Downregulation of ATP1A1 promotes cancer development in renal cell carcinoma.

abstract：Background:Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods:B-Cd and 88 plasma ...

journal_title：Clinical proteomics

authors： Borné Y,Fagerberg B,Sallsten G,Hedblad B,Persson M,Melander O,Nilsson J,Orho-Melander M,Barregard L,Engström G

更新日期：2019-05-15 00:00:00

abstract：:The greatest unmet needs in biomarker discovery are those discoveries that lead to the development of clinical diagnostic tests. These clinical diagnostic tests can provide early intervention when a patient would present otherwise healthy (e.g., cancer or cardiovascular disease) and aid clinical decision making with i...

journal_title：Clinical proteomics

authors： Crutchfield CA,Thomas SN,Sokoll LJ,Chan DW

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new test uses a robust assay format-electrochemiluminescence immunoassays-to quantify protein concentratio...

journal_title：Clinical proteomics

authors： Croner LJ,Dillon R,Kao A,Kairs SN,Benz R,Christensen IJ,Nielsen HJ,Blume JE,Wilcox B

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:Angiotensin-II (Ang II) mediates progression of autosomal-dominant polycystic kidney disease (ADPKD) and other chronic kidney diseases (CKD). However, markers of kidney Ang II activity are lacking. We previously defined 83 Ang II-regulated proteins in vitro, which reflected kidney Ang II activity in vivo. M...

journal_title：Clinical proteomics

authors： Konvalinka A,Batruch I,Tokar T,Dimitromanolakis A,Reid S,Song X,Pei Y,Drabovich AP,Diamandis EP,Jurisica I,Scholey JW

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate several other KLK proteases, triggering the stimulation of tissue microenvironment proteolytic c...

journal_title：Clinical proteomics

authors： Avgeris M,Papachristopoulou G,Polychronis A,Scorilas A

更新日期：2011-05-31 00:00:00

abstract：Background:Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is stil...

journal_title：Clinical proteomics

authors： Ali N,Ljunggren S,Karlsson HM,Wierzbicka A,Pagels J,Isaxon C,Gudmundsson A,Rissler J,Nielsen J,Lindh CH,Kåredal M

更新日期：2018-05-11 00:00:00

abstract：Background:There is a need to demonstrate a proof of principle that proteomics has the capacity to analyze plasma from breast cancer versus other diseases and controls in a multisite clinical trial design. The peptides or proteins that show a high observation frequency, and/or precursor intensity, specific to breast ca...

journal_title：Clinical proteomics

authors： Dufresne J,Bowden P,Thavarajah T,Florentinus-Mefailoski A,Chen ZZ,Tucholska M,Norzin T,Ho MT,Phan M,Mohamed N,Ravandi A,Stanton E,Slutsky AS,Dos Santos CC,Romaschin A,Marshall JC,Addison C,Malone S,Heyland D,Schelte

更新日期：2019-12-23 00:00:00

abstract：:The tryptic peptides from ice cold versus room temperature plasma were identified by C18 liquid chromatography and micro electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Samples collected on ice showed low levels of endogenous tryptic peptides compared to the same samples incubated at room temperature....

journal_title：Clinical proteomics

authors： Dufresne J,Florentinus-Mefailoski A,Ajambo J,Ferwa A,Bowden P,Marshall J

更新日期：2017-12-02 00:00:00

abstract：Background:Inflammatory arthritis (IA) is an immunological disorder in which loss of immune tolerance to endogenous self-antigens perpetuates synovitis and eventual destruction of the underlying cartilage and bone. Pathological changes in the joint are expected to be represented by synovial fluid (SF) proteins and pept...

journal_title：Clinical proteomics

authors： Mahendran SM,Keystone EC,Krawetz RJ,Liang K,Diamandis EP,Chandran V

更新日期：2019-05-30 00:00:00

abstract：:Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of abe...

journal_title：Clinical proteomics

authors： Liu H,Zhang N,Wan D,Cui M,Liu Z,Liu S

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Purified protein derivative (PPD) has been used for more than half a century as an antigen for the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated as "purified," in reality, the composition of PPD is highly complex and remains ill-defined. In this report, high ...

journal_title：Clinical proteomics

authors： Prasad TS,Verma R,Kumar S,Nirujogi RS,Sathe GJ,Madugundu AK,Sharma J,Puttamallesh VN,Ganjiwale A,Myneedu VP,Chatterjee A,Pandey A,Harsha H,Narayana J

