Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling.

Abstract:

:Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of this study is to explore the gastroprotective effect of the Aronia melanocarpa hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of omeprazole, significantly inhibited the gastric injury formation. The ethanol-induced ulcer group showed significant increases of malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor (TNF)-α, nuclear factor-kappaB p65 (NF-κB p65), and monocyte chemoattractant protein (MCP)-1, and decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), and interleukin (IL)-4. However, AMHAE (200 mg/kg) pretreatment significantly reversed the altered pathophysiological levels of these biomolecules to near normal stages. The gastroprotective activity of AMHAE was abolished by pretreatment with l-NAME, naloxone, capsazepine, and indomethacin, demonstrating the participation of nitric oxide (NO), opioids, TRPV (vanilloid receptor-related transient receptor potential), and prostaglandins in AMHAE-assisted gastroprotection against ethanol-induced gastric injuries. This gastroprotective effect of AMHAE might be due to the downregulation of TNF-α-based NF-κB, MCP-1 signaling and strong antioxidant properties.

journal_name

Int J Mol Sci

authors

Paulrayer A,Adithan A,Lee JH,Moon KH,Kim DG,Im SY,Kang CW,Kim NS,Kim JH

doi

10.3390/ijms18061195

subject

Has Abstract

pub_date

2017-06-05 00:00:00

issue

6

issn

1422-0067

pii

ijms18061195

journal_volume

18

pub_type

杂志文章
  • Disulfide Bond Engineering of an Endoglucanase from Penicillium verruculosum to Improve Its Thermostability.

    abstract::Endoglucanases (EGLs) are important components of multienzyme cocktails used in the production of a wide variety of fine and bulk chemicals from lignocellulosic feedstocks. However, a low thermostability and the loss of catalytic performance of EGLs at industrially required temperatures limit their commercial applicat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071602

    authors: Bashirova A,Pramanik S,Volkov P,Rozhkova A,Nemashkalov V,Zorov I,Gusakov A,Sinitsyn A,Schwaneberg U,Davari MD

    更新日期:2019-03-30 00:00:00

  • Thyroid Hormone Disruptors Interfere with Molecular Pathways of Eye Development and Function in Zebrafish.

    abstract::The effects of thyroid hormone disrupting chemicals (THDCs) on eye development of zebrafish were investigated. We expected THDC exposure to cause transcriptional changes of vision-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. Zebrafish w...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071543

    authors: Baumann L,Segner H,Ros A,Knapen D,Vergauwen L

    更新日期:2019-03-27 00:00:00

  • Metformin: An Old Drug with New Applications.

    abstract::Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19102863

    authors: Zhou J,Massey S,Story D,Li L

    更新日期:2018-09-21 00:00:00

  • Biofilms Positively Contribute to Bacillus amyloliquefaciens 54-induced Drought Tolerance in Tomato Plants.

    abstract::Drought stress is a major obstacle to agriculture. Although many studies have reported on plant drought tolerance achieved via genetic modification, application of plant growth-promoting rhizobacteria (PGPR) to achieve tolerance has rarely been studied. In this study, the ability of three isolates, including Bacillus ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20246271

    authors: Wang DC,Jiang CH,Zhang LN,Chen L,Zhang XY,Guo JH

    更新日期:2019-12-12 00:00:00

  • Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer.

    abstract::Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17071125

    authors: Hojeij R,Domingos-Pereira S,Nkosi M,Gharbi D,Derré L,Schiller JT,Jichlinski P,Nardelli-Haefliger D

    更新日期:2016-07-14 00:00:00

  • Chemical Profile and Antioxidant, Anti-Inflammatory, Antimutagenic and Antimicrobial Activities of Geopropolis from the Stingless Bee Melipona orbignyi.

    abstract::Geopropolis is a resin mixed with mud, produced only by stingless bees. Despite being popularly known for its medicinal properties, few scientific studies have proven its biological activities. In this context, the objective of this study was to determine the chemical composition and antioxidant, anti-inflammatory, an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18050953

    authors: Santos HFD,Campos JF,Santos CMD,Balestieri JBP,Silva DB,Carollo CA,de Picoli Souza K,Estevinho LM,Dos Santos EL

    更新日期:2017-05-03 00:00:00

  • Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects.

    abstract::The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20143430

    authors: Freitas J,Santos SG,Gonçalves RM,Teixeira JH,Barbosa MA,Almeida MI

    更新日期:2019-07-12 00:00:00

  • Reduced Expression of CbUFO Is Associated with the Phenotype of a Flower-Defective Cosmos bipinnatus.

    abstract::LEAFY (LFY) and UNUSUAL FLORAL ORGANS (UFO) homologous genes have been reported to play key roles in promoting the initiation of floral meristems in raceme- and cyme-type plants. Asteraceae, a large family of plants with more than 23,000 species, has a unique head-like inflorescence termed capitulum. Here, we report a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20102503

    authors: Li F,Lan W,Zhou Q,Liu B,Chen F,Zhang S,Bao M,Liu G

    更新日期:2019-05-21 00:00:00

  • Wound Dressing Selection Is Critical to Enhance Platelet-Rich Fibrin Activities in Wound Care.

