Abstract:
OBJECTIVES:Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS:Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire. The G. biloba groups received 60 mg/kg oral G. biloba extract once daily. No medication was given to the control groups. On days 7, 21 and 35, both sets of femurs were evaluated radiologically and histopathologically. RESULTS:Histological evaluation revealed that the G. biloba groups had significant differences at 21 and 35 days (p<0.05). The G. biloba group showed a significant difference in terms of bone formation on day 21 when compared to the control group (p<0.05). CONCLUSIONS:This study indicated that the use of G. biloba extract accelerated fracture healing. Both radiological and histological differences were detected, but the histological differences were more remarkable. Level of Evidence I, High Quality Randomized Trial. OBJETIVOS:O extrato de Ginkgo biloba (EGb 761) é um extrato vegetal obtido das folhas da árvore Ginkgo biloba. O objetivo deste estudo foi avaliar os efeitos histológicos e radiológicos do extrato de Ginkgo biloba sobre a consolidação de fraturas em um modelo experimental de fratura em fêmures de rato. MÉTODOS:Foram utilizados 48 ratos Sprague-Dawley fêmeas (peso: 195-252 g, idade: 20 semanas). Os ratos foram divididos randomicamente em seis grupos (n = 8). Uma fratura transversal foi feita no meio do fêmur direito de cada rato e fixada com fio de Kirschner. Os grupos G. biloba receberam 60 mg/kg de G. biloba por via oral uma vez por dia. Não foi administrada nenhuma medicação aos grupos de controle. Nos dias 7, 21 e 35, ambos os fêmures foram avaliados radiológica e histopatologicamente. RESULTADOS:A avaliação histológica revelou que os grupos G. biloba apresentaram diferenças significativas aos 21 e 35 dias (p < 0,05). O grupo G. biloba mostrou uma diferença significativa em termos de formação óssea no dia 21 quando comparado com o grupo controle (p < 0,05). CONCLUSÕES:Este estudo indicou que o uso de extrato de G. biloba acelerou a consolidação de fraturas. As diferenças radiológicas e histológicas foram detectadas, mas as diferenças histológicas foram mais notáveis. Nível de Evidência I, Estudo Clínico Randomizado de Alta Qualidade.
journal_name
Acta Ortop Brasjournal_title
Acta ortopedica brasileiraauthors
Guzel N,Sayit E,Aynaci O,Kerimoglu S,Yulug E,Topbas Mdoi
10.1590/1413-785220172503156966subject
Has Abstractpub_date
2017-05-01 00:00:00pages
95-98issue
3eissn
1413-7852issn
1809-4406journal_volume
25pub_type
杂志文章abstract::The apophyseal fracture or avulsion of the greater trochanter occurs in skeletally immature patients. It has at etiological factors indirect mechanisms (avulsion) and direct mechanisms (trauma on the trochanter), the latter being the most common. The clinical presentation is easily identified and a simple X- ray can c...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章,评审
doi:10.1590/1413-785220162403155803
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To establish the radiographic images of the femoral insertion of the posterior cruciate ligament (PCL), in order to assist the creation of anatomical femoral tunnels during surgeries, and to be used as parameters in postoperative evaluation of the location of these tunnels. METHODS:Thirty adult cadaver knees...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522013000600005
更新日期:2013-01-01 00:00:00
abstract:Objective:Epidural fibrosis is one of the main reasons for requiring repeated surgical intervention. Our objective was to compare the effect of Platelet Rich Plasma (PRP) on the development of epidural fibrosis with collagen dural matrix and free autogenous fat graft. Methods:Male rats were separated into 3 groups. La...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220202801218823
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To study the shoulder of this group of patients using magnetic resonance imaging to detect clinical and subclinical disorders and establish a rehabilitation program. METHODS:Nine patients with spinal cord injury followed in the Laboratory of Biomechanics and Rehabilitation of the Locomotive System at HC/UNIC...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522012000500009
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To report clinical and epidemiological characteristics and risk factors of patients with Carpal Tunnel Syndrome (CTS) on sick leave admitted in a University Hospital. METHODS:This is a transversal study conducted with patients admitted sequentially over 18 years of age, without distinction of gender and race...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220152305145784
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:: Analyze the effects of physical exertion during a soccer match on the functional capacity and stability of the lower limbs of young soccer players. METHODS:: We analyzed 10 soccer players who underwent functional capacity assessment of the lower limbs by a Hop Test protocol and evaluation of the level of p...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522013000300005
