当前位置： SCI文献检索 > Pharmacognosy Magazine期刊下所有文献 > Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana.

Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana.

Abstract：

AIMS:The study is conducted to evaluate the immunomodulatory, cytotoxicity, and antioxidant potential of Ziziphus mauritiana (Rhamnaceae). Phytochemical analysis of Z. mauritiana revealed the presence of alkaloids, anthraquinone glycoside, cardiac glycoside, saponin, tannin, and flavonoids. METHODOLOGY:The cytotoxicity of the plant Z. mauritiana was evaluated by brine shrimp lethality test. Antioxidant parameters such as superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) levels were calculated in the plasma of rats after chronic administration of 400 mg/kg of Z. mauritiana for 6 weeks. RESULTS:The dichloromethane extract of the plant exhibited significant immunomodulatory activity, with inhibitory concentration 50% of 55.43 ± 7.9. The dichloromethane extracts of the plant showed 70% mortality at concentration 1000 μg/ml. SOD and T-AOC levels were increased while MDA level in the plasma was reduced in the plasma of rats treated with dichloromethane Z. mauritiana. CONCLUSION:This can be deduced that the root of Z. mauritiana has immunomodulatory, cytotoxic, and antioxidant potential. SUMMARY:Roots of Z. mauritiana was exhibited immunomodulator, cytotoxic and antioxidant activitiesZ. mauritiana showed potential antioxidant activity in rats Abbreviations used: SOD: Superoxide dismutase; T-AOC: Total antioxidant capacity; MDA: Malondialdehyde; ZMRD: Z. mauritiana root extract of dichloromethane fraction; LD50: Z. mauritiana root extract of methanol fraction ZMRM, lethal dose 50.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Afzal S,Batool M,Ch BA,Ahmad A,Uzair M,Afzal K

doi

10.4103/pm.pm_398_16

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

S262-S265

issue

Suppl 2

eissn

0973-1296

issn

0976-4062

pii

PM-13-262

journal_volume

13

pub_type

杂志文章

相关文献

Pharmacognosy Magazine文献大全