当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies.

In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies.

Abstract：

:Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was conducted in Manhiça, Mozambique, to assess the in-vivo efficacy of chloroquine to clear plasmodium falciparum (Pf) asymptomatic infections. Primary study endpoint was the rate of adequate and parasitological response (ACPR) to therapy on day 28 (PCR-corrected). Day 0 isolates were analyzed to assess the presence of the PfCRT-76T CQ resistance marker. A total of 52 and 27 male adults were included in the CQ and Placebo group respectively. PCR-corrected ACPR was significantly higher in the CQ arm 89.4% (95%CI 80-98%) compared to the placebo (p < 0.001). CQ cleared 49/50 infections within the first 72 h while placebo cleared 12/26 (LRT p < 0.001). The PfCRT-76T mutation was present only in one out of 108 (0.9%) samples at baseline, well below the 84% prevalence found in 1999 in the same area. This study presents preliminary evidence of a return of chloroquine sensitivity in Mozambican Pf isolates, and calls for its further evaluation in community-based malaria elimination efforts, in combination with other effective anti-malarials. TRIAL REGISTRATION:www.clinicalTrials.gov NCT02698748.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Galatas B,Nhamussua L,Candrinho B,Mabote L,Cisteró P,Gupta H,Rabinovich R,Menéndez C,Macete E,Saute F,Mayor A,Alonso P,Bassat Q,Aide P

doi

10.1038/s41598-017-01365-4

subject

Has Abstract

pub_date

2017-05-02 00:00:00

pages

1356

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01365-4

journal_volume

7

pub_type

杂志文章,随机对照试验

相关文献

Scientific Reports文献大全
  • Clinicopathologic significance of MYD88 L265P mutation in diffuse large B-cell lymphoma: a meta-analysis.

    abstract：:The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 publis...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-01998-5

    authors： Lee JH,Jeong H,Choi JW,Oh H,Kim YS

    更新日期：2017-05-11 00:00:00

  • TRAF3 negatively regulates platelet activation and thrombosis.

    abstract：:CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-depende...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17189-1

    authors： Zhang R,Zhang G,Xiang B,Chen X,Tang L,Shi S,Liu Y,Ai X,Xie P,Li Z

    更新日期：2017-12-07 00:00:00

  • Characterization of Chinese liquor aroma components during aging process and liquor age discrimination using gas chromatography combined with multivariable statistics.

    abstract：:Chinese liquor aroma components were characterized during the aging process using gas chromatography (GC). Principal component and cluster analysis (PCA, CA) were used to discriminate the Chinese liquor age which has a great economic value. Of a total of 21 major aroma components identified and quantified, 13 componen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39671

    authors： Xu ML,Yu Y,Ramaswamy HS,Zhu SM

    更新日期：2017-01-06 00:00:00

  • Development and external validation of a prostate health index-based nomogram for predicting prostate cancer.

    abstract：:To develop and externally validate a prostate health index (PHI)-based nomogram for predicting the presence of prostate cancer (PCa) at biopsy in Chinese men with prostate-specific antigen 4-10 ng/mL and normal digital rectal examination (DRE). 347 men were recruited from two hospitals between 2012 and 2014 to develop...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15341

    authors： Zhu Y,Han CT,Zhang GM,Liu F,Ding Q,Xu JF,Vidal AC,Freedland SJ,Ng CF,Ye DW

    更新日期：2015-10-16 00:00:00

  • A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples.

    abstract：:Extravillous trophoblasts (EVTs) have the potential to provide the entire fetal genome for prenatal testing. Previous studies have demonstrated the presence of EVTs in the cervical canal and the ability to retrieve a small quantity of these cells by cervical sampling. However, these small quantities of trophoblasts ar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48346-3

    authors： Bailey-Hytholt CM,Sayeed S,Kraus M,Joseph R,Shukla A,Tripathi A

    更新日期：2019-08-20 00:00:00

  • Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.

    abstract：:The archetypal TRPM2-like channel of the sea anemone Nematostella vectensis is gated by ADPR like its human orthologue but additionally exhibits properties of other vertebrate TRPM channels. Thus it can help towards an understanding of gating and regulation of the whole subfamily. To elucidate further the role of Ca2+...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07652-4

    authors： Kühn FJP,Mathis W,Cornelia K,Hoffmann DC,Lückhoff A

    更新日期：2017-08-03 00:00:00

  • Molecular dissection of transcriptional reprogramming of steviol glycosides synthesis in leaf tissue during developmental phase transitions in Stevia rebaudiana Bert.

    abstract：:Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12025-y

    authors： Singh G,Singh G,Singh P,Parmar R,Paul N,Vashist R,Swarnkar MK,Kumar A,Singh S,Singh AK,Kumar S,Sharma RK

    更新日期：2017-09-19 00:00:00

  • Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.