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the functional outcome of patients with surgically treated terrible triad of the elbow. METHODS:A retrospective evaluation was performed using the MEPS score (Mayo Elbow Performance Score) of patients diagnosed with terrible triad of the elbow who underwent surgical treatment. RESULTS:14 patien...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-78522015230301008
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The aim of the treatment of tibial plateau fractures is to obtain a pain-free and fully functional knee with closed reduction, percutaneous cannulated screw fixation and hexapodal external fixator reconstruction for high energy compound upper tibial fractures. METHODS:Patients with comminuted tibial plateau...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522014000100008
更新日期:2014-01-01 00:00:00
abstract:Objective:To evaluate the radiation dose received by staff in spine surgeries, including those who are not considered occupationally exposed workers. Methods:All spinal surgeries performed in the same department during a period of 12 months were evaluated with regard to the exposure of surgeons, scrub nurses, and auxi...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract:Objective:To evaluate the mechanical behavior of the proximal end of the femur submitted to the X-shaped polymethylmethacrylate (PMMA) reinforcement technique. Methods:Fifteen synthetic femurs, with a Nacional® density of 10 PCF, were divided into two groups: the DX group, with 5 units that were submitted to PMMA rein...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220182604187691
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the value of post-treatment follow-up in osteosarcoma patients. METHODS:Data were collected through a clinical record, with socio-demographic and clinical data, and information relating to the medical appointment. Descriptive analysis of the data was carried out. The Chi-squared test was used to ...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522012000400009
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To quantify the FHL length difference obtained through a single approach and by a double combined approach. METHODS:16 fresh cadavers, a total of 32 feet, were used to measure the FHL graft length. With the cadaver positioned in ventral decubitus, a posteromedial incision in the ankle and a second incision i...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-78522014220300846
更新日期:2014-01-01 00:00:00
abstract:Objective:To compare postoperative radiographic outcomes of Schatzker type V and VI tibial plateau fractures treated with double-plate or single lateral locked plate. Methods:Sixty-three patients operated from December 2011 to February 2016 were selected, 47 from the double-plate group and 16 from the single lateral l...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220202804233122
更新日期:2020-07-01 00:00:00
abstract:Objective:To assess the knowledge and technical preferences of Brazilian knee surgeons in relation to the treatment of Anterior Cruciate Ligament (ACL) injuries using intra-articular reconstruction in combination with extra-articular reconstruction. Methods:A questionnaire consisting of 16 questions about intra-articu...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220192704192828
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To analyze the characteristics of patients with Lisfranc injuries and their associated fractures . METHODS:This is a retrospective analysis on 42 patients with Lisfranc injuries hospitalized at Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Fa...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220172501168995
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:: To evaluate clinically and radiologically the elbows of spinal cord injured patients and compare them to the control group. METHODS:: Twenty patients (10 paraplegics and 10 tetraplegics) were clinically evaluated through assessment of pain scale, measurement of active and passive range of motion, degree o...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220162402154665
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Retrospective clinical evaluation of 31 patients who underwent ulnar nerve decompression at the elbow and subcutaneous anterior transposition. METHODS:From January 2000 to December 2013, 71 patients underwent subcutaneous anterior transposition of the ulnar nerve. Thirty-one patients returned for evaluation...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220162404157171
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Cervical myelopathy is a spinal cord dysfunction related to degeneration typical of aging. Its primary pathology is related to ischemia and spinal cord compression. Patients with myelopathy present many clinical problems; more severe cases may lead to quadriplegia if not treated in a timely manner. Because th...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522012000300009
更新日期:2012-01-01 00:00:00
