p75 neurotrophin receptor: A potential surface marker of tongue squamous cell carcinoma stem cells.

abstract：:Trefoil factor 3 (TFF3) serves an important role in intestinal mucosal damage and healing, and contributes to the pathogenesis and treatment of inflammatory bowel disease (IBD). The aim of the present study was to determine the association between TFF3 and microRNA‑7‑5p (miR‑7‑5p) in IBD. Tissue immunohistochemistry w...

journal_title：Molecular medicine reports

authors： Guo J,Sun M,Teng X,Xu L

更新日期：2017-08-01 00:00:00

abstract：:Diabetic nephropathy (DN) is by far the most common cause of end‑stage renal disease (ESRD) in industrial countries, accounting for ~45% of all new ESRD cases in the United States. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants, with an antioxidant ability 50‑fold greater than that of vitamin E ...

journal_title：Molecular medicine reports

authors： Gao Z,Liu G,Hu Z,Shi W,Chen B,Zou P,Li X

更新日期：2018-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a neg...

journal_title：Molecular medicine reports

authors： Jiang T,Huang Z,Zhang S,Zou W,Xiang L,Wu X,Shen Y,Liu W,Zeng Z,Zhao A,Zhou S,Zeng Q

更新日期：2018-08-01 00:00:00

abstract：:The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑2...

journal_title：Molecular medicine reports

authors： Wu L,Li Y,Fan JM,Zhang ZM,Ouyang JL,Ni TT,Wu HX,Li H

更新日期：2015-06-01 00:00:00

abstract：:The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported ...

journal_title：Molecular medicine reports

authors： Xu CW,Cai XY,Shao Y,Li Y,Shi MW,Zhang LY,Wang L,Zhang YP,Wang LP,Tian YW

更新日期：2015-09-01 00:00:00

abstract：:Core2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) forms an N-acetylglucosamine branch in the O-glycans (core2 O-glycans) of cell surface glycoproteins. We previously revealed that the expression of C2GnT is positively correlated with poor prognosis in prostate cancer patients. However, the detailed mechanisms underl...

journal_title：Molecular medicine reports

authors： Okamoto T,Yoneyama MS,Hatakeyama S,Mori K,Yamamoto H,Koie T,Saitoh H,Yamaya K,Funyu T,Fukuda M,Ohyama C,Tsuboi S

更新日期：2013-02-01 00:00:00

abstract：:The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat mo...

journal_title：Molecular medicine reports

authors： Xiang T,Ge S,Wen J,Xie J,Yang L,Wu X,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:Extraocular dissemination is the main cause of death in patients with retinoblastoma (RB) in developing countries, and there are few molecular markers that are useful for the evaluation of minimal disseminated disease. The GD2 ganglioside is known to be expressed by RB cells that metastasize in bone marrow, and the ac...

journal_title：Molecular medicine reports

authors： Laurent VE,Otero LL,Vazquez V,Camarero S,Gabri MR,Labraga M,De Dávila MT,Chantada GL,Alonso DF

更新日期：2010-03-01 00:00:00

abstract：:Brain‑type glycogen phosphorylase (PYGB) is an enzyme that metabolizes glycogen, whose function is to provide energy for an organism in an emergency state. The present study purposed to investigate the role and mechanism of PYGB silencing on the growth and apoptosis of prostate cancer cells. A cell counting kit‑8 assa...

journal_title：Molecular medicine reports

authors： Wang Z,Han G,Liu Q,Zhang W,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Taraxacum coreanum Nakai is a dandelion that is native to Korea, and is widely used as an edible and medicinal herb. The present study revealed the neuroprotective effect of this plant against glutamate-induced oxidative stress in HT22 murine hippocampal neuronal cells. Ethanolic extracts from the aerial (TCAE) and th...

journal_title：Molecular medicine reports

authors： Yoon CS,Ko W,Lee DS,Kim DC,Kim J,Choi M,Beom JS,An RB,Oh H,Kim YC

更新日期：2017-04-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to investigate the dose-dependent modulating effect of estriol (E3), an estrogen predominantly produced during human pregnancy, on antigen‑induced production of specific antibodies in female BALB/c mice. The animals were immunized either with bovine serum albumin (BSA) or the pneumococcal polys...

journal_title：Molecular medicine reports

authors： Ding J,Zhu BT

更新日期：2016-01-01 00:00:00

abstract：:Postmenopausal osteoporosis (OPM) is a common type of osteoporosis in females. It is a systemic, chronic bone disease that presents as microstructure degradation of osseous tissue, decreased bone mineral density and increased osteopsathyrosis caused by hypoovarianism and reduced estrogen levels in the body following m...

journal_title：Molecular medicine reports

authors： Qiu J,Huang G,Na N,Chen L

更新日期：2018-05-01 00:00:00

abstract：:IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein, which is aberrantly expressed in several tumor types and is closely associated with the development, metastasis and prognosis of cancer. Several studies have demonstrated that IQGAP1 has broad prospects in the basic and clinical research o...

