Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives.

Abstract:

:Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Here we use an human-induced pluripotent stem cell-based platform to demonstrate adverse impacts of obesogenic endocrine disrupting chemicals in the developing endocrine system. We delineate the effects upon physiological low-dose exposure to ubiquitous endocrine disrupting chemicals including, perfluoro-octanoic acid, tributyltin, and butylhydroxytoluene, in endocrine-active human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons. Endocrine disrupting chemicals induce endoplasmic reticulum stress, perturb NF-κB, and p53 signaling, and diminish mitochondrial respiratory gene expression, spare respiratory capacity, and ATP levels. As a result, normal production and secretion of appetite control hormones, PYY, α-MSH, and CART, are hampered. Blocking NF-κB rescues endocrine disrupting chemical-induced aberrant mitochondrial phenotypes and endocrine dysregulation, but not ER-stress and p53-phosphorylation changes.Harmful chemicals that disrupt the endocrine system and hormone regulation have been associated with obesity. Here the authors apply a human pluripotent stem cell-based platform to study the effects of such compounds on developing gut endocrine and neuroendocrine systems.

journal_name

Nat Commun

journal_title

Nature communications

authors

Rajamani U,Gross AR,Ocampo C,Andres AM,Gottlieb RA,Sareen D

doi

10.1038/s41467-017-00254-8

subject

Has Abstract

pub_date

2017-08-09 00:00:00

pages

219

issue

1

issn

2041-1723

pii

10.1038/s41467-017-00254-8

journal_volume

8

pub_type

杂志文章,收录出版
  • Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization.

    abstract::Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In th...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1004

    authors: Satoh K,Ozawa S,Mizutani M,Nagai K,Kamigaito M

    更新日期:2010-04-12 00:00:00

  • Physiological constraints to climate warming in fish follow principles of plastic floors and concrete ceilings.

    abstract::Understanding the resilience of aquatic ectothermic animals to climate warming has been hindered by the absence of experimental systems experiencing warming across relevant timescales (for example, decades). Here, we examine European perch (Perca fluviatilis, L.) from the Biotest enclosure, a unique coastal ecosystem ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11447

    authors: Sandblom E,Clark TD,Gräns A,Ekström A,Brijs J,Sundström LF,Odelström A,Adill A,Aho T,Jutfelt F

    更新日期:2016-05-17 00:00:00

  • Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS.

    abstract::A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs)...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14413-x

    authors: Wan WL,Tian B,Lin YJ,Korupalli C,Lu MY,Cui Q,Wan D,Chang Y,Sung HW

    更新日期:2020-01-27 00:00:00

  • Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus.

    abstract::Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with features that vary by ethnicity. A systematic characterization of the genomic landscape of Chinese ccRCC is lacking, and features of ccRCC associated with tumor thrombus (ccRCC-TT) remain poorly understood. Here, we applied whole-exome sequencing ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14601-9

    authors: Wang XM,Lu Y,Song YM,Dong J,Li RY,Wang GL,Wang X,Zhang SD,Dong ZH,Lu M,Wang SY,Ge LY,Luo GD,Ma RZ,George Rozen S,Bai F,Wu D,Ma LL

    更新日期:2020-02-06 00:00:00

  • Non-uniform membrane diffusion enables steady-state cell polarization via vesicular trafficking.

    abstract::Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2370

    authors: Slaughter BD,Unruh JR,Das A,Smith SE,Rubinstein B,Li R

    更新日期:2013-01-01 00:00:00

  • NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.

    abstract::NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07573-4

    authors: Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R

    更新日期:2018-12-05 00:00:00

  • Ultrafast collisional ion heating by electrostatic shocks.

    abstract::High-intensity lasers can be used to generate shockwaves, which have found applications in nuclear fusion, proton imaging, cancer therapies and materials science. Collisionless electrostatic shocks are one type of shockwave widely studied for applications involving ion acceleration. Here we show a novel mechanism for ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9905

    authors: Turrell AE,Sherlock M,Rose SJ

    更新日期:2015-11-13 00:00:00

  • Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway.

    abstract::Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentially providing clues to improve heterologou...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18018-2

    authors: Johnston CW,Badran AH,Collins JJ

    更新日期:2020-08-21 00:00:00

  • Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

    abstract::In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the spec...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05692-6

    authors: Adhikari H,Counter CM

    更新日期:2018-09-07 00:00:00

  • Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat.

    abstract::Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02677-9

    authors: Li H,Wu G,Fang Q,Zhang M,Hui X,Sheng B,Wu L,Bao Y,Li P,Xu A,Jia W

    更新日期:2018-01-18 00:00:00

  • Tornado outbreak variability follows Taylor's power law of fluctuation scaling and increases dramatically with severity.

    abstract::Tornadoes cause loss of life and damage to property each year in the United States and around the world. The largest impacts come from 'outbreaks' consisting of multiple tornadoes closely spaced in time. Here we find an upward trend in the annual mean number of tornadoes per US tornado outbreak for the period 1954-201...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10668

    authors: Tippett MK,Cohen JE

    更新日期:2016-02-29 00:00:00

  • Coral-associated bacteria demonstrate phylosymbiosis and cophylogeny.

