Efficacy and safety of ultra rapid iron polymaltose infusion during general anaesthesia.


:To assess the efficacy and safety of ultra rapid (15 minute) infusion of iron polymaltose to iron deficient patients during general anaesthesia, we performed a prospective, interventional non-randomised study on 99 adult patients with iron deficiency with or without anaemia presenting for surgery under general anaesthesia. Over 15 minutes during the maintenance phase of anaesthesia, patients were given iron polymaltose, 500 mg if not anaemic, or 1,000 mg if anaemic. Haemodynamic stability, immediate or delayed iron-related side-effects and efficacy at six weeks were assessed. The incidence of significant hypotension or the requirement for vasopressor was not different before, during or after the iron infusion. There were no serious intraoperative events (allergic reactions or skin staining). Mean (standard deviation, SD) haemoglobin rose from 121 (14) g/l preoperatively to 131 (12) g/l at six weeks (P <0.001). Mean (SD) ferritin rose from 17 (12) μg/l to 110 (83) μg/l by six weeks (P <0.001). At six weeks only four out of 64 contactable patients (6.25%) had a ferritin of <30 μg/l. The incidence of immediate or delayed side-effects was similar to patients undergoing outpatient iron polymaltose infusions and reflective of a post-surgical population. We conclude that up to 1,000 mg of iron polymaltose can be given over 15 minutes without significant haemodynamic compromise to selected patients undergoing general anaesthesia. Iron polymaltose administered in this way appears efficacious in treating iron deficiency.


Anaesth Intensive Care


Browning RM,Alakeson N,O'Loughlin EJ




Has Abstract


2017-05-01 00:00:00














  • A mobile telephone-based SMS and internet survey system for self-assessment in Australian anaesthesia: experience of a single practitioner.

    abstract::Self-assessment and audit in anaesthesia require a systematic approach to postoperative data collection. The increasing prevalence of mobile internet technology offers a new data collection method for anaesthetists. In this paper, a system for mobile internet data collection is described and the preliminary experience...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Belavy D

    更新日期:2014-11-01 00:00:00

  • Strategies to reduce inappropriate laboratory blood test orders in intensive care are effective and safe: a before-and-after quality improvement study.

    abstract::Unnecessary pathology tests performed in intensive care units (ICU) might lead to increased costs of care and potential patient harm due to unnecessary phlebotomy. We hypothesised that a multimodal intervention program could result in a safe and effective reduction in the pathology tests ordered in our ICU. We conduct...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Dhanani JA,Barnett AG,Lipman J,Reade MC

    更新日期:2018-05-01 00:00:00

  • The etymology and use of the word 'anaesthesia' Oliver Wendell Holmes' letter to W. T. G. Morton.

    abstract::Two published versions of a letter in which Oliver Wendell Holmes, MD, recommended the name anaesthesia were identified from publications supportive of the claims of W. T. G. Morton. The earliest known publication of Holmes' letter is in a pamphlet published by Edward Warren in May-June 1847. Another version of the le...

    journal_title:Anaesthesia and intensive care

    pub_type: 传,历史文章,杂志文章


    authors: Haridas RP

    更新日期:2016-07-01 00:00:00

  • Dapsone-associated methaemoglobinaemia in patients with a haematologic malignancy.

    abstract::Methaemoglobinaemia is an uncommon problem which can significantly impact on oxygen carriage and may necessitate intensive care management. The occurrence of symptomatic methaemoglobinaemia over a three-month period in four patients with haematological malignancies on dapsone for Pneumocystis jiroveci pneumonia prophy...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Subramaniam A,Corallo C,Nagappan R

    更新日期:2010-11-01 00:00:00

  • Trends in intra-aortic balloon counterpulsation: comparison of a 669 record Australian dataset with the multinational Benchmark Counterpulsation Outcomes Registry.

    abstract::The aim of this study was to review and describe indications for intraaortic balloon counterpulsation (IABP) use and identify the impact these have on outcomes at an Australian cardiothoracic tertiary referral hospital. A secondary aim was comparison of the Australian practice with a large multinational IABP data regi...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Lewis PA,Mullany DV,Townsend S,Johnson J,Wood L,Courtney M,Joseph D,Walters DL

