Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss.

Abstract:

BACKGROUND:Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding factors. METHODS:CRS and healthy non-CRS control subjects undergoing endoscopic sinus or skull-base surgery were prospectively enrolled and completed olfactory testing utilizing the 40-item Smell Identification Test (SIT) immediately prior to surgery. Histopathological evaluation of tissue excised from the ethmoid bulla was performed by a pathologist in a blinded fashion. Disease severity and patient-reported outcomes were measured via the Lund-Mackay computed tomography (CT) grading system and 22-item Sino-Nasal Outcome Test (SNOT-22), respectively. The associations between olfactory function, tissue eosinophilia, and disease severity were analyzed using Spearman rank order correlation and multiple linear regression. RESULTS:Twenty-seven (27) subjects with CRS without nasal polyps (CRSsNP), 32 subjects with CRS with nasal polyps (CRSwNP), and 10 healthy non-CRS controls were enrolled. CRSwNP was associated with higher mean tissue eosinophil counts (71.6 vs 28.1 eosinophils/high-power field [HPF], p < 0.05) and lower age/sex-adjusted SIT scores (-17.4 vs -6.2, p < 0.001) when compared to CRSsNP. SIT scores were strongly negatively correlated with tissue eosinophil counts in CRSwNP (r = -0.60, p = 0.0003), but not CRSsNP (r = 0.16, p = 0.42). The correlation between olfactory function and tissue eosinophilia in CRSwNP persisted after adjusting for disease severity. CONCLUSION:Tissue eosinophilia is associated with olfactory loss in CRSwNP, independent of disease severity. These results suggest a possible role for eosinophils or eosinophil-associated cytokines in CRS-associated olfactory loss.

authors

Hauser LJ,Chandra RK,Li P,Turner JH

doi

10.1002/alr.21994

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

957-962

issue

10

eissn

2042-6976

issn

2042-6984

journal_volume

7

pub_type

杂志文章
  • Immunology.

    abstract:BACKGROUND:Knowledge of our immune system functions is critical for understanding allergic airway disease development as well as for selection of appropriate diagnostic and therapeutic options for patients with respiratory allergies. METHODS:This review explains the current understanding of the basic immunology of the...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21380

    authors: Toskala E

    更新日期:2014-09-01 00:00:00

  • Association between allergic rhinitis and poor sleep parameters in U.S. adults.

    abstract:BACKGROUND:Evidence suggests relationships between allergic rhinitis (AR) and poor sleep parameters, but population-based studies in the United States are lacking. This study investigates the relationship between AR and sleep parameters in a representative sample of U.S. adults. METHODS:Cross-sectional study of 5563 p...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22174

    authors: Roxbury CR,Qiu M,Shargorodsky J,Lin SY

    更新日期:2018-10-01 00:00:00

  • Allergen immunotherapy: exploring areas for further inquiry.

    abstract:BACKGROUND:Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METH...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22016

    authors: Ramsey T,Lai W,Svider PF,Hojjat H,Eloy JA,Folbe AJ

    更新日期:2017-12-01 00:00:00

  • Predictive factors in patients undergoing endoscopic sinus surgery for odontogenic sinusitis.

    abstract:BACKGROUND:Odontogenic sinusitis (OS) presents a therapeutic dilemma. Evidence is lacking whether dental treatment alone is sufficient or whether patients will eventually require endoscopic sinus surgery (ESS). Our aim was to identify predictors of OS patients undergoing ESS. METHODS:Retrospective review performed of ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21736

    authors: Mattos JL,Ferguson BJ,Lee S

    更新日期:2016-07-01 00:00:00

  • Evaluation of olfactory function in adults with primary hypothyroidism.

    abstract:BACKGROUND:Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. METHODS:Forty-five patients aged between 18 and 60 years who were diagnosed with cli...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21565

    authors: Günbey E,Karlı R,Gökosmanoğlu F,Düzgün B,Ayhan E,Atmaca H,Ünal R

    更新日期:2015-10-01 00:00:00

  • Characterization and implications of the lingual process of the sphenoid bone: a cadaveric and radiographic study.

    abstract:BACKGROUND:The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22594

    authors: Li L,London NR Jr,Chen X,Prevedello DM,Carrau RL

    更新日期:2020-12-01 00:00:00

  • Chronic rhinosinusitis without nasal polyps is associated with increased expression of trefoil factor family peptides.

    abstract:BACKGROUND:Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hyp...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21334

    authors: Li P,Turner JH

    更新日期:2014-07-01 00:00:00

  • Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease.

