Abstract:
BACKGROUND:The Paris System for Reporting Urinary Cytology represents a significant improvement in classification of urinary specimens. The system acknowledges the difficulty in cytologically diagnosing low-grade urothelial carcinomas and has developed categories to deal with this issue. The system uses six categories: unsatisfactory, negative for high-grade urothelial carcinoma (NHGUC), atypical urothelial cells, suspicious for high-grade urothelial carcinoma, high-grade urothelial carcinoma, other malignancies and a seventh subcategory (low-grade urothelial neoplasm). METHODS:Three hundred and fifty-seven urine specimens were independently reviewed by four cytopathologists unaware of the previous diagnoses. Each cytopathologist rendered a diagnosis according to the Paris System categories. Agreement was assessed using absolute agreement and weighted chance-corrected agreement (kappa). Disagreements were classified as low impact and high impact based on the potential impact of a misclassification on clinical management. RESULTS:The average absolute agreement was 65% with an average expected agreement of 44%. The average chance-corrected agreement (kappa) was 0.32. Nine hundred and ninety-nine of 1902 comparisons between rater pairs were in agreement, but 12% of comparisons differed by two or more categories for the category NHGUC. Approximately 15% of the disagreements were classified as high clinical impact. CONCLUSIONS:Our findings indicated that the scheme recommended by the Paris System shows adequate precision for the category NHGUC, but the other categories demonstrated unacceptable interobserver variability. This low level of diagnostic precision may negatively impact the applicability of the Paris System for widespread clinical application.
journal_name
Cytojournaljournal_title
CytoJournalauthors
Long T,Layfield LJ,Esebua M,Frazier SR,Giorgadze DT,Schmidt RLdoi
10.4103/cytojournal.cytojournal_12_17subject
Has Abstractpub_date
2017-07-24 00:00:00pages
17eissn
0974-5963issn
1742-6413pii
CJ-14-17journal_volume
14pub_type
杂志文章相关文献
CytoJournal文献大全abstract::Breast augmentation with implantation represents a challenge for subsequent radiographic imaging and pathological sampling. Fine-needle aspiration biopsy (FNAB) is an excellent technique to sample suspicious lesions that are adjacent to fragile implants. We report a case of a 51-year-old woman with breast implants pre...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.149844
更新日期:2015-01-22 00:00:00
abstract::Ki-67 (MIB-1) immunostaining to quantify the proliferative index of neuroendocrine tumors (NETs) has been recommended (especially for small biopsies). However, this has a number of challenges with nonrepresentative Ki-67 index due to interference by Ki-67 immunoreactive proliferating lymphocytes infiltrating the tumor...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.25259/Cytojournal_92_2019
更新日期:2020-03-31 00:00:00
abstract::To analyze the impact of using a hand held fan to speed the air-drying process during immediate adequacy evaluation of Fine Needle Aspirations. The effect on turn around time and staining quality is evaluated. Two mirror image air-dried smears for each pass were prepared. One was subjected to a small hand-held fan wit...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-3-12
更新日期:2006-04-19 00:00:00
abstract:BACKGROUND:Nodular fasciitis (NF) is a benign myofibroblastic proliferation in soft tissue. The most common sites are extremities, followed by the trunk and head and neck region. It is infrequently seen in the post-auricular region of pinna. CASE PRESENTATION:We present here an interesting case of a young male who had...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.44242
更新日期:2008-11-26 00:00:00
abstract::Urachal carcinoma is rare comprising less than 1% of all bladder carcinomas. Metastases of urachal carcinoma have been reported to meninges, brain, ovary, lung, and maxilla. Cytologic features of metastatic urachal carcinoma have not been previously reported. We present a case of metastatic urachal adenocarcinoma in b...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.106684
更新日期:2013-01-31 00:00:00
abstract:BACKGROUND:Pancreatic neuroendocrine tumors (PNETs) are rare tumors of the pancreas, which are increasingly diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this retrospective study, we assessed the performance of EUS-FNA in diagnosing PNETs. MATERIALS AND METHODS:We identified 48 cases o...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.112648
更新日期:2013-05-29 00:00:00
abstract::Visceral leishmaniasis (VL), also known as kala-azar, is a life-threatening systemic disease caused by the obligate intracellular protozoan, Leishmania, and transmitted to humans by the female phlebotomine sand fly (Phlebotomus argentipes). The disease is fatal, if left untreated. We report a case of a patient clinica...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.205312
更新日期:2017-04-28 00:00:00
abstract:OBJECTIVE:The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The pur...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-3-14
更新日期:2006-05-10 00:00:00
abstract:BACKGROUND:Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of ne...
