Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats.

Abstract:

OBJECTIVES:Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS:Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire. The G. biloba groups received 60 mg/kg oral G. biloba extract once daily. No medication was given to the control groups. On days 7, 21 and 35, both sets of femurs were evaluated radiologically and histopathologically. RESULTS:Histological evaluation revealed that the G. biloba groups had significant differences at 21 and 35 days (p<0.05). The G. biloba group showed a significant difference in terms of bone formation on day 21 when compared to the control group (p<0.05). CONCLUSIONS:This study indicated that the use of G. biloba extract accelerated fracture healing. Both radiological and histological differences were detected, but the histological differences were more remarkable. Level of Evidence I, High Quality Randomized Trial. OBJETIVOS:O extrato de Ginkgo biloba (EGb 761) é um extrato vegetal obtido das folhas da árvore Ginkgo biloba. O objetivo deste estudo foi avaliar os efeitos histológicos e radiológicos do extrato de Ginkgo biloba sobre a consolidação de fraturas em um modelo experimental de fratura em fêmures de rato. MÉTODOS:Foram utilizados 48 ratos Sprague-Dawley fêmeas (peso: 195-252 g, idade: 20 semanas). Os ratos foram divididos randomicamente em seis grupos (n = 8). Uma fratura transversal foi feita no meio do fêmur direito de cada rato e fixada com fio de Kirschner. Os grupos G. biloba receberam 60 mg/kg de G. biloba por via oral uma vez por dia. Não foi administrada nenhuma medicação aos grupos de controle. Nos dias 7, 21 e 35, ambos os fêmures foram avaliados radiológica e histopatologicamente. RESULTADOS:A avaliação histológica revelou que os grupos G. biloba apresentaram diferenças significativas aos 21 e 35 dias (p < 0,05). O grupo G. biloba mostrou uma diferença significativa em termos de formação óssea no dia 21 quando comparado com o grupo controle (p < 0,05). CONCLUSÕES:Este estudo indicou que o uso de extrato de G. biloba acelerou a consolidação de fraturas. As diferenças radiológicas e histológicas foram detectadas, mas as diferenças histológicas foram mais notáveis. Nível de Evidência I, Estudo Clínico Randomizado de Alta Qualidade.

journal_name

Acta Ortop Bras

authors

Guzel N,Sayit E,Aynaci O,Kerimoglu S,Yulug E,Topbas M

doi

10.1590/1413-785220172503156966

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

95-98

issue

3

eissn

1413-7852

issn

1809-4406

journal_volume

25

pub_type

杂志文章
  • DOES RECTUS FEMORIS TRANSFER INCREASE KNEE FLEXION DURING STANCE PHASE IN CEREBRAL PALSY?

    abstract:OBJECTIVE:To evaluate whether distal rectus femoris transfer (DRFT) is related to postoperative increase of knee flexion during the stance phase in cerebral palsy (CP). METHODS:The inclusion criteria were Gross Motor Function Classification System (GMFCS) levels I-III, kinematic criteria for stiff-knee gait at baselin...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220162401145765

    authors: de Morais MC,Blumetti FC,Kawamura CM,Lopes JA,Neves DL,Cardoso Mde O

    更新日期:2016-01-01 00:00:00

  • COMPARISON OF BICONDYLAR TIBIAL PLATEAU FRACTURES WITH DOUBLE OR SINGLE LATERAL LOCKED PLATE.

    abstract:Objective:To compare postoperative radiographic outcomes of Schatzker type V and VI tibial plateau fractures treated with double-plate or single lateral locked plate. Methods:Sixty-three patients operated from December 2011 to February 2016 were selected, 47 from the double-plate group and 16 from the single lateral l...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220202804233122

    authors: Arouca MM,da Costa GHR,Leonhardt MC,Barbosa D,Silva JDS,Kojima KE

    更新日期:2020-07-01 00:00:00

  • COMPLICATIONS AND MIDTERM OUTCOMES OF HEMIARTHROPLASTY IN HEMODIALYSIS PATIENTS.

