important but neglected public health problem in many countries where onchocerciasis is still endemic. MAIN TEXT:On October 12-14th 2017, ...

    journal_title:Infectious diseases of poverty

    pub_type: 社论

    doi:10.1186/s40249-018-0400-0

    authors: Colebunders R,Mandro M,Njamnshi AK,Boussinesq M,Hotterbeekx A,Kamgno J,O'Neill S,Hopkins A,Suykerbuyk P,Basáñez MG,Post RJ,Pedrique B,Preux PM,Stolk WA,Nutman TB,Idro R

    更新日期:2018-03-22 00:00:00

  • Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa: a review.

    abstract::Mechanisms and outcomes of host-parasite interactions during malaria co-infections with gastrointestinal helminths are reasonably understood. In contrast, very little is known about such mechanisms in cases of malaria co-infections with tissue-dwelling parasites. This is lack of knowledge is exacerbated by misdiagnosi...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s40249-015-0070-0

    authors: Onkoba NW,Chimbari MJ,Mukaratirwa S

    更新日期:2015-08-29 00:00:00

  • Effect of temperature on the Bulinus globosus - Schistosoma haematobium system.

    abstract:BACKGROUND:Given that increase in temperature may alter host-parasite relationships, the anticipated rise in temperature due to global warming might change transmission patterns of certain diseases. However, the extent to which this will happen is not well understood. METHODS:Using a host-parasite system involving Bul...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-017-0260-z

    authors: Kalinda C,Chimbari MJ,Mukaratirwa S

    更新日期:2017-05-01 00:00:00

  • Changes in the epidemiology of hepatitis A in three socio-economic regions of China, 1990-2017.

    abstract:BACKGROUND:Hepatitis A (HepA) vaccination and economic transitions can change the epidemiology of HepA. China's Gross Domestic Product (GDP) per capita was known to be inversely associated with the incidence of HepA, but a deeper understanding of the epidemiology of HepA in different socio-economic regions is lacking. ...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-019-0591-z

    authors: Sun XJ,Zhang GM,Zhou RJ,Zheng H,Miao N,Yin ZD,Wang FZ

    更新日期:2019-10-03 00:00:00

  • Onchocerca volvulus as a risk factor for developing epilepsy in onchocerciasis endemic regions in the Democratic Republic of Congo: a case control study.

    abstract:BACKGROUND:A high prevalence of epilepsy has been observed in onchocerciasis endemic areas in the Democratic Republic of Congo (DRC). With this study we aimed to investigate whether Onchocerca volvulus infection is a risk factor for developing epilepsy in onchocerciasis endemic regions in the DRC. METHODS:Between Octo...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s40249-018-0465-9

    authors: Mandro M,Suykerbuyk P,Tepage F,Rossy D,Ngave F,Hasan MN,Hotterbeekx A,Mambandu G,Kashama JM,Laudisoit A,Colebunders R

    更新日期:2018-10-08 00:00:00

  • Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China: a hospital-based study.

    abstract:BACKGROUND:The prevalence of infection with Toxoplasma gondii (T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease (HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is know...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-015-0088-3

    authors: Wang S,Lan C,Zhang L,Zhang H,Yao Z,Wang D,Ma J,Deng J,Liu S

    更新日期:2015-12-10 00:00:00

  • Household perceptions and subjective valuations of indoor residual spraying programmes to control malaria in northern Uganda.

    abstract:BACKGROUND:Insecticide-based tools remain critical for controlling vector-borne diseases in Uganda. Securing public support from targeted populations for such tools is an important component in sustaining their long-run effectiveness. Yet little quantitative evidence is available on the perceived benefits and costs of ...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-016-0190-1

    authors: Brown ZS,Kramer RA,Ocan D,Oryema C

    更新日期:2016-10-06 00:00:00

  • Malaria over-diagnosis in Cameroon: diagnostic accuracy of Fluorescence and Staining Technologies (FAST) Malaria Stain and LED microscopy versus Giemsa and bright field microscopy validated by polymerase chain reaction.

