Secretoneurin-A inhibits aromatase B (cyp19a1b) expression in female goldfish (Carassius auratus) radial glial cells.


:In the teleost brain, radial glial cells (RGCs) are the main macroglia and are stem-like progenitors that express key steroidogenic enzymes, including the estrogen-synthesizing enzyme, aromatase B (cyp19a1b). As a result, RGCs are integral to neurogenesis and neurosteroidogenesis, however little is known about the regulatory factors and signaling mechanisms that control these functions. A potential new role of the secretogranin II-derived neuropeptide secretoneurin A (SNa) in the control of goldfish (Carassius auratus) RGC function is the subject of this study. Immunohistochemistry revealed a close neuroanatomical relationship between RGCs and soma of SNa-immunoreactive magnocellular and parvocellular neurons in the preoptic nucleus of female goldfish. Five hours following intracerebroventricular injection of 0.2ng/g SNa cyp19a1b mRNA levels were decreased by 86% (P<0.05) in the hypothalamus and by 88% (P<0.05) in the telencephalon. In vitro, 24 h incubation with 500nM SNa decreased cyp19a1b mRNA by 51% (P<0.05) in cultured RGCs. These data provide evidence that SNa can regulate aromatase expression in goldfish RGCs. By regulating neuroestrogen production in RGCs SNa may therefore be implicated in the control of major estrogen-dependent functions of the preoptic region such as reproductive behavior and osmoregulation.


Gen Comp Endocrinol


Da Fonte DF,Xing L,Mikwar M,Trudeau VL




Has Abstract


2018-02-01 00:00:00












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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Hur SP,Takeuchi Y,Itoh H,Uchimura M,Takahashi K,Kang HC,Lee YD,Kim SJ,Takemura A

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Cyr DG,Eales JG

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Down NE,Peter RE,Leatherland JF

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    journal_title:General and comparative endocrinology

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    authors: Basili D,Gioacchini G,Todisco V,Candelma M,Marisaldi L,Pappalardo L,Carnevali O

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    authors: Nagle CA,Mendizábal AF,Lahoz MM,Porta MM,Torres MI

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    authors: Goldsmith AR,Nicholls TJ

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    authors: Iwamatsu T,Kobayashi H,Sagegami R,Shuo T

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    journal_title:General and comparative endocrinology

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    authors: Cherry BA,Cadigan B,Mansourian N,Nelson C,Bradley EL

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    authors: Stoker C,Beldoménico PM,Bosquiazzo VL,Zayas MA,Rey F,Rodríguez H,Muñoz-de-Toro M,Luque EH

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    journal_title:General and comparative endocrinology

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    authors: Himick BA,Golosinski AA,Jonsson AC,Peter RE

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    journal_title:General and comparative endocrinology

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    authors: Yasuda A,Tatsu Y,Shigeri Y

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    journal_title:General and comparative endocrinology

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    authors: Nocillado JN,Levavi-Sivan B,Carrick F,Elizur A

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    authors: Vijayan MM,Flett PA,Leatherland JF

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    authors: Hyde CJ,Nguyen T,Fitzgibbon QP,Elizur A,Smith GG,Ventura T

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    authors: Gibson LA,Koch I,Reimer KJ,Cullen WR,Langlois VS

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    journal_title:General and comparative endocrinology

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    authors: Zhang Y,Tang Z,Lin W,Yuan X,Jia J,Sun C,Li W

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    journal_title:General and comparative endocrinology

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    authors: Millspaugh JJ,Washburn BE

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    journal_title:General and comparative endocrinology

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    authors: Ni J,Zeng Z,Kong D,Hou L,Huang H,Ke C

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Garnier DH,Joly J

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  • Estrogen prevents cardiac and vascular failure in the 'listless' zebrafish (Danio rerio) developmental model.

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    journal_title:General and comparative endocrinology

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    authors: Allgood OE Jr,Hamad A,Fox J,Defrank A,Gilley R,Dawson F,Sykes B,Underwood TJ,Naylor RC,Briggs AA,Lassiter CS,Bell WE,Turner JE

    更新日期:2013-08-01 00:00:00

  • A possible involvement of prostaglandin F2 alpha (PGF2 alpha) in Rana esculenta ovulation: effects of mammalian gonadotropin-releasing hormone on in vitro PGF2 alpha and 17 beta-estradiol production from ovary and oviduct.

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Gobbetti A,Zerani M

    更新日期:1992-08-01 00:00:00

  • Effects of angiotensin II and C-type natriuretic peptide on the in situ perfused trunk preparation of the dogfish, Scyliorhinus canicula.

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Wells A,Anderson WG,Cains JE,Cooper MW,Hazon N

    更新日期:2006-01-15 00:00:00

  • Climate change impacts on fish reproduction are mediated at multiple levels of the brain-pituitary-gonad axis.

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Servili A,Canario AVM,Mouchel O,Muñoz-Cueto JA

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Cánepa MM,Zhu Y,Fossati M,Stiller JW,Vissio PG

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Zhang H,Chen H,Zhang Y,Li S,Lu D,Zhang H,Meng Z,Liu X,Lin H

    更新日期:2013-01-15 00:00:00

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Bentley GE

    更新日期:2003-11-01 00:00:00

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    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Pickering AD,Pottinger TG,Carragher J,Sumpter JP

    更新日期:1987-11-01 00:00:00