Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.

abstract：:D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding af...

journal_title：International journal of molecular sciences

authors： Park YK,Bold B,Lee WK,Jeon MH,An KH,Jeong SY,Shim YK

更新日期：2011-01-01 00:00:00

abstract：:Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide p...

journal_title：International journal of molecular sciences

authors： Xu X,Yue M,Jiang L,Deng X,Zhang Y,Zhang Y,Zhu D,Xiao W,Zhou Z,Yao W,Kong J,Yu X,Wei J

更新日期：2014-06-03 00:00:00

abstract：:In this study, the effect of the acetone extract of Arctotis arctotoides (L.f.) O. Hoffm. (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS was analyzed by means of scanning electron microscope (SEM). Remarkable morphological alterations in the fungal mycelia which were...

journal_title：International journal of molecular sciences

authors： Otang WM,Grierson DS,Ndip RN

更新日期：2011-01-01 00:00:00

abstract：:Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular mice...

journal_title：International journal of molecular sciences

authors： Ilhami FB,Peng KC,Chang YS,Alemayehu YA,Tsai HC,Lai JY,Chiao YH,Kao CY,Cheng CC

更新日期：2020-12-25 00:00:00

abstract：:Circadian clock not only functions as a cellular time-keeping mechanism, but also acts as a master regulator to coordinate the tradeoff between plant growth and defense in higher plants by timing a few kinds of phytohormone biosynthesis and signaling, including jasmonic acid (JA). Notably, circadian clock and JA pathw...

journal_title：International journal of molecular sciences

authors： Zhang Y,Bo C,Wang L

更新日期：2019-10-23 00:00:00

abstract：:To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...

journal_title：International journal of molecular sciences

authors： Vojtechova Z,Tachezy R

更新日期：2018-04-17 00:00:00

abstract：:The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approac...

journal_title：International journal of molecular sciences

authors： Peng XL,Jiang P

更新日期：2017-02-20 00:00:00

abstract：:Resveratrol exhibits not only anti-melanogenic property by inhibiting microphthalmia-associated transcription factor (MITF), but also anti-aging property by activating sirtuin-1 (SIRT1). In this study, the relationship between depigmenting effect of resveratrol and SIRT1/forkhead box O (FOXO) 3a activation and was inv...

journal_title：International journal of molecular sciences

authors： Kwon SH,Choi HR,Kang YA,Park KC

更新日期：2017-06-07 00:00:00

abstract：:Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichlori...

journal_title：International journal of molecular sciences

authors： Zhang Y,Wang J,Wang C,Li Z,Liu X,Zhang J,Lu J,Wang D

更新日期：2018-05-21 00:00:00

abstract：:Despite improvements in diagnosis and treatment, breast cancer is still the most common cancer type among non-smoking females. TGF-β can inhibit breast cancer development by inducing cell cycle arrest in both, cancer cells and, as part of a senescence program in normal human mammary epithelial cells (HMEC). Moreover, ...

journal_title：International journal of molecular sciences

authors： Melzer C,von der Ohe J,Hass R,Ungefroren H

更新日期：2017-07-20 00:00:00

abstract：PURPOSE:to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. METHODS AND MATERIALS:the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) ...

journal_title：International journal of molecular sciences

authors： Antoni D,Clavier JB,Pop M,Schumacher C,Lefebvre F,Noël G

更新日期：2014-05-02 00:00:00

abstract：:Juglone, a major naphthalenedione component of walnut trees, has long been used in traditional medicine as an antimicrobial and antitumor agent. Nonetheless, its impact on oocyte and preimplantation embryo development has not been entirely clarified. Using the bovine model, we sought to elucidate the impact of juglone...

journal_title：International journal of molecular sciences

authors： Mesalam AA,El-Sheikh M,Joo MD,Khalil AAK,Mesalam A,Ahn MJ,Kong IK

更新日期：2020-12-26 00:00:00

abstract：:Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. Since the completion of its genome and transcriptome sequencing, genes relating to C. semilaevis development have been extensively studied. R-spondin 3 (Rspo3) is a member of the R-spondin family. It plays an important ...

journal_title：International journal of molecular sciences

authors： Niu J,Guan J,Li R,Li X,Zhai J,Qi J,He Y

更新日期：2018-06-29 00:00:00

abstract：:The TiO2-montmorillonite (TiO2-MMT) complex was prepared by blending TiO2 sol and MMT with certain ratio, and its properties as an enzyme immobilization support were investigated. The pristine MMT and TiO2-MMT calcined at 800 °C (TiO2-MMT800) were used for comparison to better understand the immobilization mechanism. ...

journal_title：International journal of molecular sciences

authors： Wang Q,Peng L,Li G,Zhang P,Li D,Huang F,Wei Q

更新日期：2013-06-14 00:00:00

abstract：:The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the thre...

journal_title：International journal of molecular sciences

authors： Mace ML,Olgaard K,Lewin E

更新日期：2020-11-20 00:00:00

abstract：:A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4,...

journal_title：International journal of molecular sciences

authors： Bao B,Meng Z,Li N,Meng Z,Zhang L,Cao Y,Yao W,Shan M,Ding A

更新日期：2013-08-20 00:00:00

abstract：:The complexity of immune system is tempered by precise regulation to maintain stabilization when exposed to various conditions. A subtle change in gene expression may be magnified when drastic changes are brought about in cellular development and function. Posttranslational modifications (PTMs) timely alter the functi...

journal_title：International journal of molecular sciences

authors： Wang Z,Yin H,Lau CS,Lu Q

更新日期：2016-09-22 00:00:00

abstract：:The prostate gland contains a high level of intracellular zinc, which is dramatically diminished during prostate cancer (PCa) development. Owing to the unclear role of zinc in this process, therapeutic applications using zinc are limited. This study aimed to clarify the role of zinc and its underlying mechanism in the...

