SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.

abstract：:Vegetative amoebae of Dictyostelium discoideum (strain AX2) adhere to columns of hydrophobic beads (Bio-Beads SM-2) which have been coated with axenic growth medium. This binding is blocked by sodium azide and other inhibitors of aerobic respiration. Bound cells are not detached by lowering the temperature but they ca...

journal_title：Experimental cell research

authors： Glynn PJ,Clarke KR

更新日期：1984-05-01 00:00:00

abstract：:The nucleoside analogs 9-beta-D-arabinofuranosylguanine (araG) and 1-beta-d-arabinofuranosylthymine (araT) are substrates of mitochondrial nucleoside kinases and have previously been shown to be predominantly incorporated into mtDNA of cells, but the pharmacological importance of their accumulation in mtDNA is not kno...

journal_title：Experimental cell research

authors： Curbo S,Johansson M,Balzarini J,Lewis LD,Karlsson A

更新日期：2009-09-10 00:00:00

abstract：:Sepsis is a major cause of mortality in seriously ill patients characterized by a series of severe systemic inflammatory responses due to an infection. Thus, there is a critically need to search more accurate biomarkers and targets for diagnosis and treatment of sepsis. Our study showed that miR-212-3p was up-regulate...

journal_title：Experimental cell research

authors： Chen W,Ma X,Zhang P,Li Q,Liang X,Liu J

更新日期：2017-01-15 00:00:00

abstract：:The degree of polymorphism, i.e., DNA sequence divergence, of short AT-rich tandemly arranged simple sequence repeats at or near promoters and 5'- untranslated regions of mRNA may quantitatively regulate transcription of tissue-specific genes. Less polymorphic repeats allow greater gene expression. Preferential bindin...

journal_title：Experimental cell research

authors： Flickinger R

更新日期：2020-05-15 00:00:00

abstract：:Galectin-3, a beta-galactoside-binding protein, has been shown to be involved in multiple biological processes through interaction with its complementary glycoconjugates. Here we provide the first evidence of galectin-3 as a mitogen. Incubation of quiescent cultures of normal human lung fibroblast IMR-90 cells with re...

journal_title：Experimental cell research

authors： Inohara H,Akahani S,Raz A

更新日期：1998-12-15 00:00:00

abstract：:Recent studies report mitochondrial carrier homolog 2 (MTCH2) as a novel and uncharacterized protein that acts as a receptor-like protein for the truncated BH3-interacting domain death agonist (tBID) protein in the outer membrane of mitochondria. These studies, using mouse embryonic stem cells and fibroblasts as well ...

journal_title：Experimental cell research

authors： Robinson AJ,Kunji ER,Gross A

更新日期：2012-07-01 00:00:00

abstract：:FTO, a demethylase for N6-methyladenosine (m6A) modification, has been implicated in multiple tumors. However, its roles in esophageal squamous cell carcinoma (ESCC) remain uncovered. This study aims to evaluate the clinical relevance and functional roles in this disease. Through immunohistochemistry, qRT-PCR and West...

journal_title：Experimental cell research

authors： Liu S,Huang M,Chen Z,Chen J,Chao Q,Yin X,Quan M

更新日期：2020-04-01 00:00:00

abstract：:Defects in the regulation of programmed cell death play a fundamental role in the development of neoplasia and neurological disorders, both of which are linked to the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infection. We previously showed that the HTLV-1 Tax protein protects from apoptosis induced by seru...

journal_title：Experimental cell research

authors： Trevisan R,Daprai L,Paloschi L,Vajente N,Chieco-Bianchi L,Saggioro D

更新日期：2006-05-01 00:00:00

abstract：:The establishment of cell lines allows reproductible in vitro studies that would be far more difficult to perform using primary cells that rapidly undergo phenotypical alterations in culture. The purpose of this work was to establish an endothelial cell line appropriate for in vitro study of endothelial cell activatio...

journal_title：Experimental cell research

authors： Malassagne B,Taboit F,Conti F,Batteux F,Atia N,Chéreau C,Conjeaud H,Théron MC,Attal J,Braet F,Houdebine LM,Calmus Y,Houssin D,Weill B

更新日期：1998-01-10 00:00:00

abstract：:A method for coating liposomes with transferrin is described. Such liposomes have been used for carrying exogenous DNA to rabbit bone marrow (BM) precursor cells, in vivo. A large amount of the DNA contained in the liposomes was delivered specifically into the erythroblasts of the test animals. ...

