Abstract:
:In the teleost brain, radial glial cells (RGCs) are the main macroglia and are stem-like progenitors that express key steroidogenic enzymes, including the estrogen-synthesizing enzyme, aromatase B (cyp19a1b). As a result, RGCs are integral to neurogenesis and neurosteroidogenesis, however little is known about the regulatory factors and signaling mechanisms that control these functions. A potential new role of the secretogranin II-derived neuropeptide secretoneurin A (SNa) in the control of goldfish (Carassius auratus) RGC function is the subject of this study. Immunohistochemistry revealed a close neuroanatomical relationship between RGCs and soma of SNa-immunoreactive magnocellular and parvocellular neurons in the preoptic nucleus of female goldfish. Five hours following intracerebroventricular injection of 0.2ng/g SNa cyp19a1b mRNA levels were decreased by 86% (P<0.05) in the hypothalamus and by 88% (P<0.05) in the telencephalon. In vitro, 24 h incubation with 500nM SNa decreased cyp19a1b mRNA by 51% (P<0.05) in cultured RGCs. These data provide evidence that SNa can regulate aromatase expression in goldfish RGCs. By regulating neuroestrogen production in RGCs SNa may therefore be implicated in the control of major estrogen-dependent functions of the preoptic region such as reproductive behavior and osmoregulation.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Da Fonte DF,Xing L,Mikwar M,Trudeau VLdoi
10.1016/j.ygcen.2017.04.014subject
Has Abstractpub_date
2018-02-01 00:00:00pages
106-112eissn
0016-6480issn
1095-6840pii
S0016-6480(17)30310-6journal_volume
257pub_type
杂志文章abstract::Sex-linked dwarfism is a recessive mutation that causes a reduction in body weight gain and long bone growth of chickens. We examined the effect of the dwarfing gene on body weight, hepatic GH-binding activity, and the structure and expression of the growth hormone receptor (GHR) gene in two different lines of sex-lin...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90190-u
更新日期:1992-10-01 00:00:00
abstract::In this study, the effect of acute and chronic insulin treatments on major factors involved in the control of muscle protein turnover were investigated in rainbow trout (Oncorhynchus mykiss). We found that acute but not chronic insulin administration leads to the induction of the phosphorylation of several key factors...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.03.026
更新日期:2011-07-01 00:00:00
abstract::Hyperglycemia that is caused by the release of crustacean hyperglycemic hormone (CHH) from the sinus gland to hemolymph is one of the hallmark physiological phenomena, occurring in decapod crustaceans experiencing stressful conditions. However, the mechanism(s) by which such elevated glucose levels return to resting l...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.01.012
更新日期:2014-04-01 00:00:00
abstract::Dihydrotestosterone (DHT) and 17β-estradiol (E2) are sex hormones that regulate human hair follicle (HF) growth and are produced by peripheral reduction and aromatization of testosterone. However, the expression patterns of DHT and E2 synthesis-related proteins and their receptors in male yak skin during different HF ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2019.113245
更新日期:2020-01-15 00:00:00
abstract::In a series of experiments, the effect of cortisol on the ability of rainbow trout (Salmo gairdneri) ovarian follicles to secrete sex steroids in vitro was investigated. The basal rate of secretion of sex steroids (oestradiol and testosterone) was suppressed in a dose-dependent manner by the addition of cortisol to th...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(90)90230-j
更新日期:1990-03-01 00:00:00
abstract::Estrogen signalling is critical for ovarian differentiation in reptiles with temperature-dependent sex determination (TSD). To elucidate the involvement of estrogen in this process, adrenal-kidney-gonadal (AKG) expression of estrogen receptor (ERα) was studied at female-producing temperature (FPT) in the developing em...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.08.003
更新日期:2015-09-01 00:00:00
abstract::The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhi...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90233-8
