Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration.

abstract：:The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...

journal_title：Scientific reports

authors： Cole AJ,Dwight T,Gill AJ,Dickson KA,Zhu Y,Clarkson A,Gard GB,Maidens J,Valmadre S,Clifton-Bligh R,Marsh DJ

更新日期：2016-05-18 00:00:00

abstract：:With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Tit...

journal_title：Scientific reports

authors： Eger M,Sterer N,Liron T,Kohavi D,Gabet Y

更新日期：2017-01-06 00:00:00

abstract：:Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower foetal than matern...

journal_title：Scientific reports

authors： Stapleton NM,Brinkhaus M,Armour KL,Bentlage AEH,de Taeye SW,Temming AR,Mok JY,Brasser G,Maas M,van Esch WJE,Clark MR,Williamson LM,van der Schoot CE,Vidarsson G

更新日期：2019-05-14 00:00:00

abstract：:In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...

journal_title：Scientific reports

authors： Barth C,Laffon C,Olbrich R,Ranguis A,Parent P,Reichling M

更新日期：2016-02-16 00:00:00

abstract：:Dehydration (water loss >2.0% of body weight) has significant negative effects on physical and mental performance. In two studies the effects of minor hypo-hydration (water loss <1.0% of body weight) on CNS function, mood and cardiovascular functioning were measured. Study 1: On two mornings twelve male participants w...

journal_title：Scientific reports

authors： Young HA,Cousins A,Johnston S,Fletcher JM,Benton D

更新日期：2019-11-11 00:00:00

abstract：:Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...

journal_title：Scientific reports

authors： Wang X,Zhang R,Song W,Han L,Liu X,Sun X,Luo M,Chen K,Zhang Y,Yang H,Yang G,Zhao Y,Zhao J

更新日期：2019-03-05 00:00:00

abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...

journal_title：Scientific reports

authors： Zheng C,Zheng Z,Sun J,Zhang Y,Wei C,Ke X,Liu Y,Deng L,Wang H

更新日期：2017-11-27 00:00:00

abstract：:The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among struct...

journal_title：Scientific reports

authors： Ren Z,Ren PX,Balusu R,Yang X

更新日期：2016-09-23 00:00:00

abstract：:Kinkarakawa-gami wallpapers are unique works of art produced in Japan between 1870 and 1905 and exported in European countries, although only few examples are nowadays present in Europe. So far, neither the wallpapers nor the composing materials have been characterised, limiting the effective conservation-restoration ...

journal_title：Scientific reports

authors： Piacenza E,Presentato A,Di Salvo F,Alduina R,Ferrara V,Minore V,Giannusa A,Sancataldo G,Chillura Martino DF

更新日期：2020-10-02 00:00:00

abstract：:The alpine meadow on the Tibetan Plateau is the highest and largest pasture in the world, and its formation and distribution are mainly controlled by Indian summer monsoon effects. However, little is known about how monsoon-related cues may trigger spring phenology of the vast alpine vegetation. Based on the 7-year ob...

journal_title：Scientific reports

authors： Li R,Luo T,Mölg T,Zhao J,Li X,Cui X,Du M,Tang Y

更新日期：2016-02-09 00:00:00

abstract：:Selection may favour individuals of the same population to differ consistently in nutritional preference, for example, because optimal diets covary with morphology or personality. We provided Southern field crickets (Gryllus bimaculatus) with two synthetic food sources (carbohydrates and proteins) and quantified repea...

journal_title：Scientific reports

authors： Han CS,Jäger HY,Dingemanse NJ

更新日期：2016-06-30 00:00:00

abstract：:Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer case...

journal_title：Scientific reports

authors： Sankhwar M,Sankhwar SN,Bansal SK,Gupta G,Rajender S

更新日期：2016-06-01 00:00:00

abstract：:Protein tyrosine kinase (PTK) activity has been implicated in pro-inflammatory gene expression following tumor necrosis factor-α (TNF-α) or interkeukin-1β (IL-1β) stimulation. However, the identity of responsible PTK(s) in cytokine signaling have not been elucidated. To evaluate which PTK is critical to promote the cy...

journal_title：Scientific reports

authors： Murphy JM,Jeong K,Rodriguez YAR,Kim JH,Ahn EE,Lim SS

更新日期：2019-05-20 00:00:00

abstract：:This study investigates the association between an index of mesozooplankton biomass, derived from the Continuous Plankton Recorder survey and satellite-derived productivity fronts in the North Atlantic. While chlorophyll-a content (CHL) is commonly described as a proxy for phytoplankton biomass, the size of productivi...

journal_title：Scientific reports

authors： Druon JN,Hélaouët P,Beaugrand G,Fromentin JM,Palialexis A,Hoepffner N

更新日期：2019-03-18 00:00:00

abstract：:Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repea...

journal_title：Scientific reports

authors： Harlé A,Guillet J,Thomas J,Sastre-Garau X,Rouyer M,Ramacci C,Gilson P,Dubois C,Dolivet G,Leroux A,Salleron J,Merlin JL

更新日期：2018-07-27 00:00:00

abstract：:Subclinical hypothyroidism (SH) may influence both ventricular functions. The aim of this study was to evaluation the findings of Tissue Doppler Imaging (TDI) and other echocardiography modalities in children with SH. We compared left ventricular mass index (LVMI) and TDI parameters of patients with SH and children wi...

