Abstract:
BACKGROUND:Interventions are currently being used against 'infectious diseases of poverty', which remain highly debilitating and deadly in most endemic countries, especially malaria, schistosomiasis, echinococcosis and African sleeping sickness. However, major limitations of current 'traditional' methods for diagnosis are neither simple nor convenient for population surveillance, and showed low sensitivity and specificity. Access to novel technologies for the development of adequate and reliable tools are expressly needed. A collaborative project between African Network for Drugs and Diagnostics Innovation and partner institutions in Africa and China aims to screen suitable serological biomarkers for diagnostic pipelines against these 'diseases of the poor'. METHODS:Parasite-specific exposed versus unexposed individuals were screened and sera or urine/stools were collected through case-control studies in China and African countries. Target genes/open reading frames were selected, then will be cloned and cell-free expressed, quantified and immuno-detected. Target antigens/epitopes will be probed and screened with sera from exposed or unexposed individuals using a high-throughput antigen screening platform as the study progresses. The specificity and sensitivity of highly immunoreactive biomarkers will be evaluated as well, using enzyme-linked immunosorbent assays or dipsticks. DISCUSSION:This roadmap explicitly unfolds the integrated operating procedures with focus on malaria and schistosomiasis, for the identification of suitable biomarkers that will aid the prioritization of diagnostics for population use. However, there is need to further validate any new diagnostic through comparison with standard methods in field deployable tests for each region. Our expectations for the future are to seek regulatory approval and promote the use of diagnostics in endemic areas.
journal_name
Infect Dis Povertyjournal_title
Infectious diseases of povertyauthors
Kassegne K,Zhang T,Chen SB,Xu B,Dang ZS,Deng WP,Abe EM,Shen HM,Hu W,Guyo TG,Nwaka S,Chen JH,Zhou XNdoi
10.1186/s40249-017-0344-9subject
Has Abstractpub_date
2017-10-02 00:00:00pages
130issue
1eissn
2095-5162issn
2049-9957pii
10.1186/s40249-017-0344-9journal_volume
6pub_type
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journal_title:Infectious diseases of poverty
pub_type: 社论
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,已发布勘误
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
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pub_type: 杂志文章
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
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journal_title:Infectious diseases of poverty
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