更新日期:1984-01-01 00:00:00
abstract::PCB 77 is a dioxin-like PCB that has been shown to reduce circulating thyroid hormone (TH) levels. This may be an important factor contributing to its neurotoxicity, since THs are essential for normal brain development. In this study, we investigated the changes in TH activating and inactivating iodothyronine deiodina...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2006.04.003
更新日期:2006-09-15 00:00:00
abstract::Factors potentially regulating hepatic growth hormone (GH) receptors in coho salmon (Oncorhynchus kisutch) have been investigated. From December to June of the first year, relative changes in hepatic 125I-sGH binding and 35SO4 incorporation by ceratobranchial cartilage were similar. Stunted salmon, which in seawater h...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90256-j
更新日期:1992-11-01 00:00:00
abstract::Two types of somatostatin (SST 14)-immunoreactive cells are identified by immunogold staining in the Lowicryl-embedded principal islet of Sparus auratus: D1 cells, having large moderate to low electron dense granules, located between A cells in the islet periphery and D2 cells, containing smaller electron-dense granul...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(90)90199-v
更新日期:1990-01-01 00:00:00
abstract::Human pro-IGF-I Eb-peptide (hEb) and rainbow trout pro-IGF-I Ea-4-peptide (rtEa-4) have recently been shown to share unique biological activities [Gen. Comp. Endocrinol. 126 (2002) 342; Cell. Exp. Cell. Res. 280 (2002) 75]. To further understand the action mechanism of these proteins, we studied the binding properties...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/s0016-6480(03)00089-3
更新日期:2003-06-15 00:00:00
abstract::Saline extracts of the corpus cardiacum (CC) of Locusta migratoria activate glycogen phosphorylase in locust fat body. The response of phosphorylase to CC extracts and to synthetic adipokinetic hormone (AKH) suggests that the factor responsible for the activating effect of the CC on phosphorylase is AKH, supplemented ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(83)90222-8
更新日期:1983-05-01 00:00:00
abstract::The effect of corticosteroid hormones in fish are mediated through intracellular receptors that act as ligand-binding transcription factors. Many studies have been devoted to cortisol binding using radiolabeled ligand in fish and allowed characterization of a single class of high affinity binding sites in various tiss...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.ygcen.2006.01.015
更新日期:2006-05-15 00:00:00
abstract::Plasma profiles of several gonadal steroids and cortisol were examined in a field population of the protandrous, sex-changing anemonefish Amphiprion melanopus to elucidate potential roles of these hormones in gonadal sex change. Sex change was experimentally induced in males by removal of their dominant female pair ma...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1114
更新日期:1993-08-01 00:00:00
abstract::The objective of this study was to examine if RU486, a corticosteroid antagonist, modified hepatocyte metabolism and blocked the metabolic effects of exogenously administered cortisol in rainbow trout (Oncorhynchus mykiss). The fish were given a single intraperitoneal implant of either coconut oil alone or coconut oil...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1160
更新日期:1994-10-01 00:00:00
abstract::Studies of the ontogeny of IGF-I mRNA during embryonic and larval development of the gilthead sea bream Sparus aurata showed its expression during these early developmental stages. The present study applies in situ hybridization to localize IGF-I and IGF receptor mRNAs in 16-day larvae of S. aurata. Paraffin sections ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1997.6935
更新日期:1997-09-01 00:00:00
abstract::125I-labeled bovine and tilapia growth hormones were used to assess the presence of growth hormone receptors in membranes prepared from tissues of the tilapia Oreochromis mossambicus. The highest level of specific binding was detected in liver membranes from animals of both sexes and the binding was protein-dependent....
