Abstract：
PURPOSE:To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. METHODS:Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. RESULTS:Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (WMDamblyopia versus fellow = 49.24, 95% CI of 30.22 to 68.27, p < 0.001; WMDamblyopia versus control = 54.51, 95% CI of 32.17 to 76.85, p < 0.001). There were no differences between the fellow and control eyes (WMD = 13.81, 95% CI of 1.16 to 28.77, p = 0.071). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. CONCLUSIONS:The CT in the amblyopic eyes was thicker than that in the fellow and control eyes.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Liu Y,Dong Y,Zhao Kdoi
10.1155/2017/2915261subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2915261eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
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