Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine.

Abstract:

:Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury. 10-mm full-thickness excisional wounds were also generated on the dorsal skin of rats treated with 10 mg/kg SB431542 and all wounds were treated with 0.5% PVI for 5 days. PVI treatment enhanced wound healing via promotion of expression of α SMA and TGF β, neovascularization and re-epithelialization. Interleukin 6 was reduced following PVI treatment. Inhibition of TGF β abolished the effect of PVI treatment on wound closure. These data show that topical application of 0.5% PVI could promote acute skin wound healing though increased expression of TGF β leading to enhanced formation of granulation tissue, even in the absence of obvious infection.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang L,Qin W,Zhou Y,Chen B,Zhao X,Zhao H,Mi E,Mi E,Wang Q,Ning J

doi

10.1038/s41598-017-01116-5

subject

Has Abstract

pub_date

2017-04-20 00:00:00

pages

991

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01116-5

journal_volume

7

pub_type

杂志文章
  • Visualization of a Mammalian Mitochondrion by Coherent X-ray Diffractive Imaging.

    abstract::We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01833-x

    authors: Kim Y,Kim C,Kwon OY,Nam D,Kim SS,Park JH,Kim S,Gallagher-Jones M,Kohmura Y,Ishikawa T,Song C,Tae G,Noh DY

    更新日期:2017-05-12 00:00:00

  • Chromium exposure and incidence of metabolic syndrome among American young adults over a 23-year follow-up: the CARDIA Trace Element Study.

    abstract::Studies suggest that chromium deficiency is associated with elevated levels of fasting blood glucose, circulating insulin, cholesterol and triglycerides, and decreased proportion of lean body mass. However, data directly relating chromium levels to metabolic syndrome (MetS) risk are lacking. A total of 3,648 American ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15606

    authors: Bai J,Xun P,Morris S,Jacobs DR Jr,Liu K,He K

    更新日期:2015-10-22 00:00:00

  • Distinct climate influences on the risk of typhoid compared to invasive non-typhoid Salmonella disease in Blantyre, Malawi.

    abstract::Invasive Salmonella diseases, both typhoid and invasive non-typhoidal Salmonella (iNTS), are seasonal bloodstream infections causing important morbidity and mortality globally in Africa. The reservoirs and transmission of both are not fully understood. We hypothesised that differences in the time-lagged relationships ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56688-1

    authors: Thindwa D,Chipeta MG,Henrion MYR,Gordon MA

    更新日期:2019-12-30 00:00:00

  • Chronic hepatitis C liver microenvironment: role of the Th17/Treg interplay related to fibrogenesis.

    abstract::The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13777-3

    authors: Rios DA,Valva P,Casciato PC,Frias S,Soledad Caldirola M,Gaillard MI,Bezrodnik L,Bandi J,Galdame O,Ameigeiras B,Krasniansky D,Brodersen C,Mullen E,Matteo EN,Preciado MV

    更新日期:2017-10-16 00:00:00

  • Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.

    abstract::Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA dou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58746-5

    authors: Belmans N,Gilles L,Vermeesen R,Virag P,Hedesiu M,Salmon B,Baatout S,Lucas S,Lambrichts I,Jacobs R,Moreels M,DIMITRA Research Group.

    更新日期:2020-02-07 00:00:00

  • A novel approach for separating bacteriophages from other bacteriophages using affinity chromatography and phage display.

    abstract::Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03220

    authors: Ceglarek I,Piotrowicz A,Lecion D,Miernikiewicz P,Owczarek B,Hodyra K,Harhala M,Górski A,Dąbrowska K

    更新日期:2013-11-14 00:00:00

  • Population genetics and forensic utility of 23 autosomal PowerPlex Fusion 6C STR loci in the Kuwaiti population.

    abstract::This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from the Kuwaiti population, of which four markers (D10S1248, D22S1045, D2S441 and SE33) are reported for the first time for Kuwait. All the markers were shown to exhibit no deviation from Hardy-Weinberg equilibrium, n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81425-y

    authors: Haidar M,Abbas FA,Alsaleh H,Haddrill PR

    更新日期:2021-01-21 00:00:00

  • CRISPR-PCS: a powerful new approach to inducing multiple chromosome splitting in Saccharomyces cerevisiae.