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90132-4
更新日期:1992-04-01 00:00:00
abstract::Corticosterone, at baseline and moderately elevated levels, is thought to regulate energy mobilization during the predictable life-history cycle. In birds, corticosterone is known to be moderately elevated during migration, and some experiments on captive, but migratory active birds have shown that exogenous corticost...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2013.02.042
更新日期:2013-06-01 00:00:00
abstract::The neuroendocrine light green cells (LGCs), 4 clusters of together approximately 150 giant neurons in the cerebral ganglia of the freshwater gastropod, Lymnaea stagnalis, have been suggested to be involved in the control of growth. The present study examines in greater detail this role and possible actions on energy ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90068-u
更新日期:1992-06-01 00:00:00
abstract::Faecal glucocorticoid metabolite (fGCM) concentrations have been used to evaluate adrenal activity in a variety of species; including as an indicator of the physiological response to social stress. However, across studies, the relationships between dominance rank, social behaviours and adrenal responses can be inconsi...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2013.02.023
更新日期:2013-06-01 00:00:00
abstract::Urinary corticosterone metabolite responses to capture have recently been shown for the first time in amphibians, and in the present study urinary corticosterone metabolite responses to capture and to confinement in captivity were measured in adult cane toads (Rhinella marina) in Queensland, Australia. An adrenocortic...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.06.015
更新日期:2011-09-01 00:00:00
abstract::The renal roles of physiologically relevant doses of angiotensin II (Ang II) and C-type natriuretic peptide (CNP) were investigated in the dogfish, Scyliorhinus canicula, using an in situ perfused trunk preparation. Perfusion with 10(-9) M Ang II resulted in a glomerular antidiuresis and decreases in perfusate flow ra...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2005.08.002
更新日期:2006-01-15 00:00:00
abstract::The androgen concentration in birds' eggs varies with laying order, breeding conditions, and mate attractiveness. In passerine birds, mate attractiveness depends upon song quality. The aim of our study was to evaluate the effect of one criterion used by females to assess male song quality that is to say the presence o...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2004.05.010
更新日期:2004-09-01 00:00:00
abstract::Orexin A (OXA), a hypothalamic neuropeptide, and its receptor (OX1R) are primarily expressed in lateral hypothalamus and are involved in the control of various biological functions. Expressions of OXA and OX1R have also been reported in peripheral organs like gastrointestinal and genital tracts. In the present study, ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2015.11.005
更新日期:2016-12-01 00:00:00
abstract::Chemical identification of neurohypophysial hormones from about 80 vertebrate species reveals that two evolutionary lineages can be traced in bony vertebrates, a vasopressin-like hormone line and an oxytocin-like hormone line, which were derived from the duplication of an ancestral gene that may have been present in a...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1006/gcen.1996.0057
更新日期:1996-05-01 00:00:00
abstract::This study investigated the role of gonadotrophin and steroids in the induction of in vitro oocyte maturation in dab (Limanda limanda) and plaice (Pleuronectes platessa), two marine flatfish (Pleuronectiformes) in which the oocytes mature and ovulate in groups (or batches). Clusters of folliculated oocytes were incuba...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(90)90301-2
更新日期:1990-02-01 00:00:00
abstract::Arginine vasotocin (AVT) and isotocin (IT) are fish nonapeptides synthesized in separate hypothalamic neurons from where they are transported to the neurohypophysis for storage and release into circulation. AVT is known to modulate aggression, courtship and parental care or social communication in many species, includ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.11.022
更新日期:2012-01-15 00:00:00
abstract::The investigation of calcitonin-like immunoreactivity performed in whole extracts of the terrestrial crustacean Orchestia cavimana using radioimmunoassay revealed large amounts of these peptides varying in concentration according to the stages of the molt cycle. Their level is maximum at the time of the exuviation. Th...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(89)90057-9
更新日期:1989-01-01 00:00:00
abstract::In the coevolutionary dynamic of avian brood parasites and their hosts, maternal (or transgenerational) effects have rarely been investigated. We examined the potential role of elevated yolk testosterone in eggs of the principal brood parasite in North America, the brown-headed cowbird, and three of its frequent host ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2016.10.004
更新日期:2017-01-01 00:00:00
abstract::Using frog ovarian follicles in vitro we assessed the role of the theca/epithelium (THEP) layer and granulosa cells in the production of steroids. The THEP layer and granulosa cell-enclosed oocytes (GCEOs) were separated from ovarian follicles of the frog, Rana nigromaculata, by microdissection. Intact follicles (IFs)...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1077
更新日期:1994-05-01 00:00:00