    abstract:BACKGROUND:Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-017-0251-0

    authors: Parsel SM,Gustafson SA,Friedlander E,Shnyra AA,Adegbulu AJ,Liu Y,Parrish NM,Jamal SA,Lofthus E,Ayuk L,Awasom C,Henry CJ,McArthur CP

    更新日期:2017-04-04 00:00:00

  • Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China.

    abstract:BACKGROUND:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. CASE PRESENTATION:We present the c...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-00707-1

    authors: Song SH,Chen TL,Deng LP,Zhang YX,Mo PZ,Gao SC,Hu WJ,Xiong Y,Ma ZY

    更新日期:2020-07-02 00:00:00

  • Malaria epidemiology in Kobeni department, southeastern Mauritania from 2015 to 2017.

    abstract:BACKGROUND:Plasmodium falciparum malaria is endemic in the southern sahelian zone of Mauritania where intense internal and trans-border human and livestock movement occurs. The risk of importation and spread of drug-resistant parasites need to be regularly assessed in this region. The objective of the study was to asse...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-0634-5

    authors: Diallo SM,Bogreau H,Papa Mze N,Ould Ahmedou Salem MS,Ould Khairy ML,Parola P,Basco L,Ould Mohamed Salem Boukhary A

    更新日期:2020-02-12 00:00:00

  • Correction to: prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa.

    abstract::Unfortunately, the original article [1] contained some errors. The table title of Tables 4, 5, 6, 7 were interchanged by mistake and displayed incorrectly in the article. The correct table titles of Tables 4, 5, 6, 7 can be found below. ...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s40249-018-0415-6

    authors: M'bondoukwé NP,Kendjo E,Mawili-Mboumba DP,Lengongo JVK,Mbouoronde CO,Nkoghe D,Touré F,Bouyou-Akotet MK

    更新日期:2018-04-20 00:00:00

  • Disability progression among leprosy patients released from treatment: a survival analysis.

    abstract:BACKGROUND:Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT,...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-00669-4

    authors: Dos Santos AR,Silva PRS,Steinmann P,Ignotti E

    更新日期:2020-05-24 00:00:00

  • Why more research needs to be done on echinococcosis in Pakistan.

    abstract:BACKGROUND:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent. Due to the frequent outbreaks in different parts of Pakistan in the recent past, echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic dis...

    journal_title:Infectious diseases of poverty

    pub_type: 信件

    doi:10.1186/s40249-017-0309-z

    authors: Ahmed H,Ali S,Afzal MS,Khan AA,Raza H,Shah ZH,Simsek S

    更新日期:2017-07-03 00:00:00

  • Are tuberculosis patients adherent to prescribed treatments in China? Results of a prospective cohort study.

    abstract:BACKGROUND:Tuberculosis (TB) patients face numerous difficulties adhering to the long-term, rigorous TB treatment regimen. Findings on TB patients' treatment adherence vary across existing literature and official reports. The present study attempted to determine the actual treatment adherence of new TB patients and to ...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-016-0134-9

    authors: Lei X,Huang K,Liu Q,Jie YF,Tang SL

    更新日期:2016-05-05 00:00:00

  • Neglected tropical diseases and global burden of disease in China.

    abstract::Recently, the mortality of 240 causes in China including a subnational analysis during 1990-2013 was published in The Lancet. This comprehensive analysis will undoubtedly impact policymaking regarding public health in China. However, it is unfavourable in some degree to neglected tropical diseases, which is the subjec...

    journal_title:Infectious diseases of poverty

    pub_type: 信件

    doi:10.1186/s40249-017-0237-y

    authors: Qian MB

    更新日期:2017-02-03 00:00:00

  • Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory.