    更新日期:2007-02-01 00:00:00

  • Prone ventilation--it's time.

    abstract::Prone positioning to improve oxygenation in acute lung injury was first reported over 20 years ago. Although this and several subsequent studies have shown that prone positioning improved oxygenation in the majority of patients, it has failed to become common practice in intensive care units. This paper reviews the me...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审


    authors: Tobin A,Kelly W

    更新日期:1999-04-01 00:00:00

  • Retroperitoneal haematoma associated with low molecular weight heparin.

    abstract::Enoxaparin (a low molecular weight heparin) has been used extensively for its antithrombotic properties. Complications of its haemorrhagic side-effects have previously been described. We report two cases of extensive retroperitoneal haematoma requiring blood transfusion and inotropic support. One patient developed acu...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Power GE,Rogers P

    更新日期:2002-10-01 00:00:00

  • Epidural opioids in obstetrics--a review.

    abstract::Epidural opioids have been used in obstetrics since 1980. Various opioids are reviewed in relation to their pharmacology, their efficacy in labour, during caesarean section and for postoperative analgesia, their side-effects and safety. In this patient population it appears safe to administer epidural opioids on the g...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,评审


    authors: Westmore MD

    更新日期:1990-08-01 00:00:00

  • Safe duration of postoperative monitoring for malignant hyperthermia susceptible patients.

    abstract::Postoperative management of malignant hyperthermia (MH) susceptible patients has changed substantially over the last 20 years, with many patients now managed as day cases. Our previous policy was to monitor known MH susceptible patients (and relatives of known MH susceptible individuals not yet investigated by muscle ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Pollock N,Langtont E,Stowell K,Simpson C,McDonnell N

    更新日期:2004-08-01 00:00:00

  • Nerve blocks around the knee in children.

    abstract::Analgesia below the knee can be achieved by blocking the tibial nerve and the common peroneal nerve in the popliteal fossa, and the saphenous nerve adjacent to the knee. The anatomy and technique of nerve block in the popliteal fossa is described, the nerve being located prior to blockade using a peripheral nerve stim...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Kempthorne PM,Brown TC

    更新日期:1984-02-01 00:00:00

  • Association between perioperative glucose levels and adverse outcomes in infants receiving open-heart surgery with cardiopulmonary bypass for congenital heart disease.

    abstract::There is no consensus that hyperglycaemia is an independent predictor of morbidity-mortality in children. This retrospective observational study aimed to assess the association between abnormal perioperative glucose levels and adverse outcomes in infants receiving open-heart surgery with cardiopulmonary bypass. The re...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Huang XZ,Wang H,Xu HZ,Ye M,Jiang P,Xu Y

    更新日期:2012-09-01 00:00:00

  • A comparison of outcomes among hospital survivors with and without severe comorbidity admitted to the intensive care unit.

    abstract::Little is known about the experiences of patients with severe comorbidity discharged from Intensive Care Units (ICUs). This project aimed to determine the effects of an ICU stay for patients with severe comorbidity by comparing 1) quality of life (QOL), 2) the symptom profile of hospital survivors and 3) health servic...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Williams TA,McConigley R,Leslie GD,Dobbs GJ,Phillips M,Davies H,Aoun S

    更新日期:2015-03-01 00:00:00

  • The comparative effects of propofol versus thiopentone on left ventricular function during electroconvulsive therapy.

    abstract::The purpose of this study was to compare the effect of propofol versus thiopentone on haemodynamics during electroconvulsive therapy (ECT), as estimated by echocardiography. Twenty-eight ASA 1 or 2 patients scheduled for ECT were randomly divided into two groups, to receive propofol 1 mg/kg (propofol group, n = 14) or...

    journal_title:Anaesthesia and intensive care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kadoi Y,Saito S,Ide M,Toda H,Sekimoto K,Seki S,Takahashi K,Goto F

    更新日期:2003-04-01 00:00:00

  • Randomised controlled trial comparing the Ambu® aScope™2 with a conventional fibreoptic bronchoscope in orotracheal intubation of anaesthetised adult patients.