    abstract:BACKGROUND:Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is co...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21456

    authors: Chen JY,Hour TC,Yang SF,Chien CY,Chen HR,Tsai KL,Ko JY,Wang LF

    更新日期:2015-02-01 00:00:00

  • Comparing the efficacy of Silastic and gloved-Merocel middle meatal spacers for functional endoscopic sinus surgery: a randomized controlled trial.

    abstract:BACKGROUND:Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer remov...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22119

    authors: Manji J,Habib AR,Macias-Valle L,Finkelstein A,Alsaleh S,Dadgostar A,Al-Asousi F,Okpaleke C,Javer AR

    更新日期:2018-03-30 00:00:00

  • The impact of race and insurance status on baseline histopathology profile in patients with chronic rhinosinusitis.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is an inflammatory disease process characterized by different phenotypes and histopathology profiles. Race and access to care have been implicated in CRS disease severity. Structural histopathology reporting may aid in delineating the inflammatory burden responsible for this effe...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22295

    authors: Kuhar HN,Ganti A,Eggerstedt M,Mahdavinia M,Gattuso P,Ghai R,Batra PS,Tajudeen BA

    更新日期:2019-06-01 00:00:00

  • Surgical management of rhinosinusitis in endoscopic-endonasal skull-base surgery.

    abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21476

    authors: Nyquist GG,Friedel ME,Singhal S,Beahm DD,Farrell CJ,Evans JJ,Rosen MR

    更新日期:2015-04-01 00:00:00

  • Sites of attachment of Schneiderian papilloma: a retrospective analysis.

    abstract:BACKGROUND:Inverted papilloma is a benign sinonasal tumor that arises from a localized attachment site. These attachment sites, however, have not been fully characterized in the literature. The objective of this research was to determine the specific distribution of attachment sites in patients with sinonasal papilloma...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20054

    authors: Schneyer MS,Milam BM,Payne SC

    更新日期:2011-07-01 00:00:00

  • Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects.

    abstract:BACKGROUND:Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susce...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21725

    authors: Zhao Y,Zhang Y,Zhang L

    更新日期:2016-05-01 00:00:00

  • Factors impacting revision surgery in patients with chronic rhinosinusitis with nasal polyposis.

    abstract:BACKGROUND:Surgical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) has evolved over the last decade as rhinologists have increasingly used topical steroid therapies and altered surgical techniques. It is important to understand the changes in success rates of surgery and frequency of revision endosco...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22505

    authors: Loftus CA,Soler ZM,Desiato VM,Koochakzadeh S,Yoo F,Storck KA,Schlosser RJ

    更新日期:2020-03-01 00:00:00

  • Sinonasal extramedullary plasmacytoma: a systematic review of 175 patients.

    abstract:BACKGROUND:This study reviews the published literature related to extramedullary sinonasal plasmacytomas. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal plasmacytomas from 1950 to 2012 was conducted. A PubMed data...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21254

    authors: D'Aguillo C,Soni RS,Gordhan C,Liu JK,Baredes S,Eloy JA

    更新日期:2014-02-01 00:00:00

  • Cadaveric comparison of canine fossa vs transnasal maxillary sinus access.

    abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20022

    authors: Feldt BA,McMains KC,Weitzel EK

    更新日期:2011-05-01 00:00:00

  • The impact of culturable bacterial community on histopathology in chronic rhinosinusitis.

    abstract:BACKGROUND:The influence of the microbial community on inflammatory subtype in chronic rhinosinusitis (CRS) has been proposed. Superantigen mechanisms potentially create a T helper 2 (Th-2)/eosinophilic dominated inflammation as a product of local flora rather than an intrinsic mucosal process. The associations between...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21220

    authors: Rom D,Snidvongs K,Sacks PL,Dalgorf D,Pratt E,Earls P,Sacks R,Harvey RJ

    更新日期:2014-01-01 00:00:00

  • Association of the sinonasal bacterial microbiome with clinical outcomes in chronic rhinosinusitis: a systematic review.

    abstract:BACKGROUND:The association between sinonasal microbiome and clinical outcomes of patients with chronic rhinosinusitis (CRS) is unclear. We performed a systematic review of prior studies evaluating the CRS microbiome in relation to clinical outcomes. METHODS:Computerized searches of PubMed/Medline, Cochrane, and EMBASE...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22524

    authors: Wang JC,Moore CA,Epperson MV,Sedaghat AR

    更新日期:2020-04-01 00:00:00

  • Sinonasal squamous cell carcinoma and the prognostic implications of its histologic variants: a population-based study.

