Abstract:
:As most genes are shared between females and males, DNA methylation is assumed to play a crucial role in sex-biased gene expression. DNA methylation exclusively occurs at CpG dinucleotides, and therefore, we would expect that CpG density around transcription start sites (TSSs) relate to sex-biased gene expression. Here we investigated the relationship between CpG densities around TSSs and the ratio of gene expression levels between sexes in the guppy (Poecilia reticulata), which displays remarkable sexual dimorphisms. We found that genes with sex-biased gene expression had different CpG densities downstream of TSSs compared with genes lacking sex-biased gene expression. Intriguingly, male-biased expression genes with intermediate CpG density downstream of TSSs exhibited greater differences in gene expression between sexes in the gonad and tail. Our findings suggested the possibility that CpGs around TSSs, especially in the downstream regions, play a crucial role in sex-biased gene expression through DNA methylation.
journal_name
Genome Biol Evoljournal_title
Genome biology and evolutionauthors
Tamagawa K,Makino T,Kawata Mdoi
10.1093/gbe/evx083subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1204-1211issue
5issn
1759-6653pii
3766286journal_volume
9pub_type
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