当前位置： SCI文献检索 > BRAIN & DEVELOPMENT期刊下所有文献 > Quantitative EEG findings and response to treatment with antiepileptic medications in children with epilepsy.

Quantitative EEG findings and response to treatment with antiepileptic medications in children with epilepsy.

Abstract：

BACKGROUND:Epilepsy is a common chronic disorder in pediatric neurology. Nowadays, a variety of antiepileptic drugs (AEDs) are available. A scientific method designed to evaluate the effectiveness of AEDs in the early stage of treatment has not been reported. PURPOSE:In this study, we try to use quantitative EEG (QEEG) analysis as a biomarker to evaluate therapeutic effectiveness. METHODS:20 epileptic children were enrolled in this study. Participants were classified as effective if they achieved a reduction in seizure frequency over 50%. Ineffective was defined as a reduction in seizure frequency less than 50%. Eleven participants were placed in the effective group, the remaining 9 participants were placed in the ineffective group. EEG segments before and after 1-3months of antiepileptic drugs start/change were analyzed and compared by QEEG analysis. The follow-up EEG segments after the 2nd examinations were used to test the accuracy of the analytic results. RESULTS:Six crucial EEG feature descriptors were selected for classifying the effective and ineffective groups. Significantly increased RelPowAlpha_avg_AVG, RelPowAlpha_snr_AVG, HjorthM_avg_AVG, and DecorrTime_snr_AVG values were found in the effective group as compared to the ineffective group. On the contrary, there were significantly decreases in DecorrTime_std_AVG, and Wavelet_db4_EnergyBand_5_avg_AVG values in the effective group as compared to the ineffective group. The analyses yielded a precision rate of 100%. When the follow-up EEG segments were used to test the analytic results, the accuracy was 83.3%. CONCLUSION:The developed method is a useful tool in analyzing the effectiveness of antiepileptic drugs. This method may assist pediatric neurologists in evaluating the efficacy of AEDs and making antiepileptic drug adjustments when managing epileptic patients in the early stage.

journal_name

Brain Dev

journal_title

Brain & development

authors

Ouyang CS,Chiang CT,Yang RC,Wu RC,Wu HC,Lin LC

doi

10.1016/j.braindev.2017.07.004

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

26-35

issue

1

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(17)30187-0

journal_volume

40

pub_type

杂志文章

相关文献

BRAIN & DEVELOPMENT文献大全
  • Risk factors for recurrence after drug withdrawal in childhood epilepsy.

    abstract：BACKGROUND:Several studies have been conducted to determine the risk of recurrence after withdrawal of antiepileptic drugs (AEDs) in recent years. There is no consensus concerning the circumstances affecting discontinuation of AEDs. This study was designed to determine the recurrence rate of epilepsy after withdrawal o...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2019.08.012

    authors： Karalok ZS,Guven A,Öztürk Z,Gurkas E

    更新日期：2020-01-01 00:00:00

  • Retrocerebellar arachnoid cysts in siblings with mental retardation and undescended testis.

    abstract：:Arachnoid cysts comprise approximately 1% of all intracranial space-occupying lesions and usually occur sporadically. We report retrocerebellar arachnoid cysts in two male siblings with mental retardation and undescended testis, suggesting the possibility of a genetic basis for at least some cases of retrocerebellar a...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/s0387-7604(02)00061-x

    authors： Suzuki H,Takanashi J,Sugita K,Barkovich AJ,Kohno Y

    更新日期：2002-08-01 00:00:00

  • Quantitative assessment of fine motor skills in children using magnetic sensors.

    abstract：AIM:We aimed to establish objective and quantitative data on fine motor development in typically developing children using magnetic sensors. METHODS:The study included 110 Japanese elementary school children volunteers (57 boys, 53 girls). The participants were instructed to tap their thumbs and index fingers together...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2020.03.004

    authors： Enokizono T,Ohto T,Tanaka M,Maruo K,Sano Y,Kandori A,Takada H

    更新日期：2020-06-01 00:00:00

  • Brain gliomas, hydrocephalus and idiopathic aqueduct stenosis in children with neurofibromatosis type 1.

    abstract：PURPOSE:To evaluate the incidence and clinical importance of brain gliomas - optic pathway gliomas (OPGs) and especially gliomas outside the optic pathway (GOOP) for children with neurofibromatosis type 1 (NF1), additionally, to assess the causes of obstructive hydrocephalus in NF1 children with an emphasis on cases ca...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2019.04.003

    authors： Glombova M,Petrak B,Lisy J,Zamecnik J,Sumerauer D,Liby P

    更新日期：2019-09-01 00:00:00

  • Temporal trends in perinatal mortality and cerebral palsy: A regional population-based study in southern Japan.