    abstract::Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07275-x

    authors: Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

    更新日期:2018-11-22 00:00:00

  • Benchmarking monolayer MoS2 and WS2 field-effect transistors.

    abstract::Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20732-w

    authors: Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

    更新日期:2021-01-29 00:00:00

  • Electron tunneling at the molecularly thin 2D perovskite and graphene van der Waals interface.

    abstract::Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19331-6

    authors: Leng K,Wang L,Shao Y,Abdelwahab I,Grinblat G,Verzhbitskiy I,Li R,Cai Y,Chi X,Fu W,Song P,Rusydi A,Eda G,Maier SA,Loh KP

    更新日期:2020-10-30 00:00:00

  • Experimental demonstration of graph-state quantum secret sharing.

    abstract::Quantum communication and computing offer many new opportunities for information processing in a connected world. Networks using quantum resources with tailor-made entanglement structures have been proposed for a variety of tasks, including distributing, sharing and processing information. Recently, a class of states ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6480

    authors: Bell BA,Markham D,Herrera-Martí DA,Marin A,Wadsworth WJ,Rarity JG,Tame MS

    更新日期:2014-11-21 00:00:00

  • Nanomechanics of individual aerographite tetrapods.

    abstract::Carbon-based three-dimensional aerographite networks, built from interconnected hollow tubular tetrapods of multilayer graphene, are ultra-lightweight materials recently discovered and ideal for advanced multifunctional applications. In order to predict the bulk mechanical behaviour of networks it is very important to...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14982

    authors: Meija R,Signetti S,Schuchardt A,Meurisch K,Smazna D,Mecklenburg M,Schulte K,Erts D,Lupan O,Fiedler B,Mishra YK,Adelung R,Pugno NM

    更新日期:2017-04-12 00:00:00

  • Author Correction: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.

    abstract::This corrects the article DOI: 10.1038/ncomms15732. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/ncomms16183

    authors: Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

    更新日期:2018-03-12 00:00:00

  • Myths and reality of HPbI3 in halide perovskite solar cells.

    abstract::All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07204-y

    authors: Ke W,Spanopoulos I,Stoumpos CC,Kanatzidis MG

    更新日期:2018-11-14 00:00:00

  • A transient self-assembling self-replicator.

    abstract::Developing physical models of complex dynamic systems showing emergent behaviour is key to informing on persistence and replication in biology, how living matter emerges from chemistry, and how to design systems with new properties. Herein we report a fully synthetic small molecule system in which a surfactant replica...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04670-2

    authors: Colomer I,Morrow SM,Fletcher SP

    更新日期:2018-06-08 00:00:00

  • Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

    abstract::Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism and tumor development remains poorly defined. Here, we show that upon glucose intake, the splicing factor SRSF5 is specifically induced...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04815-3

    authors: Chen Y,Huang Q,Liu W,Zhu Q,Cui CP,Xu L,Guo X,Wang P,Liu J,Dong G,Wei W,Liu CH,Feng Z,He F,Zhang L

    更新日期:2018-06-25 00:00:00

  • Author Correction: Quantum nanophotonics with group IV defects in diamond.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 已发布勘误

    doi:10.1038/s41467-020-14316-x

    authors: Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

    更新日期:2020-01-14 00:00:00

  • Truly work-like work extraction via a single-shot analysis.

    abstract::The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2712

    authors: Aberg J

    更新日期:2013-01-01 00:00:00

  • Human and mouse essentiality screens as a resource for disease gene discovery.

    abstract::The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14284-2

    authors: Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

    更新日期:2020-01-31 00:00:00

  • Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins.

    abstract::Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving s...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01099-x

    authors: Yoneda N,Fujii Y,Matsumoto A,Asano K,Matsubara S

    更新日期:2017-11-09 00:00:00

  • Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.

    abstract::Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes c...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18208-y

    authors: Park DR,Kim J,Kim GM,Lee H,Kim M,Hwang D,Lee H,Kim HS,Kim W,Park MC,Shim H,Lee SY

    更新日期:2020-08-28 00:00:00

  • A global strategy to mitigate the environmental impact of China's ruminant consumption boom.

    abstract::Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06381-0

    authors: Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

    更新日期:2018-10-08 00:00:00

  • The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.

    abstract::It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somatic cell nuclear transfer (SCNT). However, it is not known whether a specific mitotic factor plays a critical role in reprogramming. Here we identify an isoform of human bro...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10869

    authors: Shao Z,Zhang R,Khodadadi-Jamayran A,Chen B,Crowley MR,Festok MA,Crossman DK,Townes TM,Hu K

    更新日期:2016-03-07 00:00:00

  • Author Correction: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41467-020-18510-9

    authors: Calejman CM,Trefely S,Entwisle SW,Luciano A,Jung SM,Hsiao W,Torres A,Hung CM,Li H,Snyder NW,Villén J,Wellen KE,Guertin DA

    更新日期:2020-09-08 00:00:00

  • Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.

    abstract::The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19191-0

    authors: Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

    更新日期:2020-11-10 00:00:00

  • A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

    abstract::Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can reco...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6683

    authors: Williams PR,Marincu BN,Sorbara CD,Mahler CF,Schumacher AM,Griesbeck O,Kerschensteiner M,Misgeld T

    更新日期:2014-12-16 00:00:00