Abstract：
:To investigate the optimal dosage which can improve clinical efficacy and minimize resistance, pharmacokinetics/pharmacodynamics model of enrofloxacin was established. Effect of enrofloxacin treatments on clearance of Salmonella in experimentally infected chickens and simultaneously resistance selection in Salmonella and coliforms were evaluated in three treatment groups (100, PK/PD designed dosage of 4, 0.1 mg/kg b.w.) and a control group. Treatment duration was three rounds of 7-day treatment alternated with 7-day withdrawal. Results showed that 100 mg/kg b.w. of enrofloxacin completely eradicated Salmonella, but resistant coliforms (4.0-60.8%) were selected from the end of the second round's withdrawal period till the end of the experiment (days 28-42). PK/PD based dosage (4 mg/kg b.w.) effectively reduced Salmonella for the first treatment duration. However upon cessation of medication, Salmonella repopulated chickens and persisted till the end with reduced susceptibility (MICCIP = 0.03-0.25 mg/L). Low frequency (5-9.5%) of resistant coliforms was selected (days 39-42). Enrofloxacin at dosage of 0.1 mg/kg b.w. was not able to eliminate Salmonella and selected coliforms with slight decreased susceptibility (MICENR = 0.25 mg/L). In conclusion, short time treatment (7 days) of enrofloxacin at high dosage (100 mg/kg b.w.) could be effective in treating Salmonella infection while minimizing resistance selection in both Salmonella and coliforms.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li J,Hao H,Cheng G,Wang X,Ahmed S,Shabbir MAB,Liu Z,Dai M,Yuan Zdoi
10.1038/s41598-017-12294-7subject
Has Abstractpub_date
2017-09-15 00:00:00pages
11676issue
1issn
2045-2322pii
10.1038/s41598-017-12294-7journal_volume
7pub_type
杂志文章abstract：:Duck Tembusu virus (DTMUV), a mosquito-borne Flavivirus, has caused serious economic losses for the Chinese poultry industry. The genome is translated into a polyprotein that is cleaved to mature protein by host and viral proteases in the host cell, and this proteolytic process is important for the viral life cycle. H...
journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52913-z
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pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-03-24 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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更新日期：2017-01-25 00:00:00
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更新日期：2018-09-11 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
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更新日期：2015-06-03 00:00:00
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journal_title：Scientific reports
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