journal_title：International journal of molecular sciences

authors： To PK,Do MH,Cho YS,Kwon SY,Kim MS,Jung C

更新日期：2018-10-08 00:00:00

abstract：:Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading and recycling cellular components under stress conditions. The degradation pathway that is mediated by autophagy receptors is called selective autophagy,...

journal_title：International journal of molecular sciences

authors： Fan S,Wu K,Zhao M,Zhu E,Ma S,Chen Y,Ding H,Yi L,Zhao M,Chen J

更新日期：2020-03-16 00:00:00

abstract：:We show that, under in vitro conditions, the vulnerability of astroglia to hypoxia is reflected by alterations in endothelin (ET)-1 release and capacity of erythropoietin (EPO) to regulate ET-1 levels. Exposure of cells to 24 h hypoxia did not induce changes in ET-1 release, while 48-72 h hypoxia resulted in increase ...

journal_title：International journal of molecular sciences

authors： Schäfer R,Mueller L,Buecheler R,Proksch B,Schwab M,Gleiter CH,Danielyan L

更新日期：2014-02-19 00:00:00

abstract：:Two mesenchymal zinc transporters, ZIP7 and ZIP13, play critical roles in dermal development. ZIP7 and ZIP13 are the closest among the conserved mammalian zinc transporters. However, whether their functions are complementary remains a controversial issue. In the present study, we found that the expression of ZIP13, bu...

journal_title：International journal of molecular sciences

authors： Lee MG,Bin BH

更新日期：2019-08-13 00:00:00

abstract：:Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Phy...

journal_title：International journal of molecular sciences

authors： Rahali K,Ben Messaoud G,Kahn CJF,Sanchez-Gonzalez L,Kaci M,Cleymand F,Fleutot S,Linder M,Desobry S,Arab-Tehrany E

更新日期：2017-12-10 00:00:00

abstract：:The Duchenne muscular dystrophy (DMD) gene has a complex expression pattern regulated by multiple tissue-specific promoters and by alternative splicing (AS) of the resulting transcripts. Here, we used an RNAi-based approach coupled with DMD-targeted RNA-seq to identify RNA-binding proteins (RBPs) that regulate splicin...

journal_title：International journal of molecular sciences

authors： Miro J,Bougé AL,Murauer E,Beyne E,Da Cunha D,Claustres M,Koenig M,Tuffery-Giraud S

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:This study aims to investigate: (a) the putative association between the presence of microcalcifications and the expression of both epithelial-to-mesenchymal transition and bone biomarkers, (b) the role of microcalcifications in the breast osteoblast-like cells (BOLCs) formation, and (c) the association betw...

journal_title：International journal of molecular sciences

authors： Scimeca M,Bonfiglio R,Menichini E,Albonici L,Urbano N,De Caro MT,Mauriello A,Schillaci O,Gambacurta A,Bonanno E

更新日期：2019-11-11 00:00:00

abstract：:The aging kidney is a marked by a number of structural and functional changes, including an increased susceptibility to acute kidney injury (AKI). Previous studies from our laboratory have shown that aging male Fischer 344 rats (24 month) are more susceptible to apoptosis-mediated injury than young counterparts. In th...

journal_title：International journal of molecular sciences

authors： Grunz-Borgmann EA,Nichols LA,Wang X,Parrish AR

更新日期：2017-02-10 00:00:00

abstract：:Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following tr...

journal_title：International journal of molecular sciences

authors： Ahn TK,Kim KT,Joshi HP,Park KH,Kyung JW,Choi UY,Sohn S,Sheen SH,Shin DE,Lee SH,Han IB

更新日期：2020-06-16 00:00:00

abstract：:A fundamental step for cell growth and differentiation is the cell adhesion. The purpose of this study was to determine the adhesion of different cell lineages, adipose derived stromal cells, osteoblasts, and gingival fibroblast to titanium and zirconia dental implants with different surface treatments. Primary cells ...

journal_title：International journal of molecular sciences

authors： Jung S,Bohner L,Hanisch M,Kleinheinz J,Sielker S

更新日期：2020-06-09 00:00:00

abstract：:Acute lung injury (ALI) is a life-threatening syndrome characterized by acute and severe hypoxemic respiratory failure. Visfatin, which is known as an obesity-related cytokine with pro-inflammatory activities, plays a role in regulation of inflammatory cytokines. The mechanisms of ALI remain unclear in critically ill ...

journal_title：International journal of molecular sciences

authors： Lee YC,Lin CY,Chen YH,Chiu WC,Wang YY,Hsu C,Hu SC,Su YH,Yuan SF

更新日期：2019-04-04 00:00:00

abstract：:Alternatively translated from the ENO gene and expressed in an array of vertebrate and plant tissues, c-Myc binding protein 1 (MBP-1) participates in the regulation of growth in organisms, their development and their environmental responses. As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 ...

journal_title：International journal of molecular sciences

authors： Liu Z,Zhang A,Zheng L,Johnathan AF,Zhang J,Zhang G

更新日期：2018-12-04 00:00:00

abstract：:Amyloid precursor protein (APP) is processed along both the nonamyloidogenic pathway preventing amyloid beta peptide (Aβ) production and the amyloidogenic pathway, generating Aβ, whose accumulation characterizes Alzheimer's disease. Items of evidence report that the intracellular trafficking plays a key role in the ge...

journal_title：International journal of molecular sciences

authors： Bhattacharya A,Limone A,Napolitano F,Cerchia C,Parisi S,Minopoli G,Montuori N,Lavecchia A,Sarnataro D

更新日期：2020-03-04 00:00:00