Abstract:
BACKGROUND:Although FGF19 gene aberrations are associated with carcinogenesis and progression in human cancers, the roles of FGF19 genetic amplification and expression in Chinese patients with lung squamous cell carcinoma (LSCC) and FGF19 amplification as a potential therapeutic target for LSCC are not well understood. METHODS:Fluorescence in situ hybridization analysis and quantitative real-time-PCR was used to detect FGF19 genetic amplification and FGF19 messenger RNA expression in LSCC tumor and paired adjacent samples. Small interfering RNA and short hairpin RNA were used to knockdown FGF19 in vitro and in vivo. RESULTS:FGF19 amplification was identified in a subset of LSCC patients (37.5%, 15/40), and upregulation of FGF19 expression was found in 60% (24/40) of tumor tissues compared to adjacent non-tumorous tissues. Correlation analysis with clinicopathologic parameters showed that FGF19 upregulation was significantly associated with heavy smoking. Small interfering RNA knockdown of FGF19 led to the significant inhibition of cell growth and induced apoptosis in LSCC cells carrying the amplified FGF19 gene, but these effects was not observed in non-amplified LSCC cells. Interfering FGF19 expression with short hairpin RNA also resulted in tumor growth inhibition and induced apoptosis in LSCC xenografts with amplified FGF19 in tumor cells. CONCLUSION:Our results suggested that FGF19 signaling activation is required for cell growth and survival of FGF19 amplified LSCC cells, both in vitro and in vivo. Intervention of FGF19 activation could be a potential therapeutic strategy for LSCC patients with FGF19 amplification.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Zhang X,Kong M,Zhang Z,Xu S,Yan F,Wei L,Zhou Jdoi
10.1111/1759-7714.12504subject
Has Abstractpub_date
2017-11-01 00:00:00pages
655-665issue
6eissn
1759-7706issn
1759-7714journal_volume
8pub_type
杂志文章相关文献
Thoracic Cancer文献大全abstract::This article features the case study of a 32-year-old female patient who had undergone surgery to remove a cervical spine tumor and who later developed cervical esophagus necrosis secondary to the erosion caused by an osteosynthesis 13 years after her prosthetic cervical surgery. Barium swallow did not show anything a...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/j.1759-7714.2012.00112.x
更新日期:2013-02-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used in patients with EGFR-mutant lung cancer. Meanwhile, thermal ablation such as microwave ablation has been an option for selected patients. Herein, we describe three cases of pneumothorax that occurred in microwave ablation (MWA) ...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13466
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The abundance of tumor infiltrating CD8 T cells is an important parameter for antitumor effect of PD-1/PD-L1 immune checkpoint inhibitors, which is less in epidermal growth factor receptor (EGFR) mutation than wild-type non-small cell lung cancer (NSCLC). The mechanism still requires further study. METHODS:...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13504
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:This study was conducted to investigate the gene expression profiles associated with thymoma to better understand the molecular mechanism underlying the pathogenesis of thymoma. METHODS:Eight patients with thymomas (type A, AB, B1, and B2) and four controls with thymic cysts were analyzed using microarray p...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13053
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The combination of EGFR tyrosine kinase inhibitors (TKIs) and chemotherapy is thought to increase treatment efficacy in non-small-cell lung cancer (NSCLC). This study investigated the efficacy and potential mechanisms of different combined modes of icotinib plus pemetrexed in EGFR-mutant lung adenocarcinoma ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12818
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Increasing evidence has demonstrated that circular RNAs (circRNAs) may play an important role in oncogenesis and tumor development; however, their role in lung adenocarcinoma (LUAD) remains unclear. We identified the differentially expressed circRNAs in LUAD and investigated the potential mechanisms for canc...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12761
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Tumor recurrence or residual tumor after targeted therapy is common in patients with advanced non-small cell lung cancer (NSCLC). There is a lack of high-level evidence on which type of treatment should be employed for these patients and the role of salvage surgery has not been well reported in the literatur...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13366
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the characteristics of active anti-cancer treatment (AAT) compared with best supportive care (BSC) in elderly patients with advanced non-small cell lung cancer (NSCLC). METHODS:A retrospective analysis of 144 patients, aged 70 or older, with stage IIIb/IV NSCLC from 672 patients...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12066
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the cytotoxic and antitumor activity of spider venom (SV). METHODS:Cell proliferation and cytotoxicity were determined by 3 H-methyl thymidine incorporation ([3 H]-TDR) assay. DNA fragmentation and cell cycle kinetics were analyzed by FACS. In vivo inhibition of tumor s...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12020
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:We investigated the effect of micro-RNA 24 (miR-24) and WWOX on non-small cell lung cancer (NSCLC) cell proliferation and migration in vitro and in vivo. METHODS:We performed bioinformatics analysis and 3' untranslated region luciferase assay to investigate the direct target of miR-24. Proliferation, apopto...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12824
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The study was conducted to compare the clinicopathological characteristics, survival outcomes, and metastatic patterns between pulmonary large cell neuroendocrine carcinoma (LCNEC) and other non-small cell lung cancer (ONSCLC), and to identify the prognostic factors of LCNEC. METHODS:Data of patients diagno...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12993
更新日期:2019-04-01 00:00:00
abstract::ROS1 rearrangement is a validated therapeutic driver gene in non-small cell lung cancer (NSCLC) and represents a small subset (1-2%) of NSCLC. A total of 17 different fusion partner genes of ROS1 in NSCLC have been reported. The multi-targeted MET/ALK/ROS1 tyrosine kinase inhibitor (TKI) crizotinib has demonstrated re...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.12617