更新日期：2013-07-19 00:00:00

abstract：Background:Cytauxzoonosis is a disease of felids in North America caused by the tick-transmitted apicomplexan parasite Cytauxzoon felis. Cytauxzoonosis is particularly virulent for domestic cats, but no vaccine currently exists. The parasite cannot be cultivated in vitro, presenting a significant limitation for vaccine...

journal_title：Clinical proteomics

authors： Schreeg ME,Marr HS,Tarigo JL,Sherrill MK,Outi HK,Scholl EH,Bird DM,Vigil A,Hung C,Nakajima R,Liang L,Trieu A,Doolan DL,Thomas JE,Levy MG,Reichard MV,Felgner PL,Cohn LA,Birkenheuer AJ

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:Placental syncytiotrophoblast microvesicles (STBM) are shed into the maternal circulation during normal pregnancy. STBM circulate in significantly increased amounts in preeclampsia (PE) and are considered to be among contributors to the exaggerated proinflammatory, procoagulant state of PE. However, protein ...

journal_title：Clinical proteomics

authors： Baig S,Kothandaraman N,Manikandan J,Rong L,Ee KH,Hill J,Lai CW,Tan WY,Yeoh F,Kale A,Su LL,Biswas A,Vasoo S,Choolani M

更新日期：2014-11-19 00:00:00

abstract：Background:Cancer-associated fibroblasts (CAFs) are one of the most important components of tumor stroma and play a key role in modulating tumor growth. However, a mechanistic understanding of how CAFs communicate with tumor cells to promote their proliferation and invasion is far from complete. A major reason for this...

journal_title：Clinical proteomics

authors： Wu X,Zahari MS,Renuse S,Sahasrabuddhe NA,Chaerkady R,Kim MS,Fackler MJ,Stampfer M,Gabrielson E,Sukumar S,Pandey A

更新日期：2018-06-15 00:00:00

abstract：:CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a ge...

journal_title：Clinical proteomics

authors： Azevedo R,Gaiteiro C,Peixoto A,Relvas-Santos M,Lima L,Santos LL,Ferreira JA

更新日期：2018-06-27 00:00:00

abstract：:Hepatic ischemia/reperfusion (I/R) injury represents a major risk factor for liver transplantation and is related to graft dysfunction and acute/chronic rejection. However, a significant part of these processes remain poorly characterized. To reveal differences in the proteome during liver I/R injury, we collected hum...

journal_title：Clinical proteomics

authors： Cai H,Qi S,Yan Q,Ling J,Du J,Chen L

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary protein profiles, aiming to discover disease-specific biomarkers of these three common diseases in NS...

journal_title：Clinical proteomics

authors： Choi YW,Kim YG,Song MY,Moon JY,Jeong KH,Lee TW,Ihm CG,Park KS,Lee SH

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Management of lung cancer is hindered by high false-positive rates due to difficulty resolving between beni...

journal_title：Clinical proteomics

authors： Fahrmann JF,Grapov D,Phinney BS,Stroble C,DeFelice BC,Rom W,Gandara DR,Zhang Y,Fiehn O,Pass H,Miyamoto S

更新日期：2016-10-27 00:00:00

abstract：Background:It is difficult to distinguish benign pulmonary nodules (PNs) from malignant PNs by conventional examination. Therefore, novel biomarkers that can identify the nature of PNs are needed. Exosomes have recently been identified as an attractive alternative approach since tumor-specific molecules can be found in...

journal_title：Clinical proteomics

authors： Kuang M,Tao X,Peng Y,Zhang W,Pan Y,Cheng L,Yuan C,Zhao Y,Mao H,Zhuge L,Zhou Z,Chen H,Sun Y

更新日期：2019-02-02 00:00:00

abstract：:Reversible protein phosphorylation represents a key mechanism by which signals are transduced in eukaryotic cells. Dysregulated phosphorylation is also a hallmark of carcinogenesis and represents key drug targets in the precision medicine space. Thus, methods that preserve phosphoprotein integrity in the context of cl...

journal_title：Clinical proteomics

authors： Hunt AL,Pierobon M,Baldelli E,Oliver J,Mitchell D,Gist G,Bateman NW,Larry Maxwell G,Petricoin EF,Conrads TP