    abstract：:Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08900-3

    authors： Hegarty SV,Wyatt SL,Howard L,Stappers E,Huylebroeck D,Sullivan AM,O'Keeffe GW

    更新日期：2017-08-17 00:00:00

  • Intraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases.

    abstract：:Circulating tumor cells (CTC) have been studied extensively in various tumor types and are a well-established prognosticator in colorectal cancer (CRC). This is the first study to isolate CTC directly from the tumor outflow in secondary lung tumors. For this purpose in 24 patients with CRC who underwent pulmonary meta...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26410-8

    authors： Le UT,Bronsert P,Picardo F,Riethdorf S,Haager B,Rylski B,Czerny M,Beyersdorf F,Wiesemann S,Pantel K,Passlick B,Kaifi JT,Schmid S

    更新日期：2018-06-08 00:00:00

  • Appropriate usage of food thickening agents to prevent non-disintegration of magnesium oxide tablets.

    abstract：:Food thickening agents are used to aid the administration of medicine to elderly patients with dysphagia. Magnesium oxide tablets are sometimes administered with food thickening agents. Non-disintegration and disintegration delay of these tablets in the body are problems associated with food thickening agent use. Howe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73135-8

    authors： Matsuo T,Sato A,Kudo K,Sadzuka Y,Tomita T

    更新日期：2020-09-30 00:00:00

  • Human platelet antigen 1-6, 9 and 15 in the Iranian population: An anthropological genetic analysis.

    abstract：:Human platelet antigens (HPAs) are membranous glycoproteins considered as alloantigens due to their polymorphisms. HPA-incompatibility in multiple pregnancies or blood transfusion can induce the development of alloantibodies leading to thrombocytopenia. The frequency of HPAs varies among populations, so that deep know...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64469-4

    authors： Kazemi MH,Malakootikhah F,Momeni-Varposhti Z,Falak R,Delbandi AA,Tajik N

    更新日期：2020-05-04 00:00:00

  • Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules.

    abstract：:The mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade is a vital component of plant cellular signalling. Despite this, MAPK signalling cascade is less characterized in crop legumes. To fill this void, we present here a comprehensive phylogeny of MAPK kinases (MKKs) and MAPKs identified from 16 l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04913-0

    authors： Purayannur S,Kumar K,Kaladhar VC,Verma PK

    更新日期：2017-07-10 00:00:00

  • Metro system in Guangzhou as a hazardous reservoir of methicillin-resistant Staphylococci: findings from a point-prevalence molecular epidemiologic study.

    abstract：:Staphylococci are common causes of healthcare-associated and community-associated infections. However, limited data are available on the prevalence, phenotypes and molecular characteristics of Staphylococci in metro system around the world. 320 surface samples were collected from the Guangzhou metro system to isolate ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16087

    authors： Peng Y,Ou Q,Lin D,Xu P,Li Y,Ye X,Zhou J,Yao Z

    更新日期：2015-10-29 00:00:00

  • Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men.

    abstract：:Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...

    journal_title：Scientific reports

    pub_type： 杂志文章,评审

    doi：10.1038/srep05801

    authors： Li J,Shi Q,Pu C,Tang Y,Bai Y,Yuan H,Li X,Dong Q,Wei Q,Yuan J,Han P

    更新日期：2014-07-23 00:00:00

  • Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice.

    abstract：:Current anti-influenza therapy depends on administering drugs soon after infection, which is often impractical. We assessed whether combinations of oseltamivir (a neuraminidase inhibitor) and T-705 (a nonspecific inhibitor of viral polymerases) could extend the window for treating lethal infection with highly pathogen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26742

    authors： Marathe BM,Wong SS,Vogel P,Garcia-Alcalde F,Webster RG,Webby RJ,Najera I,Govorkova EA

    更新日期：2016-05-25 00:00:00

  • Significant plastic accumulation on the Cocos (Keeling) Islands, Australia.

    abstract：:For over 60 years, our oceans have been a reservoir for exponentially increasing amounts of plastic waste. Plastic has been documented at all levels of the marine food web, from the deepest oceanic trenches to the most far-flung beaches. Here, we present data on the presence of significant quantities of plastic on the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43375-4

    authors： Lavers JL,Dicks L,Dicks MR,Finger A

    更新日期：2019-05-16 00:00:00

  • Synthesis and Characterization of PtTe2 Multi-Crystallite Nanoparticles using Organotellurium Nanocomposites.

    abstract：:Herein, we report the synthesis of new PtTe2 multi-crystallite nanoparticles (NPs) in different sizes through an annealing process using new nanostructured Pt-Te organometallic NPs as a single source precursor. This precursor was obtained in a single reaction step using Ph2Te2 and H2PtCl6 and could be successfully siz...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10239-8

    authors： Fernández-Lodeiro J,Rodríguez-Gónzalez B,Novio F,Fernández-Lodeiro A,Ruiz-Molina D,Capelo JL,Santos AAD,Lodeiro C