abstract:Objective:To analyze and follow-up patients previously selected by pediatricians at the time of birth who presented altered initial physical examination results to identify the pathological changes in their hips. Methods:A prospective cohort study was conducted involving 34 newborns (68 hips) out of a total of 1273 li...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220192706220630
更新日期:2019-11-01 00:00:00
abstract:Objective:This study aims to establish the current panorama of the anterior cruciate ligament reconstruction surgery in Brazil. Methods:A survey that consisted of a 24-item questionnaire including surgeon's demographics, preferred technique, graft selection, graft positioning, use of braces, drains, antibiotic prophyl...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220192703182208
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To determine intra and interobserver agreement of the grading system for femoral cementation in hip arthroplasty proposed by Barrack. METHODS:Immediate anteroposterior and lateral postoperative radiographs of 55 primary total hip arthroplasties were assessed by two observers familiar with the use of this gra...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522013000100006
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to describe concepts of health economics in order to update and provide the orthopedic practitioner decision making parameters based on preferences. Four basic types of studies of economical evaluation were presented (cost minimization analysis, cost-benefit, cost-effectiveness and cost-utili...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-78522014220200456
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To translate and culturally adapt the Rowe score for use in Brazil. METHODS:The translation and cross-cultural adaptation process initially involved the steps of translation, synthesis, back-translation and revision by the Translation Group. The pre-final version of the questionnaire was then created. The St...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522012000600007
更新日期:2012-12-01 00:00:00
abstract:Objectives:To describe the surgical treatment of fractures that involves the hallux interphalangeal joint, current indications and management options. Methods:we performed a literature review of relevant clinical studies in multiple databases, including PubMed, MedLine and Scopus, from January 1989 to October 2020. R...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章,评审
doi:10.1590/1413-785220202806236612
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To compare the value of Q angle in different positions, in the external and internal rotations of lower limbs. METHODS:This is a descriptive cross-sectional study. We have evaluated 62 volunteers, 32 women and 30 men in the following positions: supine positions with parallel feet, supine with abduction (exte...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-78522014220600451
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether distal rectus femoris transfer (DRFT) is related to postoperative increase of knee flexion during the stance phase in cerebral palsy (CP). METHODS:The inclusion criteria were Gross Motor Function Classification System (GMFCS) levels I-III, kinematic criteria for stiff-knee gait at baselin...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220162401145765
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To analyze whether association between bone fragility and risk of fracture depends on the trauma level. METHOD:All participants along with their mothers underwent DXA scan and body measurements. The subjects answered a self-report questionnaire about their physical activities and the precipitating causes. Th...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220172502163455
更新日期:2017-03-01 00:00:00
abstract:Objective:To compare the classification of CTS by the Phalen test with electromyography. Methods:Cross-sectional observational study. Patients at orthopedic outpatient clinic with carpal tunnel syndrome were evaluated by the Phalen test and compared with the result of the electroneuromyography. Results:Sample of 33 p...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220202803225744
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The influence of dose of low power lasertherapy (AsGaAl, 830 nm) on the regeneration of the fibular nerve of rats after a crush injury was evaluated by means of the functional gait analysis and histomorphometric parameters. METHODS:Controlled crush injury of the right common fibular nerve, immediately follow...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/S1413-78522013000500005
更新日期:2013-01-01 00:00:00
abstract:Objective:To evaluate the age in which the secondary ossification centers of the elbow appear and fuse in the Brazilian population. Methods:Nearly thirty radiographs were randomly selected for each age group from 0 to 18 years, with a total of 544 radiographs from 439 patients, between 2010 and 2015, without abnormali...
journal_title:Acta ortopedica brasileira
pub_type: 杂志文章
doi:10.1590/1413-785220172506170954
更新日期:2017-11-01 00:00:00