Pooled analysis on the necessity of random 4-quadrant cervical biopsies and endocervical curettage in women with positive screening but negative colposcopy.


:Controversy remains over whether random cervical biopsies and endocervical curettage (ECC) should be used in women with positive screening but negative colposcopy. Our paper aims to determine the indications for random biopsies and ECC among these screened positive women.Three thousand two hundred thirteen women with any positive screening test result but negative colposcopy, who received random 4-quadrant biopsies, were pooled from 17 population-based cervical cancer screening studies done in China from 1999 to 2008. The detection rates of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and CIN grade 3 or worse (CIN3+) stratified by cytology and high-risk human papillomavirus (HR-HPV) status were assessed, as well as the false negative rates for CIN2+ and CIN3+ by random biopsies without ECC.Compared with women with negative cytology and positive HR-HPV, those with atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion (ASC-US/LSIL) and negative HR-HPV had the equivalent lower risks of CIN2+ and CIN3+, but ascending risks were observed in the groups of ASC-US/LSIL and positive HR-HPV, and atypical glandular cells/atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion/high-grade squamous intraepithelial lesion or worse (AGC/ASC-H/HSIL+). If random biopsies were only taken without ECC, 9.3% of CIN2+ and 18.5% of CIN3+ would have been missed.For women with any positive screening but negative colposcopy, in areas with good cytological infrastructure, it was necessary to perform random biopsies plus ECC on those with cytological ASC-US/LSIL and positive HR-HPV, AGC, ASC-H, or HSIL+. In contrast, those with other results should be followed up.


Medicine (Baltimore)




Hu SY,Zhang WH,Li SM,Li N,Huang MN,Pan QJ,Zhang X,Han Y,Zhao FH,Chen W,Qiao YL




Has Abstract


2017-04-01 00:00:00
















  • Establishment of normal reference values of NT-proBNP and its application in diagnosing acute heart failure in children with severe hand foot and mouth disease [corrected].

    abstract::Hand, foot, and mouth disease (HFMD), caused by enteroviruses, is an acute contagious disease in children. Some severe infections caused by human enterovirus 71 (HEV71) lead to rapid death in children with acute heart failure (HF). N-terminal probrain natriuretic peptide (NT-proBNP) is an important indicator of HF; ho...


    pub_type: 杂志文章


    authors: Li S,Xiao Z,Li L,Hu B,Zhou Z,Yi S,Luo J,Xie L,Nie B,Mo L,Wang S

    更新日期:2018-09-01 00:00:00

  • Modified 2-port laparoscopic herniorrhaphy with Kirschner wire in children: A retrospective review.

    abstract:BACKGROUND:Pediatric inguinal hernia is one of the most common diseases in children, and laparoscopy is the main surgical method. This study aims to evaluate the efficacy of a new modified 2-port laparoscopic herniorrhaphy with Kirschner wire (TLHK) for inguinal hernia in children. METHODS:A total of 5304 children wit...


    pub_type: 杂志文章


    authors: Cao Z,Chen J,Li Z,Li G

    更新日期:2018-10-01 00:00:00

  • Resistin polymorphisms are associated with rheumatoid arthritis susceptibility in Chinese Han subjects.

    abstract::Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. To date, the specific mechanisms that drive RA disease remain unknown and provide the impetus for genetic investigations into the development of RA. Researchers hope to identify gene polymorphisms that could serve as treatment targets in patients wi...


    pub_type: 杂志文章


    authors: Wang L,Tang CH,Lu T,Sun Y,Xu G,Huang CC,Yang SF,Su CM

    更新日期:2018-03-01 00:00:00

  • Spontaneous closure of an iatrogenic coronary artery fistula during recanalization of a chronic total occlusion lesion: A case report.

    abstract:RATIONALE:Coronary perforation leading to fistula directed to the right ventricle is a rare complication of percutaneous coronary intervention (PCI). The reported outcomes vary from a stable state to rapid deterioration. PATIENT CONCERNS:An 86-year-old man was diagnosed with non-ST elevation myocardial infarction, and...


    pub_type: 杂志文章


    authors: Yu X,Wang X,Zhang R,Xu F,Ji F

    更新日期:2019-01-01 00:00:00

  • Cardiorespiratory arrest after iso-osmolar iodinated contrast injection: A case report of contrast-induced encephalopathy following contrast-enhanced computed-tomography.

    abstract:RATIONALE:Contrast-induced encephalopathy (CIE) is a rare complication caused by administration of intravascular contrast media and characterized by acute reversible neurological disturbance. Most of the CIE cases are reported after arterial administration of contrast media such as during cerebral or coronary angiograp...


