Abstract:
BACKGROUND:Kawasaki disease, which is characterised by systemic vasculitides accompanied by acute fever, is regularly treated by intravenous immunoglobulin to avoid lesion formation in the coronary artery; however, the mechanism of intravenous immunoglobulin therapy is unclear. Hence, we aimed to analyse the global expression profile of serum exosomal proteins before and after administering intravenous immunoglobulin. METHODS:Two-dimensional electrophoresis coupled with mass spectrometry analysis was used to identify the differentially expressed proteome of serum exosomes in patients with Kawasaki disease before and after intravenous immunoglobulin therapy. RESULTS:Our analysis revealed 69 differential protein spots in the Kawasaki disease group with changes larger than 1.5-fold and 59 differential ones in patients after intravenous immunoglobulin therapy compared with the control group. Gene ontology analysis revealed that the acute-phase response disappeared, the functions of the complement system and innate immune response were enhanced, and the antibacterial humoral response pathway of corticosteroids and cardioprotection emerged after administration of intravenous immunoglobulin. Further, we showed that complement C3 and apolipoprotein A-IV levels increased before and decreased after intravenous immunoglobulin therapy and that the insulin-like growth factor-binding protein complex acid labile subunit displayed reverse alteration before and after intravenous immunoglobulin therapy. These observations might be potential indicators of intravenous immunoglobulin function. CONCLUSIONS:Our results show the differential proteomic profile of serum exosomes of patients with Kawasaki disease before and after intravenous immunoglobulin therapy, such as complement C3, apolipoprotein A-IV, and insulin-like growth factor-binding protein complex acid labile subunit. These results may be useful in the identification of markers for monitoring intravenous immunoglobulin therapy in patients with Kawasaki disease.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Zhang L,Song QF,Jin JJ,Huang P,Wang ZP,Xie XF,Gu XQ,Gao XJ,Jia HLdoi
10.1017/S1047951117001433subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1786-1796issue
9eissn
1047-9511issn
1467-1107pii
S1047951117001433journal_volume
27pub_type
杂志文章abstract::Professionals working in the arena of health care face a variety of challenges as their careers evolve and develop. In this review, we analyze the role of mentorship, learning curves, and balance in overcoming challenges that all such professionals are likely to encounter. These challenges can exist both in profession...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951107001266
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:Aetiology of protein-losing enteropathy in single-ventricle type CHD is multi-factorial. REPORT:We describe two Fontan patients with protein-losing enteropathy who presented with cytomegalovirus-associated colitis. DISCUSSION:Fontan patients display risk factors for cytomegalovirus-induced gastroenteropa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000049
更新日期:2020-03-01 00:00:00
abstract::Fetal constriction of the ductus arteriosus is a complication of maternal non-steroidal anti-inflammatory drug use and polyphenol-rich food intake. It is unclear as to whether polyphenol-containing topical treatments have similar effects. We present a case of fetal constriction of the ductus arteriosus, severe right v...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001924
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the family psycho-social outcomes of children with Down syndrome and atrioventricular septal defect, and examine the impact of these variables on the child's neurodevelopmental outcome. METHODS:This was a cross-sectional study that consisted of 57 children with Down syndrome - 20 cases and 37 con...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115000062
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:The term cor triatriatum is used to describe a fibromuscular partition that divides an atrium into two compartments. It was first used by Borst in 1905, although the lesion had been described before by Church in 1868. Both described divided left atrial chamber (also referred to as cor triatriatum sinister)...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951114001073
更新日期:2015-02-01 00:00:00
abstract::Two paediatric congenital heart disease patients presented with a brief history of low-grade fever without any focal symptoms. Their clinical features and laboratory tests were unremarkable; however, their blood cultures were positive that prompted further work-up. Infective endocarditis should be considered in any pa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795112000195X
更新日期:2020-09-01 00:00:00
abstract::An infant developed severe desaturation within a few hours of construction of a modified Blalock-Taussig shunt. Echocardiography revealed that the shunt had become occluded, and this was confirmed angiographically. At catheterisation, therefore, we passed a 0.014" percutaneous transluminal coronary angioplasty wire th...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100008957
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Children with congenital cardiac disease experience challenges in developing healthy patterns of physical activity due to decreased exercise capacity and parental fear and confusion about what is permissible. The purpose of this study was to describe physical activity habits in children 10-14 years of age wi...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111000540
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Anomalous left coronary artery from the pulmonary artery is a rare congenital heart disease (CHD) with diverse clinical presentations despite the same anatomy. Factors determining this heterogeneous presentation are not well understood. METHOD AND RESULTS:We retrospectively investigated 14 patients (12 fema...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119003299
更新日期:2020-03-01 00:00:00
abstract::Purpose The aim of this study was to determine whether the exercise tolerance test can provide diagnostic and prognostic information regarding children and young adults and help predict outcome. METHODS:A total of 87 patients, aged 7-29 years (median 13, mean 13.4) were selected retrospectively. They underwent exerci...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000233
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Placement of peritoneal drainage catheters intra-operatively has been shown to help prevent fluid overload in children recovering from surgery for two-ventricle heart disease. We aimed to determine whether this practice is also helpful in children recovering from Fontan palliation. MATERIAL AND METHODS:A ret...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000693
更新日期:2014-06-01 00:00:00
abstract::Behçet's disease is a chronic autoimmune disease with vascular complications that are most frequently manifested as thromboembolism in veins and pseudoaneurysm in arteries. We report the case of a 13-year-old boy admitted for clinical and biological signs of rheumatic fever associated with chest pain. The clinical exa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000498
更新日期:2014-04-01 00:00:00
abstract::We describe 3 siblings with muscular ventricular septal defects, two requiring surgical closure. One of their offspring had a rare congenital aneurysm of the muscular ventricular septum, also requiring surgery. Another had a small muscular ventricular septal defect which closed spontaneously. Their father had echocard...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951107000996
更新日期:2007-10-01 00:00:00
abstract::Persistent fifth - double-lumen - aortic arch is a rarely seen entity, which is usually associated with other cardiac anomalies; it has been previously reported only in children. We report a new case of double-lumen aortic arch with a systemic-to-systemic connection diagnosed incidentally during cardiac multi-detector...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111001855
更新日期:2012-06-01 00:00:00
abstract::Valvar heart disease can be complicated by hemodynamic derangements, depending on the degree of the abnormality. Stenosis causes pressure overload of the chamber draining through the valve and regurgitation results in volume overload. Many lesions have a component of both, resulting in both pressure and volume overloa...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001978
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Transcatheter closure of atrial septal defects is performed under fluoroscopy, but echocardiography has gained an important role in the procedure. With the new Amplatzer Septal Occluder a device has become available which is easy to implant with minimal fluoroscopy time. We developed an interventional proced...
journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100008349
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Altered mesenteric perfusion may be a contributor to the development of necrotising enterocolitis in patients with hypoplastic left heart syndrome. The goal of this study was to document mesenteric flow patterns in patients with hypoplastic left heart syndrome pre- and post-hybrid procedure. METHODS:A prosp...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114001607
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:This study aimed to examine the differences between arterial and inferior caval vein oxygen saturation, fractional oxygen extraction, and the shunt index, which were calculated in the diagnosis of patent ductus arteriosus. METHODS:Twenty-seven preterm infants were included in this study and were divided int...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113000772
更新日期:2014-08-01 00:00:00
abstract::We describe a case of transcatheter occlusion of a large and tortuose coronary artery fistula in an 8-year-old girl. During 2.5 years' of follow-up, she had no complaints and developed normally. This method of reserving the guide wire in cardiac catheterisation is extremely useful. Through the application of a patent ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111000137X
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:There is a great need for echocardiographic criterions for accurate diagnosis of carditis in acute rheumatic fever. AIM:To test the efficacy of proposed echocardiographic criterions for the diagnosis of carditis. MATERIALS AND METHODS:We studied 333 patients suspected of having acute rheumatic fever, under...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951108003107
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:Developmental care of neonates with CHD is essential for proper neurodevelopment. Measurement of developmental care specific to these neonates is needed to ensure consistent implementation within and across cardiac ICUs. The purpose of this study was to psychometrically test the Developmental Care Scale for Neo...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951119000337
更新日期:2019-06-01 00:00:00
abstract::Severe cyanosis due to pulmonary arteriovenous fistulas occurs often after a bidirectional superior cavopulmonary anastomosis (Glenn operation) and also in some congenital anomalies in which hepatic venous blood bypasses the lungs in the first passage. Relocation of hepatic flow into the lungs usually causes these fis...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951113000140
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of a continuous infusion of basic fibroblast growth factor on the adaptive potential of the right ventricular myocardium after 30 days of mechanically induced overload in rats. Materials and methods We banded the pulmonary trunk, so as...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111002034
更新日期:2012-08-01 00:00:00
abstract:AIMS:To assess results of closure of atrial septal defects within the oval fossa by devices delivered by catheterisation in symptomatic infants and children under 2 years of age. METHODS AND RESULTS:The Amplatzer septal occluder was used. Results, and complications of transcatheter device treatment in patients aged be...
journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100008234
更新日期:2000-09-01 00:00:00
abstract::We studied the duration and dispersion of the P wave in patients after a Senning operation, assessing its value in detecting the risk of atrial tachycardias.We measured the duration and dispersion of the wave in surface 12 lead electrocardiograms obtained from 18 patients with sinus rhythm, having a mean age of 12.8 y...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951109991892
更新日期:2009-12-01 00:00:00
abstract::Communications between the pulmonary artery and left atrium cause cyanosis. The images document serial haemodynamic changes in such a fistula from fetal life to the postnatal period with a successful transcatheter intervention. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118000616
更新日期:2018-10-01 00:00:00
abstract::Innocent murmurs in childhood are common, and often they do not reflect cardiac disease. We have performed a prospective review, by means of a questionnaire, to clarify the parental perception of the innocent murmur identified in their child. Whenever possible, depending on age, we also sought the input of the child. ...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102001063
更新日期:2002-12-01 00:00:00
abstract::Catecholaminergic polymorphic ventricular tachycardia is a rare life-threatening arrhythmogenic disorder. An association with paroxysmal atrial fibrillation and other atrial arrhythmias has been described, but in all published cases the initial manifestation of the disease was ventricular arrhythmia. This is the first...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951113001091
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:To describe the echocardiographic features, underlying causes, and outcome of fetuses with dilated cardiomyopathy. DESIGN:A retrospective observational study between 1983 and 2003 at a tertiary centre for fetal cardiology. PATIENTS:Affected fetuses were identified using a computerised database. We included...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105000855
更新日期:2005-08-01 00:00:00
abstract::The recommendations of the Association for European Paediatric and Congenital Cardiology for basic training in paediatric and congenital cardiology required to be recognised as a paediatric cardiologist by the Association for European Paediatric and Congenital Cardiology are described below. Those wishing to achieve m...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120003455
更新日期:2020-11-01 00:00:00