    abstract：AIM:The prevalence of cerebral palsy (CP) has not decreased in developed countries over the past 30 years. We examined gestational age-specific trends in the prevalence of CP. METHODS:This unselected, population-based study was conducted in Miyazaki prefecture, Japan (10,000 deliveries annually), where 102,999 deliver...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.10.002

    authors： Kodama Y,Sameshima H,Ikenoue T

    更新日期：2016-04-01 00:00:00

  • Idiopathic hypereosinophilic syndrome complicated by central sinovenous thrombosis.

    abstract：:Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder affecting cardiac, pulmonary and nervous systems with peripheral neuropathy, encephalopathy and cerebral thromboembolism. We report a 7-year-old boy with IHES who developed central sinovenous thrombosis and cerebral hemorrhage. Although he had hypereosino...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.08.004

    authors： Sakuta R,Tomita Y,Ohashi M,Nagai T,Murakami N

    更新日期：2007-04-01 00:00:00

  • Sensorineural deafness in siblings with adenosine deaminase deficiency.

    abstract：:Two siblings with adenosine deaminase deficiency were successfully treated with allogeneic bone marrow transplantation without conditioning. Although the patients were free from infections after immunologic reconstitution, both showed sensorineural deafness at 1 year of age. Because there were no structural abnormalit...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(96)00014-9

    authors： Tanaka C,Hara T,Suzaki I,Maegaki Y,Takeshita K

    更新日期：1996-07-01 00:00:00

  • A clinical study of attention-deficit/hyperactivity disorder in preschool children--prevalence and differential diagnoses.

    abstract：OBJECTIVE:We aimed to examine (1) the prevalence and characteristics of ADHD in preschool children, and (2) differential diagnoses among children who display symptoms of inattention and hyperactivity-impulsivity in early childhood. METHODS:The participants were children living in Kanie-cho, in Japan's Aichi Prefecture...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2013.11.004

    authors： Nomura K,Okada K,Noujima Y,Kojima S,Mori Y,Amano M,Ogura M,Hatagaki C,Shibata Y,Fukumoto R

    更新日期：2014-10-01 00:00:00

  • Advances in neonatal neurology.

    abstract：:The recent advances in neonatal neurology which are discussed include i) the improved organization of perinatal medical services, ii) technological advances including ultrasonography, brainstem auditory evoked responses and intracranial pressure monitoring and, iii) new developments in therapeutics. The development of...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(84)80095-9

    authors： Ouvrier RA

    更新日期：1984-01-01 00:00:00

  • The evolution of electroencephalographic features in lissencephaly syndrome.

    abstract：:The electroencephalographic features and their evolutional changes with age were described in three cases of lissencephaly syndrome diagnosed by CT scan. The case with more severe lissencephaly displayed very similar EEG findings. In early or middle infancy when infantile spasms began, EEG showed very high amplitude (...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(79)80042-x

    authors： Hakamada S,Watanabe K,Hara K,Miyazaki S

    更新日期：1979-01-01 00:00:00

  • Rett syndrome: discrimination of typical and variant forms.

    abstract：:Eighteen female patients are described with the clinical features of Rett syndrome. Fifteen patients fulfill the criteria established by Hagberg et al hereas three represent clinical variants. Detailed biochemical and neurodiagnostic assessment was conducted in all patients. Reduction in cerebrospinal biogenic amine m...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(87)80063-3

    authors： Percy AK,Zoghbi HY,Glaze DG

    更新日期：1987-01-01 00:00:00

  • Neurological presentation of Griscelli syndrome: obstructive hydrocephalus without haematological abnormalities or organomegaly.

    abstract：:Griscelli syndrome is a rare autosomal-recessive disorder characterised by partial albinism, immunodeficiency, organomegaly and accelerated phases. During accelerated phases, pancytopenia, haemophagocytosis, hypoproteinemeia occur which may be accompanied by neurological deterioration. Primary neurological presentatio...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.09.007

    authors： Rajadhyax M,Neti G,Crow Y,Tyagi A

    更新日期：2007-05-01 00:00:00

  • The test of variables of attention (TOVA) is useful in the diagnosis of Japanese male children with attention deficit hyperactivity disorder.

    abstract：:The purpose of this study was to evaluate the ability of the test of variables of attention (TOVA) to distinguish between 6- to 12-year-old Japanese male children with attention deficit hyperactivity disorder (ADHD group; n=17) meeting DSM-IV and ICD-10 criteria, and age-matched, normal Japanese male controls (control...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00168-6

    authors： Wada N,Yamashita Y,Matsuishi T,Ohtani Y,Kato H

    更新日期：2000-09-01 00:00:00

  • Epilepsy phenotypes in siblings with Norrie disease.