    pub_type: 杂志文章


    authors: Yao LD,Zhu XL,Yang RL,Zhang MM

    更新日期:2021-01-15 00:00:00

  • Spinal epidural hematoma occurring at a distance from the transforaminal epidural injection site: A case report.

    abstract:RATIONALE:Transforaminal epidural steroid injection (TFESI) is a conservative method to treat back pain due to radiculopathy. However, epidural hematoma can occur after the procedure by various mechanisms, which can cause serious complications. PATIENT CONCERNS:An 82-year-old man with spinal stenosis was treated with ...


    pub_type: 杂志文章


    authors: Kim SI,Lee DH,Kim SH,Cho YH

    更新日期:2019-07-01 00:00:00

  • Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.

    abstract::Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wou...


    pub_type: 杂志文章


    authors: Li YH,Zheng Z,Yang J,Su LL,Liu Y,Han F,Liu JQ,Hu DH

    更新日期:2017-04-01 00:00:00

  • Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol: Report of 3 Pediatric Cases and Literature Review.

    abstract::Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis assoc...


    pub_type: 杂志文章,评审


    authors: Zhou YH,Xia FQ,Van Poucke S,Zheng MH

    更新日期:2016-02-01 00:00:00

  • Modeling the effectiveness of nebulized terbutaline for decompensated chronic obstructive pulmonary disease patients in the emergency department.

    abstract::Short-acting β2-agonists (SABA) are widely used in the emergency department (ED) to treat patients with decompensated chronic obstructive pulmonary disease (COPD). We sought to model the effectiveness of nebulized SABA (terbutaline) on clinically relevant parameters associated with a reduction in work of breathing or ...


    pub_type: 杂志文章


    authors: Gueho F,Beaune S,Devillier P,Urien S,Faisy C

    更新日期:2016-08-01 00:00:00

  • Delayed degeneration of the left fornical crus with verbal memory impairment in a patient with mild traumatic brain injury: A case report.

    abstract:RATIONALE:We report on a patient who showed delayed degeneration of the left fornical crus with verbal memory impairment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT). PATIENT CONCERNS:: fter flexion and hyperextension of her head to the opposite side, the pa...


    pub_type: 杂志文章


    authors: Jang SH,Seo JP

    更新日期:2017-12-01 00:00:00

  • The effects of blood pressure components on cardiovascular events in a Korean hypertensive population according to age and sex: A nationwide population-based cohort study.

    abstract::There is no known study regarding the usefulness of each blood pressure (BP) component based on stratification by age and sex for predicting cardiovascular (CV) events among hypertensive populations without chronic kidney disease (CKD) or diabetes mellitus (DM). This study was performed to investigate the association ...


    pub_type: 杂志文章


    authors: Kang E,Lee S,Ha E,Oh HJ,Ryu DR

    更新日期:2019-08-01 00:00:00

  • Comorbid depression is differentially associated with longitudinal medication nonadherence by race/ethnicity in patients with type 2 diabetes.

    abstract::The aim of the study was to examine whether depression impacts medication nonadherence (MNA) over time and determine if race has a differential impact on MNA in patients with type 2 diabetes and comorbid depression.Generalized estimating equations were used with a longitudinal national cohort of 740,197 veterans with ...


    pub_type: 杂志文章,多中心研究


    authors: Axon RN,Gebregziabher M,Hunt KJ,Lynch CP,Payne E,Walker RJ,Egede LE

    更新日期:2016-06-01 00:00:00

  • A morphologic and quantitative comparison of mechanoreceptors in the tibial remnants of the ruptured human anterior cruciate ligament.

    abstract::Reconstruction of the ruptured anterior cruciate ligament (ACL) does not always result in expected successful outcome. A satisfactory outcome depends not only on the tightness or strength of the graft but also on the quality of proprioceptive restoration. Mechanoreceptors of ACL are supposed to play considerable roles...


    pub_type: 杂志文章


    authors: Sha L,Xie G,Zhao S,Zhao J

    更新日期:2017-02-01 00:00:00

  • Clinical and radiographic outcomes of treatment of comminuted Mason type II radial head fractures with a new implant.

    abstract::This study aims to evaluate the clinical and radiographic treatment outcomes of comminuted Mason type II radial head fractures, which underwent open reduction and internal fixation (ORIF) using a new implant (mother-child screw, MCS).This study included 16 patients (7 male and 9 female patients; mean age: 40.9 years, ...


    pub_type: 杂志文章


    authors: Shi Y,Wang GF,Mei K,Zhang J,Yun CJ,Qian C,Sun JY

    更新日期:2018-03-01 00:00:00

  • Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis.

