Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer.

abstract：:Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid d...

journal_title：Scientific reports

authors： Chang JC,Yen AM,Chen HH,Chen SL,Chiu SY,Fann JC,Lee CS

更新日期：2017-01-27 00:00:00

abstract：:The benefits that physical exercise confers on cardiovascular health are well known, whereas the notion that physical exercise can also improve cognitive performance has only recently begun to be explored and has thus far yielded only controversial results. In the present study, we used a sample of young male subjects...

journal_title：Scientific reports

authors： Perini R,Bortoletto M,Capogrosso M,Fertonani A,Miniussi C

更新日期：2016-05-05 00:00:00

abstract：:Air pollution has aroused significant public concern in China, therefore, long-term air-quality data with high temporal and spatial resolution are needed to understand the variations of air pollution in China. However, the yearly variations with high spatial resolution of air quality and six air pollutants are still u...

journal_title：Scientific reports

authors： Guo H,Gu X,Ma G,Shi S,Wang W,Zuo X,Zhang X

更新日期：2019-10-23 00:00:00

abstract：:The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (su...

journal_title：Scientific reports

authors： Kondili M,Fust A,Preussner J,Kuenne C,Braun T,Looso M

更新日期：2017-06-01 00:00:00

abstract：:The interpenetrating morphology formed by the electron donor and acceptor materials is critical for the performance of polymer:fullerene bulk heterojunction (BHJ) photovoltaic (PV) cells. In this work we carried out a systematic investigation on a high PV efficiency (>6%) BHJ system consisting of a newly developed 5,6...

journal_title：Scientific reports

authors： Xiao T,Xu H,Grancini G,Mai J,Petrozza A,Jeng US,Wang Y,Xin X,Lu Y,Choon NS,Xiao H,Ong BS,Lu X,Zhao N

更新日期：2014-06-09 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Shin Y,Kim ST,Kim K,Kim MY,Oh S,Jeong JK

更新日期：2018-05-15 00:00:00

abstract：:Inertial and deformability- based particles separations gradually attract more significant attentions. In this work, we present a hybrid chip by combining the advantages of inertial and deformability -based principle. The chip is a triplet parallelizing spiral inertial microfluidic chip interconnected with numerable t...

journal_title：Scientific reports

authors： Chen H

更新日期：2018-03-06 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Wolpe N,Zhang J,Nombela C,Ingram JN,Wolpert DM,Cam-CAN.,Rowe JB

更新日期：2018-11-22 00:00:00

abstract：:DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Wester...

journal_title：Scientific reports

authors： He TY,Wu DW,Lin PL,Wang L,Huang CC,Chou MC,Lee H

更新日期：2016-02-19 00:00:00

abstract：:Laryngeal squamous cell carcinoma is a major medical problem worldwide. Although our understanding of genetic changes and their consequences in laryngeal cancer has opened new therapeutic pathways over the years, the diagnostic as well as treatment options still need to be improved. In our previous study, we identifie...

journal_title：Scientific reports

authors： Kostrzewska-Poczekaj M,Bednarek K,Jarmuz-Szymczak M,Bodnar M,Filas V,Marszalek A,Bartochowska A,Grenman R,Kiwerska K,Szyfter K,Giefing M

更新日期：2020-01-08 00:00:00

abstract：:Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties v...

journal_title：Scientific reports

authors： Yang M,Weng L,Zhu H,Zhang F,Fan T,Zhang D

更新日期：2017-12-07 00:00:00

abstract：:Next generation sequencing has disrupted genetic testing, allowing far more scope in the tests applied. The appropriate sections of the genome to be tested can now be readily selected, from single mutations to whole-genome sequencing. One product offering within this spectrum are focused exomes, targeting ~5,000 genes...

journal_title：Scientific reports

authors： Pengelly RJ,Ward D,Hunt D,Mattocks C,Ennis S

更新日期：2020-02-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cencetti G,Clusella P,Fanelli D

更新日期：2020-02-18 00:00:00

abstract：:The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...

journal_title：Scientific reports

authors： Yen HY,Tsao CW,Lin YW,Kuo CC,Tsao CH,Liu CY

更新日期：2019-11-21 00:00:00

abstract：:Atmospheric nitrated polycyclic aromatic hydrocarbons (NPAHs), which have been shown to have adverse health effects such as carcinogenicity, are formed in part through nitration reactions of their parent polycyclic aromatic hydrocarbons (PAHs) in the atmosphere. However, little is known about heterogeneous nitration r...

journal_title：Scientific reports

authors： Kameda T,Azumi E,Fukushima A,Tang N,Matsuki A,Kamiya Y,Toriba A,Hayakawa K

更新日期：2016-04-14 00:00:00

abstract：:Autosomal dominant North Carolina macular dystrophy (NCMD) is believed to represent a failure of macular development. The disorder has been linked to two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13). Recently, non-coding variants upstream of PRDM13 (MCDR1) and a duplication including IRX1 (MCDR3) have...

journal_title：Scientific reports

authors： Cipriani V,Silva RS,Arno G,Pontikos N,Kalhoro A,Valeina S,Inashkina I,Audere M,Rutka K,Puech B,Michaelides M,van Heyningen V,Lace B,Webster AR,Moore AT

