Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Abstract:

:Recent studies reveal that polycystic ovary syndrome (PCOS) might be associated with cardiovascular autonomic dysfunction, but with inconsistent results. The aim of this meta-analysis was to study whether women with PCOS have cardiovascular autonomic dysfunction. PubMed, Web of Science, Cochrane Library and SCOPUS were searched for studies comparing cardiovascular function between women with PCOS and controls. A random-effects model was used to evaluate cardiac autonomic modulation and muscle sympathetic nerve activity (MSNA) between women with PCOS and controls. Eight studies were included, including 243 PCOS and 211 controls. Overall, women with PCOS had significantly lower standard deviation of normal-to-normal RR intervals (SDNN) and percentage of the number of interval differences of successive normal-to-normal RR intervals greater than 50 ms among the total number of RR intervals (pNN50), higher MSNA frequency and higher MSNA incidence than controls. Therefore, this meta-analysis provides evidence that women with PCOS might show cardiovascular autonomic dysfunction, with reduced total and parasympathetic cardiac modulation, and increased sympathetic activity.

journal_name

Reprod Biomed Online

authors

Gui J,Wang RH

doi

10.1016/j.rbmo.2017.03.018

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

113-120

issue

1

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(17)30152-9

journal_volume

35

pub_type

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