    abstract::Ataxia-telangiectasia is a syndrome with many facets, involving a progressive cerebellar ataxia, immunodeficiency, cancer susceptibility, radiosensitivity, defects in DNA repair/processing, chromosomal breakage and rearrangements, elevated serum alphafetoprotein, and premature aging. Ataxia-telangiectasia is an autoso...


    pub_type: 杂志文章,评审


    authors: Gatti RA,Boder E,Vinters HV,Sparkes RS,Norman A,Lange K

    更新日期:1991-03-01 00:00:00

  • A novel mutation of the HNF1B gene associated with hypoplastic glomerulocystic kidney disease and neonatal renal failure: a case report and mutation update.

    abstract::Hepatocyte nuclear factor 1 beta (HNF1B) plays an important role in embryonic development, namely in the kidney, pancreas, liver, genital tract, and gut. Heterozygous germline mutations of HNF1B are associated with the renal cysts and diabetes syndrome (RCAD). Affected individuals may present a variety of renal develo...


    pub_type: 杂志文章


    authors: Alvelos MI,Rodrigues M,Lobo L,Medeira A,Sousa AB,Simão C,Lemos MC

    更新日期:2015-02-01 00:00:00

  • Purulent pericarditis: report of 2 cases and review of the literature.

    abstract::Purulent pericarditis, a localized infection within the pericardial space, has become a rare entity in the modern antibiotic era. Although historically a disease of children and young adults, this is no longer the case: the median age at the time of diagnosis has increased by nearly 30 years over the past 6 decades. D...


    pub_type: 杂志文章,评审


    authors: Parikh SV,Memon N,Echols M,Shah J,McGuire DK,Keeley EC

    更新日期:2009-01-01 00:00:00

  • An observational study on the association between major dietary patterns and non-alcoholic fatty liver disease in Chinese adolescents.

    abstract::Data on the association of dietary patterns with non-alcoholic fatty liver disease (NAFLD) among adolescents are scarce. Hence, the purpose of this study was to ascertain the influence of dietary patterns and key foods on NAFLD among adolescents in Shandong, China. Data were extracted from Linyi Nutrition and Health s...


    pub_type: 杂志文章


    authors: Liu X,Peng Y,Chen S,Sun Q

    更新日期:2018-04-01 00:00:00

  • Gram-negative bacillary pneumonia in the compromised host.

    abstract::The clinical and radiological characteristics of 217 consecutive episodes of gram-negative bacillary pneumonia occurring in 189 adult cancer patients between November 1968 and December 1974 were analyzed. The majority of patients had acute leukemia (54%). Fever larger than or equal to 101 degrees F was the single mos...


    pub_type: 杂志文章


    authors: Valdivieso M,Gil-extremera B,Zornoza J,Rodriquez V,Bodey GP

    更新日期:1977-05-01 00:00:00

  • Estimated Glomerular Filtration Rate Trajectories in HIV-Infected Subjects Treated With Different Ritonavir-Boosted Protease Inhibitors and Tenofovir Disoproxil Fumarate or Abacavir.

    abstract::The aim of the study was to evaluate in human immunodeficiency virus (HIV)-infected patients estimated glomerular filtration rate (eGFR) trajectories during treatment with different protease inhibitors (PIs) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus tenofovir (TDF) or abacavir (ABC) and lamivudi...


    pub_type: 杂志文章


    authors: Gianotti N,Galli L,Poli A,Salpietro S,Nozza S,Carbone A,Merli M,Ripa M,Lazzarin A,Castagna A

    更新日期:2016-05-01 00:00:00

  • Effect of extracorporeal shock-wave therapy for treating patients with chronic rotator cuff tendonitis.

    abstract:BACKGROUND:This study aimed to determine the efficacy and safety of extracorporeal shock-wave therapy (ESWT) for treating patients with chronic rotator cuff tendonitis (CRCT). METHODS:In this study, 84 patients with CRCT were randomly divided into intervention and control groups in a ratio of 1:1. Patients in the inte...


    pub_type: 杂志文章,随机对照试验


    authors: Li W,Zhang SX,Yang Q,Li BL,Meng QG,Guo ZG

    更新日期:2017-09-01 00:00:00

  • Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report.

    abstract:INTRODUCTION:Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management usi...


    pub_type: 杂志文章


    authors: Lai H,Wang K,Dong Q,Zhu X,Li X,Qi S

    更新日期:2019-04-01 00:00:00

  • The disadvantage of morning blood pressure management in hypertensive patients.