    更新日期：2017-08-29 00:00:00

  • Particulate matter (PM2.5) as a potential SARS-CoV-2 carrier.

    abstract：:The rapid spread of the SARS-CoV-2 in the COVID-19 pandemic had raised questions on the route of transmission of this disease. Initial understanding was that transmission originated from respiratory droplets from an infected host to a susceptible host. However, indirect contact transmission of viable virus by fomites ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81935-9

    authors： Nor NSM,Yip CW,Ibrahim N,Jaafar MH,Rashid ZZ,Mustafa N,Hamid HHA,Chandru K,Latif MT,Saw PE,Lin CY,Alhasa KM,Hashim JH,Nadzir MSM

    更新日期：2021-01-28 00:00:00

  • A novel IgM-H-ficolin complement pathway to attack allogenic cancer cells in vitro.

    abstract：:The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by ac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07824

    authors： Lei X,Liu C,Azadzoi K,Li C,Lu F,Xiang A,Sun J,Guo Y,Zhao Q,Yan Z,Yang J

    更新日期：2015-01-16 00:00:00

  • Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.

    abstract：:The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists alt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01886

    authors： Cuervo R,Chimal-Monroy J

    更新日期：2013-01-01 00:00:00

  • In-situ ToF-SIMS analyses of deuterium re-distribution in austenitic steel AISI 304L under mechanical load.

    abstract：:Hydrocarbons fuel our economy. Furthermore, intermediate goods and consumer products are often hydrocarbon-based. Beside all the progress they made possible, hydrogen-containing substances can have severe detrimental effects on materials exposed to them. Hydrogen-assisted failure of iron alloys has been recognised mor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60370-2

    authors： Röhsler A,Sobol O,Hänninen H,Böllinghaus T

    更新日期：2020-02-27 00:00:00

  • CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.

    abstract：:CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45138-7

    authors： Alisson-Silva F,Mantuano NR,Lopes AL,Vasconcelos-Dos-Santos A,Vale AM,Costa MM,Cannon JL,Oliveira AC,Todeschini AR

    更新日期：2019-06-13 00:00:00

  • Scaling Effect of Phosphorene Nanoribbon - Uncovering the Origin of Asymmetric Current Transport.

    abstract：:In this paper, phosphorene nanoribbons (PNRs) are theoretically studied using a multiscale simulation flow from the ab initio level to the tight binding (TB) level. The scaling effects of both armchair PNRs (aPNRs) and zigzag PNRs (zPNRs) from material properties to device properties are explored. The much larger effe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38009

    authors： Lv Y,Chang S,Huang Q,Wang H,He J

    更新日期：2016-11-29 00:00:00

  • Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.

    abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30943-3

    authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

    更新日期：2018-08-17 00:00:00

  • PI3K induces B-cell development and regulates B cell identity.

    abstract：:Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which pl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19460-5

    authors： Abdelrasoul H,Werner M,Setz CS,Okkenhaug K,Jumaa H

    更新日期：2018-01-22 00:00:00

  • Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration.

    abstract：:Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37862-3

    authors： Abdullah CS,Alam S,Aishwarya R,Miriyala S,Bhuiyan MAN,Panchatcharam M,Pattillo CB,Orr AW,Sadoshima J,Hill JA,Bhuiyan MS

    更新日期：2019-02-14 00:00:00

  • The Making of the Andrea Wave and other Rogues.

    abstract：:Unexpectedly large ocean waves or 'rogues' are sometimes claimed to be the cause of damage to ships at sea and to offshore structures. While wind-driven wave models are capable of predicting the average characteristics of waves, the maximum height of rogues that may occur is yet unknown. Rogues form in the open ocean ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44124

    authors： Donelan MA,Magnusson AK

    更新日期：2017-03-08 00:00:00

  • 3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition.

    abstract：:Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule investigations have been limited to bi-dimensional studies owing to the complexity of 3d-tracking techniques. Here, we present a novel method for ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16088

    authors： Gardini L,Capitanio M,Pavone FS

    更新日期：2015-11-03 00:00:00

  • β1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model.

    abstract：:β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate development and carcinogenesis remains unknown. To assess the role of β1 integrin in vivo, we conditionally deleted β1 integrin from prostate ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00526

    authors： Moran-Jones K,Ledger A,Naylor MJ

    更新日期：2012-01-01 00:00:00

  • Usefulness of Different Pathological Scores to Assess Healing of the Mucosa in Inflammatory Bowel Diseases: A Real Life Study.

    abstract：:The concept of remission for patients with inflammatory bowel diseases has recently evolved, and should also include histological healing of the mucosa, difficult to evaluate since there is no agreement on pathological scores and those available are quite complex to use in the daily routine. We evaluated the possible ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07338-x

    authors： Villanacci V,Antonelli E,Lanzarotto F,Bozzola A,Cadei M,Bassotti G

    更新日期：2017-07-28 00:00:00