    abstract::Fibreoptic intubation remains an essential skill for anaesthetists to master. In addition to the reusable fibrescope, an alternative disposable videoscope is available (aScope(™)2, Ambu®, Ballerup, Denmark). A total of 60 anaesthetised adult patients were randomised to either having orotracheal intubation using the aS...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章,随机对照试验


    authors: Chan JK,Ng I,Ang JP,Koh SM,Lee K,Mezzavia P,Morris J,Loh F,Segal R

    更新日期:2015-07-01 00:00:00

  • Clinical trial of continuous infusion of alphaxalone/alphadolone in intensive care patients.

    abstract::The safety and efficacy of prolonged infusion of alphaxalone/alphadolone (Alfathesin: Glaxo) was assessed in 20 critically ill patients needing sedation during intermittent positive pressure ventilation in a general intensive care unit. The mean dose of Alfathesin infused was 1542 ml (range: 225 to 4820 ml) over 6.9 d...

    journal_title:Anaesthesia and intensive care

    pub_type: 临床试验,杂志文章


    authors: Stewart GO,Dobb GJ,Craib IA

    更新日期:1983-05-01 00:00:00

  • Inhalational induction with sevoflurane in an adult with severe complex central airways obstruction.

    abstract::Sevoflurane is a newly available volatile anaesthetic agent which is suitable for inhalational induction of anaesthesia. Due to concerns about obstructing the upper airway as anaesthesia deepens, its use has until now been avoided in patients with upper airway obstruction. We used its smooth induction and recovery pro...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Watters MP,McKenzie JM

    更新日期:1997-12-01 00:00:00

  • Anaesthetic management of a patient with Emery-Dreifuss muscular dystrophy.

    abstract::Emery-Dreifuss muscular dystrophy is a rare form of muscular dystrophy associated with cardiac implications such as cardiomyopathy and arrhythmias leading to sudden death. We describe the anesthetic management of a patient with Emery-Dreifuss muscular dystrophy who presented for orthopaedic surgery and discuss the dis...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Shende D,Agarwal R

    更新日期:2002-06-01 00:00:00

  • A new model for the oxyhaemoglobin dissociation curve.

    abstract::This paper describes a new model for the oxygen-haemoglobin dissociation curve in humans. The model is based on the known structural alterations that occur in the quaternary haemoglobin molecule during oxygenation and deoxygenation. The two alternative structures, tense and relaxed, are described using hyperbolic tang...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Anstey C

    更新日期:2003-08-01 00:00:00

  • Hypoxia in children following general anaesthesia.

    abstract::The oxygen saturations of 152 children were studied for the first 30 minutes following general anaesthesia with a pulse oximeter. Thirty-six patients (24%) recorded oxygen saturations of less than 90% while breathing room air and in all cases this occurred during the first ten minutes. Intubation (P less than 0.001), ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Tomkins DP,Gaukroger PB,Bentley MW

    更新日期:1988-05-01 00:00:00

  • Assessment of an unplanned admission to the intensive care unit as a global safety indicator in surgical patients.

    abstract::An unplanned intensive care unit admission within 24 hours of a procedure with an anaesthetist in attendance (UIA) is a recommended clinical indicator It is designed to identify preventable iatrogenic complications. Often understood as a specific anaesthetic outcome, its value has been repeatedly questioned. Iatrogeni...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Haller G,Myles PS,Langley M,Stoelwinder J,McNeil J

    更新日期:2008-03-01 00:00:00

  • Joseph Clover and the cobra: a tale of snake envenomation and attempted resuscitation with bellows in London, 1852.

    abstract::The Industrial Revolution saw the creation of many new jobs, but probably none more curious than that of zookeeper. The London Zoological Gardens, established for members in 1828, was opened to the general public in 1847. In 1852 the "Head Keeper in the Serpent Room", Edward Horatio Girling, spent a night farewelling ...

    journal_title:Anaesthesia and intensive care

    pub_type: 历史文章,杂志文章


    authors: Ball C

    更新日期:2010-07-01 00:00:00

  • A technique of nasotracheal intubation in patients with recent facio-maxillary injury.

