Assessing the Risk of Occult Cancer and 30-day Morbidity in Women Undergoing Risk-reducing Surgery: A Prospective Experience.


STUDY OBJECTIVE:To investigate the incidence and predictive factors of 30-day surgery-related morbidity and occult precancerous and cancerous conditions for women undergoing risk-reducing surgery. DESIGN:A prospective study (Canadian Task Force classification II-1). SETTING:A gynecologic oncology referral center. PATIENTS:Breast-related cancer antigen (BRCA) mutation carriers and BRCAX patients (those with a significant family history of breast and ovarian cancer). INTERVENTIONS:Minimally invasive risk-reduction surgery. MEASUREMENTS AND MAIN RESULTS:Overall, 85 women underwent risk-reducing surgery: 30 (35%) and 55 (65%) had hysterectomy plus bilateral salpingo-oophorectomy (BSO) and BSO alone, respectively. Overall, in 6 (7%) patients, the final pathology revealed unexpected cancer: 3 early-stage ovarian/fallopian tube cancers, 2 advanced-stage ovarian cancers (stage IIIA and IIIB), and 1 serous endometrial carcinoma. Additionally, 3 (3.6%) patients had incidental finding of serous tubal intraepithelial carcinoma. Four (4.7%) postoperative complications within 30 days from surgery were registered, including fever (n = 3) and postoperative ileus (n = 1); no severe (grade 3 or more) complications were observed. All complications were managed conservatively. The presence of occult cancer was the only factor predicting the development of postoperative complications (p = .02). CONCLUSION:Minimally invasive risk-reducing surgery is a safe and effective strategy to manage BRCA mutation carriers. Patients should benefit from an appropriate counseling about the high prevalence of undiagnosed cancers observed at the time of surgery.


Bogani G,Tagliabue E,Signorelli M,Chiappa V,Carcangiu ML,Paolini B,Casarin J,Scaffa C,Gennaro M,Martinelli F,Borghi C,Ditto A,Lorusso D,Raspagliesi F




Has Abstract


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  • Transverse Vaginal Septum With Secondary Infertility: A Rare Case.

    abstract:STUDY OBJECTIVE:To demonstrate the technique of laparoscopic vaginal reconstruction in a rare case of mid-vaginal septum with secondary infertility. DESIGN:A step-by-step explanation of the technique using videos and pictures (Canadian Task Force classification IV). SETTING:Transverse vaginal septum is a rare conditi...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Rahman H,Trehan N,Singh S,Goyal M

    更新日期:2016-07-01 00:00:00

  • Hysteroscopic resection in the management of early-stage endometrial cancer: report of 2 cases and review of the literature.

    abstract::Although endometrial cancer, the most common gynecologic malignancy, is most often diagnosed in postmenopausal women, it affects young women who wish to preserve fertility. The purpose of this article is to describe 2 cases of stage IA endometrial cancer managed conservatively by a combination of hysteroscopic surgery...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Arendas K,Aldossary M,Cipolla A,Leader A,Leyland NA

    更新日期:2015-01-01 00:00:00

  • Laparoscopic mesh sacrohysteropexy with concurrent laparoscopic myomectomy for treatment of multiple myomas: case report and literature review.

    abstract::Conservative surgical management of uterine prolapse with uterine conservation has become an alternative treatment in women who wish to maintain their uterus. Vaginal and abdominal approaches for uterine suspension have been described and reported. Certain concomitant pathologic conditions of the uterus such as uterin...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Chinthakanan O,Miklos JR,Moore RD

    更新日期:2013-11-01 00:00:00

  • Impact of isthmocele on assisted reproductive treatment outcomes: an age-matched retrospective study.

    abstract:STUDY OBJECTIVE:To evaluate whether the presence of an ultrasonographic visible isthmocele has an impact on the chance of pregnancy in women undergoing embryo transfer. DESIGN:An age-matched retrospective study SETTING: Private assisted reproductive center PATIENTS: The study included a total of 150 patients with a pr...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Asoglu MR,Celik C,Ozturk E,Cavkaytar S,Bahceci M

    更新日期:2020-10-07 00:00:00

  • Ethanol Sclerotherapy versus Laparoscopic Surgery for Endometrioma Treatment: A Prospective, Multicenter, Cohort Pilot Study.