    abstract:OBJECTIVE:The aim of this study was to evaluate the functional results, complications, and morbidity and mortality rates in patients with end-stage chronic renal failure (ESCRF) with collum femoris fractures who were treated with hemiarthroplasty. METHODS:From 2005 to 2013, patients with ESCRF admitted to our hospital...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220172505167473

    authors: Salduz A,Polat G,Akgül T,Ergin ON,Şahin K,Yazicioğlu Ö

    更新日期:2017-09-01 00:00:00

  • EFFECT OF PLATELET-RICH PLASMA, FAT PAD AND DURAL MATRIX IN PREVENTING EPIDURAL FIBROSIS.

    abstract:Objective:Epidural fibrosis is one of the main reasons for requiring repeated surgical intervention. Our objective was to compare the effect of Platelet Rich Plasma (PRP) on the development of epidural fibrosis with collagen dural matrix and free autogenous fat graft. Methods:Male rats were separated into 3 groups. La...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220202801218823

    authors: Guler S,Akcali O,Sen B,Micili SC,Sanli NK,Cankaya D

    更新日期:2020-01-01 00:00:00

  • Health economics and health preference concepts to orthopedics practitioners.

    abstract::The aim of this study was to describe concepts of health economics in order to update and provide the orthopedic practitioner decision making parameters based on preferences. Four basic types of studies of economical evaluation were presented (cost minimization analysis, cost-benefit, cost-effectiveness and cost-utili...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522014220200456

    authors: Araújo CD,Veiga DF,Hochman B,Abla LE,Novo NF,Ferreira LM

    更新日期:2014-01-01 00:00:00

  • Flexor hallux tendon transfer: comparative study through double or single approach.

    abstract:OBJECTIVE:To quantify the FHL length difference obtained through a single approach and by a double combined approach. METHODS:16 fresh cadavers, a total of 32 feet, were used to measure the FHL graft length. With the cadaver positioned in ventral decubitus, a posteromedial incision in the ankle and a second incision i...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522014220300846

    authors: Sakaki MH,Godoy-Santos AL,Ortiz RT,Araújo A,Fernandes TD

    更新日期:2014-01-01 00:00:00

  • RELATIONSHIP BETWEEN BONE MINERAL DENSITY AND BODY COMPOSITION IN ELDERLY.

    abstract:Objective:To evaluate the association between bone mineral density (BMD) and body composition in healthy older adults at different skeletal sites. Methods:We analyzed 87 medical records and BMD along with the body composition of men ranging from 60 to 87 years of age (mean: 68.5, standard deviation: 6.5). Inclusion cr...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220182601182340

    authors: Alonso AC,Gonçalves TA,Almeida JKA,Machado-Lima A,Ernandes RC,Greve JMD,Garcez-Leme LE

    更新日期:2018-01-01 00:00:00

  • METHOD FOR REMOVING BROKEN PROXIMAL FEMORAL NAILS USING EXISTING SCREW HOLE.

    abstract::The use of intramedullary nailing to treat proximal femoral fractures has increased in recent years. Nail breakage is a rare complication of intramedullary nailing of the femur, and generally occurs at the non-united fracture site. Removal of the distal fragment of a broken nail is a challenging problem. In this artic...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220182601148079

    authors: Man CH,Bae MW

    更新日期:2018-01-01 00:00:00

  • Role of early shoulder tomography on the obstetric brachial plexus palsy.

    abstract:OBJECTIVE:To demonstrate the importance of performing early shoulder tomography in patients with obstetric brachial plexus palsy (OBPP). METHODS:This series of cases retrospective study with level evidence IV was conducted by consulting 76 patient's medical records with OBPP divided into three age groups: ≤12 months, ...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522015230101023

    authors: Silva BL,Kimura LK,Crepaldi BE,Mattar R Jr,Cho ÁB,Oviedo RM

    更新日期:2015-01-01 00:00:00

  • NEUROMUSCULAR ELECTRICAL STIMULATION OF MEDIUM AND LOW FREQUENCY ON THE QUADRICEPS FEMORIS.