journal_title:CytoJournal
pub_type: 杂志文章,评审
doi:10.4103/1742-6413.143304
更新日期:2014-10-21 00:00:00
abstract:BACKGROUND:Hashimoto's thyroiditis (HT) is an autoimmune disease and it is more prevalent in Asians. The incidence of HT seems to be increasing in the recent times. It is one of the most common cause of hypothyroidism. The purpose of this study is to review the cytomorphologic spectrum of HT and correlate it with clini...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.131741
更新日期:2014-04-29 00:00:00
abstract::BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological features quite similar to other small round blue cells tumors. We described four cases of DSRCT with cytological sampling: one obt...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-2-6
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:Death from cancer is high in Sudan, with low survival rates, as most of the patients present with advanced disease. Most patients receive high and repeated doses of radiotherapy or chemotherapy. The aim of this study was to investigate the feasibility of using cytological evaluation to detect oral epithelial...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.51332
更新日期:2009-05-16 00:00:00
abstract:BACKGROUND:Multiple Myeloma presenting as a pleural effusion is extremely rare. It is usually a late complication and is associated with a poor prognosis. CASE PRESENTATION:A 40-year-old male presented with dyspnea and fever of six months duration. Clinical diagnosis of pulmonary tuberculosis was considered. X-ray che...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-4-17
更新日期:2007-09-07 00:00:00
abstract:BACKGROUND:Next-generation sequencing (NGS) with a multi-gene panel is now available for patients with lung adenocarcinoma, but the performance characteristics and clinical utility of this testing are not well-described. We present the results of an extended 467 gene panel in a series of advanced, highly selected nonsm...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.202602
更新日期:2017-03-20 00:00:00
abstract:BACKGROUND:Methanol fixed and paraffin embedded (MFPE) cellblocks are an essential cytology preparation. However, MFPE cellblocks often contain limited material and their relatively small size has caused them to be overlooked in biomarker discovery. Advances in the field of molecular biotechnology have made it possible...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.122299
更新日期:2013-11-28 00:00:00
abstract::Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystoure...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.95528
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The most common site for the metastasis of papillary carcinoma of the thyroid (PTC) is regional lymph nodes. Ultrasound (US) imaging may identify abnormal appearing lymph nodes, suspicious for PTC recurrence. Although fine needle aspiration biopsy (FNAB) of abnormal lymph nodes is often diagnostic of recur...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-5-1
更新日期:2008-01-31 00:00:00
abstract:Objective:Squamous cell carcinoma (SCC) rarely causes malignant effusions. Distinguishing between SCC and adenocarcinoma in effusion cytology can be a challenge. p63 and p40 have been frequently used to support squamous cell differentiation in both histological and cytological specimens. However, similar results in cyt...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.25259/Cytojournal_78_2019
更新日期:2020-06-08 00:00:00
abstract::Paragangliomas (PGLs) are uncommon tumors. Although PGLs are known to occur in the head and neck region, especially the carotid body, middle ear, and larynx, involvement of the parotid glands has not been reported. In this article, we report the fine needle aspiration features of tumor in an unusual location, presenti...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.105119
更新日期:2012-01-01 00:00:00
abstract::[This corrects the article on p. 15 in vol. 13, PMID: 27563338.]. ...
journal_title:CytoJournal
pub_type: 已发布勘误
doi:10.4103/1742-6413.192192
更新日期:2016-10-13 00:00:00
abstract::BACKGROUND: Anal smears are increasingly being used as a screening test for anal squamous intraepithelial lesions (ASILs). This study was undertaken to assess the usefulness and limitations of anal smears in screening for ASILs. METHODS: The cytomorphological features of 200 consecutive anal smears collected in liquid...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-2-4
更新日期:2005-02-16 00:00:00
abstract::Most of the scientific work presented as abstracts (platforms and posters) at various conferences have the potential to be published as articles in peer-reviewed journals. This DIY (Do It Yourself) article on how to achieve that goal is an extension of the symposium presented at the 36(th) European Congress of Cytolog...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.92545
更新日期:2012-01-01 00:00:00
abstract::Amyloidomas are rare tumors composed of deposits of amyloid protein not associated with systemic amyloidosis. They can present as an initial manifestation of a systemic disease process or can be a completely localized phenomenon. We present a case of amyloidoma associated with insulin injection site found incidentally...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.161602
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:To evaluate and compare the role of Ziehl-Neelsen (ZN) staining and mycobacterial culture in diagnosis of tuberculous lymphadenitis. MATERIALS AND METHODS:A total of 56 fine needle aspirations (FNAs) from patients who were clinically suspected to have tuberculous lymphadenitis were included. Acid-fast Bacil...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.187070
更新日期:2016-07-27 00:00:00
abstract::The Pap smear is one of the modern success stories in the field of preventive medicine. Since its introduction as a screening test, there has been a dramatic reduction in the incidence of cervical cancer. However, the search for a better screening test continues. The new technologies, including liquid-based cytology (...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-4-16
更新日期:2007-08-16 00:00:00
abstract::Cell-blocks are paraffin-embedded versions of cytology specimens comparable to the formalin-fixed paraffin-embedded (FFPE) tissue from surgical pathology specimens. They allow various elective ancillary studies on a variety of specimens with enhanced cytopathologic interpretation, including opportunity to perform mole...
journal_title:CytoJournal
pub_type: 杂志文章,评审
doi:10.4103/cytojournal.cytojournal_20_19
更新日期:2019-06-28 00:00:00
abstract:Background:Leishmaniasis is the prevalent in tropical and subtropical regions of the world. Demonstration of Leishman-Donovan (LD) bodies in the bone marrow aspirates (BMA) is vital to diagnosis of visceral leishmaniasis (VL). In the present study, we studied the clinicohematological parameters encountered in VL and co...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/cytojournal.cytojournal_38_17
更新日期:2018-08-27 00:00:00
abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial fine-needle aspiration is a minimally invasive technique for diagnosis of mediastinal lesions. Although most studies have reported the utility of EBUS-FNA in malignancy, its use has been extended to the benign conditions as well. OBJECTIVE:To evaluate the diagn...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.165947
更新日期:2015-09-22 00:00:00
abstract:BACKGROUND:Desmoplastic melanoma is a variant of malignant melanoma that can range in appearance from sarcomatoid to scar-like. Cytomorphology of desmoplastic melanoma has been previously described on conventional smears; however, to our knowledge, detailed cytomorphology on ThinPrep has so far not been described. Here...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-4-18
更新日期:2007-09-19 00:00:00
abstract:BACKGROUND:Research and publications are critical to advancements in the quality of healthcare delivery. This article attempts to highlight the prospects and challenges of fine needle aspiration (FNA) cytology as a tool for research in Nigeria. MATERIALS AND METHODS:Data available in local and international bibliograp...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.82277
更新日期:2011-01-01 00:00:00