journal_title：Molecular medicine reports

authors： Diao B,Liu Y,Zhang Y,Yu J,Xie J,Xu GZ

更新日期：2017-04-01 00:00:00

abstract：:Adoptive transfer of bone marrow‑derived mesenchymal stem cells (BMSCs) significantly alleviates smoking‑induced chronic obstructive pulmonary disease (COPD) in rats. Considering the critical roles of T cells during COPD development, the present study aimed to further identify the molecular mechanisms underlying the a...

journal_title：Molecular medicine reports

authors： Li X,Xu J,Li P

更新日期：2020-05-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis accelerated by hyperglycemia. Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice al...

journal_title：Molecular medicine reports

authors： Chen GP,Zhang XQ,Wu T,Han J,Ye D

更新日期：2017-05-01 00:00:00

abstract：:Glucocorticoids (GCs) are important stress hormones, which are used as a concomitant medication during malignant tumor chemotherapy. Clinical and preclinical studies have linked GCs to melanoma growth and progression. However, the effects and mechanism of action of GCs on the adhesion and survival of melanoma cells ar...

journal_title：Molecular medicine reports

authors： Huang GX,Qi MF,Li XL,Tang F,Zhu L

更新日期：2018-02-01 00:00:00

abstract：:The high risk of developing colorectal carcinoma (CRC), from ulcerative colitis (UC), is well known. Macrophages are widely distributed immune cells that have an indispensable role in UC, as well as in CRC. However, little is currently known about the dynamic changes that occur in macrophage and M1/M2 macrophage subpo...

journal_title：Molecular medicine reports

authors： Wang W,Li X,Zheng D,Zhang D,Peng X,Zhang X,Ai F,Wang X,Ma J,Xiong W,Li G,Zhou Y,Shen S

更新日期：2015-04-01 00:00:00

abstract：:De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and fa...

journal_title：Molecular medicine reports

authors： Wayhelova M,Oppelt J,Smetana J,Hladilkova E,Filkova H,Makaturova E,Nikolova P,Beharka R,Gaillyova R,Kuglik P

更新日期：2019-07-01 00:00:00

abstract：:NOP2/Sun domain family member 2 (NSUN2) is upregulated in numerous types of tumors and may be implicated in multiple biological processes, including cell proliferation, migration and human tumorigenesis. However, little is known about how NSUN2 serves a role in these processes. In the present study, expression profile...

journal_title：Molecular medicine reports

authors： Sun Z,Xue S,Xu H,Hu X,Chen S,Yang Z,Yang Y,Ouyang J,Cui H

更新日期：2019-04-01 00:00:00

abstract：:Diabetes mellitus is known to cause kidney impairment; however, the mechanism remains elusive. The aim of this study was to investigate the role of C/EBP homologous protein (CHOP), an important protein in endoplasmic reticulum stress‑mediated mesangial cell apoptosis in hyperglycemia. Mesangial cells were cultured in ...

journal_title：Molecular medicine reports

authors： He D,Li J,Zhao J,Fei J,Zhang X

更新日期：2013-02-01 00:00:00

abstract：:The present study aimed to investigate the effects of electrical stimulation (ES) on cell activity, cell cycle and apoptosis in injured rat dorsal root ganglion (DRG) cells induced by cyclic mechanical stretching (CMS). The present study also investigated whether the Wnt/β‑catenin pathway is involved in this process. ...

journal_title：Molecular medicine reports

authors： Hu M,Hong L,He S,Huang G,Cheng Y,Chen Q

更新日期：2020-06-01 00:00:00

abstract：:Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a perm...

journal_title：Molecular medicine reports

authors： Perletti G,Skerk V,Magri V,Markotic A,Mazzoli S,Parnham MJ,Wagenlehner FM,Naber KG

更新日期：2011-11-01 00:00:00

abstract：:Previous studies have demonstrated that calcium channel blockers have protective effects on damaged brains. In the present study, the protective effect of the calcium channel blocker nicardipine against rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells was investigated...

journal_title：Molecular medicine reports

authors： Park HJ,Kim HJ

更新日期：2013-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogenesis of abnormal arterial remodeling, aneurysm formation and atherosclerotic plaque instability. It has been confirmed that lipopolysa...

journal_title：Molecular medicine reports

authors： Li H,Xu H,Sun B

更新日期：2012-10-01 00:00:00

abstract：:The baseline concentration of C-reactive protein (CRP) has been associated with a wide array of human diseases. In epidemiological studies and in the clinic, CRP is typically measured as a pentamer, composed of 5 identical CRP subunits. The present study aimed to determine whether other isoforms were present in the bl...

journal_title：Molecular medicine reports

authors： Li Q,Xu W,Xue X,Wang Q,Han L,Li W,Lv S,Liu D,Richards J,Shen Z,Ma L,Song Q

更新日期：2016-12-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were to construct a recurrence risk prediction model and to reveal important OC genes or pathways. RNA sequencing data was obtained for 307 OC samples, and the corresponding clinical data were ...

journal_title：Molecular medicine reports

authors： Cheng L,Li L,Wang L,Li X,Xing H,Zhou J

更新日期：2018-09-01 00:00:00

abstract：:Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study demonstrated that administration of MG caused inhibition of the...

journal_title：Molecular medicine reports

authors： Huang F,Zhang RY,Song L

更新日期：2017-10-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00