    abstract:Objective:The purpose of this study was to investigate the effects of neuromuscular electrical stimulation (NMES) in different frequencies on the quadriceps femoris. A randomized, controlled, blind cross-sectional study. Methods:Thirty subjects (12 men and 18 women), with an average age of 24.67 years, weight of 65.62...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220182605178164

    authors: Pinfildi CE,Andraus RAC,Iida LM,Prado RP

    更新日期:2018-01-01 00:00:00

  • ELBOW ULNAR NEUROPATHY: TREATMENT BY ANTERIOR TRANSPOSITION OF THE ULNAR NERVE.

    abstract:OBJECTIVES:Retrospective clinical evaluation of 31 patients who underwent ulnar nerve decompression at the elbow and subcutaneous anterior transposition. METHODS:From January 2000 to December 2013, 71 patients underwent subcutaneous anterior transposition of the ulnar nerve. Thirty-one patients returned for evaluation...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220162404157171

    authors: Neder AT Filho,Alves RA,Pardini AG Júnior,Riberto M,Mazer M

    更新日期:2016-07-01 00:00:00

  • Ascorbic acid iontophoresis for chondral gain in rats with arthritis.

    abstract:OBJECTIVES:To examine the cellularity and thickness of the articular cartilage of the femur in rats with arthritis after treatment with iontophoresis. METHODS:To evaluate these objectives, a histological analysis was performed on hematoxylin and eosin, where cellularity and cartilage thickness were observed and evalua...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522014220400769

    authors: de Arruda MF,Cassettari LL,Neves LM,Oliveira OM,Marcolino AM

    更新日期:2014-01-01 00:00:00

  • Evaluation of Q angle in differents static postures.

    abstract:OBJECTIVE:To compare the value of Q angle in different positions, in the external and internal rotations of lower limbs. METHODS:This is a descriptive cross-sectional study. We have evaluated 62 volunteers, 32 women and 30 men in the following positions: supine positions with parallel feet, supine with abduction (exte...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522014220600451

    authors: Sanchez HM,Sanchez EG,Baraúna MA,Canto RS

    更新日期:2014-01-01 00:00:00

  • Static evaluation of scapular positioning in healthy individuals.

    abstract:OBJECTIVE:Evaluate the static positioning of the scapula on the rib cage in healthy subjects by means of clinical and radiographic evaluation to assess inter-examiner reliability of clinical examination and verify the reliability of this evaluation method compared to the radiographic examination. METHODS:We selected 3...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522013000400005

    authors: Pontin JC,Stadniky SP,Suehara PT,Costa TR,Chamlian TR

    更新日期:2013-07-01 00:00:00

  • Follow-up of treated osteosarcoma patient.

    abstract:OBJECTIVE:To evaluate the value of post-treatment follow-up in osteosarcoma patients. METHODS:Data were collected through a clinical record, with socio-demographic and clinical data, and information relating to the medical appointment. Descriptive analysis of the data was carried out. The Chi-squared test was used to ...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522012000400009

    authors: Martins GE,Perez SV

    更新日期:2012-01-01 00:00:00

  • PROFILE OF PATIENTS ON SICK LEAVE WITH CARPAL TUNNEL SYNDROME.

    abstract:OBJECTIVE:To report clinical and epidemiological characteristics and risk factors of patients with Carpal Tunnel Syndrome (CTS) on sick leave admitted in a University Hospital. METHODS:This is a transversal study conducted with patients admitted sequentially over 18 years of age, without distinction of gender and race...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220152305145784

    authors: de Azevedo JW,de Oliveira AB,Nascimento Vd,de Paiva HR Jr,Viecili L,Rocha MA

    更新日期:2015-09-01 00:00:00

  • ROLE OF ARTERIOVENOUS VASCULAR LOOPS IN MICROSURGICAL RECONSTRUCTION OF THE EXTREMITIES.

