Abstract:
BACKGROUND:The prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in Chinese patients with curatively resected NSCLC. METHODS:A total of 1466 consecutive NSCLC patients who received curative surgery from January 1, 2005 to December 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study. Correlations between each blood test parameter and overall survival were examined by Kaplan-Meier method or Cox proportional hazards regression, followed by a stratification analysis of significant variables. RESULTS:Optimal cut-off values of 0.55 for neutrophil/white blood cell ratio (NWR), 0.28 for lymphocyte/white blood cell ratio (LWR), 0.09 for monocyte/white blood cell ratio (MWR), 2.06 for NLR, 0.35 for MLR, 204.00 for PLR, and 38.25 for platelet/white blood cell ratio (PWR) were identified using X-tile software. Univariate analysis suggested that NWR ≥ 0.55, LWR < 0.28, MWR ≥ 0.09, NLR ≥ 2.06, MLR ≥ 0.35, and PLR ≥ 204.00 predicted a poor prognosis in NSCLC patients. However, only NWR and MLR were identified as independent significant prognostic factors in multivariable analysis, especially in tumor node metastasis stage I and I/II/III NSCLCs. CONCLUSION:Pretreatment NWR, MWR, LWR, NLR, MLR, and PLR values are associated with poor overall survival for patients with curatively resected NSCLC. NWR and MLR are independent prognostic factors in curatively resected NSCLC.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Yuan C,Li N,Mao X,Liu Z,Ou W,Wang SYdoi
10.1111/1759-7714.12454subject
Has Abstractpub_date
2017-07-01 00:00:00pages
350-358issue
4eissn
1759-7706issn
1759-7714journal_volume
8pub_type
杂志文章相关文献
Thoracic Cancer文献大全abstract::Here, we present a case of invasive thymoma with intraluminal growth into the left and right brachiocephalic veins, superior vena cava and the right atrium. Resection of the mass, double partial upper lobe lobectomy and superior vena cava, and left and right brachiocephalic vein replacement were performed. Pathologica...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13242
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcino...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12422
更新日期:2017-05-01 00:00:00
abstract::A 69-year-old woman visited our hospital complaining of right chest pain. Chest computed tomography showed a 55 × 45 mm tumor in the right upper lobe. Bronchoscopy revealed displaced anomalous B 1 and B 2+3 arising from the right main bronchus, and the patient was diagnosed with lung adenocarcinoma by transbronchial l...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.12362
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Growing evidence indicates that high phosphoserine phosphatase (PSPH) expression is associated with tumor prognosis in many types of cancers. However, the role of PSPH in non-small cell lung cancer (NSCLC) is unclear. The purpose of this study was to investigate the clinical significance of PSPH in NSCLC. M...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13064
更新日期:2019-05-01 00:00:00
abstract::After an initial benefit, non-small-cell lung cancer (NSCLC) patients receiving therapy with tyrosine kinase inhibitors develop drug resistance through a variety of mechanisms. Among these, tumor histology changes are a mechanism of acquired resistance in epidermal growth factor receptor-mutated and anaplastic lymphom...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.12416
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Sphingosine 1-phosphate (S1P), a bioactive lipid, has been shown to mediate cancer processes. Therefore, accurate qualitative and quantitative determination is essential. The current assay method is still cumbersome to be of practical use worldwide and the aim of this study was therefore to develop a fast, a...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13409
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:ALK-tyrosine kinase inhibitors (TKIs) have been proven effective for treating ALK-positive non-small cell lung cancer (NSCLC), although patients present with variable responses and disease progression courses. The detailed underlying molecular mechanisms require further investigation to yield a better progno...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12791
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to report a single referral center experience in robotic extended thymectomy for clinical early stage thymomas, evaluating its safety, feasibility and efficacy, with special regard to oncological outcomes. METHODS:Between January 2009 and December 2012, we retrospectively selected ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12097
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Previous studies have reported that soluble fms-like tyrosine kinase-1 (sFlt-1) possesses anti-tumor effects by inhibiting angiogenesis in many cancers. Exosomes can be engineered as delivery vehicles for transferring functional biomolecules, such as proteins, lipids, and nucleic acids (DNA, mRNA, and miRNA)...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13175
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Accumulated evidence has revealed that the dysregulation of micro ribonucleic acids (miRNAs) may contribute to esophageal squamous cell carcinoma (ESCC). MiR-93, which is a member of the miRNA cluster miR-106b∼25, has been widely studied for its tumor promoting effect on different types of cancers. However, ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12242
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:This study investigates the outcome of synchronous stage IV non-small cell lung cancer (NSCLC) patients who received radical thoracic radiotherapy (TRT). METHODS:We retrospectively reviewed the charts of stage IV NSCLC patients treated with TRT between January 2007 and December 2011. Radiotherapy was consid...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12305
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:If anaplastic lymphoma kinase (ALK) gene rearrangement in lung cancer is identified, ALK-tyrosine kinase inhibitors (ALK-TKIs) can be an effective treatment. However, the details of drug-induced lung injury (DILI) caused by ALK-TKI, which can be a serious side effect of ALK-TKIs, remains unclear. This study ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13416
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Lung cancer is the leading cause of cancer-related deaths. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations, some patients experience little or no response. The Glasgow prognostic score (GPS...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13526
