Abstract:
:n/a.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kobori M,Takahashi Y,Sakurai M,Ni Y,Chen G,Nagashimada M,Kaneko S,Ota Tdoi
10.3390/ijms18050994subject
Has Abstractpub_date
2017-05-05 00:00:00issue
5issn
1422-0067pii
ijms18050994journal_volume
18pub_type
评论,杂志文章abstract::Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major cause of pain and disability in older adult individuals. Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) (such as diclofenac, DIC) or intra-articular injected gluco-corticosteroids (such as dexamethasone, DEX) w...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020665
更新日期:2021-01-11 00:00:00
abstract::Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020807
更新日期:2021-01-15 00:00:00
abstract::Previously, we showed that lipocalin2 (LCN2) serum levels increased after liver irradiation and during acute-phase conditions. Here, we evaluate LCN2 expression and serum levels after single-dose lung irradiation with 25 Gy, percutaneously administered to the lung of randomly-paired male Wistar rats. Due to the concav...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17050637
更新日期:2016-04-28 00:00:00
abstract::The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197267
更新日期:2020-10-01 00:00:00
abstract::The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HyStem™-HP) with differ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20236017
更新日期:2019-11-29 00:00:00
abstract::Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following tr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124274
更新日期:2020-06-16 00:00:00
abstract::In this paper, we investigated the activation energies of the aggregation−disaggregation self-oscillation induced by the Belousov-Zhabotinsky (BZ) reaction by utilizing the nonthermoresponsive polymer chain in a wide temperature range. This is because the conventional type self-oscillating polymer chain, with thermore...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131216281
更新日期:2012-12-03 00:00:00
abstract::It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia. Balb/c mice were randomly divided into groups of chemical pretr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150610999
更新日期:2014-06-18 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. GBM often invades surrounding regions of the brain during its early stages, making successful treatment difficult. Osthole, an active constituent isolated from the dried C. monnieri fruit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15033889
更新日期:2014-03-04 00:00:00
abstract::Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance regulator (CFTR) is crucially involved in airway fluid secretion and dexamethasone (dexa) has previously been shown to elevate CFTR activity in airway epithelial cell...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081807
更新日期:2017-08-19 00:00:00
abstract::In order to determine the effect of different gelation temperatures (80 °C and 90 °C) on the structural arrangements in 1,3-β-d-glucan (curdlan) matrices, spectroscopic and microscopic approaches were chosen. Attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) and Raman spectroscopy are wel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176154
更新日期:2020-08-26 00:00:00
abstract::Despite the low mortality rates, well-differentiated thyroid carcinomas (WDTC) frequently relapse. BRAF and TERT mutations have been extensively related to prognosis in thyroid cancer. In this study, the methylation levels of selected CpGs (5-cytosine-phosphate-guanine-3) comprising a classifier, previously reported b...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20061334
更新日期:2019-03-16 00:00:00
abstract::Critical limb ischemia is the most serious form of peripheral artery disease, characterized by severe functional consequences, difficult clinical management and reduced life expectancy. The goal of this study was to investigate the miR-210 role in the neo-angiogenic response after acute limb ischemia. Complementary ap...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010129
更新日期:2019-12-24 00:00:00
abstract::We would like to submit the following correction to the published paper [1], the reason for this action is that the data in Table 3 were reanalyzed by one more accurate statistic method: On page 12, the sentence of paragraph three "OR and 95% CI were calculated by limited backward-LR (likelihood ratio) logistic regres...
journal_title:International journal of molecular sciences
pub_type: 已发布勘误
doi:10.3390/ijms18091899
更新日期:2017-09-04 00:00:00
abstract::MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071510
更新日期:2017-07-14 00:00:00
abstract::Antioxidant capacity (AOC) against peroxyl radical and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical cation was measured for a series of p-hydroxybenzoic (HB) and p-hydroxycinnamic (HC) acids at different pH. Quantum-chemical computation was performed using Gaussian 3.0 softwa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150916351
更新日期:2014-09-16 00:00:00
abstract::Environmental or biomedical exposure to nanoparticles (NPs) can results in translocation and accumulation of NPs in the brain, which can lead to health-related problems. NPs have been shown to induce toxicity to neuronal cells through several direct mechanisms, but only a few studies have also explored the indirect ef...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197030
更新日期:2020-09-24 00:00:00
abstract::The majority of the human genome is comprised of non-protein-coding genes, but the relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class of non-coding RNAs is long non-coding RNAs or lncRNAs, many of which have been identified to play a range of roles in transcription and translati...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22031094
更新日期:2021-01-22 00:00:00
abstract::G protein-coupled receptors are linked to various intracellular transducers, each pathway associated with different physiological effects. Biased ligands, capable of activating one pathway over another, are gaining attention for their therapeutic potential, as they could selectively activate beneficial pathways whilst...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249728
更新日期:2020-12-20 00:00:00
abstract::Proliferation and apoptosis are important physiological processes of preadipocytes. Rev-erbα is a circadian clock gene, and its activity contributes to several physiological processes in various cells. Previous studies demonstrated that Rev-erbα promotes preadipocyte differentiation, but a role of Rev-erbα on preadipo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184524
更新日期:2019-09-12 00:00:00
abstract::This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Mor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18112277
更新日期:2017-10-30 00:00:00
abstract::Traumatic brain injury (TBI) represents an important problem of global health. The damage related to TBI is first due to the direct injury and then to a secondary phase in which neuroinflammation plays a key role. NLRP3 inflammasome is a component of the innate immune response and different diseases, such as neurodege...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21176204
更新日期:2020-08-27 00:00:00
abstract::Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18030476
更新日期:2017-02-23 00:00:00
abstract::To further investigate the regulation role of two chemokine genes CCL3 and CCL4 in chondrocytes in response to resistin, human primary chondrocytes and T/C-28a2 cells were cultured. The function of resistin on the chemokine genes, and the expression of C/EBPβ, NF-κB isoforms were tested using qPCR. The methods used to...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151017242
更新日期:2014-09-26 00:00:00
abstract::Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment of obesity and related disorders warrants more investigation. Peroxisome proliferator activator receptor gamma (PPAR-γ) is the mast...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071618
更新日期:2019-04-01 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated in esophageal squamous cell carcinoma (ESCC), the roles and mechanisms of down-regulation of miR-145-5p in ESCC are still largely unknown. Using microRNA microarray and Gen...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091833
更新日期:2017-08-23 00:00:00
abstract::Acute rejection (AR) of a kidney graft in renal transplant recipients is associated with microvascular injury in graft dysfunction and, ultimately, graft failure. Circulating long noncoding RNAs (lncRNAs) may be suitable markers for vascular injury in the context of AR. Here, we first investigated the effect of AR aft...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21165616
更新日期:2020-08-05 00:00:00
abstract::Chemotherapy is one of the most common strategies for tumor treatment but often associated with post-therapy tumor recurrence. While chemotherapeutic drugs are known to induce tumor cell senescence, the roles and mechanisms of senescence in tumor recurrence remain unclear. In this study, we used doxorubicin to induce ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020849
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010227
更新日期:2019-12-28 00:00:00
abstract::Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation and function in crops are limited. Tea (Camellia sinensis) is an important crop in China. α-Farnesene is a common HIPV produced in tea plants in response to diff...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174151
更新日期:2019-08-25 00:00:00