    abstract::The use of platelet-rich fibrin (PRF) is investigated in ulcer management because it provides a healing milieu rich in growth factors and cytokines. Although crucial, the relevance of secondary dressings is under-researched and no data support the use of any particular dressing in preference to another. We assessed th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21020624

    authors: Del Amo C,Perez-Valle A,Perez-Zabala E,Perez-Del-Pecho K,Larrazabal A,Basterretxea A,Bully P,Andia I

    更新日期:2020-01-17 00:00:00

  • TRPV4: A Physio and Pathophysiologically Significant Ion Channel.

    abstract::Transient Receptor Potential (TRP) channels are a family of ion channels whose members are distributed among all kinds of animals, from invertebrates to vertebrates. The importance of these molecules is exemplified by the variety of physiological roles they play. Perhaps, the most extensively studied member of this fa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21113837

    authors: Rosenbaum T,Benítez-Angeles M,Sánchez-Hernández R,Morales-Lázaro SL,Hiriart M,Morales-Buenrostro LE,Torres-Quiroz F

    更新日期:2020-05-28 00:00:00

  • Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers.

    abstract::Promising targeted therapy and personalized medicine are making molecular profiling of tumours a priority. For colorectal cancer (CRC) patients, international guidelines made RAS (KRAS and NRAS) status a prerequisite for the use of anti-epidermal growth factor receptor agents (anti-EGFR). Daily, new data emerge on the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17122117

    authors: Fontanges Q,De Mendonca R,Salmon I,Le Mercier M,D'Haene N

    更新日期:2016-12-16 00:00:00

  • Binding of ochratoxin A to a urinary globulin: a new concept to account for gender difference in rat nephrocarcinogenic responses.

    abstract::SDS-gradient mini-gel electrophoresis and immunoblotting of urine of rats given ochratoxin A (OTA), showed OTA binding to an alpha2u-globulin. Perceived potential internalised delivery of OTA to proximal tubule epithelia by the carrier, specific only to adult male rats and augmenting other uptake mechanisms, suggests ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms9050719

    authors: Mantle PG,Nagy JM

    更新日期:2008-05-01 00:00:00

  • CES2, ABCG2, TS and Topo-I primary and synchronous metastasis expression and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI regimen.

    abstract::Enzymatic activation of irinotecan (CPT-11) is due to carboxylesterase (CES), and its pharmacological behavior is influenced by drug resistance-related proteins. We previously reported that the clinical response and prognosis of metastatic colorectal cancer (mCRC) patients did not differ in tumors with different thymi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms150915767

    authors: Silvestris N,Simone G,Partipilo G,Scarpi E,Lorusso V,Brunetti AE,Maiello E,Paradiso A,Mangia A

    更新日期:2014-09-05 00:00:00

  • Microbiological, Physicochemical, and Immunological Analysis of a Commercial Cashew Nut-Based Yogurt.

    abstract::Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218267

    authors: Mattison CP,Aryana KJ,Clermont K,Prestenburg E,Lloyd SW,Grimm CC,Wasserman RL

    更新日期:2020-11-04 00:00:00

  • Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.

    abstract::Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19010102

    authors: Ambrosi N,Guerrieri D,Caro F,Sanchez F,Haeublein G,Casadei D,Incardona C,Chuluyan E

    更新日期:2018-01-04 00:00:00

  • Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling.

    abstract::Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of antiapoptotic BCL-2 family proteins is closely linked to neoplastic progression and chemoresistance. Obatoclax is a clinically developed drug, which binds antiapoptotic BCL-2, BCL-xL...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21051773

    authors: Or CR,Huang CW,Chang CC,Lai YC,Chen YJ,Chang CC

    更新日期:2020-03-05 00:00:00

  • A Next-Generation Sequencing Approach to Identify Gene Mutations in Early- and Late-Onset Hypertrophic Cardiomyopathy Patients of an Italian Cohort.

    abstract::Sequencing of sarcomere protein genes in patients fulfilling the clinical diagnostic criteria for hypertrophic cardiomyopathy (HCM) identifies a disease-causing mutation in 35% to 60% of cases. Age at diagnosis and family history may increase the yield of mutations screening. In order to assess whether Next-Generation...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17081239

    authors: Rubattu S,Bozzao C,Pennacchini E,Pagannone E,Musumeci BM,Piane M,Germani A,Savio C,Francia P,Volpe M,Autore C,Chessa L

    更新日期:2016-07-30 00:00:00

  • Chemical reaction of soybean flavonoids with DNA: a computational study using the implicit solvent model.

    abstract::Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13021269

    authors: Abdallah HH,Mavri J,Repič M,Lee VS,Wahab HA

    更新日期:2012-01-01 00:00:00

  • Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development.