    abstract:Objective:To analyze 10 consecutive cases of microsurgical arteriovenous loops created to reconstruct complex injuries from March 2011 to May 2012. Methods:This observational cohort-type study conducted by the Hand and Microsurgery Group at the HC-FMUSP included patients who were candidates for microsurgical reconstru...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220182602187220

    authors: Silva GB,Veronesi BA,Torres LR,Imaguchi RB,Cho AB,Nakamoto HA

    更新日期:2018-03-01 00:00:00

  • Radiographic grading of femoral stem cementation in hip arthroplasty.

    abstract:OBJECTIVE:To determine intra and interobserver agreement of the grading system for femoral cementation in hip arthroplasty proposed by Barrack. METHODS:Immediate anteroposterior and lateral postoperative radiographs of 55 primary total hip arthroplasties were assessed by two observers familiar with the use of this gra...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522013000100006

    authors: Garcia FL,Sugo AT,Picado CH

    更新日期:2013-01-01 00:00:00

  • Effects of laser therapy in peripheral nerve regeneration.

    abstract:OBJECTIVE:The influence of dose of low power lasertherapy (AsGaAl, 830 nm) on the regeneration of the fibular nerve of rats after a crush injury was evaluated by means of the functional gait analysis and histomorphometric parameters. METHODS:Controlled crush injury of the right common fibular nerve, immediately follow...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522013000500005

    authors: Sene GA,Sousa FF,Fazan VS,Barbieri CH

    更新日期:2013-01-01 00:00:00

  • Influence of nitric oxide in the improvement of muscle power.

    abstract:OBJECTIVE:To evaluate whether nitric oxide (NO) supplementa-tion is directly related to increased muscle power in response to strength exercise training. METHODS:The study included 36 individuals who underwent training for eight weeks (three times per week) with weights, who were randomly divided into two groups, both...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220152306148249

    authors: Bernardo DN,Bryk FF,Fucs PM

    更新日期:2015-11-01 00:00:00

  • PREFERED SURGICAL TECHNIQUE USED BY ORTHOPEDISTS IN ACUTE ACROMIOCLAVICULAR DISLOCATION.

    abstract:OBJECTIVE:To determine whether training on shoulder and elbow surgery influences the orthopedist surgeons' preferred technique to address acute acromioclavicular joint dislocation (ACD). METHODS:A survey was conducted with shoulder and elbow specialists and general orthopedists on their preferred technique to address ...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220162405156380

    authors: Nishimi AY,Arbex DS,Martins DL,Gusmão CV,Bongiovanni RR,Pascarelli L

    更新日期:2016-09-01 00:00:00

  • RADIATION EXPOSURE DURING SPINE SURGERY USING C-ARM FLUOROSCOPY.

    abstract:Objective:To evaluate the radiation dose received by staff in spine surgeries, including those who are not considered occupationally exposed workers. Methods:All spinal surgeries performed in the same department during a period of 12 months were evaluated with regard to the exposure of surgeons, scrub nurses, and auxi...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220192701172722

    authors: Cristante AF,Barbieri F,da Silva AAR,Dellamano JC

    更新日期:2019-01-01 00:00:00

  • Correlation between the clinic and the index of cervical myelopathy Torg.

    abstract:OBJECTIVE:Cervical myelopathy is a spinal cord dysfunction related to degeneration typical of aging. Its primary pathology is related to ischemia and spinal cord compression. Patients with myelopathy present many clinical problems; more severe cases may lead to quadriplegia if not treated in a timely manner. Because th...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522012000300009

    authors: Lozorio AR,Borges M,Batista Junior JL,Chacob Junior C,Machado IC,Rezende R

    更新日期:2012-01-01 00:00:00

  • STUDY OF SECONDARY OSSIFICATION CENTERS OF THE ELBOW IN THE BRAZILIAN POPULATION.