    abstract::A technique of nasotracheal intubation in patients with recent facial injury is described. Oral intubation is performed initially to ensure the safety of the patient during the procedure of nasal intubation. ...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Why KS

    更新日期:1975-05-01 00:00:00

  • Anaesthetic aspects of implanting diaphragmatic pacing in patients with spinal cord injury.

    abstract::Some patients with high cervical spinal cord injury are largely or completely dependent on mechanical ventilator support. Diaphragmatic phrenic nerve pacing is a new technique that offers some patients greater independence from mechanical ventilation. In selected patients, electrodes are placed on the abdominal side o...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Story D,Mariampillai E,Nikfarjam M,Howard M,Nunn A,Onders R

    更新日期:2010-07-01 00:00:00

  • Tubeless anaesthesia for microlaryngeal surgery.

    abstract::An anaesthetic technique for laryngeal microsurgery is described and evaluated using intravenous propofol infusion and topical lignocaine with the patient breathing spontaneously without an endotracheal tube. Eighty adult patients divided into two groups according to their ASA status (Group A; 58 ASA I and II; Group B...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Aun CS,Houghton IT,So HY,Van Hasselt CA,Oh TE

    更新日期:1990-11-01 00:00:00

  • Prediction of the mediastinal drainage after coronary artery bypass surgery.

    abstract::Using multiple correlation and linear regression approaches, we investigated the association between the amount of mediastinal drainage for the first 24 postoperative hours and clinical variables as well as multiple haematological tests performed at three time points: before anaesthesia induction, 10 minutes after pro...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Liu G,McNicol PL,McCall PR,Bellomo R,Connellan J,McInnes F,Przybylowski GM,Bowkett J,Choo F,Thurlow PJ

    更新日期:2000-08-01 00:00:00

  • Should autologous blood transfusion be rediscovered?

    abstract::With a greater appreciation and understanding of reactions to homologous blood transfusion there has been a renewed interest in autologous blood transfusion. The techniques and indications for preoperative banked autologous blood, perioperative haemodilution and recycled salvaged autologous blood transfusion are descr...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Isbister JP,Davis R

    更新日期:1980-05-01 00:00:00

  • Terlipressin infusion in catecholamine-resistant shock.

    abstract::Catecholamine-resistant shock is not uncommon in intensive care. Bolus dose terlipressin (a vasopressin analogue) has been used successfully in this setting allowing cessation of other vasopressor agents. The relative vasopressin deficiency in combination with the restoration of the vascular tone (by blocking adenosin...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Jolley DH,De Keulenaer BL,Potter A,Stephens DP

    更新日期:2003-10-01 00:00:00

  • Charging for intensive care using direct nursing hours as the cost marker.

    abstract::The hypothesis that direct nursing hours correlate with the cost of a patient stay in intensive care was tested. One hundred and thirty-nine patients were studied and the data collected included: (a) direct nursing hours applied to each patient; (b) a daily TISS score: (c) a detailed costing of each patient (all costs...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Havill JH,Caspari M,McConnell H,Alexander M,Montgomery C

    更新日期:1997-08-01 00:00:00

  • The prevention of gastric inflation--a neglected benefit of cricoid pressure.

    abstract::The ability of cricoid pressure to prevent inflation of the stomach during mask ventilation of a patient was studied. Fifty patients were randomly allocated to either have or not have cricoid pressure applied during a three-minute period of standardised mask ventilation. Patients who had had cricoid pressure applied h...

    journal_title:Anaesthesia and intensive care

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Petito SP,Russell WJ

    更新日期:1988-05-01 00:00:00

  • The Lack and Bain systems in spontaneous respiration.

    abstract::In conscious subjects breathing spontaneously the performance of the Lack semi-closed system resembled the Magill attachment in that rebreathing was only detected at fresh gas flows of less than resting minute volume. With the Bain semi-closed system rebreathing was detectable at fresh gas flows of the order of 2.5 ti...

    journal_title:Anaesthesia and intensive care

    pub_type: 杂志文章


    authors: Nott MR,Walters FJ,Norman J

    更新日期:1982-11-01 00:00:00