Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis.


:Recent studies reveal that polycystic ovary syndrome (PCOS) might be associated with cardiovascular autonomic dysfunction, but with inconsistent results. The aim of this meta-analysis was to study whether women with PCOS have cardiovascular autonomic dysfunction. PubMed, Web of Science, Cochrane Library and SCOPUS were searched for studies comparing cardiovascular function between women with PCOS and controls. A random-effects model was used to evaluate cardiac autonomic modulation and muscle sympathetic nerve activity (MSNA) between women with PCOS and controls. Eight studies were included, including 243 PCOS and 211 controls. Overall, women with PCOS had significantly lower standard deviation of normal-to-normal RR intervals (SDNN) and percentage of the number of interval differences of successive normal-to-normal RR intervals greater than 50 ms among the total number of RR intervals (pNN50), higher MSNA frequency and higher MSNA incidence than controls. Therefore, this meta-analysis provides evidence that women with PCOS might show cardiovascular autonomic dysfunction, with reduced total and parasympathetic cardiac modulation, and increased sympathetic activity.


Reprod Biomed Online


Gui J,Wang RH




Has Abstract


2017-07-01 00:00:00














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    journal_title:Reproductive biomedicine online

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    authors: Lin YH,Hwang JL,Seow KM,Huang LW,Chen HJ,Tzeng CR

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  • Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination.

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    journal_title:Reproductive biomedicine online

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    authors: Belloc S,Cohen-Bacrie P,Benkhalifa M,Cohen-Bacrie M,De Mouzon J,Hazout A,Ménézo Y

    更新日期:2008-09-01 00:00:00

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    journal_title:Reproductive biomedicine online

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    authors: Kolte AM,Olsen LR,Christiansen OB,Schmidt L,Nielsen HS

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    journal_title:Reproductive biomedicine online

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    更新日期:2020-04-01 00:00:00

  • PGD for X-linked and gender-dependent disorders using a robust, flexible single-tube PCR protocol.

    abstract::X-linked genetic diseases include a wide range of disorders such as the dystrophinopathies. Additionally in some rare genetic diseases, severity of expression is gender dependent. Prevention of such disorders usually involves prenatal diagnosis and termination of affected pregnancies, while preimplantation genetic dia...

    journal_title:Reproductive biomedicine online

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    authors: Christofidou C,Sofocleous C,Vrettou C,Destouni A,Traeger-Synodinos J,Kekou K,Palmer G,Kokkali G,Mavrou A,Kitsiou S,Kanavakis E

    更新日期:2009-09-01 00:00:00

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    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章


    authors: Braude P

    更新日期:2018-08-01 00:00:00

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    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验


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    更新日期:2017-08-01 00:00:00

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    journal_title:Reproductive biomedicine online

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    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章


    authors: Connolly M

    更新日期:2011-12-01 00:00:00

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    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Bahadur G,Iqbal M,Malik S,Sanyal A,Wafa R,Noble R

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    authors: Rísquez F,Gil M,D'Ommar G,Poo M,Sosa A,Piras M

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    pub_type: 杂志文章


    authors: Findikli N,Kahraman S,Kumtepe Y,Donmez E,Biricik A,Sertyel S,Berkil H,Melil S

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    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验


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    authors: Verlinsky Y,Rechitsky S,Verlinsky O,Strom C,Kuliev A

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    journal_title:Reproductive biomedicine online

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    authors: Wolfenson C,Groisman J,Couto AS,Hedenfalk M,Cortvrindt RG,Smitz JE,Jespersen S

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    authors: Couture V,Dubois MA,Drouin R,Moutquin JM,Bouffard C

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    authors: van Tol HT,Vernooij JC,Colenbrander B,Gutknecht D,Macklon NS,Roelen BA

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    journal_title:Reproductive biomedicine online

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    更新日期:2006-02-01 00:00:00

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    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Ulug U,Ben-Shlomo I,Turan E,Erden HF,Akman MA,Bahceci M

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    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Inhorn MC

    更新日期:2011-11-01 00:00:00