Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9.

abstract：:Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (journal_title：eLife

authors： Rousseaux MW,Revelli JP,Vázquez-Vélez GE,Kim JY,Craigen E,Gonzales K,Beckinghausen J,Zoghbi HY

更新日期：2018-06-04 00:00:00

abstract：:Rodents are emerging as increasingly popular models of visual functions. Yet, evidence that rodent visual cortex is capable of advanced visual processing, such as object recognition, is limited. Here we investigate how neurons located along the progression of extrastriate areas that, in the rat brain, run laterally to...

journal_title：eLife

authors： Tafazoli S,Safaai H,De Franceschi G,Rosselli FB,Vanzella W,Riggi M,Buffolo F,Panzeri S,Zoccolan D

更新日期：2017-04-11 00:00:00

abstract：:SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...

journal_title：eLife

authors： Daniel JA,Cooper BH,Palvimo JJ,Zhang FP,Brose N,Tirard M

更新日期：2017-06-09 00:00:00

abstract：:D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally expressing the isoforms in dopamine neurons of D2 receptor knockout mice, th...

journal_title：eLife

authors： Gantz SC,Robinson BG,Buck DC,Bunzow JR,Neve RL,Williams JT,Neve KA

更新日期：2015-08-26 00:00:00

abstract：:Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this influences tumour formation, we chemically induced tumours in EPI-/- mice, which lack three barrier proteins-Envoplakin, Periplakin, and Involucrin. EPI-/- mic...

journal_title：eLife

authors： Cipolat S,Hoste E,Natsuga K,Quist SR,Watt FM

更新日期：2014-05-05 00:00:00

abstract：:Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animal...

journal_title：eLife

authors： Sakurai A,Tamvacakis AN,Katz PS

更新日期：2014-06-11 00:00:00

abstract：:Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activat...

journal_title：eLife

authors： Palomo-Guerrero M,Fadó R,Casas M,Pérez-Montero M,Baena M,Helmer PO,Domínguez JL,Roig A,Serra D,Hayen H,Stenmark H,Raiborg C,Casals N

更新日期：2019-12-23 00:00:00

abstract：:Many marine animals, ranging from corals to fishes, synchronise reproduction to lunar cycles. In the annelid Platynereis dumerilii, this timing is orchestrated by an endogenous monthly (circalunar) clock entrained by moonlight. Whereas daily (circadian) clocks cause extensive transcriptomic and proteomic changes, the ...

journal_title：eLife

authors： Schenk S,Bannister SC,Sedlazeck FJ,Anrather D,Minh BQ,Bileck A,Hartl M,von Haeseler A,Gerner C,Raible F,Tessmar-Raible K

更新日期：2019-02-15 00:00:00

abstract：:A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarde...

journal_title：eLife

authors： Jagannathan M,Cummings R,Yamashita YM

更新日期：2018-03-26 00:00:00

abstract：:Transparent reporting is essential for the critical evaluation of studies. However, the reporting of statistical methods for studies in the biomedical sciences is often limited. This systematic review examines the quality of reporting for two statistical tests, t-tests and ANOVA, for papers published in a selection of...

journal_title：eLife

authors： Weissgerber TL,Garcia-Valencia O,Garovic VD,Milic NM,Winham SJ

更新日期：2018-12-21 00:00:00

abstract：:The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...

journal_title：eLife

authors： Kim KW,Tang NH,Piggott CA,Andrusiak MG,Park S,Zhu M,Kurup N,Cherra SJ 3rd,Wu Z,Chisholm AD,Jin Y

更新日期：2018-11-21 00:00:00

abstract：:Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified extensive afferent synaptic inputs to OPCs residing in secondary m...

journal_title：eLife

authors： Mount CW,Yalçın B,Cunliffe-Koehler K,Sundaresh S,Monje M

更新日期：2019-10-18 00:00:00

abstract：:Cells use multiple feedback controls to regulate metabolism in response to nutrient and signaling inputs. However, feedback creates the potential for unstable network responses. We examined how concentrations of key metabolites and signaling pathways interact to maintain homeostasis in proliferating human cells, using...

journal_title：eLife

authors： Hung YP,Teragawa C,Kosaisawe N,Gillies TE,Pargett M,Minguet M,Distor K,Rocha-Gregg BL,Coloff JL,Keibler MA,Stephanopoulos G,Yellen G,Brugge JS,Albeck JG

更新日期：2017-12-14 00:00:00

abstract：:Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein ...

journal_title：eLife

authors： Chau KF,Shannon ML,Fame RM,Fonseca E,Mullan H,Johnson MB,Sendamarai AK,Springel MW,Laurent B,Lehtinen MK

更新日期：2018-05-10 00:00:00

abstract：:The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...

journal_title：eLife

authors： Wack A

更新日期：2018-05-24 00:00:00

abstract：:To restore vision for the blind, several prosthetic approaches have been explored that convey raw images to the brain. So far, these schemes all suffer from a lack of bandwidth. An alternate approach would restore vision at the cognitive level, bypassing the need to convey sensory data. A wearable computer captures vi...

