Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.


:Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.


PLoS Genet


PLoS genetics


Graff M,Scott RA,Justice AE,Young KL,Feitosa MF,Barata L,Winkler TW,Chu AY,Mahajan A,Hadley D,Xue L,Workalemahu T,Heard-Costa NL,den Hoed M,Ahluwalia TS,Qi Q,Ngwa JS,Renström F,Quaye L,Eicher JD,Hayes JE,Corneli




Has Abstract


2017-04-27 00:00:00














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    abstract::Here we report a stop-mutation in the BOD1 (Biorientation Defective 1) gene, which co-segregates with intellectual disability in a large consanguineous family, where individuals that are homozygous for the mutation have no detectable BOD1 mRNA or protein. The BOD1 protein is required for proper chromosome segregation,...

    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Esmaeeli-Nieh S,Fenckova M,Porter IM,Motazacker MM,Nijhof B,Castells-Nobau A,Asztalos Z,Weißmann R,Behjati F,Tzschach A,Felbor U,Scherthan H,Sayfati SM,Ropers HH,Kahrizi K,Najmabadi H,Swedlow JR,Schenck A,Kuss AW

    更新日期:2016-05-11 00:00:00

  • Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.

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    authors: Hu M,Bai Y,Zhang C,Liu F,Cui Z,Chen J,Peng J

    更新日期:2016-02-22 00:00:00

  • Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system.

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    更新日期:2019-12-23 00:00:00

  • Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.

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    pub_type: 杂志文章


    authors: Sakai D,Dixon J,Dixon MJ,Trainor PA

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    journal_title:PLoS genetics

    pub_type: 杂志文章,meta分析


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    journal_title:PLoS genetics

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    authors: Matsuo T,Iida T,Ohmura A,Gururaj M,Kato D,Mutoh R,Ihara K,Ishiura M

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    pub_type: 杂志文章


    authors: O'Geen H,Squazzo SL,Iyengar S,Blahnik K,Rinn JL,Chang HY,Green R,Farnham PJ

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  • Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    authors: Zheng GX,Ravi A,Calabrese JM,Medeiros LA,Kirak O,Dennis LM,Jaenisch R,Burge CB,Sharp PA

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    pub_type: 杂志文章


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    authors: Yang Q,Feng B,Zhang K,Guo YY,Liu SB,Wu YM,Li XQ,Zhao MG

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  • ATPase-independent type-III protein secretion in Salmonella enterica.

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Erhardt M,Mertens ME,Fabiani FD,Hughes KT

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    journal_title:PLoS genetics

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    authors: Meng L,Person RE,Huang W,Zhu PJ,Costa-Mattioli M,Beaudet AL

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Shibata Y,Sheffield NC,Fedrigo O,Babbitt CC,Wortham M,Tewari AK,London D,Song L,Lee BK,Iyer VR,Parker SC,Margulies EH,Wray GA,Furey TS,Crawford GE

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Kim S,Park SY,Kim KS,Rho HS,Chi MH,Choi J,Park J,Kong S,Park J,Goh J,Lee YH

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Göpel Y,Görke B

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Searle JS,Wood MD,Kaur M,Tobin DV,Sanchez Y

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Hayward JJ,White ME,Boyle M,Shannon LM,Casal ML,Castelhano MG,Center SA,Meyers-Wallen VN,Simpson KW,Sutter NB,Todhunter RJ,Boyko AR

    更新日期:2019-09-16 00:00:00

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Gómez-Santos N,Pérez J,Sánchez-Sutil MC,Moraleda-Muñoz A,Muñoz-Dorado J

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Lind AL,Wisecaver JH,Smith TD,Feng X,Calvo AM,Rokas A

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Rodríguez-Marí A,Cañestro C,Bremiller RA,Nguyen-Johnson A,Asakawa K,Kawakami K,Postlethwait JH

    更新日期:2010-07-22 00:00:00

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    journal_title:PLoS genetics

    pub_type: 杂志文章


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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Bouyer D,Heese M,Chen P,Harashima H,Roudier F,Grüttner C,Schnittger A

    更新日期:2018-11-30 00:00:00

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    journal_title:PLoS genetics

    pub_type: 杂志文章


    authors: Clemente-Ruiz M,González-Prieto R,Prado F

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