    abstract:STUDY OBJECTIVE:To compare the cost-effectiveness of ultrasound (US)-guided aspiration and ethanol sclerotherapy versus laparoscopic surgery for benign-appearing ovarian endometrioma. DESIGN:Prospective, cohort pilot study. SETTING:Multiple centers, Spain. PATIENTS:Forty patients with suspected ovarian endometrioma ...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,多中心研究


    authors: Garcia-Tejedor A,Martinez-Garcia JM,Candas B,Suarez E,Mañalich L,Gomez M,Merino E,Castellarnau M,Regueiro P,Carreras M,Martinez-Franco E,Carrarrach M,Subirats N,Barbera J,Gonzalez S,Climent M,Fernández-Montolí E,Ponce J

    更新日期:2020-01-01 00:00:00

  • Hysteroscopic Resection in Fertility-Sparing Surgery for Atypical Hyperplasia and Endometrial Cancer: Safety and Efficacy.

    abstract:STUDY OBJECTIVES:To evaluate the rate of intrauterine adhesions after hysteroscopic resection of hyperplastic and/or cancer areas and the efficacy of combined treatment. DESIGN:Observational retrospective study. SETTING:Patients affected by endometrial atypical hyperplasia of the endometrium or early stage endometria...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: De Marzi P,Bergamini A,Luchini S,Petrone M,Taccagni GL,Mangili G,Colombo G,Candiani M

    更新日期:2015-11-01 00:00:00

  • Cost-minimization analysis of robotic-assisted, laparoscopic, and abdominal sacrocolpopexy.

    abstract:STUDY OBJECTIVE:To perform a cost-minimization analysis comparing robotic-assisted, laparoscopic, and abdominal sacrocolpopexy. DESIGN:Cost-minimization analysis using a micro-costing approach (Canadian Task Force classification III). MEASUREMENTS AND MAIN RESULTS:A decision model was developed to compare the costs (...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Judd JP,Siddiqui NY,Barnett JC,Visco AG,Havrilesky LJ,Wu JM

    更新日期:2010-07-01 00:00:00

  • Novel Vaginal "paper roll" uterine morcellation technique for removal of large (>500 g) uterus.

    abstract::At laparoscopic-assisted vaginal hysterectomy with a novel "paper roll" vaginal morcellation technique, large uteri (> or = 500 g) can be removed via the vagina with safety, speed, and ease. The technique provides protection for the bladder and rectum, and large uteri can be removed in 1 piece, allowing the pathologis...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Wong WS,Lee TC,Lim CE

    更新日期:2010-05-01 00:00:00

  • Power Morcellator Features Affecting Tissue Spill in Gynecologic Laparoscopy: An In-Vitro Study.

    abstract:STUDY OBJECTIVE:To assess features of power morcellators (blade diameter, circular vs oscillating cutting, blade rotation speed, experience level) regarding their effect on the amount of tissue spill. In addition, the amount of tissue spill after the initial two-thirds and final one-third of the morcellated specimen wa...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: van den Haak L,Arkenbout EA,Sandberg EM,Jansen FW

    更新日期:2016-01-01 00:00:00

  • Tigers in the Sidewall: Surgical Approaches to Excision of Lateral Deep Infiltrating Endometriosis.

    abstract:OBJECTIVE:To describe the surgical approaches and excisional techniques used in an extreme case of deep infiltrating endometriosis (DIE) affecting the lateral pelvic side wall. DESIGN:A technical video showing the excision of advanced lateral DIE. SETTING:An academic tertiary care hospital. INTERVENTIONS:A 32-year-o...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Peters A,Rindos NB,Lee TTM

    更新日期:2020-02-01 00:00:00

  • Surgical management of recurrent ureteric endometriosis causing recurrent hypertension in a postmenopausal woman.

    abstract::Endometriosis is a common condition that affects as many as 10% to 20% of women of reproductive age. Because of the subtle clinical signs and symptoms and limitations of imaging methods, the diagnosis is frequently delayed or missed, with serious consequences including hypertension, hydronephrosis, and loss of kidney ...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Khong SY,Lam A,Coombes G,Ford S

    更新日期:2010-01-01 00:00:00

  • Laparoscopy and ovarian cancer: a paradigm change in the management of ovarian cancer?

    abstract::A MEDLINE search was conducted using the keywords "laparoscopy ovarian cancer," "laparoscopy and borderline ovarian tumors," "advanced stage ovarian cancer," "laparoscopic cytoreduction ovarian cancer," "laparoscopy intraperitoneal catheter," "port-site metastases," and "carbon dioxide pneumoperitoneum." The publicati...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Liu CS,Nagarsheth NP,Nezhat FR

    更新日期:2009-05-01 00:00:00

  • Endometriosis of the diaphragm: four cases treated with a combination of laparoscopy and thoracoscopy.

