Abstract:
OBJECTIVE:It was uncertain whether an algorithm that involves increasing insulin dosages by 1 unit/day may cause more hypoglycemia with the longer-acting insulin glargine 300 units/mL (GLA-300). The objective of this study was to compare safety and efficacy of 2 titration algorithms, INSIGHT and EDITION, for GLA-300 in people with uncontrolled type 2 diabetes mellitus, mainly in a primary care setting. METHODS:This was a 12-week, open-label, randomized, multicentre pilot study. Participants were randomly assigned to 1 of 2 algorithms: they either increased their dosage by 1 unit/day (INSIGHT, n=108) or the dose was adjusted by the investigator at least once weekly, but no more often than every 3 days (EDITION, n=104). The target fasting self-monitored blood glucose was in the range of 4.4 to 5.6 mmol/L. RESULTS:The percentages of participants reaching the primary endpoint of fasting self-monitored blood glucose ≤5.6 mmol/L without nocturnal hypoglycemia were 19.4% (INSIGHT) and 18.3% (EDITION). At week 12, 26.9% (INSIGHT) and 28.8% (EDITION) of participants achieved a glycated hemoglobin value of ≤7%. No differences in the incidence of hypoglycemia of any category were noted between algorithms. Participants in both arms of the study were much more satisfied with their new treatment as assessed by the Diabetes Treatment Satisfaction Questionnaire. Most health-care professionals (86%) preferred the INSIGHT over the EDITION algorithm. The frequency of adverse events was similar between algorithms. CONCLUSIONS:A patient-driven titration algorithm of 1 unit/day with GLA-300 is effective and comparable to the previously tested EDITION algorithm and is preferred by health-care professionals.
journal_name
Can J Diabetesjournal_title
Canadian journal of diabetesauthors
Yale JF,Berard L,Groleau M,Javadi P,Stewart J,Harris SBdoi
10.1016/j.jcjd.2017.06.007subject
Has Abstractpub_date
2017-10-01 00:00:00pages
478-484issue
5eissn
1499-2671issn
2352-3840pii
S1499-2671(17)30014-Xjournal_volume
41pub_type
杂志文章,多中心研究,随机对照试验abstract::Cerebral edema (CE) is a rare but potentially fatal complication of diabetic ketoacidosis (DKA) in children with type 1 diabetes. CE is frequently mentioned as being more common in young children. The primary objective of this study was to review the evidence suggesting that younger age is a risk factor for the develo...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2019.04.013
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:East African (EA) women are a subpopulation who are at very high risk for gestational diabetes (GDM) and poor obstetric outcomes, but little is known about the care experiences of this understudied group. The objective of this study was to document the impact of a diagnosis of GDM and the perceptions of diab...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2018.01.013
更新日期:2018-12-01 00:00:00
abstract::The importance of glycemic control in hospitalized patients has been a relatively recent revelation. There is somewhat contradictory evidence concerning the optimal glycemic target in critically ill patients. There is only indirect evidence in non-critically ill patients. This article reviews the evidence for glycemic...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2014.01.001
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:Hypokalemia, a frequently cited complication of diabetic ketoacidosis (DKA) treatment, can have critical implications, including arrhythmias and death. We assessed the prevalence of hypokalemia and its associated factors in patients with DKA at our tertiary-care centre and identified opportunities to improve...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2015.10.002
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Examining the diets of people living with type 2 diabetes may improve understanding of how diet affects disease progression. We derived dietary patterns in adults living with type 2 diabetes and explored associations among patterns, sociodemographic variables and cardiometabolic risk factors. METHODS:Dietar...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2015.11.006
更新日期:2016-08-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF), a member of neurotrophin growth factor family, physiologically mediates induction of neurogenesis and neuronal differentiation, promotes neuronal growth and survival and maintains synaptic plasticity and neuronal interconnections. Unlike the central nervous system, its secreti...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2016.08.228
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in p...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2015.01.004
更新日期:2015-08-01 00:00:00
abstract::Patients with diabetes who are in emerging adulthood, defined as the life stage between 18 and 29 years of age, have unique challenges in managing their illness and are at risk for acute complications and loss to follow up. This study's objective was to describe emergency department (ED) utilization because of hypergl...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2017.06.016
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:With the expanding armamentarium of noninsulin therapies for type 2 diabetes mellitus, the use of insulin with various oral agents is becoming more common. In this study, we assessed the efficacy and cardiovascular (CV) safety of the dipeptidyl peptidase-4 inhibitor linagliptin as add-on to insulin in patient...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcjd.2015.06.010
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:There are currently no recommendations on following the ketogenic diet (KD) in the context of diabetes and, therefore, health-care professionals may not be comfortable in supporting this dietary regimen. In this qualitative study, we aim to understand the perspective of patients with diabetes when following ...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2020.06.016
更新日期:2020-06-27 00:00:00
abstract:OBJECTIVES:South Asian immigrants are generally healthy upon arrival, but precipitously develop diabetes after immigration. Whether cultural and psychosocial factors contribute to diabetes risk in this ethnic minority group remains unclear. Existing prediction models focus primarily on clinical and lifestyle factors. T...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2019.04.015
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The effects of hyperglycemia and normoglycemia on gallbladder emptying have not been studied in detail. This prospective case-control study was designed to investigate the gallbladder ejection fraction in patients with newly detected diabetes and to assess the impact of restoring normoglycemia on gallbladder ...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2014.07.223
