Clinical Correlates of Treatment Response among Patients with Schizophrenia in a Tertiary Nigerian Hospital.

Abstract:

:A significant proportion of patients treated for schizophrenia respond poorly to medication. Few studies have systematically examined the impact of clinical characteristics of patients to antipsychotic response in our environment. The study aimed to identify clinical variables associated with response in patients with schizophrenia. A total of 172 participants diagnosed with schizophrenia, placed on antipsychotics, who presented for the first time to the hospital or have stopped medication in the preceding six months, whose responses were assessed after four to six weeks were studied. Improvement was defined as 20% or greater reduction in PANSS scores. Good response was associated with good medication adherence, good pre-morbid functioning, fewer negative symptoms, less cognitive impairment, absence of co-morbid personality disorder, and short duration of untreated psychosis. Due consideration of the impact of clinical variables could help detect poor responders early, hence avoiding unnecessary exposure to ineffective treatments and their side effects while effective interventions are delayed.

authors

Ezeme MS,Uwakwe R,Ndukuba AC,Igwe MN,Odinka PC,Amadi K,Obayi NO

doi

10.1353/hpu.2017.0070

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

721-738

issue

2

eissn

1049-2089

issn

1548-6869

pii

S1548686917200254

journal_volume

28

pub_type

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