journal_title：Experimental cell research

authors： Stavridis JC,Deliconstantinos G,Psallidopoulos MC,Armenakas NA,Hadjiminas DJ,Hadjiminas J

更新日期：1986-06-01 00:00:00

abstract：:In the mammalian sperm head, the nucleus is tightly associated with the calyx, a cell type-specific cytoskeletal structure. Previously, we have identified and characterized some basic proteins such as calicin and cylicins I and II as major calyx components of bovine and human spermatids and spermatozoa. Surprisingly w...

journal_title：Experimental cell research

authors： von Bülow M,Rackwitz HR,Zimbelmann R,Franke WW

更新日期：1997-05-25 00:00:00

abstract：:Recently, SIRT5 was reported to be a predominant desuccinylase and demalonylase in mitochondria. Ablation of SIRT5 enhances the systemic succinylation and malonylation of mitochondrial proteins, including various metabolic enzymes; however, its function in pancreatic β cells has not yet been clarified. In this study, ...

journal_title：Experimental cell research

authors： Wang Y,Liu Q,Huan Y,Li R,Li C,Sun S,Guo N,Yang M,Liu S,Shen Z

更新日期：2018-10-01 00:00:00

abstract：:The goal of this study was to assess the in vitro differentiation capacity of human bone marrow-derived stem cells (hBMSCs) along retinal lineages. Mononuclear cells (MNC) were isolated from bone marrow (BM) and mobilized peripheral blood (mPB) using Ficoll-Paque density gradient centrifugation, and were sorted by mag...

journal_title：Experimental cell research

authors： Mathivanan I,Trepp C,Brunold C,Baerlocher G,Enzmann V

更新日期：2015-04-10 00:00:00

abstract：:The results of Phase I/II clinical trials indicate that ricin A-chain-containing immunotoxins cause vascular leak syndrome, characterized by hypoalbuminemia with resultant weight gain and edema. Vascular leak syndrome may be a dose-limiting factor during treatment with ricin A-chain-containing immunotoxins. In this re...

journal_title：Experimental cell research

authors： Soler-Rodríguez AM,Ghetie MA,Oppenheimer-Marks N,Uhr JW,Vitetta ES

更新日期：1993-06-01 00:00:00

abstract：:Poly (ADP-ribose) polymerase-1 (PARP1) is a DNA damage sensor that gets activated in proportion to the damage, helping cells to determine whether to repair the damage or initiate cell death processes. We have previously shown PARP1's significance in the developmental processes of Dictyostelium discoideum in addition t...

journal_title：Experimental cell research

authors： Mir H,Rajawat J,Vohra I,Vaishnav J,Kadam A,Begum R

更新日期：2020-12-15 00:00:00

abstract：:Skin fibroblasts from patients with inherited adenomatosis of the large bowel (ACR-SF) possess alterations in actin microfilament (MF) organization which serve to distinguish "predisposed" cells from fibroblasts derived from normal individuals (NSF). MF bundle frequency and diameter were considerably reduced in ACR-SF...

journal_title：Experimental cell research

authors： Higgins PJ,Kopelovich L

更新日期：1991-08-01 00:00:00

abstract：:Most developing lymphocytes spontaneously die in the thymus during positive and negative selection of the T cell repertoire. By evaluating the expression of the proliferation antigens Ki-67 and PCNA, we demonstrated here that more than 95% of thymocytes are potentially proliferating. The coincidence within the same ce...

journal_title：Experimental cell research

authors： Pellicciari C,Bottone MG,Schaack V,Barni S,Manfredi AA

更新日期：1996-12-15 00:00:00

abstract：:Endothelial cells are exposed to fluid shear stress profiles that vary in magnitude, pulsatility, and directionality due to regional variations in blood vessel structure. Laminar flow at physiological levels is atheroprotective; multidirectional or reversing low (disturbed) flow promotes inflammation and disease; and ...

journal_title：Experimental cell research

authors： Min E,Schwartz MA

更新日期：2019-03-01 00:00:00

abstract：:We have been studying mouse F9 embryonic carcinoma cells which contain no detectable vinculin protein (5.51 cells), and compared them with F9 wild-type cells. Employing atomic force microscopy, we probed the elastic properties of individual F9 wild-type and 5.51 cells by measuring the dynamic response of controlled lo...