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND: The 12th National Lung Cancer Academic Conference was held in Wu Han, China in 2011. METHODS: The content of the conference involved recent research achievements and progress in the field of lung cancer, including the epidemiology of lung cancer and molecules, new methods and technology for early-screeni...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/j.1759-7714.2012.00125.x
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:CalliSpheres are drug-eluting beads used for tumor artery embolization, with clinical benefits in a number of cancer types. The aim of the study was to examine the clinical benefits and complications of patients with stage II-IV lung cancer treated with CalliSpheres drug-eluting beads for embolization versus...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13522
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The combination of EGFR tyrosine kinase inhibitors (TKIs) and chemotherapy is thought to increase treatment efficacy in non-small-cell lung cancer (NSCLC). This study investigated the efficacy and potential mechanisms of different combined modes of icotinib plus pemetrexed in EGFR-mutant lung adenocarcinoma ...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12818
更新日期:2018-09-01 00:00:00
abstract::Carcinosarcoma of the esophagus is a rare malignant neoplasm with both epithelial and mesenchymal (sarcomatous) components. We describe a case of a 72-year-old man with a huge esophageal tumor which could often have been considered inoperable. However, the patient underwent a curative resection and had a good prognosi...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/j.1759-7714.2011.00069.x
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the influence of image-guided tumor localization modality (Synchrony tracking vs. Xsight spine-based localization) on the local efficacy of CyberKnife treatment in lung cancer and lung metastases. METHODS:Retrospective analysis of 64 patients with pulmonary metastases an...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12174
更新日期:2015-05-01 00:00:00
abstract::We report a case of primary inflammatory myofibroblastic tumor of the diaphragm in a 64-year-old man. The patient was hospitalized for a computed tomography (CT)-detected large tissue mass at the left lower lung field. Complete tumor excision followed by pathological investigation was performed. Microscopically, the t...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/j.1759-7714.2012.00155.x
更新日期:2013-11-01 00:00:00
abstract::ROS1 rearrangement is a validated therapeutic driver gene in non-small cell lung cancer (NSCLC) and represents a small subset (1-2%) of NSCLC. A total of 17 different fusion partner genes of ROS1 in NSCLC have been reported. The multi-targeted MET/ALK/ROS1 tyrosine kinase inhibitor (TKI) crizotinib has demonstrated re...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.12617
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There is a lack of information about the clinical and pathological features related with survival in the Latin American population. METHODS:The MeSO-CLICaP registry identified 302 patients with advanced MPM diagnose...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12967
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Both hypoxia and oncogenic mutations rewire tumor metabolism. In this study, glucose and glutamine metabolism-related markers were examined in stage I - resectable stage IIIA non-small cell lung cancer (NSCLC). Furthermore, expression of metabolism-related markers was correlated with mutational status to exa...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13226
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND: The optimal strategy was not established for patients who initially responded to gefitinib although re-administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been proven to be an option. Gefitinib and erlotinib were compared as salvage treatment after gefitinib fail...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/j.1759-7714.2012.00152.x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Malignant pleural mesothelioma (MPM) is an aggressive cancer refractory to current therapies. Reduced expression of micro ribonucleic acid (miR)-591 in a range of cancer types has suggested it is a potent tumor suppressor, and overexpression has been shown to inhibit tumor cell growth. The role of miR-591 in...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12336
更新日期:2016-04-26 00:00:00
abstract:BACKGROUND:Many randomized clinical trials have demonstrated that epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are advantageous over standard chemotherapy, either as front-line treatment or as further management of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC). Howev...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12275
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Immunotherapy is a new paradigm for the treatment of non-small-cell lung cancer (NSCLC), and targeting the PD-1 or PD-L1 pathway is a promising therapeutic option. Although PD-1/PD-L1 inhibitors are more effective than standard chemotherapy in lung cancer, clinicians are afraid to actively use them because o...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12877
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Plasmid construction of small fragments of interest (such as insertion of small fragment marker genes, expression of shRNA, siRNA, etc) is the basis of many biomolecular experiments. Here, we describe a method to clone short DNA into vectors by polymerase chain reaction (PCR), named one-step PCR cloning. Our...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.13660
更新日期:2020-11-01 00:00:00
abstract::SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a new clinical entity characterized by SMARCA4 inactivation and has a dismal prognosis because of rapid growth. Effective treatments for SMARCA4-DTS have not yet been developed. Most recently, anti-programmed cell death 1 receptor (PD-1) blockade has been effective f...
journal_title:Thoracic cancer
pub_type:
doi:10.1111/1759-7714.13215
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas (STSs) are rare malignant tumors of embryogenic mesoderm origin. Primary thoracic STSs account for a small percentage of all STSs and limited published information is available. This study aimed to identify the prognostic factors for thoracic STSs and evaluate the disease's clinical outc...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12150
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Computed tomography (CT)-guided percutaneous implantation of 125 Iodine radioactive seeds requires the precise arrangement of seeds by tumor shape. We tested whether selecting target areas, including subclinical areas around tumors, can influence locoregional recurrence in patients with non-small cell lung c...
journal_title:Thoracic cancer
pub_type: 杂志文章
doi:10.1111/1759-7714.12415
更新日期:2017-05-01 00:00:00