    abstract:STUDY OBJECTIVE:We aim to describe the clinical characteristics and the principles of combined laparoscopic and thoracoscopic management of women with diaphragmatic endometriosis at our institution. DESIGN:Case series (Canadian Task Force Classification II2). SETTING:Tertiary care referral center. PATIENTS:Four wome...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Nezhat C,Nicoll LM,Bhagan L,Huang JQ,Bosev D,Hajhosseini B,Beygui RE

    更新日期:2009-09-01 00:00:00

  • Laparoscopic vessel sealing technologies.

    abstract::Laparoscopic vessel sealing devices have revolutionized modern laparoscopy. These devices fall into 2 major categories: advanced bipolar and ultrasonic instruments. The range of tissue effects available with these technologies is more limited than with conventional monopolar electrosurgery; however, both advanced bipo...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Lyons SD,Law KS

    更新日期:2013-05-01 00:00:00

  • Preoperative Conization and Risk of Recurrence in Patients Undergoing Laparoscopic Radical Hysterectomy for Early Stage Cervical Cancer: A Multicenter Study.

    abstract:STUDY OBJECTIVE:To investigate the factors associated with poorer oncologic outcomes in patients undergoing laparoscopic radical hysterectomy (LRH) for early stage cervical cancer. DESIGN:Multicenter retrospective study. SETTING:Three gynecologic oncology referral centers. PATIENTS:Patients with International Federa...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Casarin J,Bogani G,Papadia A,Ditto A,Pinelli C,Garzon S,Donadello N,Laganà AS,Cromi A,Mueller M,Raspagliesi F,Ghezzi F

    更新日期:2021-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Chen I,Mallick R,Allaire C,Bajzak KI,Belland LM,Bougie O,Cassell KA,Choudhry AJ,Cundiff GW,Kroft J,Leyland NA,Maheux-Lacroix S,Rajakumar C,Randle E,Robertson D,Thiel JA,Tulandi T,Yong PJ,Laberge PY

    更新日期:2021-01-18 00:00:00

  • Robotic Radical Hysterectomy Is Not Superior to Laparoscopic Radical Hysterectomy in Perioperative Urologic Complications: A Meta-Analysis of 23 Studies.

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,meta分析


    authors: Hwang JH,Kim BW,Kim SR,Kim JH

    更新日期:2020-01-01 00:00:00

  • Sterility of Selected Operative Sites During Total Laparoscopic Hysterectomy.

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Shockley ME,Beran B,Nutting H,Arnolds K,Sprague ML,Zimberg S

    更新日期:2017-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Jacobs VR,Morrison JE Jr,Paepke S,Fischer T,Kiechle M

    更新日期:2006-05-01 00:00:00

  • Transcatheter embolization of uterine arteriovenous malformation: report of 2 cases and review of literature.

    abstract::Arteriovenous malformation (AVM) of the uterus is a rare cause of menorrhagia and may at times lead to life-threatening hemorrhage. The clinical findings may not always be reliable in the diagnosis of uterine AVM, and a high index of suspicion is important because, unlike many other causes of menorrhagia, curettage ma...

    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Molvi SN,Dash K,Rastogi H,Khanna SB

    更新日期:2011-11-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Healey M,Cheng C,Kaur H

    更新日期:2014-11-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Dueholm M,Hjorth IM,Secher P,Jørgensen A,Ørtoft G

    更新日期:2015-11-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Lo TS,Tan YL,Cortes EF,Pue LB,Wu PY,Al-Kharabsheh A

    更新日期:2015-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Ramirez PT,Nick AM,Frumovitz M,Schmeler KM

    更新日期:2013-11-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,多中心研究


    authors: Comptour A,Pereira B,Lambert C,Chauvet P,Grémeau AS,Pouly JL,Canis M,Bourdel N

    更新日期:2020-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Erian J,El-Toukhy T,Chandakas S,Theodoridis T,Hill N

    更新日期:2005-07-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Einarsson JI,Audbergsson BO,Thorsteinsson A

    更新日期:2008-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章


    authors: Protopapas A,Giannoulis G,Chatzipapas I,Athanasiou S,Grigoriadis T,Kathopoulis N,Vlachos DE,Zaharakis D,Loutradis D

    更新日期:2019-01-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,评审


    authors: Martin DC

    更新日期:2006-11-01 00:00:00

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    journal_title:Journal of minimally invasive gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Aytan H,Nazik H,Narin R,Api M,Tok EC

    更新日期:2014-07-01 00:00:00