Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.




Int J Mol Sci


Kobori M,Takahashi Y,Sakurai M,Ni Y,Chen G,Nagashimada M,Kaneko S,Ota T




Has Abstract


2017-05-05 00:00:00










  • Hyaluronan-Loaded Liposomal Dexamethasone-Diclofenac Nanoparticles for Local Osteoarthritis Treatment.

    abstract::Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major cause of pain and disability in older adult individuals. Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) (such as diclofenac, DIC) or intra-articular injected gluco-corticosteroids (such as dexamethasone, DEX) w...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chang MC,Chiang PF,Kuo YJ,Peng CL,Chen KY,Chiang YC

    更新日期:2021-01-11 00:00:00

  • Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome.

    abstract::Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects o...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Baliño P,Romero-Cano R,Muriach M

    更新日期:2021-01-15 00:00:00

  • Induction of Lipocalin2 in a Rat Model of Lung Irradiation.

    abstract::Previously, we showed that lipocalin2 (LCN2) serum levels increased after liver irradiation and during acute-phase conditions. Here, we evaluate LCN2 expression and serum levels after single-dose lung irradiation with 25 Gy, percutaneously administered to the lung of randomly-paired male Wistar rats. Due to the concav...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sultan S,Ahmad S,Rave-Fränk M,Malik IA,Hess CF,Christiansen H,Cameron S

    更新日期:2016-04-28 00:00:00

  • Growth Factors in the Carotid Body-An Update.

    abstract::The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Stocco E,Barbon S,Tortorella C,Macchi V,De Caro R,Porzionato A

    更新日期:2020-10-01 00:00:00

  • Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons.

    abstract::The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HyStem™-HP) with differ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Civita P,M Leite D,Pilkington GJ

    更新日期:2019-11-29 00:00:00

  • Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis.

    abstract::Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following tr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ahn TK,Kim KT,Joshi HP,Park KH,Kyung JW,Choi UY,Sohn S,Sheen SH,Shin DE,Lee SH,Han IB

    更新日期:2020-06-16 00:00:00

  • Activation energy of aggregation-disaggregation self-oscillation of polymer chain.

    abstract::In this paper, we investigated the activation energies of the aggregation−disaggregation self-oscillation induced by the Belousov-Zhabotinsky (BZ) reaction by utilizing the nonthermoresponsive polymer chain in a wide temperature range. This is because the conventional type self-oscillating polymer chain, with thermore...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hara Y,Jahan RA

    更新日期:2012-12-03 00:00:00

  • The effects of CoCl2 on HIF-1α protein under experimental conditions of autoprogressive hypoxia using mouse models.

    abstract::It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia. Balb/c mice were randomly divided into groups of chemical pretr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang YB,Wang X,Meister EA,Gong KR,Yan SC,Lu GW,Ji XM,Shao G

    更新日期:2014-06-18 00:00:00

  • Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression.

    abstract::Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. GBM often invades surrounding regions of the brain during its early stages, making successful treatment difficult. Osthole, an active constituent isolated from the dried C. monnieri fruit...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tsai CF,Yeh WL,Chen JH,Lin C,Huang SS,Lu DY

    更新日期:2014-03-04 00:00:00

  • Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone.

    abstract::Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance regulator (CFTR) is crucially involved in airway fluid secretion and dexamethasone (dexa) has previously been shown to elevate CFTR activity in airway epithelial cell...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bossmann M,Ackermann BW,Thome UH,Laube M

    更新日期:2017-08-19 00:00:00

  • Effect of Gelation Temperature on the Molecular Structure and Physicochemical Properties of the Curdlan Matrix: Spectroscopic and Microscopic Analyses.

    abstract::In order to determine the effect of different gelation temperatures (80 °C and 90 °C) on the structural arrangements in 1,3-β-d-glucan (curdlan) matrices, spectroscopic and microscopic approaches were chosen. Attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) and Raman spectroscopy are wel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gieroba B,Sroka-Bartnicka A,Kazimierczak P,Kalisz G,Pieta IS,Nowakowski R,Pisarek M,Przekora A

    更新日期:2020-08-26 00:00:00

  • PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas.

