Abstract:
:Many gene- and pathway-based association tests have been proposed in the literature. Among them, the SKAT is widely used, especially for rare variants association studies. In this paper, we investigate the connection between SKAT and a principal component analysis. This investigation leads to a procedure that encompasses SKAT as a special case. Through simulation studies and real data applications, we compare the proposed method with some existing tests.
journal_name
Stat Appl Genet Mol Biolauthors
Chen Z,Han S,Wang Kdoi
10.1515/sagmb-2016-0061subject
Has Abstractpub_date
2017-07-26 00:00:00pages
189-198issue
3eissn
2194-6302issn
1544-6115pii
/j/sagmb.ahead-of-print/sagmb-2016-0061/sagmb-2016journal_volume
16pub_type
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