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:This study describes associations between depressive symptoms and indices of obesity in a community sample of adults with prediabetes. The strengths of these associations were compared to those observed in individuals with normal blood glucose levels. METHODS:Cross-sectional data came from the baseline asse...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2018.05.005
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:No research to date has compared the beliefs of adolescents, parents and physicians with respect to type 1 diabetes mellitus self-care perceptions and barriers. This study examined how adolescents with type 1 diabetes, their parents and physicians perceive 4 key diabetes self-care behaviours (testing blood gl...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2013.02.057
更新日期:2013-06-01 00:00:00
abstract::Glucagon-like peptide-1 receptor agonists and sodium-dependent glucose cotransporter-2 inhibitors have demonstrated clinically significant benefits on glycated hemoglobin, weight, blood pressure and cardiorenal outcomes. The emerging evidence from clinical trials and meta-analyses that assessed the combination of thes...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2020.09.005
更新日期:2020-09-14 00:00:00
abstract:OBJECTIVE:To explore perspectives on the meaning of health to Aboriginal adults and youth living in a northern Manitoba First Nations community. METHODS:Six focus groups with 29 youth and individual interviews with 10 adults were audio-recorded, transcribed verbatim and thematically analyzed. RESULTS:Adults and older...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/S1499-2671(08)22008-3
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether perinatal outcomes differ between Caucasian and Asian subgroups of women with gestational diabetes mellitus (GDM) through use of standard vs ethnicity-specific birthweight curves. METHODS:This retrospective cohort study included 537 women with GDM, within the et...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2019.06.006
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Routine food insecurity screening is recommended in diabetes care to inform more tailored interventions that better support diabetes self-management among food-insecure patients. This pilot study explored the acceptability and feasibility of a food insecurity screening initiative within a diabetes care setti...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2017.06.004
更新日期:2018-06-01 00:00:00
abstract::While dysglycemia (hyperglycemia, hypoglycemia and glucose variability) is clearly associated with increased mortality in critically ill patients, target range of blood glucose control remains controversial. Standardized insulin infusion protocols constitute the basis of treatment of these patients. The choice of prot...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.jcjd.2014.01.016
更新日期:2014-04-01 00:00:00
abstract::The most common presentation of chronic disease is multimorbidity. Disease management strategies are similar across most chronic diseases. Given the prevalence of multimorbidity and the commonality in approaches, fragmented single disease management must be replaced with integrated care of the whole person. The Albert...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2013.04.001
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD becaus...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2016.07.005
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To enhance the dietary education presented to women with gestational diabetes (GDM) by exploring the reasons and experiences that women with GDM reported in making their food-choice decisions after receipt of dietary education from a healthcare professional. METHODS:Food Choice Map (FCM) semi-structured in-d...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2013.08.263
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:People with type 2 diabetes and increased systolic blood pressure (SBP) are at high risk of cardiovascular disease (CVD). In this study, we aimed to investigate the association between CVD-related hospital payments and SBP and tested whether this association is influenced by diabetes peer support. METHODS:T...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2020.07.008
更新日期:2020-08-10 00:00:00
abstract:OBJECTIVE:The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS:Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and we...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2017.03.003
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:New-onsetdiabetes after transplant (NODAT) is a major contributor to cardiovascular disease after transplantation. Kidney transplantation (KT) recipients have low levels of exercise capacity. Resistance training (RT) might be of special benefit in this population because underlying disease and immunosuppress...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2015.08.014
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:This article describes a qualitative research study that examines the encounters by patients of low socioeconomic status with a group medical visit (GMV) program for individuals with or at risk for diabetes. The goal of this study was to generate insights that could be used to guide the development of an inne...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2014.03.012
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To examine the relationship of inadequate health literacy (HL) with changes in depressive symptoms, health-related quality of life and cardiometabolic outcomes in patients with type 2 diabetes mellitus recently screened positive for depression. METHODS:Secondary analysis of data from a clinical trial (N=154)...
journal_title:Canadian journal of diabetes
pub_type: 临床试验,杂志文章
doi:10.1016/j.jcjd.2014.11.005
更新日期:2015-08-01 00:00:00
abstract::Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMe...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章,meta分析
doi:10.1016/j.jcjd.2017.12.002
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:We evaluated the prevalence of type 2 diabetes, obesity and metabolic syndrome according to International Diabetes Federation criteria in the First Nations Cree community of Mistissini, Quebec. METHODS:A cross-sectional study of 172 adults was performed as part of a broader regional environmental study. RES...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/S1499-2671(09)33006-3
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Diabetes frequently coexists with other conditions, resulting in poorer diabetes self-management and quality of life, higher risk for diabetes-related complications and higher health service use compared to those with diabetes only. Few Canadian studies have undertaken a comprehensive, population-level analy...
journal_title:Canadian journal of diabetes
pub_type: 杂志文章
doi:10.1016/j.jcjd.2015.09.002
更新日期:2016-02-01 00:00:00