更新日期：2020-03-09 00:00:00

abstract：:Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond merely inventorying protein species, and address sophisticated questions on cardiac physiology. The advent of ...

journal_title：Clinical proteomics

authors： Lam MP,Lau E,Ng DC,Wang D,Ping P

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Curcumin, derived from the rhizome Curcuma longa, is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well established, detailed understanding of the signaling pathways altered by curcumin is still lacking. I...

journal_title：Clinical proteomics

authors： Sathe G,Pinto SM,Syed N,Nanjappa V,Solanki HS,Renuse S,Chavan S,Khan AA,Patil AH,Nirujogi RS,Nair B,Mathur PP,Prasad TSK,Gowda H,Chatterjee A

更新日期：2016-06-15 00:00:00

abstract：Background:Cerebrospinal fluid (CSF) is an important source of potential biomarkers that affect the brain. Biomarkers for neurodegenerative disorders are needed to assist in diagnosis, monitoring disease progression and evaluating efficacy of therapies. Recent studies have demonstrated the involvement of tyrosine kinas...

journal_title：Clinical proteomics

authors： Sathe G,Na CH,Renuse S,Madugundu A,Albert M,Moghekar A,Pandey A

更新日期：2018-09-12 00:00:00

abstract：Background:Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal function. Recent studies suggested that patients with non-alcoholic fatty liver disease (NAFLD), inc...

journal_title：Clinical proteomics

authors： Rao PK,Merath K,Drigalenko E,Jadhav AYL,Komorowski RA,Goldblatt MI,Rohatgi A,Sarzynski MA,Gawrieh S,Olivier M

更新日期：2018-03-06 00:00:00

abstract：:Bovine milk and its products (e.g. cheese, yoghurt) are an important part of human diet with beneficial effects for all ages. Although analyses of different milk components (e.g. proteins, lipids) pose huge challenges, the use of mass spectrometric (MS)-based techniques is steadily improving our understanding of the c...

journal_title：Clinical proteomics

authors： Verma A,Ambatipudi K

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC. METHODS:We used serological proteome analysis to identify candidate autoantibodies against tumor-associ...

journal_title：Clinical proteomics

authors： Lin LH,Xu YW,Huang LS,Hong CQ,Zhai TT,Liao LD,Lin WJ,Xu LY,Zhang K,Li EM,Peng YH

更新日期：2017-02-01 00:00:00

abstract：:Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is being extensively used for both basic as well as translation research in the areas of infectious and immune di...

journal_title：Clinical proteomics

authors： Mukherjee S,Bandyopadhyay A

更新日期：2016-11-05 00:00:00

abstract：Background:N-linked glycoprotein is a highly interesting class of proteins for clinical and biological research. The large-scale characterization of N-linked glycoproteins accomplished by mass spectrometry-based glycoproteomics has provided valuable insights into the interdependence of glycoprotein structure and protei...

journal_title：Clinical proteomics

authors： Sun S,Hu Y,Ao M,Shah P,Chen J,Yang W,Jia X,Tian Y,Thomas S,Zhang H

更新日期：2019-09-07 00:00:00

abstract：BACKGROUND:The carbohydrate portions of salivary glycoproteins play important roles, including mediating bacterial and leukocyte adhesion. Salivary glycosylation is complex. Many of its glycoproteins present ABO and Lewis blood group determinants. An individual's genetic complement and secretor status govern the expres...

journal_title：Clinical proteomics

authors： Albertolle ME,Hassis ME,Ng CJ,Cuison S,Williams K,Prakobphol A,Dykstra AB,Hall SC,Niles RK,Ewa Witkowska H,Fisher SJ

更新日期：2015-12-30 00:00:00

abstract：PURPOSE:To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycline-taxane-based systemic therapy (NST). METHODS:Reverse phase protein array (RPPA) using 146 antibodi...

journal_title：Clinical proteomics

authors： Gonzalez-Angulo AM,Hennessy BT,Meric-Bernstam F,Sahin A,Liu W,Ju Z,Carey MS,Myhre S,Speers C,Deng L,Broaddus R,Lluch A,Aparicio S,Brown P,Pusztai L,Symmans WF,Alsner J,Overgaard J,Borresen-Dale AL,Hortobagyi GN,Co

更新日期：2011-07-08 00:00:00