    abstract::Despite the low mortality rates, well-differentiated thyroid carcinomas (WDTC) frequently relapse. BRAF and TERT mutations have been extensively related to prognosis in thyroid cancer. In this study, the methylation levels of selected CpGs (5-cytosine-phosphate-guanine-3) comprising a classifier, previously reported b...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Camargo Barros-Filho M,Barreto Menezes de Lima L,Bisarro Dos Reis M,Bette Homem de Mello J,Moraes Beltrami C,Lopes Pinto CA,Kowalski LP,Rogatto SR

    更新日期:2019-03-16 00:00:00

  • Hypoxia-Induced miR-210 Is Necessary for Vascular Regeneration upon Acute Limb Ischemia.

    abstract::Critical limb ischemia is the most serious form of peripheral artery disease, characterized by severe functional consequences, difficult clinical management and reduced life expectancy. The goal of this study was to investigate the miR-210 role in the neo-angiogenic response after acute limb ischemia. Complementary ap...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zaccagnini G,Maimone B,Fuschi P,Longo M,Da Silva D,Carrara M,Voellenkle C,Perani L,Esposito A,Gaetano C,Martelli F

    更新日期:2019-12-24 00:00:00

  • Correction: Xingchen Zhou, et al. Whole Exome Sequencing in Psoriasis Patients Contributes to Studies of Acitretin Treatment Difference. Int. J. Mol. Sci. 2017, 18, 295.

    abstract::We would like to submit the following correction to the published paper [1], the reason for this action is that the data in Table 3 were reanalyzed by one more accurate statistic method: On page 12, the sentence of paragraph three "OR and 95% CI were calculated by limited backward-LR (likelihood ratio) logistic regres...

    journal_title:International journal of molecular sciences

    pub_type: 已发布勘误


    authors: Zhou X,He Y,Kuang Y,Li J,Zhang J,Chen M,Chen W,Su J,Zhao S,Liu P,Chen M,Shen M,Chen X,Zhu W,Chen X

    更新日期:2017-09-04 00:00:00

  • miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway.

    abstract::MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tang R,Ma F,Li W,Ouyang S,Liu Z,Wu J

    更新日期:2017-07-14 00:00:00

  • Evaluation of the antiradical properties of phenolic acids.

    abstract::Antioxidant capacity (AOC) against peroxyl radical and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical cation was measured for a series of p-hydroxybenzoic (HB) and p-hydroxycinnamic (HC) acids at different pH. Quantum-chemical computation was performed using Gaussian 3.0 softwa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Koroleva O,Torkova A,Nikolaev I,Khrameeva E,Fedorova T,Tsentalovich M,Amarowicz R

    更新日期:2014-09-16 00:00:00

  • Analysis of the Direct and Indirect Effects of Nanoparticle Exposure on Microglial and Neuronal Cells In Vitro.

    abstract::Environmental or biomedical exposure to nanoparticles (NPs) can results in translocation and accumulation of NPs in the brain, which can lead to health-related problems. NPs have been shown to induce toxicity to neuronal cells through several direct mechanisms, but only a few studies have also explored the indirect ef...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lojk J,Babič L,Sušjan P,Bregar VB,Pavlin M,Hafner-Bratkovič I,Veranič P

    更新日期:2020-09-24 00:00:00

  • 8q24.21 Locus: A Paradigm to Link Non-Coding RNAs, Genome Polymorphisms and Cancer.

    abstract::The majority of the human genome is comprised of non-protein-coding genes, but the relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class of non-coding RNAs is long non-coding RNAs or lncRNAs, many of which have been identified to play a range of roles in transcription and translati...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Wilson C,Kanhere A

    更新日期:2021-01-22 00:00:00

  • Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT2B Receptors.

    abstract::G protein-coupled receptors are linked to various intracellular transducers, each pathway associated with different physiological effects. Biased ligands, capable of activating one pathway over another, are gaining attention for their therapeutic potential, as they could selectively activate beneficial pathways whilst...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Denzinger K,Nguyen TN,Noonan T,Wolber G,Bermudez M

    更新日期:2020-12-20 00:00:00

  • Rev-erbα Inhibits Proliferation and Promotes Apoptosis of Preadipocytes through the Agonist GSK4112.

    abstract::Proliferation and apoptosis are important physiological processes of preadipocytes. Rev-erbα is a circadian clock gene, and its activity contributes to several physiological processes in various cells. Previous studies demonstrated that Rev-erbα promotes preadipocyte differentiation, but a role of Rev-erbα on preadipo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chu G,Zhou X,Hu Y,Shi S,Yang G

