Chronic Kidney Disease and Exposure to Nephrotoxic Metals.

Abstract:

:Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.

journal_name

Int J Mol Sci

authors

Orr SE,Bridges CC

doi

10.3390/ijms18051039

subject

Has Abstract

pub_date

2017-05-12 00:00:00

issue

5

issn

1422-0067

pii

ijms18051039

journal_volume

18

pub_type

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