journal_title：eLife

authors： Liu Y,Stiles NR,Meister M

更新日期：2018-11-27 00:00:00

abstract：:Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration ...

journal_title：eLife

authors： Sinigaglia C,Peron S,Eichelbrenner J,Chevalier S,Steger J,Barreau C,Houliston E,Leclère L

更新日期：2020-09-07 00:00:00

abstract：:Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown how native TA proteins on mitochondria and peroxisomes evade Msp1 surv...

journal_title：eLife

authors： Weir NR,Kamber RA,Martenson JS,Denic V

更新日期：2017-09-14 00:00:00

abstract：:Accurate protein localization is crucial to generate and maintain organization in all cells. Achieving accuracy is challenging, as the molecular signals that dictate a protein's cellular destination are often promiscuous. A salient example is the targeting of an essential class of tail-anchored (TA) proteins, whose so...

journal_title：eLife

authors： Rao M,Okreglak V,Chio US,Cho H,Walter P,Shan SO

更新日期：2016-12-07 00:00:00

abstract：:hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid spine of hIAPP. Usin...

journal_title：eLife

authors： Krotee P,Rodriguez JA,Sawaya MR,Cascio D,Reyes FE,Shi D,Hattne J,Nannenga BL,Oskarsson ME,Philipp S,Griner S,Jiang L,Glabe CG,Westermark GT,Gonen T,Eisenberg DS

更新日期：2017-01-03 00:00:00

abstract：:The organization and biophysical properties of the cytosol implicitly govern molecular interactions within cells. However, little is known about mechanisms by which cells regulate cytosolic properties and intracellular diffusion rates. Here, we demonstrate that the intracellular environment of budding yeast undertakes...

journal_title：eLife

authors： Joyner RP,Tang JH,Helenius J,Dultz E,Brune C,Holt LJ,Huet S,Müller DJ,Weis K

更新日期：2016-03-22 00:00:00

abstract：:Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...

journal_title：eLife

authors： Chang JT,Kumsta C,Hellman AB,Adams LM,Hansen M

更新日期：2017-07-04 00:00:00

abstract：:The progenitor cells of the developing liver can differentiate toward both hepatocyte and biliary cell fates. In addition to the established roles of TGFβ and Notch signaling in this fate specification process, there is increasing evidence that liver progenitors are sensitive to mechanical cues. Here, we utilized micr...

journal_title：eLife

authors： Kaylan KB,Berg IC,Biehl MJ,Brougham-Cook A,Jain I,Jamil SM,Sargeant LH,Cornell NJ,Raetzman LT,Underhill GH

更新日期：2018-12-27 00:00:00

abstract：:Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate whole-brain gene delivery by retro-orbital injection of virus, but slow and sparse expression and the large injection volumes required make this approach cumbersom...

journal_title：eLife

authors： Hamodi AS,Martinez Sabino A,Fitzgerald ND,Moschou D,Crair MC

更新日期：2020-05-18 00:00:00

abstract：:Evolutionary changes in transcription networks are an important source of diversity across species, yet the quantitative consequences of network evolution have rarely been studied. Here we consider the transcriptional 'rewiring' of the three GAL genes that encode the enzymes needed for cells to convert galactose to gl...

journal_title：eLife

authors： Dalal CK,Zuleta IA,Mitchell KF,Andes DR,El-Samad H,Johnson AD

更新日期：2016-09-10 00:00:00

abstract：:Coat protein complex II (COPII) mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. The inner COPII proteins bind to cargo and membrane, linking them to the outer COPII components that form a cage around the vesicle. Regulated flexibility in coat architect...

journal_title：eLife

authors： Zanetti G,Prinz S,Daum S,Meister A,Schekman R,Bacia K,Briggs JA

更新日期：2013-09-17 00:00:00

abstract：:Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. Here we present the 1.8 Å resolution crystal structure of the Chlamydomonas IFT-B protein IFT80, which reveals the architecture of two N-terminal β-propelle...

journal_title：eLife

authors： Taschner M,Lorentzen A,Mourão A,Collins T,Freke GM,Moulding D,Basquin J,Jenkins D,Lorentzen E

更新日期：2018-04-16 00:00:00

abstract：:INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cβ, PLCβ), a key step for the fast kinetics of the light...

journal_title：eLife

authors： Ye F,Huang Y,Li J,Ma Y,Xie C,Liu Z,Deng X,Wan J,Xue T,Liu W,Zhang M

更新日期：2018-12-10 00:00:00

abstract：:Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest ...

journal_title：eLife

authors： van den Berg R,Anandalingam K,Zylberberg A,Kiani R,Shadlen MN,Wolpert DM

更新日期：2016-02-01 00:00:00

abstract：:Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples from The Cancer Ge...

journal_title：eLife

authors： Grosso AR,Leite AP,Carvalho S,Matos MR,Martins FB,Vítor AC,Desterro JM,Carmo-Fonseca M,de Almeida SF

更新日期：2015-11-17 00:00:00