Post-receptor modulation of the effects of cyclic AMP in isolated cardiac myocytes.


:The actions of cyclic AMP are subject to several levels of post-receptor modulation in cardiac tissue. Isoproterenol and prostaglandin E1 both stimulate cAMP accumulation, but only isoproterenol causes activation of particulate cAMP-dependent protein kinase, leading to activation of phosphorylase kinase and glycogen phosphorylase, and inhibition of glycogen synthase. Through the use of isolated, adult ventricular myocytes, we have determined that the hormone-specific activation of glycogen phosphorylase is due to subcellular compartmentation of cAMP. There is some evidence that cyclic nucleotide phosphodiesterases, whose activity is stimulated by alpha 1-adrenergic agonists in isolated myocytes, may have a role in compartmentation. Phosphoinositide hydrolysis is stimulated by alpha 1 and muscarinic agonists, presumably leading to activation of protein kinase C, which in turn has multiple effects on hormone-sensitive adenylate cyclase.


Mol Cell Biochem


Bode DC,Brunton LL




Has Abstract


1988-07-01 00:00:00












  • Evolution of the family of intracellular lipid binding proteins in vertebrates.

    abstract::Members of the family of intracellular lipid binding proteins (iLBPs) have been implicated in cytoplasmic transport of lipophilic ligands, such as long-chain fatty acids and retinoids. iLBPs are low molecular mass proteins (14-16 kDa) sharing a common structural fold. The iLBP family likely arose through duplication a...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Schaap FG,van der Vusse GJ,Glatz JF

    更新日期:2002-10-01 00:00:00

  • Perifosine as potential anti-cancer agent inhibits proliferation, migration, and tube formation of human umbilical vein endothelial cells.

    abstract::Targeting angiogenesis is considered an effective strategy for treating the expansion and metastasis of tumors. The aim of this study is to assess the effects of perifosine, an inhibitor of Akt, on cell proliferation, apoptosis, angiogenesis, and VEGF-induced cell migration in cultured human umbilical vein endothelial...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Wang FZ,Fei HR,Li XQ,Shi R,Wang de C

    更新日期:2012-09-01 00:00:00

  • Rat red blood cell hexokinase purification, properties and age-dependence.

    abstract::Rat erythrocytes, in contrast to red blood cells from other mammals, have been shown to contain only one hexokinase isozymic form identified as type I by chromatographic and kinetic properties. Rat reticulocytes contain 3.6-times the hexokinase activity found in mature erythrocytes but exactly the same isozyme. By a c...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Serafini G,Magnani M,Stocchi V,Dachà M,Forniani G

    更新日期:1986-02-01 00:00:00

  • Biomarker study of the biological parameter and neurotransmitter levels in autistics.

    abstract::Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two gro...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Meyyazhagan A,Balasubramanian B,Easwaran M,Alagamuthu KK,Shanmugam S,Kuchi Bhotla H,Pappusamy M,Arumugam VA,Thangaraj A,Kaul T,Keshavarao S,Cacabelos R

    更新日期:2020-11-01 00:00:00

  • Thr11 phosphorylated H3 is associated with centromere DNA during mitosis in MCF-7 cells.

    abstract::In this study, indirect immunofluorescence labeling was used to examine the cellular dynamic distribution of Thr11 phosphorylated H3 at mitosis in MCF-7 cells. The Thr11 phosphorylation was observed beginning at prophase at centromeres. Upon progression of mitosis, fluorescence signal was enhanced in the central regio...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Zhou H,Li D,Song L,Liu R,Chen J,Huang X

    更新日期:2008-04-01 00:00:00

  • Subchronic exposure of cardiomyocytes to low concentrations of tumor necrosis factor alpha attenuates the positive inotropic response not only to catecholamines but also to cardiac glycosides and high calcium concentrations.

    abstract::The main purpose of this study was to determine the subchronic effects of low concentrations of tumor necrosis factor alpha (TNF alpha) on the inotropic response and on the cellular level of high energy phosphates of cardiomyocytes. Therefore, the inotropic response of cultured neonatal rat heart cells to 10(-5) M iso...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Boekstegers P,Kainz I,Giehrl W,Peter W,Werdan K

    更新日期:1996-03-23 00:00:00

  • MicroRNAs: novel biomarkers for gastrointestinal carcinomas.

    abstract::MicroRNAs (miRNAs) are a class of non-coding small RNAs. They play an important role as a post-transcriptional regulator in the protein synthesis and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. miRNAs give us a new perspective to understand carcinogenesis. Since the high-...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Xie L,Qian X,Liu B

    更新日期:2010-08-01 00:00:00

  • Cloning and characterizations of the Serratia marcescens metK and pfs genes involved in AI-2-dependent quorum-sensing system.

    abstract::Serratia marcescens utilizes two types of quorum-sensing signal molecules: N-acyl homoserine lactones and furanosyl borate diester (AI-2). S-adenosylmethionine synthetase (METK), S-adenosylhomocysteine nucleosidase (PFS), and S-ribosylhomocysteinase (LUXS) are three key enzymes in the biosynthetic pathway leading to A...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Zhu H,Shen YL,Wei DZ,Zhu JW