更新日期：2017-08-08 00:00:00

abstract：:In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...

journal_title：Scientific reports

authors： Ow JR,Palanichamy Kala M,Rao VK,Choi MH,Bharathy N,Taneja R

更新日期：2016-09-26 00:00:00

abstract：:It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) ...

journal_title：Scientific reports

authors： Anand A,Sharma NK,Singh R,Gupta A,Prabhakar S,Jindal N,Bhatt AK,Sharma SK,Gupta PK

更新日期：2014-02-18 00:00:00

abstract：:The present study investigated when emotion modulates working memory from the perspective of neural activation. Using fMRI, we measured brain activity during the encoding and retrieval phases of a reading span test (RST) that used emotional contexts. The emotional RST required participants to read sentences that elici...

journal_title：Scientific reports

authors： Osaka M,Yaoi K,Minamoto T,Osaka N

更新日期：2013-01-01 00:00:00

abstract：:Animal behavior is highly structured. Yet, structured behavioral patterns-or "statistical ethograms"-are not immediately apparent from the full spatiotemporal data that behavioral scientists usually collect. Here, we introduce a framework to quantitatively characterize rodent behavior during spatial (e.g., maze) navig...

journal_title：Scientific reports

authors： Donnarumma F,Prevete R,Maisto D,Fuscone S,Irvine EM,van der Meer MAA,Kemere C,Pezzulo G

更新日期：2021-01-11 00:00:00

abstract：:Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. ...

journal_title：Scientific reports

authors： Tang X,Eberhart JK,Cleves MA,Li J,Li M,MacLeod S,Nembhard WN,Hobbs CA

更新日期：2018-07-23 00:00:00

abstract：:Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intak...

journal_title：Scientific reports

authors： Zheng F,Kim YJ,Moran TH,Li H,Bi S

更新日期：2016-04-07 00:00:00

abstract：:The Sigma-1 receptor (S1R) is known to play a protective role in the central nervous system including the retina. A major barrier for understanding the underlying mechanism is an ambiguity of S1R subcellular localizations. We thus conducted the first electron microscopy (EM) study of S1R subcellular distribution in th...

journal_title：Scientific reports

authors： Mavlyutov TA,Epstein M,Guo LW

更新日期：2015-06-02 00:00:00

abstract：:Cardiomyocytes differentiated from human pluripotent stem cells provide promising tools for screening of cardiotoxic drugs. For evaluation of human pluripotent stem cell-derived cardiomyocytes for cardiotoxicity test, in the present study, human embryonic stem cells (hESCs) were differentiated to cardiomyocytes, follo...

journal_title：Scientific reports

authors： Kim HS,Yoon JW,Li H,Jeong GO,Park JJ,Shin SE,Jang IH,Kim JH,Park WS

更新日期：2017-10-23 00:00:00

abstract：:The COVID-19 pandemic has exceeded over sixty-five million cases globally. Different approaches are followed to mitigate its impact and reduce its spreading in different countries, but limiting mobility and exposure have been de-facto precautions to reduce transmission. However, a full lockdown cannot be sustained for...

journal_title：Scientific reports

authors： Parajuli RR,Mishra B,Banstola A,Ghimire BR,Poudel S,Sharma K,Dixit SM,Sah SK,Simkhada P,van Teijlingen E

更新日期：2020-12-10 00:00:00

abstract：:Biomarkers of Huntington's disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein ne...

journal_title：Scientific reports

authors： Byrne LM,Rodrigues FB,Johnson EB,De Vita E,Blennow K,Scahill R,Zetterberg H,Heslegrave A,Wild EJ

更新日期：2018-03-09 00:00:00

abstract：:The Leading Edge Vortex (LEV) is a universal mechanism enhancing lift in flying organisms. LEVs, generally illustrated as a single vortex attached to the wing throughout the downstroke, have not been studied quantitatively in freely flying insects. Previous findings are either qualitative or from flappers and tethered...

journal_title：Scientific reports

authors： Johansson LC,Engel S,Kelber A,Heerenbrink MK,Hedenström A

更新日期：2013-11-20 00:00:00

abstract：:Electromyography (EMG) is the standard technology for monitoring muscle activity in laboratory environments, either using surface electrodes or fine wire electrodes inserted into the muscle. Due to limitations such as cost, complexity, and technical factors, including skin impedance with surface EMG and the invasive n...

journal_title：Scientific reports

authors： Woodward RB,Stokes MJ,Shefelbine SJ,Vaidyanathan R

更新日期：2019-04-03 00:00:00

abstract：:The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We...

journal_title：Scientific reports

authors： Hume DA,Wollscheid-Lengeling E,Rojo R,Pridans C

更新日期：2017-12-07 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of adipogenesis. In adipocytes, ligand-dependent PPARγ activation is associated with proteasomal degradation; therefore, regulation of PPARγ degradati...

journal_title：Scientific reports

authors： Li JJ,Wang R,Lama R,Wang X,Floyd ZE,Park EA,Liao FF

更新日期：2016-12-05 00:00:00