    abstract:BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21418

    authors: Vazquez A,Khan MN,Blake DM,Patel TD,Baredes S,Eloy JA

    更新日期:2015-01-01 00:00:00

  • Draf III mucosal graft technique: long-term results.

    abstract:BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...

    journal_title:International forum of allergy & rhinology

    pub_type: 临床试验,杂志文章

    doi:10.1002/alr.21708

    authors: Illing EA,Cho do Y,Riley KO,Woodworth BA

    更新日期:2016-05-01 00:00:00

  • A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.

    abstract:BACKGROUND:Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS:A systematic literature review was ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21902

    authors: Hodzic Z,Rowan NR,Kashiwazaki R,Willson TJ,Wang EW,Lee SE

    更新日期:2017-05-01 00:00:00

  • Ethmoid-to-maxillary opacification ratio: a predictor of postoperative olfaction and outcomes in nasal polyposis?

    abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22625

    authors: Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

    更新日期:2021-01-01 00:00:00

  • Outcomes of outpatient endoscopic repair of cerebrospinal fluid rhinorrhea.

    abstract:BACKGROUND:Endoscopic repair of anterior skull-base defects has become the gold standard for management of cerebrospinal fluid (CSF) rhinorrhea. Both improved techniques and adjuvant therapies have led to accepted success rates of greater than 90%. As management has evolved, shorter hospitalizations have been required ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21810

    authors: Adams AS,Francis DO,Russell PT

    更新日期:2016-11-01 00:00:00

  • Steroid-eluting sinus implant for in-office treatment of recurrent nasal polyposis: a prospective, multicenter study.

    abstract:BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/alr.21309

    authors: Lavigne F,Miller SK,Gould AR,Lanier BJ,Romett JL

    更新日期:2014-05-01 00:00:00

  • Patient-reported sleep outcomes lack association with mucosal eosinophilia or neutrophilia in patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction follow...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22678

    authors: Farrell NF,Mace JC,Sauer DA,Thomas AJ,Geltzeiler M,Detwiller KY,Alt JA,Smith TL

    更新日期:2020-08-11 00:00:00

  • Desloratadine-montelukast combination improves quality of life and decreases nasal obstruction in patients with perennial allergic rhinitis.

    abstract:BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...

    journal_title:International forum of allergy & rhinology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/alr.21185

    authors: Cingi C,Oghan F,Eskiizmir G,Yaz A,Ural A,Erdogmus N

    更新日期:2013-10-01 00:00:00

  • High tissue eosinophilia as a marker to predict recurrence for eosinophilic chronic rhinosinusitis: a systematic review and meta-analysis.

    abstract:BACKGROUND:Patients with eosinophilic chronic rhinosinusitis (ECRS) have been shown to have greater disease severity and poorer treatment outcomes after sinus surgery. Although the inflammatory pattern of ECRS is essential to diagnosing this subtype, there is currently no consensus for diagnosis. Our aim in this study ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,meta分析

    doi:10.1002/alr.22194

    authors: McHugh T,Snidvongs K,Xie M,Banglawala S,Sommer D

    更新日期:2018-12-01 00:00:00

  • Impact of continued medical therapy in patients with refractory chronic rhinosinusitis.

    abstract:BACKGROUND:Patients with refractory chronic rhinosinusitis (RCRS) have persistent symptoms despite best medical therapy. Some evidence suggests continued medical therapy (CMT) is appropriate for patients with RCRS. The primary objective of this study was to evaluate the clinical impact of CMT in patients with RCRS who ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21238

    authors: Smith KA,Rudmik L

    更新日期:2014-01-01 00:00:00

  • Sinonasal adenoid cystic carcinoma: a population-based analysis of 694 cases.

    abstract:BACKGROUND:Currently, limited literature exists about sinonasal adenoid cystic carcinoma (SNACC). In this study, we analyze the demographics, survival, and treatment efficacy of this rare entity. METHODS:Our study was a retrospective population-based analysis of SNACC in the Surveillance, Epidemiology, and End Results...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21875

    authors: Unsal AA,Chung SY,Zhou AH,Baredes S,Eloy JA

    更新日期:2017-03-01 00:00:00

  • Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.

    abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21440

    authors: Chang EH,Tang XX,Shah VS,Launspach JL,Ernst SE,Hilkin B,Karp PH,Abou Alaiwa MH,Graham SM,Hornick DB,Welsh MJ,Stoltz DA,Zabner J

    更新日期:2015-02-01 00:00:00