    更新日期:2019-09-12 00:00:00

  • Ethnobotanic, Ethnopharmacologic Aspects and New Phytochemical Insights into Moroccan Argan Fruits.

    abstract::This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Mor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Khallouki F,Eddouks M,Mourad A,Breuer A,Owen RW

    更新日期:2017-10-30 00:00:00

  • The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a secondary phase in which neuroinflammation plays a key role. NLRP3 inflammasome is a component of the innate immune response and different diseases, such as neurodege...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Irrera N,Russo M,Pallio G,Bitto A,Mannino F,Minutoli L,Altavilla D,Squadrito F

    更新日期:2020-08-27 00:00:00

  • Pro-Resolving Molecules-New Approaches to Treat Sepsis?

    abstract::Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Buechler C,Pohl R,Aslanidis C

    更新日期:2017-02-23 00:00:00

  • Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB.

    abstract::To further investigate the regulation role of two chemokine genes CCL3 and CCL4 in chondrocytes in response to resistin, human primary chondrocytes and T/C-28a2 cells were cultured. The function of resistin on the chemokine genes, and the expression of C/EBPβ, NF-κB isoforms were tested using qPCR. The methods used to...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang Z,Zhang Z,Kang Y,Hou C,Duan X,Sheng P,Sandell LJ,Liao W

    更新日期:2014-09-26 00:00:00

  • Rosiglitazone Enhances Browning Adipocytes in Association with MAPK and PI3-K Pathways During the Differentiation of Telomerase-Transformed Mesenchymal Stromal Cells into Adipocytes.

    abstract::Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment of obesity and related disorders warrants more investigation. Peroxisome proliferator activator receptor gamma (PPAR-γ) is the mast...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Fayyad AM,Khan AA,Abdallah SH,Alomran SS,Bajou K,Khattak MNK

    更新日期:2019-04-01 00:00:00

  • miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma.

    abstract::MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated in esophageal squamous cell carcinoma (ESCC), the roles and mechanisms of down-regulation of miR-145-5p in ESCC are still largely unknown. Using microRNA microarray and Gen...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mei LL,Wang WJ,Qiu YT,Xie XF,Bai J,Shi ZZ

    更新日期:2017-08-23 00:00:00

  • Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation.

    abstract::Acute rejection (AR) of a kidney graft in renal transplant recipients is associated with microvascular injury in graft dysfunction and, ultimately, graft failure. Circulating long noncoding RNAs (lncRNAs) may be suitable markers for vascular injury in the context of AR. Here, we first investigated the effect of AR aft...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Groeneweg KE,Duijs JMGJ,Florijn BW,van Kooten C,de Fijter JW,van Zonneveld AJ,Reinders MEJ,Bijkerk R

    更新日期:2020-08-05 00:00:00

  • The Interaction of the Senescent and Adjacent Breast Cancer Cells Promotes the Metastasis of Heterogeneous Breast Cancer Cells through Notch Signaling.

    abstract::Chemotherapy is one of the most common strategies for tumor treatment but often associated with post-therapy tumor recurrence. While chemotherapeutic drugs are known to induce tumor cell senescence, the roles and mechanisms of senescence in tumor recurrence remain unclear. In this study, we used doxorubicin to induce ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang N,Ji J,Zhou D,Liu X,Zhang X,Liu Y,Xiang W,Wang M,Zhang L,Wang G,Huang B,Lu J,Zhang Y

    更新日期:2021-01-15 00:00:00

  • Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.

    abstract:BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cheng IY,Liu CC,Lin JH,Hsu TW,Hsu JW,Li AF,Ho WC,Hung SC,Hsu HS

    更新日期:2019-12-28 00:00:00

  • Formation of α-Farnesene in Tea (Camellia sinensis) Leaves Induced by Herbivore-Derived Wounding and Its Effect on Neighboring Tea Plants.

    abstract::Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation and function in crops are limited. Tea (Camellia sinensis) is an important crop in China. α-Farnesene is a common HIPV produced in tea plants in response to diff...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang X,Zeng L,Liao Y,Li J,Tang J,Yang Z

    更新日期:2019-08-25 00:00:00