    abstract::Intracranial malignancies, such as primary brain cancers and brain-localized metastases derived from peripheral cancers, are particularly difficult to treat with therapeutic agents, because the blood-brain barrier (BBB) effectively minimizes brain entry of the vast majority of agents arriving from the systemic circula...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19123905

    authors: Chen TC,da Fonseca CO,Schönthal AH

    更新日期:2018-12-06 00:00:00

  • Cooperative Binding of KaiB to the KaiC Hexamer Ensures Accurate Circadian Clock Oscillation in Cyanobacteria.

    abstract::The central oscillator generating cyanobacterial circadian rhythms comprises KaiA, KaiB, and KaiC proteins. Their interactions cause KaiC phosphorylation and dephosphorylation cycles over approximately 24 h. KaiB interacts with phosphorylated KaiC in competition with SasA, an output protein harboring a KaiB-homologous...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20184550

    authors: Murakami R,Yunoki Y,Ishii K,Terauchi K,Uchiyama S,Yagi H,Kato K

    更新日期:2019-09-13 00:00:00

  • Assessment of the Efficacy and Clinical Utility of Different Circulating Tumor Cell (CTC) Detection Assays in Patients with Chemotherapy-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC).

    abstract::We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-li...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22020925

    authors: Papadaki MA,Messaritakis I,Fiste O,Souglakos J,Politaki E,Kotsakis A,Georgoulias V,Mavroudis D,Agelaki S

    更新日期:2021-01-18 00:00:00

  • miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression.

    abstract::Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of multiple cardiometabolic pathologies, including obesity, atherosclerot...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21228675

    authors: Benito-Vicente A,Uribe KB,Rotllan N,Ramírez CM,Jebari-Benslaiman S,Goedeke L,Canfrán-Duque A,Galicia-García U,Saenz De Urturi D,Aspichueta P,Suárez Y,Fernández-Hernando C,Martín C

    更新日期:2020-11-17 00:00:00

  • Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes.

    abstract::Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, which suppress TG accumulation and stimulate a brown adipocyte-like phenotype...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21062153

    authors: Lee K,Lee YJ,Kim KJ,Chei S,Jin H,Oh HJ,Lee BY

    更新日期:2020-03-20 00:00:00

  • The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor.

    abstract::ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively. However, the specific receptor of ABA that triggers the positive and negative responses of ABA during immune resp...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165852

    authors: García-Andrade J,González B,Gonzalez-Guzman M,Rodriguez PL,Vera P

    更新日期:2020-08-14 00:00:00

  • Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy.

    abstract::Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors (HDACis) have positioned these agents as promising drug candidates in combatting cancer, autoimmune, neurodegenerative, and infectious diseases. The same has also encouraged the evaluation of multiple HDACi candidates in preclin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20092241

    authors: Banik D,Moufarrij S,Villagra A

    更新日期:2019-05-07 00:00:00

  • Validation of FRET Assay for the Screening of Growth Inhibitors of Escherichia coli Reveals Elongasome Assembly Dynamics.

    abstract::The increase in antibiotic resistant bacteria demands the development of new antibiotics against preferably new targets. The common approach is to test compounds for their ability to kill bacteria or to design molecules that inhibit essential protein activities in vitro. In the first case, the mode of action of the dr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160817637

    authors: van der Ploeg R,Goudelis ST,den Blaauwen T

    更新日期:2015-07-31 00:00:00

  • Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation.

    abstract::Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20246212

    authors: Chiesa E,Greco A,Riva F,Tosca EM,Dorati R,Pisani S,Modena T,Conti B,Genta I

    更新日期:2019-12-09 00:00:00

  • Applications of Micro-Fourier Transform Infrared Spectroscopy (FTIR) in the Geological Sciences--A Review.

    abstract::Fourier transform infrared spectroscopy (FTIR) can provide crucial information on the molecular structure of organic and inorganic components and has been used extensively for chemical characterization of geological samples in the past few decades. In this paper, recent applications of FTIR in the geological sciences ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms161226227

    authors: Chen Y,Zou C,Mastalerz M,Hu S,Gasaway C,Tao X

    更新日期:2015-12-18 00:00:00

  • Seed Germination in Oil Palm (Elaeis guineensis Jacq.): A Review of Metabolic Pathways and Control Mechanisms.

    abstract::Oil palm is an oil-producing crop of major importance at the global scale. Oil palm mesocarp lipids are used for myriads industrial applications, and market demand has been growing for decades. In addition, oil palm seeds are oleaginous, and the oil extracted therefrom can be used for several purposes, from food to co...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21124227

    authors: Cui J,Lamade E,Tcherkez G

    更新日期:2020-06-13 00:00:00

  • Transcriptome-Wide Identification and Expression Profiling Analysis of Chrysanthemum Trihelix Transcription Factors.

    abstract::Trihelix transcription factors are thought to feature a typical DNA-binding trihelix (helix-loop-helix-loop-helix) domain that binds specifically to the GT motif, a light-responsive DNA element. Members of the trihelix family are known to function in a number of processes in plants. Here, we characterize 20 trihelix f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17020198

    authors: Song A,Wu D,Fan Q,Tian C,Chen S,Guan Z,Xin J,Zhao K,Chen F

    更新日期:2016-02-02 00:00:00