Abstract:
AIM:The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS:Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were included in this study. RESULTS:The patients with good CCC had significantly higher IGF-1 levels compared with the poor ones. On the contrary, hs-CRP was significantly lower in the good CCC group. We also demonstrated that IGF-1 level was significantly related with the grade of CCC. CONCLUSION:We believe that measurement of IGF-1 level may help clinicians for predicting CCC development.
journal_name
Biomark Medjournal_title
Biomarkers in medicineauthors
Kundi H,Gok M,Kiziltunc E,Cetin M,Ornek Edoi
10.2217/bmm-2016-0354subject
Has Abstractpub_date
2017-07-01 00:00:00pages
527-534issue
7eissn
1752-0363issn
1752-0371journal_volume
11pub_type
杂志文章abstract::Biomarker discovery is essential to the advancement of our knowledge about diseases and to the development of new strategies for treatment and therapy. Among the newest technologies in this rapidly growing field is a process termed Cell SELEX by which a panel of aptamers can be generated to specifically target disease...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.09.5
更新日期:2009-04-01 00:00:00
abstract::This article focuses on biochemical markers that may be used in the diagnostics of Parkinson's disease and associated disorders, and to identify early cases and stratify patients into subgroups. We present an updated account of some currently available candidate fluid biomarkers, and discuss their diagnostic performan...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.10.84
更新日期:2010-10-01 00:00:00
abstract:AIM:To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). PATIENTS & METHODS:Hundred RA and 100 controls were included. RESULTS:MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 an...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0148
更新日期:2016-09-01 00:00:00
abstract:AIM:To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS:Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model w...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0056
更新日期:2016-07-01 00:00:00
abstract::Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary pod...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.2.6.613
更新日期:2008-12-01 00:00:00
abstract::Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowe...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0281
更新日期:2020-12-01 00:00:00
abstract::The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and t...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.13.74
更新日期:2013-08-01 00:00:00
abstract:AIM:To investigate the role of MMP-9 (-1562 C:T) polymorphism as a biomarker for susceptibility to pre-eclampsia. PATIENTS & METHODS:MMP-9 variants were detected in 160 women with mild and severe pre-eclampsia and 112 healthy pregnant women. RESULTS:A significantly higher frequency of MMP-9 CT genotype was observed i...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.12.95
更新日期:2013-02-01 00:00:00
abstract::The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to Octo...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,meta分析
doi:10.2217/bmm-2017-0420
更新日期:2018-07-01 00:00:00
abstract::The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attemp...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0369
更新日期:2017-04-01 00:00:00
abstract::Aim: To develop robust and accurate prognostic biomarkers to help clinicians optimize therapeutic strategies. Materials & methods: Differentially prognosis-related autophagy genes were identified by bioinformatics analysis method. Results: Seven prognosis-related autophagy genes were more significantly related to the ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0170
更新日期:2020-09-01 00:00:00
abstract::The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-r...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2016-0228
更新日期:2017-01-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is a highly aggressive and invasive tumor, whose incidence is expected to peak, in many countries, at the end of the present decade, 20-40 years after the peak of asbestos use (asbestos being the most important etiological factor). MPM has a poor prognosis, in part, owing to a diff...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.11.18
更新日期:2011-04-01 00:00:00
abstract::Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0326
更新日期:2017-08-01 00:00:00
abstract::Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorde...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm-2017-0124
更新日期:2017-12-01 00:00:00
abstract:AIM:To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. MATERIALS & METHODS:Electronic databases were searched to extensively identify drug-HLA association studies fro...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.15.98
更新日期:2015-01-01 00:00:00
abstract:AIM:The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown. METHODS:A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point ...
journal_title:Biomarkers in medicine
pub_type: 临床试验,杂志文章
doi:10.2217/bmm-2018-0186
更新日期:2018-12-01 00:00:00
abstract::The current cost of developing a successful drug is typically over a billion dollars, with the registration trial(s) determining the success or failure of the entire development program. Often the primary endpoint of these trials is a subjective assessment. For registration trials with subjective endpoints, a regulato...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.74
更新日期:2012-12-01 00:00:00
abstract::Cardiac troponin is the standard biomarker for the diagnosis of acute myocardial infarction (AMI) and risk stratification for short-term adverse cardiac events (death, AMI or need for revascularization). Unfortunately, the concentration of troponin in blood is normal in AMI patients who present early after the onset o...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/17520363.1.1.45
更新日期:2007-06-01 00:00:00
abstract::Background: We aimed to assess the predictive value of the absolute and relative intact parathormone (iPTH) decline levels as reliable markers of postoperative hypocalcemia. Materials & methods: iPTH levels were measured 4 h after surgery and the following morning after surgery (postoperative day 1). iPTH, absolute iP...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2020-0218
更新日期:2020-08-01 00:00:00
abstract::Acute kidney injury is a common and significant complication among pediatric patients with congenital heart disease, occurring most commonly after cardiopulmonary bypass. Current laboratory methods of diagnosis are not timely enough to guide management decisions, thus spurring interest in discovering new biomarkers of...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.12.27
更新日期:2012-06-01 00:00:00
abstract::Aim: To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients & methods: All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were a...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2019-0030
更新日期:2019-08-01 00:00:00
abstract:AIM:To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS:Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FAB...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0207
更新日期:2018-02-01 00:00:00
abstract:AIM:We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS:A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues'...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2016-0238
更新日期:2017-03-01 00:00:00
abstract::The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular flui...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.10.67
更新日期:2010-08-01 00:00:00
abstract::Increased neurohormonal activation is a key feature of heart failure (HF). Copeptin is a surrogate marker for proarginine vasopressin and the prognostic value of copeptin has been reported for multiple disease states of both nonvascular and cardiovascular etiology. Elevated plasma copeptin in HF has been associated wi...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.14.50
更新日期:2014-01-01 00:00:00
abstract:AIM:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS:128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa we...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm-2017-0371
更新日期:2018-07-01 00:00:00
abstract:AIM:This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. MATERIALS & METHODS:Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h r...
journal_title:Biomarkers in medicine
pub_type: 杂志文章
doi:10.2217/bmm.11.89
更新日期:2011-12-01 00:00:00
abstract::Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response rates remain low and ...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.15.5
更新日期:2015-01-01 00:00:00
abstract::Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid predi...
journal_title:Biomarkers in medicine
pub_type: 杂志文章,评审
doi:10.2217/bmm.14.19
更新日期:2014-01-01 00:00:00