Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspective.

Abstract:

:Self-emulsifying drug delivery systems (SEDDS) are lipid formulations that improve solubility and oral bioavailability of the incorporated drug with poor biopharmaceutical properties. As liquids they are traditionally filled into soft or hard capsules. Transformation of SEDDS into solid dosage form has been extensively investigated in the recent years because solid dosage forms improve stability, handling and patient compliance. By using different solidification techniques selfemulsifying powders, granules, pellets and tablets can be produced. Appropriate excipients, solid carriers and processing parameters must be selected for each solidification technique to enable processability and preserve the self-emulsifying ability of the system upon its transformation into the solid formulation. In the present review various industrially applicable solidification techniques and excipients used for transforming liquid SEDDS into solid dosage forms with high production yield and good perspectives for being produced in large scales are discussed.

journal_name

Int J Pharm

authors

Mandić J,Zvonar Pobirk A,Vrečer F,Gašperlin M

doi

10.1016/j.ijpharm.2017.05.036

subject

Has Abstract

pub_date

2017-11-30 00:00:00

pages

335-345

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(17)30448-9

journal_volume

533

pub_type

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