    abstract:Objective:To evaluate the age in which the secondary ossification centers of the elbow appear and fuse in the Brazilian population. Methods:Nearly thirty radiographs were randomly selected for each age group from 0 to 18 years, with a total of 544 radiographs from 439 patients, between 2010 and 2015, without abnormali...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220172506170954

    authors: Miyazaki CS,Maranho DA,Agnollitto PM,Nogueira-Barbosa MH

    更新日期:2017-11-01 00:00:00

  • EXTRA-ARTICULAR RECONSTRUCTION ASSOCIATED WITH THE ANTERIOR CRUCIATE LIGAMENT IN BRAZIL.

    abstract:Objective:To assess the knowledge and technical preferences of Brazilian knee surgeons in relation to the treatment of Anterior Cruciate Ligament (ACL) injuries using intra-articular reconstruction in combination with extra-articular reconstruction. Methods:A questionnaire consisting of 16 questions about intra-articu...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220192704192828

    authors: Helito CP,do Amaral C,Camargo DB,Bonadio MB,Pecora JR,Demange MK

    更新日期:2019-07-01 00:00:00

  • CLINICAL AND RADIOGRAPHIC EVALUATION OF ELBOWS FROM SPINAL CORD INJURIED PATIENTS.

    abstract:OBJECTIVES:: To evaluate clinically and radiologically the elbows of spinal cord injured patients and compare them to the control group. METHODS:: Twenty patients (10 paraplegics and 10 tetraplegics) were clinically evaluated through assessment of pain scale, measurement of active and passive range of motion, degree o...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220162402154665

    authors: Casimiro Fde G,de Oliveira GF,Tenório PH,Gagliardi Ida C,Zoppi A,Cliquet A Jr

    更新日期:2016-03-01 00:00:00

  • Glenoumeral dislocation: a prospective randomized study comparing spazo and kocher maneuvers.

    abstract:OBJECTIVE:To evaluate and to compare the Spaso and Kocher reduction maneuvers in terms of efficiency, time of reduction, facileness, pain, discomfort to the patient, complications and risks, besides promoting the comparison between the two maneuvers, aiming to ground the emergency conduct. METHODS:A prospective study ...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-78522015230400701

    authors: Rezende Bda R,de Almeida JI Sr,de Sousa UJ,Bomfim Lde S,Ferreira MS Jr

    更新日期:2015-07-01 00:00:00

  • BONE FRAGILITY, FRACTURE RISK AND TRAUMA:A COMPLICATED TRIANGLE IN CHILDREN.

    abstract:OBJECTIVE:To analyze whether association between bone fragility and risk of fracture depends on the trauma level. METHOD:All participants along with their mothers underwent DXA scan and body measurements. The subjects answered a self-report questionnaire about their physical activities and the precipitating causes. Th...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220172502163455

    authors: Huang DF,Lv DK,Zhao QL,Zhang LF

    更新日期:2017-03-01 00:00:00

  • CURRENT PANORAMA OF ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION SURGERY IN BRAZIL.

    abstract:Objective:This study aims to establish the current panorama of the anterior cruciate ligament reconstruction surgery in Brazil. Methods:A survey that consisted of a 24-item questionnaire including surgeon's demographics, preferred technique, graft selection, graft positioning, use of braces, drains, antibiotic prophyl...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/1413-785220192703182208

    authors: de Campos GC,Nunes LFB,Arruda LRP,Teixeira PEP,Amaral GHA,Alves WM

    更新日期:2019-05-01 00:00:00

  • The effects of exertion on the postural stability in young soccer players.

    abstract:OBJECTIVE:: Analyze the effects of physical exertion during a soccer match on the functional capacity and stability of the lower limbs of young soccer players. METHODS:: We analyzed 10 soccer players who underwent functional capacity assessment of the lower limbs by a Hop Test protocol and evaluation of the level of p...

    journal_title:Acta ortopedica brasileira

    pub_type: 杂志文章

    doi:10.1590/S1413-78522013000300005

    authors: Arliani GG,Almeida GP,Dos Santos CV,Venturini AM,Astur Dda C,Cohen M

    更新日期:2013-05-01 00:00:00