journal_title：Scientific reports

authors： Akın A,Unal E,Yildirim R,Ture M,Balik H,Haspolat YK

更新日期：2020-11-12 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...

journal_title：Scientific reports

authors： Zhu J,Zhang T,Cao L,Li A,Zheng K,Zhang N,Su B,Chen Z,Chen N,Wu H,He Q

更新日期：2017-09-29 00:00:00

abstract：:The modifier protein, ubiquitin (Ub) regulates various cellular pathways by controlling the fate of substrates to which it is conjugated. Ub moieties are also conjugated to each other, forming chains of various topologies. In cells, poly-Ub is attached to proteins and also exists in unanchored form. Accumulation of un...

journal_title：Scientific reports

authors： Blount JR,Libohova K,Marsh GB,Sutton JR,Todi SV

更新日期：2018-05-31 00:00:00

abstract：:Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not consid...

journal_title：Scientific reports

authors： Iconaru LI,Ban D,Bharatham K,Ramanathan A,Zhang W,Shelat AA,Zuo J,Kriwacki RW

更新日期：2015-10-28 00:00:00

abstract：:The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to first characterize the transparency...

journal_title：Scientific reports

authors： Shito TT,Hasegawa N,Oka K,Hotta K

更新日期：2020-11-30 00:00:00

abstract：:Temperature index (TI) models are convenient for modelling glacier ablation since they require only a few input variables and rely on simple empirical relations. The approach is generally assumed to be reliable at lower elevations (below 3500 m above sea level, a.s.l) where air temperature (Ta) relates well to the ene...

journal_title：Scientific reports

authors： Litt M,Shea J,Wagnon P,Steiner J,Koch I,Stigter E,Immerzeel W

更新日期：2019-03-27 00:00:00

abstract：:Prognostic biomarkers serve a variety of purposes in cancer treatment and research, such as prediction of cancer progression, and treatment eligibility. Despite growing interest in multi-omic data integration for defining prognostic biomarkers, validated methods have been slow to emerge. Given that breast cancer has b...

journal_title：Scientific reports

authors： Thompson JA,Christensen BC,Marsit CJ

更新日期：2018-03-26 00:00:00

abstract：:In spin-based nanosystems for quantum information processing, electron spin qubits are subject to decoherence due to their interactions with nuclear spin environments. In this paper, we present an exact master equation for a central spin-1/2 system in time-dependent external fields and coupled to a spin-half bath in t...

journal_title：Scientific reports

authors： Jing J,Wu LA

更新日期：2018-01-24 00:00:00

abstract：:Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

journal_title：Scientific reports

authors： Tao M,Isas JM,Langen R

更新日期：2020-03-24 00:00:00

abstract：:Evaluation of facial asymmetry generally involves landmark-based analyses that cannot intuitively assess differences in three-dimensional (3D) stereoscopic structures between deviation and non-deviation sides. This study tested a newly developed similarity index that uses a mirroring technique to intuitively evaluate ...

journal_title：Scientific reports

authors： Kwon SM,Hwang JJ,Jung YH,Cho BH,Lee KJ,Hwang CJ,Choi SH

更新日期：2019-07-29 00:00:00

abstract：:Phelan-McDermid Syndrome (PMS), which is defined by a deletion within 22q13, demonstrates significant phenotypic variation. Given that six mitochondrial genes are located within 22q13, including complex I and IV genes, we hypothesize that mitochondrial complex activity abnormalities may explain phenotypic variation in...

journal_title：Scientific reports

authors： Frye RE,Cox D,Slattery J,Tippett M,Kahler S,Granpeesheh D,Damle S,Legido A,Goldenthal MJ

更新日期：2016-01-29 00:00:00

abstract：:Polypyrrole complex nitrogen-doped porous carbon matrix (PPy/N-PCM) was synthesized by a simple two-step method. Firstly, graphene oxide was prepared by the modified Hummers method. Secondly, Polypyrrole was compounded on the graphene oxide substrate, and the carbon matrix with a high specific surface area was obtaine...

journal_title：Scientific reports

authors： Feng M,Lu W,Zhou Y,Zhen R,He H,Wang Y,Li C

更新日期：2020-09-21 00:00:00

abstract：:Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels. Angiogenesis has a key role in tumour growth and progression and is regulated by macrophage secret...

journal_title：Scientific reports

authors： de Araújo Pimenta L,de Almeida MES,Bretones ML,Cirillo MC,Curi R,Sampaio SC

更新日期：2019-03-12 00:00:00

abstract：:Plant derived biogenic synthesis of nanoparticles (NP) has been the recent trend in material science as featured sustainable catalysts. A great deal of the current nanocatalytic research has been oriented on the bio-inspired green catalysts based on their wide applicability. In this context, CuO NPs are synthesized fo...

journal_title：Scientific reports

authors： Veisi H,Karmakar B,Tamoradi T,Hemmati S,Hekmati M,Hamelian M

更新日期：2021-01-21 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and ...

journal_title：Scientific reports

authors： Pelusi S,Baselli G,Pietrelli A,Dongiovanni P,Donati B,McCain MV,Meroni M,Fracanzani AL,Romagnoli R,Petta S,Grieco A,Miele L,Soardo G,Bugianesi E,Fargion S,Aghemo A,D'Ambrosio R,Xing C,Romeo S,De Francesco R,Reeves

更新日期：2019-03-06 00:00:00