    abstract：:Norrie disease is an X-linked recessive disorder that is characterized by congenital blindness. Although epileptic seizures are observed in some patients with Norrie disease, little is known about this phenomenon. Here, we report the manifestation of epilepsy in siblings with Norrie disease to increase our knowledge o...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.04.004

    authors： Okumura A,Arai E,Kitamura Y,Abe S,Ikeno M,Fujimaki T,Yamamoto T,Shimizu T

    更新日期：2015-11-01 00:00:00

  • Effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease.

    abstract：:Cat scratch disease (CSD) is a zoonotic illness caused by the Gram negative bacillus Bartonella henselae characterized by a small skin lesion at the site of a bite, lick or scratch by a cat, commonly followed by regional lymphadenopathy 1 or 2 weeks later. We report herein on severe neurological complications of CSD c...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.11.001

    authors： Genizi J,Kasis I,Schif A,Shahar E

    更新日期：2007-07-01 00:00:00

  • Electrophysiological study of face inversion effects in Williams syndrome.

    abstract：OBJECTIVE:In order to evaluate whether face perception is intact or not in Williams syndrome (WS), the face inversion effects (FIE) in the event-related potential (ERP) or magnetoencephalography (MEG) were investigated in three teenaged patients with WS. METHODS:Responses to the inverted faces and upright faces were c...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2012.05.010

    authors： Nakamura M,Watanabe S,Inagaki M,Hirai M,Miki K,Honda Y,Kakigi R

    更新日期：2013-04-01 00:00:00

  • Propionic acidemia mimicking diabetic ketoacidosis.

    abstract：:Propionic acidemia manifesting with hyperglycemia is rare. Few cases have been reported mainly of the neonatal-onset form associated with high mortality. We report a 9-month-old Palestinian boy who manifested with coma, severe hyperglycemia and ketoacidosis mimicking diabetic ketoacidosis. Family history of unexplaine...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2010.06.016

    authors： Dweikat IM,Naser EN,Abu Libdeh AI,Naser OJ,Abu Gharbieh NN,Maraqa NF,Abu Libdeh BY

    更新日期：2011-05-01 00:00:00

  • A group of very preterm children characterized by atypical gaze patterns.

    abstract：OBJECTIVE:Very preterm (VP) children are at risk for social difficulties, including autism spectrum disorder (ASD). This study used eye tracking to determine viewing behaviors that may reflect these difficulties. DESIGN:The gaze patterns of 47 VP (mean gestational age: 28weeks, mean birth weight: 948g, and mean chrono...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2016.10.001

    authors： Sekigawa-Hosozawa M,Tanaka K,Shimizu T,Nakano T,Kitazawa S

    更新日期：2017-03-01 00:00:00

  • De novo HDAC8 mutation causes Rett-related disorder with distinctive facial features and multiple congenital anomalies.

    abstract：:We present a unique 11-year-old girl showing clinical features of Rett-related disorder with distinctive facial features and multiple congenital anomalies including ocular hypertelorism, arched eyebrows, a broad nose, dental anomalies, congenital heart disease, truncal obesity, and epilepsy. A novel de novo mutation i...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2017.12.013

    authors： Saikusa T,Hara M,Iwama K,Yuge K,Ohba C,Okada JI,Hisano T,Yamashita Y,Okamoto N,Saitsu H,Matsumoto N,Matsuishi T

    更新日期：2018-05-01 00:00:00

  • Neurophysiology of spasms.

    abstract：:Spasms are a form of epileptic seizure typical of infancy. From a clinical point of view, the child presents a flexor-extensor movement involving the trunk and limbs and lasting about 1s. Although asymmetry can be present, the seizure involves both sides of the body. The ictal discharge most frequently associated with...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/s0387-7604(01)00284-4

    authors： Vigevano F,Fusco L,Pachatz C

    更新日期：2001-11-01 00:00:00

  • ALDH18A1-related cutis laxa syndrome with cyclic vomiting.

    abstract：:Cutis laxa (CL) syndromes are connective tissue disorders characterized by redundant, sagging, inelastic and wrinkled skin, with organ involvement. Here, we describe a patient with ALDH18A1-related CL who developed cyclic vomiting. The patient was a 12-year-old boy who presented with poor postnatal growth, hypotonia, ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2016.01.003

    authors： Nozaki F,Kusunoki T,Okamoto N,Yamamoto Y,Miya F,Tsunoda T,Kosaki K,Kumada T,Shibata M,Fujii T

    更新日期：2016-08-01 00:00:00

  • The natural history of somatic morbidity in disintegrative psychosis and infantile autism: a validation study.