    abstract:BACKGROUND:The outbreak of Ebola virus disease (EVD) in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus (EBOV) in 1976, and the countries most strongly affected were Sierra Leone, Guinea, and Liberia. FINDINGS:The Sierra Leone-China Friendship Biological Safety La...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-016-0154-5

    authors: Wang Q,Zhou WM,Zhang Y,Wang HY,Du HJ,Nie K,Song JD,Xiao K,Lei WW,Guo JQ,Wei HJ,Cai K,Wang YH,Wu J,Kamara G,Kamara I,Wei Q,Liang MF,Wu GZ,Dong XP

    更新日期:2016-06-23 00:00:00

  • Risk factors affecting the mortality of HIV-infected patients with pulmonary tuberculosis in the cART era: a retrospective cohort study in China.

    abstract:BACKGROUND:Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries. Knowledge of the survival of HIV-infected patients with pulmonary tuberculosis (PTB) would provide important insights for the clinical management of this population, which remains to be wel...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-018-0405-8

    authors: Ji YJ,Liang PP,Shen JY,Sun JJ,Yang JY,Chen J,Qi TK,Wang ZY,Song W,Tang Y,Liu L,Zhang RF,Shen YZ,Lu HZ

    更新日期:2018-03-24 00:00:00

  • Accessing the syndemic of COVID-19 and malaria intervention in Africa.

    abstract:BACKGROUND:The pandemic of the coronavirus disease 2019 (COVID-19) has caused substantial disruptions to health services in the low and middle-income countries with a high burden of other diseases, such as malaria in sub-Saharan Africa. The aim of this study is to assess the impact of COVID-19 pandemic on malaria trans...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-00788-y

    authors: Shi B,Zheng J,Xia S,Lin S,Wang X,Liu Y,Zhou XN,Liu J

    更新日期:2021-01-07 00:00:00

  • Correction to: Routinely detected indicators in plasma have a predictive effect on the identification of HIV-infected patients with non-tuberculous mycobacterial and tuberculous infections.

    abstract:CORRECTION:After publication of this article [1] it came to our attention that the affiliation of Jun Chen and Hong-zhou Lu were incorrectly shown.Jun Chen's affiliation should have been given as Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.Hong-zhou Lu sh...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s40249-017-0376-1

    authors: Cai RT,Yu FX,Tao Z,Qian XQ,Chen J,Lu HZ

    更新日期:2017-11-23 00:00:00

  • Burden, risk assessment, surveillance and management of SARS-CoV-2 infection in health workers: a scoping review.

    abstract:BACKGROUND:Health workers (HWs) are at increased risk for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and a possible source of nosocomial transmission clusters. Despite the increased risk, the best surveillance strategy and management of exposed HWs are not yet well known. The aim of this rev...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,评审

    doi:10.1186/s40249-020-00756-6

    authors: Calò F,Russo A,Camaioni C,De Pascalis S,Coppola N

    更新日期:2020-10-07 00:00:00

  • A case of human infection with a novel Babesia species in China.

    abstract:BACKGROUND:Babesiosis is an uncommon but emerging tick-borne disease caused by the genus Babesia. In this case study, we report a case of human infection with a novel Babesia sp. in China. FINDINGS:The patient in question had been suffering from repetitive occurrences of mild fever of unknown origin and fatigue for 10...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-016-0121-1

    authors: Man SQ,Qiao K,Cui J,Feng M,Fu YF,Cheng XJ

    更新日期:2016-03-29 00:00:00

  • The global spread of Zika virus: is public and media concern justified in regions currently unaffected?

    abstract:BACKGROUND:Zika virus, an Aedes mosquito-borne flavivirus, is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in Brazil. DISCUSSION:Prior to its emergence in Latin America in 2015-2016, Zika was known to exist at a re...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-016-0132-y

    authors: Gyawali N,Bradbury RS,Taylor-Robinson AW

    更新日期:2016-04-19 00:00:00

  • Helminths of veterinary and zoonotic importance in Nigerian ruminants: a 46-year meta-analysis (1970-2016) of their prevalence and distribution.