    更新日期:2008-08-01 00:00:00

  • Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.

    abstract::Inflammatory bowel disease (IBD) is often associated with a decrease in energy-dependent nutrient uptake across the jejunum that serves as the main site for absorption in the small intestine. This association has prompted us to investigate the bioenergetics underlying the alterations in jejunal absorption in 2,4,6-tri...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Al Ojaimi Y,Khachab M,Bazzi S,Bahr GM,Echtay KS

    更新日期:2020-07-01 00:00:00

  • The role of chloroplast and cytoplasm in the NADP-glutamate dehydrogenase and glutamine synthetase synthesis in Ankistrodesmus cells.

    abstract::The effects of transcription and translation inhibitors on NADP-glutamate dehydrogenase and glutamine synthetase synthesis in nitrogen-starving Ankistrodesmus braunii cells have been studied. Considering the results obtained one can suggest that both enzymes are coded in a chloroplast genome and that during nitrogen s...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Shatilov VR,Sof'in AV,Zabrodina TM,Kretovich WL

    更新日期:1982-09-03 00:00:00

  • Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus.

    abstract::The incidence of anxiety-related diseases is increasing these days, hence there is a need to understand the mechanisms that underlie its nature and consequences. It is known that limbic structures, mainly the prefrontal cortex and amygdala, are involved in the processing of anxiety, and that projections from prefronta...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Mejia-Carmona GE,Gosselink KL,Pérez-Ishiwara G,Martínez-Martínez A

    更新日期:2015-08-01 00:00:00

  • Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats.

    abstract::The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to compare the effects of celecoxib and ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDs), on several metabolic changes observed in Walker-256 tumor-bearing ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: de Souza CO,Kurauti MA,de Fatima Silva F,de Morais H,Borba-Murad GR,de Andrade FG,de Souza HM

    更新日期:2015-01-01 00:00:00

  • Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.

    abstract::We have identified by immunoblotting and ADP-ribosylation by cholera toxin and pertussis toxin the presence of Mr 43 and 46 KDa Gs alpha, and 39 and 41 KDa Gi alpha subunits in rat parotid gland plasma membranes but not in granule membranes. A Mr 28 KDa polypeptide that served as substrate for ADP-ribosylation by both...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Ali N,Agrawal DK,Cheung P

    更新日期:1992-10-07 00:00:00

  • Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide.

    abstract::Interleukin-18 (IL-18) elicited a robust hypertrophy response in H9c2 cardiomyocytes as judged by their accelerated rates of protein synthesis and increased cell size. Evidently, IL-18 treatment also induced a cardiac hypertrophy-specific program of gene expression in H9c2 cardiomyocytes since they elicited enhanced e...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Majumdar G,Johnson IM,Kale S,Raghow R

    更新日期:2008-05-01 00:00:00

  • Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.

    abstract::Cysteine-rich secretory protein 3 (CRISP-3) is upregulated in prostate cancer as compared to the normal prostate tissue. Higher expression of CRISP-3 has been linked to poor prognosis and hence it has been thought to act as a prognostic marker for prostate cancer. It is proposed to have a role in innate immunity but i...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Pathak BR,Breed AA,Apte S,Acharya K,Mahale SD

    更新日期:2016-01-01 00:00:00

  • Effect of oxidation of alphaA- and alphaB-crystallins on their structure, oligomerization and chaperone function.

    abstract::The purpose of this study was to investigate the effect of metal-catalyzed oxidation by H(2)O(2) on the structure, oligomerization, and chaperone function of alphaA- and alphaB-crystallins. Recombinant alphaA-and alphaB-crystallins were prepared by expressing them in E. coli and purifying by size-exclusion chromatogra...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Rajan S,Horn C,Abraham EC

    更新日期:2006-08-01 00:00:00

  • Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidation induced by photosensitization.

    abstract::Using rat liver mitochondria, as model systems, we have examined the ability of the natural compound and the food-flavoring agent, vanillin to protect membranes against oxidative damage induced by photosensitization at concentrations normally used in food preparations. Vanillin, at a concentration of 2.5 mmol/L, has a...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Kamat JP,Ghosh A,Devasagayam TP

    更新日期:2000-06-01 00:00:00

  • Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction.

    abstract::Cancer stem cells (CSCs) are believed to be responsible for tumor metastasis, recurrence, and high mortality of cancer patients due to their high tumorigenicity resistance to chemo-radiotherapy. Morusin possesses anti-cancer activity through attenuation of NF-κB activity, which is up-regulated in cancer stem cells. Th...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Wang L,Guo H,Yang L,Dong L,Lin C,Zhang J,Lin P,Wang X

    更新日期:2013-07-01 00:00:00

  • Pattern expression of glycan residues in AZT-treated K562 cells analyzed by lectin cytochemistry.