    abstract：:In order to study the validity of disintegrative psychosis (DP) as defined in ICD-9, we compared the natural history of somatic morbidity of 13 patients given this diagnosis in childhood with a control group of 39 patients with infantile autism (IA) matched for gender, age, IQ and social class. Average follow-up time ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(99)00045-5

    authors： Mouridsen SE,Rich B,Isager T

    更新日期：1999-10-01 00:00:00

  • Childhood leukodystrophies: A literature review of updates on new definitions, classification, diagnostic approach and management.

    abstract：:Childhood leukodystrophies are a growing category of neurological disorders in pediatric neurology practice. With the help of new advanced genetic studies such as whole exome sequencing (WES) and whole genome sequencing (WGS), the list of childhood heritable white matter disorders has been increased to more than one h...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/j.braindev.2017.01.001

    authors： Ashrafi MR,Tavasoli AR

    更新日期：2017-05-01 00:00:00

  • Ataxia with vitamin E deficiency and severe dystonia: report of a case.

    abstract：:Mutation of the gene for alpha-tocopherol transfer protein causes ataxia with isolated vitamin E deficiency, a disorder usually stabilized or improved after vitamin E supplementation. Dystonia has rarely been described in ataxia with isolated vitamin E deficiency (AVED) patients. We present the case of a young boy wit...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(03)00054-8

    authors： Roubertie A,Biolsi B,Rivier F,Humbertclaude V,Cheminal R,Echenne B

    更新日期：2003-09-01 00:00:00

  • Coeliac disease, epilepsy and cerebral calcifications.

    abstract：:Coeliac disease, epilepsy and cerebral calcifications (CEC) syndrome is a rare clinical condition. One hundred and seventy-one patients have been reported in the literature. Patients are mostly from Italy, Spain, and Argentina, suggesting a geographically restricted condition. Epilepsy is more frequently characterized...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/j.braindev.2004.05.003

    authors： Gobbi G

    更新日期：2005-04-01 00:00:00

  • Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype.

    abstract：:Glucose transporter type I deficiency syndrome (GLUT-1 DS) is an inborn error of glucose transport characterized by seizures, developmental delay, spasticity, acquired microcephaly and ataxia. Diagnosis is based on the finding of low cerebrospinal fluid glucose, in the absence of hypoglycemia, and identification of GL...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.04.013

    authors： Veggiotti P,Teutonico F,Alfei E,Nardocci N,Zorzi G,Tagliabue A,De Giorgis V,Balottin U

    更新日期：2010-05-01 00:00:00

  • Biallelic XPR1 mutation associated with primary familial brain calcification presenting as paroxysmal kinesigenic dyskinesia with infantile convulsions.

    abstract：BACKGROUND:Mutations in the XPR1 gene are associated with primary familial brain calcifications (PFBC). All reported mutations are missense and inherited as an autosomal dominant trait. PFBC patients exhibited movement disorders, neuropsychiatric symptoms, and other associated symptoms with diverse severity, even withi...

    journal_title：Brain & development

    pub_type：

    doi：10.1016/j.braindev.2020.09.014

    authors： Tang LO,Hou BH,Zhang XN,Xi ZY,Li CX,Xu L

    更新日期：2021-02-01 00:00:00

  • Precocious puberty due to postmeningitic hydrocephalus.

    abstract：:A case of precocious puberty due to postmeningitic hydrocephalus was presented. Concentrations of serum gonadotropins and estradiol were found to be elevated, and the response of LH to LHRH was also high, similar to that in the late pubertal stage. CT scanning demonstrated marked dilatation of the third ventricle. It ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(83)80047-3

    authors： Tomono Y,Maki Y,Ito M,Nakada Y

    更新日期：1983-01-01 00:00:00

  • Clinical and MRI findings in a case of D-2-hydroxyglutaric aciduria.

    abstract：:We report the 3rd case in the literature of a 3-year-old boy with D-2-hydroxyglutaric (D-2-HG) aciduria, who presented primarily generalized hypotonia and feeding difficulty during the neonatal period, with eventual development of generalized myoclonic seizures. Gas chromatographic analysis of urinary organic acids sh...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/0387-7604(94)00123-f

    authors： Sugita K,Kakinuma H,Okajima Y,Ogawa A,Watanabe H,Niimi H

    更新日期：1995-03-01 00:00:00

  • Familial pachygyria in both genders related to a DCX mutation.

    abstract：:Doublecortin (DCX) and tubulin play critical roles in neuronal migration. DCX mutations usually cause anterior dominant lissencephaly in males and subcortical band heterotopia (SBH) in females. We used whole-exome sequencing to investigate causative gene variants in a large family with late-childhood-onset focal epile...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.12.005

    authors： Kim YO,Nam TS,Park C,Kim SK,Yoon W,Choi SY,Kim MK,Woo YJ

    更新日期：2016-06-01 00:00:00