    abstract:BACKGROUND:The livestock industry plays a vital role in the economy of Nigeria. It serves as a major source of income and livelihood for majority of Nigerians who are rural settlers and contributes about 5.2% to the National Gross Domestic Product (GDP). Helminths however, cause economic losses due to reductions in mil...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,meta分析

    doi:10.1186/s40249-018-0438-z

    authors: Karshima SN,Maikai BV,Kwaga JKP

    更新日期:2018-05-29 00:00:00

  • Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil.

    abstract:BACKGROUND:Although preventable and curable, tuberculosis (TB) still occurs in poor or developing countries, mainly in metropolitan regions of larger cities. The disease is a serious public health problem, and is directly linked to social issues. We analyzed temporal trend variations in areas at risk for concomitant TB...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-00732-0

    authors: Bruce ATI,Berra TZ,Dos Santos FL,Alves YM,Souza LLL,Ramos ACV,Arroyo LH,de Almeida Crispim J,Pinto IC,Palha PF,Monroe AA,Yamamura M,Fiorati RC,Moncaio ACS,de Oliveira Gomes DM,Arcêncio RA

    更新日期:2020-08-10 00:00:00

  • Ecohealth research in Southeast Asia: past, present and the way forward.

    abstract::Ecohealth is a comprehensive approach to understanding health at its human, animal and environmental interface in a socio-ecological systems context. This approach was introduced widely in Southeast Asia (SEA) by the Canadian International Development Research Centre (IDRC) in the late 2000s. Aimed at addressing the p...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/2049-9957-4-5

    authors: Nguyen-Viet H,Doria S,Tung DX,Mallee H,Wilcox BA,Grace D

    更新日期:2015-01-29 00:00:00

  • First detection of F1534C knockdown resistance mutation in Aedes aegypti (Diptera: Culicidae) from Cameroon.

    abstract:BACKGROUND:Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon. Here, we present the nationwide distribution of insect...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-020-00769-1

    authors: Yougang AP,Kamgang B,Bahun TAW,Tedjou AN,Nguiffo-Nguete D,Njiokou F,Wondji CS

    更新日期:2020-11-02 00:00:00

  • Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria.

    abstract:BACKGROUND:The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs). This post analyses is aimed to evaluate changes in early treatment response markers...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-019-0577-x

    authors: Sowunmi A,Ntadom G,Akano K,Ibironke FO,Ayede AI,Agomo C,Folarin OA,Gbotosho GO,Happi C,Oguche S,Okafor HU,Meremikwu M,Agomo P,Ogala W,Watila I,Mokuolu O,Finomo F,Ebenebe JC,Jiya N,Ambe J,Wammanda R,Emechebe G,

    更新日期:2019-08-06 00:00:00

  • Strongyloidiasis in Ethiopia: systematic review on risk factors, diagnosis, prevalence and clinical outcomes.

    abstract:BACKGROUND:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides stercoralis. It is estimated to infect up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic disadvantage. MAIN BODY:This systematic literature review ide...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-019-0555-3

    authors: Terefe Y,Ross K,Whiley H

    更新日期:2019-06-14 00:00:00

  • Efforts to mitigate the economic impact of the COVID-19 pandemic: potential entry points for neglected tropical diseases.

    abstract:BACKGROUND:The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted and economic growth has already evaporated, giving rise to a global recession, the likes of which w...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章,评审

    doi:10.1186/s40249-020-00790-4

    authors: Ehrenberg JP,Utzinger J,Fontes G,da Rocha EMM,Ehrenberg N,Zhou XN,Steinmann P

    更新日期:2021-01-04 00:00:00

  • Risk factors of sexually transmitted infections among female sex workers in Republic of Korea.

    abstract:BACKGROUND:Female sex workers (FSW) who live in urban areas in Republic of Korea have a particularly high risk of sexually transmitted diseases (STD). We investigated the prevalence of s STDs in FSWs in order to determine the factors associated with sexually transmitted infections in Korea. METHODS:Study data were col...

    journal_title:Infectious diseases of poverty

    pub_type: 杂志文章

    doi:10.1186/s40249-019-0516-x

    authors: Jung M

    更新日期:2019-01-22 00:00:00