    abstract::The present paper shows that human chronic myeloid (K562) cells exposed 3 h to 20 microM 3'-azido-3'-deoxythymidine (AZT) exhibit marked variations of the oligosaccharide moiety of glycoconjugates. These changes were analyzed by confocal fluorescence microscopy, upon incubation of control and AZT-treated cells with bi...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Lizzi AR,D'Alessandro AM,Bozzi A,Cinque B,Oratore A,D'Andrea G

    更新日期:2007-06-01 00:00:00

  • Involvement of GPR12 in the regulation of cell proliferation and survival.

    abstract::GPR12, a member of the orphan G-protein-coupled receptor family, constitutively activates the Gs protein and increases intracellular cyclic AMP concentrations. GPR12 can be activated by its known ligand-sphingosylphosphorylcholine, which regulates cellular physiological activities, including proliferation, neurite ext...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Lu X,Zhang N,Meng B,Dong S,Hu Y

    更新日期:2012-07-01 00:00:00

  • Rv0646c, an esterase from M. tuberculosis, up-regulates the host immune response in THP-1 macrophages cells.

    abstract::The genome sequence of Mycobacterium tuberculosis revealed the presence of several hydrolases involved in lipid metabolism including the members of Lip gene family. Rv0646c (LipG) is one of them. It is annotated as putative esterase/lipase because of the presence of consensus sequence 'GXSXG.' The gene was cloned, exp...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Rastogi R,Kumar A,Kaur J,Saini V,Kaur J,Bhatnagar A

    更新日期:2018-10-01 00:00:00

  • The functional role of cysteine residues for c-Abl kinase activity.

    abstract::S-glutathionylation, the formation of mixed disulfides of glutathione with cysteine residues of proteins, is a broadly observed physiological modification that occurs in response to oxidative stress. Since cysteine residues are particularly susceptible to oxidative modification by reactive oxygen species, S-glutathion...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Leonberg AK,Chai YC

    更新日期:2007-10-01 00:00:00

  • The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure.

    abstract::Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) induced by hypoxia regulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1α in hypoxia-promoted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Rao J,Li J,Liu Y,Lu P,Sun X,Sugumaran PK,Zhu D

    更新日期:2012-08-01 00:00:00

  • 6,4'-dihydroxy-7-methoxyflavanone protects against H2O2-induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.

    abstract::6, 4'-Dihydroxy-7-methoxyflavanone (DMF) has been shown to possess anti-inflammatory, anti-oxidative, and neuroprotective activities. However, its effect on oxidative stress-induced aging remains undemonstrated. This study aimed at investigating the anti-senescence effect of DMF on hydrogen peroxide (H2O2)-induced pre...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Li BS,Zhu RZ,Choi BM

    更新日期:2020-10-27 00:00:00

  • Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase.

    abstract::Limited proteolysis of rabbit muscle phosphorylase kinase catalyzed by chymotrypsin generates a 33 kD product whose kinase activity is independent of both calcium and pH over the range of 6.8 to 8.3 (Malencik, D.A. & Fischer, E.H. Calcium and Cell Function III: 161-188, 1982). This active preparation consists of three...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Malencik DA,Zhao Z,Anderson SR

    更新日期:1993-11-01 00:00:00

  • Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study.

    abstract::In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were s...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Kovacs V,Gasz B,Balatonyi B,Jaromi L,Kisfali P,Borsiczky B,Jancso G,Marczin N,Szabados S,Melegh B,Nasri A,Roth E

    更新日期:2014-04-01 00:00:00

  • Effects of endotoxic shock in several functions of murine peritoneal macrophages.

    abstract::Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of mac...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Víctor VM,Miñano M,Guayerbas N,Del Río M,Medina S,De la Fuente M

    更新日期:1998-12-01 00:00:00

  • High expression of NEK2 promotes lung cancer progression and drug resistance and is regulated by mutant EGFR.

    abstract::Activating mutations within the tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene are observed in 10 ~ 30% of the patients diagnosed with non-small cell lung cancer (NSCLC), and are causally related to NSCLC initiation and progression. Treatments with tyrosine kinase inhibitors (TKIs) targeti...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Chen C,Peng S,Li P,Ma L,Gan X

    更新日期:2020-12-01 00:00:00

  • TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.

    abstract::Inactivation of the Staphylococcus aureus tricarboxylic acid (TCA) cycle delays the resolution of cutaneous ulcers in a mouse soft tissue infection model. In this study, it was observed that cutaneous lesions in mice infected with wild-type or isogenic aconitase mutant S. aureus strains contained comparable inflammato...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章


    authors: Massilamany C,Gangaplara A,Gardner DJ,Musser JM,Steffen D,Somerville GA,Reddy J

    更新日期:2011-09-01 00:00:00

  • Membrane transport and disease.

    abstract::Four situations in which membrane transport is altered by disease are discussed: (a) non-specific leaks induced by poreforming agents; (b) glucose transport and cellular stress; (c) Ca2+-ATPase and hypertension; (d) Na+ channels and HSV infection. ...

    journal_title:Molecular and cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Pasternak CA

    更新日期:1989-11-23 00:00:00