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:To compare the efficiency and toxicity of bevacizumab by intrapleural or intravenous infusion in the management of malignant pleural effusion in patients with non-small-cell lung cancer (NSCLC). METHODS:Sensitizing mutation negative NSCLC patients with malignant pleural effusion were randomized into two gro...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13238
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Vagus nerve and recurrent laryngeal nerve (RLN) injury are not rare complications of lung cancer surgery and can cause lethal consequences. Until now, no optimal method other than paying greater attention during surgery has been available. METHODS:Four patients underwent lung surgery that involved RLN or va...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12619
更新日期:2018-05-01 00:00:00
abstract::Fundamental treatment for papillary thyroid carcinoma (PTC) involves total or subtotal thyroidectomy. Iodine-131 ((131)I) is routinely utilized to target remnant thyroid cancer and metastasis after thyroidectomy. The effectiveness of other therapeutic modalities remains unsatisfactory; thus, these patients have a poor...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12277
更新日期:2015-11-01 00:00:00
abstract::After sternal tumor resection, reconstruction of chest wall defects is still a challenging part of thoracic surgery. Three-dimensional (3D)-printed titanium alloy prosthesis implants provide an effective solution. The bionic bone trabecular micropore structure, which is beneficial to the human body, increases stabilit...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13655
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Advanced non-small cell lung cancer (NSCLC) has a high mortality rate and poor prognosis. However, outcomes have gradually improved after the introduction of novel immunotherapies, including immune checkpoint inhibitors (ICIs). Although programmed death-ligand 1 (PD-L1) expression in tumor tissues is a known...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13653
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:CalliSpheres are drug-eluting beads used for tumor artery embolization, with clinical benefits in a number of cancer types. The aim of the study was to examine the clinical benefits and complications of patients with stage II-IV lung cancer treated with CalliSpheres drug-eluting beads for embolization versus...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13522
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Breast cancer (BC) is a common cancer in women worldwide. Emerging evidence has indicated that circular RNA hsa-circ_0007255 (circ_0007255) is a prognostic mediator in BC progression. However, the functional role of circ_0007255 needs to be determined. METHODS:The expression of circ_0007255, microRNA (miR)-...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13306
更新日期:2020-03-01 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy-related adverse effects (irAEs) caused by activated autoreactive T cells. Glucocorticoids are the mainstream therapy for irAEs. However, the usage, dosage and c...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13589
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Plasmid construction of small fragments of interest (such as insertion of small fragment marker genes, expression of shRNA, siRNA, etc) is the basis of many biomolecular experiments. Here, we describe a method to clone short DNA into vectors by polymerase chain reaction (PCR), named one-step PCR cloning. Our...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13660
更新日期:2020-11-01 00:00:00
abstract::In the past decade, a dramatic shift has been witnessed in cancer therapy in China. Although traditional cytotoxic chemotherapy still remains the treatment of choice for many malignancies, targeted therapies are now a component of treatment for many types of cancer, including lung cancer. As molecular target agents ar...
journal_title:Thoracic cancer
pub_type: 杂志文章,评审
doi:10.1111/1759-7714.12243
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Despite recent advances in treating non-small cell lung cancer (NSCLC) with immune checkpoint inhibitors (ICIs), their role in ALK-positive NSCLC patients is unclear. We investigated the efficacy of ICIs in patients with ALK-positive NSCLC. METHODS:Between 2011 and 2018, a total of 14 ALK-positive NSCLC pat...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13195
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Our recent studies have indicated that miR-153-3p is downregulated in the esophageal squamous cell carcinoma (ESCC) cell lines and tissues. Upregulation of miR-153-3p was found to inhibit migration and invasion of ESCC cells. However, whether miR-153-3p regulates the cisplatin sensitivity in ESCC cells remai...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13326
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Currently, there are no standard regimens for metastatic breast cancer patients (MBC) who have failed ≥ 3 chemotherapy treatments. The aim of this study was to assess whether weekly low-dose bevacizumab-based regimens were well tolerated and would improve efficacy in MBC patients who had failed numerous ther...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12627
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Achaete-scute homolog 1 (ASCL1) is a basic helix-loop-helix transcription factor and is essential in the differentiation of neuroendocrine cells and neural tissues. ASCL1 is frequently overexpressed in small cell lung cancer (SCLC) and plays a crucial role in the pathogenesis of SCLC. METHODS:This study was...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13212
更新日期:2020-01-01 00:00:00
abstract::Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing the interflow of gas and liquid. Despite advances in surgical methods and the development of multimodal therapy in recent years, patients with acquired respiratory-digestive tract fistulas c...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12856
更新日期:2018-11-01 00:00:00
abstract::Both crizotinib and osimertinib have been reported to have an adverse effect of interstitial pneumonitis in the treatment of non-small cell lung cancer (NSCLC). Here, we report the case of a 60-year-old male patient with advanced NSCLC resistant to osimertinib. Crizotinib was administered in combination with osimertin...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13785
更新日期:2021-01-12 00:00:00
abstract::Tyrosine kinase inhibitors are used as first-line treatment for non-small cell lung cancer (NSCLC) patients harboring driver mutations in EGFR, ALK, ROS1, and BRAF. Currently, standard molecular testing approaches help identify single genes for such targetable driver mutations in NSCLC; however, next-generation sequen...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13694
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12454
更新日期:2017-07-01 00:00:00