    abstract::To investigate whether the control of morning blood pressure (MBP) reflects the control of blood pressure (BP) in other periods (daytime, nighttime and 24-hour) and to assess whether morning BP displays a closer association with subclinical target organ damage (TOD) than the BP measured in other periods.One thousand o...


    pub_type: 杂志文章


    authors: Liu K,Xu Y,Gong S,Li J,Li X,Ye R,Liao H,Chen X

    更新日期:2020-02-01 00:00:00

  • A new type of surgery for the treatment of bromhidrosis.

    abstract::It is common to treat bromhidrosis by surgery, but postoperative complications such as subcutaneous exudate and subcutaneous hematoma can occur and lead to delayed healing of the wound and eventually lead to the formation of unattractive scars. In this study, we evaluated our new surgical treatment for bromhidrosis, w...


    pub_type: 杂志文章


    authors: Wang Y,Sun P,Leng X,Dong Z,Bi M,Chen Z

    更新日期:2019-05-01 00:00:00

  • Successful treatment with rivaroxaban of cerebral venous thrombosis and bone marrow necrosis induced by pegaspargase: A case report and literature review.

    abstract:RATIONALE:Pegaspargase has been used in the treatment of acute lymphoblastic leukemia with promising results. However, it has also been associated with several potentially serious complications, including thrombosis. Pegaspargase-induced cerebral venous thrombosis and bone marrow necrosis are very rare. PATIENT CONCER...


    pub_type: 杂志文章,评审


    authors: Sui J,Zhang Y,Yang L,Wang H,Xu J,Wei R,Hao Y,Wang X,Peng J,Ma J

    更新日期:2017-11-01 00:00:00

  • Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review.

    abstract:BACKGROUND:Sedoanalgesia secondary iatrogenic withdrawal syndrome (IWS) in paediatric intensive units is frequent and its assessment is complex. Therapies are heterogeneous, and there is currently no gold standard method for diagnosis. In addition, the assessment scales validated in children are scarce. This paper aims...


    pub_type: 杂志文章


    authors: Ávila-Alzate JA,Gómez-Salgado J,Romero-Martín M,Martínez-Isasi S,Navarro-Abal Y,Fernández-García D

    更新日期:2020-01-01 00:00:00

  • Effect of mGluR7 on proliferation of human embryonic neural stem cells.

    abstract::This study is to investigate the effect of metabotropic glutamate receptor 7 (mGluR7) on the proliferation of human embryonic neural stem cells (NSCs) and its molecular mechanism.Human embryonic NSCs were isolated. The pCMV2-GV146-GFP-mGluR7 plasmid was transfected to over-express mGluR7 while mGluR7 siRNA was transfe...


    pub_type: 杂志文章


    authors: Zhang J,Zhao J,Chen Y,Shi H,Huang X,Wang Y,Wang Y,Wei Y,Xue W,Han J

    更新日期:2019-03-01 00:00:00

  • A randomized trial of remifentanil for analgesia in external cephalic version for breech presentation.

    abstract:BACKGROUND:Although external cephalic version (ECV) can be effective for correcting the fetus in a cephalic presentation, it may be painful for the mother. This study aimed to evaluate the efficacy and safety of remifentanil for pain relief during ECV in China. METHODS:In all, 152 Chinese parturients with singleton br...


    pub_type: 杂志文章,随机对照试验


    authors: Liu X,Xue A

    更新日期:2016-12-01 00:00:00

  • Radiologic features of primary intracranial ectopic germinomas: Case reports and literature review.

    abstract:RATIONALE:Germinomas are sensitive to radiation therapy and chemotherapy; therefore, correct imaging diagnosis is crucial for them. However, the imaging findings of germinomas originating from off-midline regions displayed different patterns from those originating from midline areas. PATIENT CONCERNS:The objective of ...


    pub_type: 杂志文章,评审


    authors: Wei XH,Shen HC,Tang SX,Gao CH,Ren JL,Ai L,Dai JP

    更新日期:2016-12-01 00:00:00

  • Comparison of the ETView Single Lumen and Macintosh laryngoscopes for endotracheal intubation in an airway manikin with immobilized cervical spine by novice paramedics: A randomized crossover manikin trial.

    abstract:CONTEXT:Management of the airway of a trauma victim is considered challenging. Various approaches have been described to achieve airway control in this setup; many of them include video-assited viewing of the larynx during intubation. ETView Single Lumen (SL) is a novice single-use endotracheal tube equiped with a vide...


    pub_type: 杂志文章,随机对照试验


    authors: Gawlowski P,Smereka J,Madziala M,Cohen B,Ruetzler K,Szarpak L

    更新日期:2017-04-01 00:00:00