journal_title：Experimental cell research

authors： Goldmann WH,Ezzell RM

更新日期：1996-07-10 00:00:00

abstract：:During the polyadenylation of pre-mRNA in vitro, poly(A) binding protein II (PAB II) binds to the growing poly(A) tail, stimulating its extension. The subcellular localization of PAB II was investigated with an antibody affinity-purified from rabbit serum raised against the purified protein. Immunofluorescence microsc...

journal_title：Experimental cell research

authors： Krause S,Fakan S,Weis K,Wahle E

更新日期：1994-09-01 00:00:00

abstract：:The voltage-gated potassium channel, Kv1.3, plays an important role in regulating membrane excitability in diverse cell types ranging from T-lymphocytes to neurons. In the present study, we test the hypothesis that the C-terminal PDZ binding domain modulates the function and localization of Kv1.3. We created a mutant ...

journal_title：Experimental cell research

authors： Doczi MA,Damon DH,Morielli AD

更新日期：2011-10-01 00:00:00

abstract：:Cultured megakaryocytes, isolated from guinea pig bone marrow, were treated with buffer or adenosine diphosphate (ADP) (10 microM) on plain or coated glass surfaces. Control cells were rounded and non-adherent. The nucleotide induced the cells to spread to several times the initial diameter, and to become flattened an...

journal_title：Experimental cell research

authors： Leven RM,Nachmias VT

更新日期：1984-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-immunogenic, multipotent cells with at least trilineage differentiation potential. They promote wound healing, improve regeneration of injured tissue, and mediate numerous other health effects. MSCs migrate to sites of injury and stimulate repair either through direct differentiat...

journal_title：Experimental cell research

authors： Naaldijk Y,Johnson AA,Ishak S,Meisel HJ,Hohaus C,Stolzing A

更新日期：2015-10-15 00:00:00

abstract：:ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main receptor for ADAM12. However, when alp...

journal_title：Experimental cell research

authors： Thodeti CK,Fröhlich C,Nielsen CK,Holck P,Sundberg C,Kveiborg M,Mahalingam Y,Albrechtsen R,Couchman JR,Wewer UM

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:CDK8 is associated with the transcriptional Mediator complex and has been shown to regulate several transcription factors implicated in cancer. As a pancreatic cancer oncogene, the role of CDK8 in cancer angiogenesis remains unclear. Here, we investigated the contribution of CDK8 in pancreatic cancer angioge...

journal_title：Experimental cell research

authors： Wei R,Kong L,Xiao Y,Yuan H,Song Y,Wang J,Yu H,Mao S,Xu W

更新日期：2018-08-15 00:00:00

abstract：:The movement of a cell through the sequential phases of apoptosis is accompanied by a progressive decrease in cell size with loss in protein mass. In lymphocytes from Hiv-infected persons, protein loss during apoptosis is due to increased protein degradation rather than decreased synthesis. To identify and characteriz...

journal_title：Experimental cell research

authors： Piedimonte G,Crinelli R,Della Salda L,Corsi D,Pennisi MG,Kramer L,Casabianca A,Sarli G,Bendinelli M,Marcato PS,Magnani M

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:Vessel formation is a crucial event in tissue repair after injury. Thus, one assumption of innovative therapeutic approaches is the understanding of its molecular mechanisms. Notwithstanding our knowledge of the role of Protein Kinase C epsilon (PKCε) in cardio-protection and vascular restenosis, its role in ...

journal_title：Experimental cell research

authors： Galli D,Carubbi C,Masselli E,Corradi D,Dei Cas A,Nouvenne A,Bucci G,Arcari ML,Mirandola P,Vitale M,Gobbi G

更新日期：2015-01-15 00:00:00

abstract：:The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The phys...

journal_title：Experimental cell research

authors： Beckwitt CH,Clark AM,Wheeler S,Taylor DL,Stolz DB,Griffith L,Wells A

更新日期：2018-02-01 00:00:00

abstract：:Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR). KGF induces keratinocyte motility and cytoskeletal rearrangement, whereas a direct role of FGF10 on keratinocyte migration is...

journal_title：Experimental cell research

authors： Ceccarelli S,Cardinali G,Aspite N,Picardo M,Marchese C,Torrisi MR,Mancini P

更新日期：2007-05-15 00:00:00

abstract：:Electrospinning permits fabrication of biodegradable matrices that can resemble the both scale and mechanical behavior of the native extracellular matrix. However, achieving high-cellular density and infiltration of cells within matrices with traditional technique remain challenging and time consuming. The cell electr...

journal_title：Experimental cell research

authors： Chen H,Liu Y,Hu Q

更新日期：2015-11-01 00:00:00