Abstract:
:The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin, the main risk factors are female gender and advanced age. Likewise, morphological changes in several glands and in the chemical composition of their secretions, such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors that maintain a steady ocular surface. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic inflammation that involves the ocular surface. DE syndrome is one of the most commonly encountered diseases in clinical practice, and many other causes related to daily life and the increase in average life expectancy will contribute to its onset. This review will consider the disorders of the ocular surface that give rise to such a widespread pathology. At the end, the most recent therapeutic options for the management of DE will be briefly discussed according to the specific underlying pathology.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Nebbioso M,Del Regno P,Gharbiya M,Sacchetti M,Plateroti R,Lambiase Adoi
10.3390/ijms18081764subject
Has Abstractpub_date
2017-08-13 00:00:00issue
8issn
1422-0067pii
ijms18081764journal_volume
18pub_type
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