Abstract:
:Human preimplantation developmental studies are difficult to accomplish due to associated ethical and moral issues. Preimplantation cells are rare and exist only in transient cell states. From a single cell, it is very challenging to analyse the origination of the heterogeneity and complexity inherent to the human body. However, recent advances in single-cell technology and data analysis have provided new insights into the process of early human development and germ cell specification. In this Review, we examine the latest single-cell datasets of human preimplantation embryos and germ cell development, compare them to bulk cell analyses, and interpret their biological implications.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Otte J,Wruck W,Adjaye Jdoi
10.1002/1873-3468.12716subject
Has Abstractpub_date
2017-08-01 00:00:00pages
2226-2240issue
15eissn
0014-5793issn
1873-3468journal_volume
591pub_type
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