    abstract::PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30278

    authors: Sasano Y,Nagasawa K,Kaboli S,Sugiyama M,Harashima S

    更新日期:2016-08-17 00:00:00

  • Nitrous Oxide Production in a Granule-based Partial Nitritation Reactor: A Model-based Evaluation.

    abstract::Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45609

    authors: Peng L,Sun J,Liu Y,Dai X,Ni BJ

    更新日期:2017-04-03 00:00:00

  • An integrated statistical model for enhanced murine cardiomyocyte differentiation via optimized engagement of 3D extracellular matrices.

    abstract::The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18705

    authors: Jung JP,Hu D,Domian IJ,Ogle BM

    更新日期:2015-12-21 00:00:00

  • Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.

    abstract::Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08900-3

    authors: Hegarty SV,Wyatt SL,Howard L,Stappers E,Huylebroeck D,Sullivan AM,O'Keeffe GW

    更新日期:2017-08-17 00:00:00

  • Mechanics of fragmentation of crocodile skin and other thin films.

    abstract::Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04966

    authors: Qin Z,Pugno NM,Buehler MJ

    更新日期:2014-05-27 00:00:00

  • Interfacial charge-mediated non-volatile magnetoelectric coupling in Co₀.₃Fe₀.₇/Ba₀.₆Sr₀.₄TiO₃/Nb:SrTiO₃ multiferroic heterostructures.

    abstract::The central challenge in realizing non-volatile, E-field manipulation of magnetism lies in finding an energy efficient means to switch between the distinct magnetic states in a stable and reversible manner. In this work, we demonstrate using electrical polarization-induced charge screening to change the ground state o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07740

    authors: Zhou Z,Howe BM,Liu M,Nan T,Chen X,Mahalingam K,Sun NX,Brown GJ

    更新日期:2015-01-13 00:00:00

  • Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice.

    abstract::Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04946-5

    authors: Sasayama D,Sugiyama N,Yonekubo S,Pawlak A,Murasawa H,Nakamura M,Hayashi M,Ogawa T,Moro M,Washizuka S,Amano N,Hongo K,Ohnota H

    更新日期:2017-07-05 00:00:00

  • p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy.

    abstract::Increased p66Shc expression has been associated with diabetic nephropathy (DN). However, whether p66Shc can serve as a potential biomarker for tubular oxidative injury in DN is unknown. We measured the expression of p66Shc in peripheral blood monocytes (PBMs) and renal biopsy tissues from DN patients and then analysed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29302

    authors: Xu X,Zhu X,Ma M,Han Y,Hu C,Yuan S,Yang Y,Xiao L,Liu F,Kanwar YS,Sun L

    更新日期:2016-07-05 00:00:00

  • Iterative consensus spectral clustering improves detection of subject and group level brain functional modules.

    abstract::Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63552-0

    authors: Gupta S,Rajapakse JC

    更新日期:2020-05-05 00:00:00

  • Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.

    abstract::Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both integrins have distinct in vivo functions. In this context, the contribution of α11 subunit cytoplasm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51689-6

    authors: Erusappan P,Alam J,Lu N,Zeltz C,Gullberg D

    更新日期:2019-10-25 00:00:00

  • Laminar flow drag reduction on soft porous media.

    abstract::While researches have focused on drag reduction of various coated surfaces such as superhydrophobic structures and polymer brushes, the insights tso understand the fundamental physics of the laminar skin friction coefficient and the related drag reduction due to the formation of finite velocity at porous surfaces is s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17141-3

    authors: Mirbod P,Wu Z,Ahmadi G

    更新日期:2017-12-08 00:00:00

  • Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells.

    abstract::Combination targeted therapy is commonly used to treat acute myeloid leukemia (AML) patients, particularly in refractory/relapse (RR) population. However, concerns have been raised regarding the safety and patient tolerance of combination chemotherapy. It is critical to choose the appropriate treatment for precision t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40361

    authors: Liang H,Zheng QL,Fang P,Zhang J,Zhang T,Liu W,Guo M,Robinson CL,Chen SB,Chen XP,Chen FP,Zeng H

    更新日期:2017-01-18 00:00:00

  • A model of the entrance pupil of the human eye.

    abstract::The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45827-3

    authors: Aguirre GK

    更新日期:2019-06-27 00:00:00

  • In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography.

    abstract::Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22792

    authors: Coughlan CA,Chou LD,Jing JC,Chen JJ,Rangarajan S,Chang TH,Sharma GK,Cho K,Lee D,Goddard JA,Chen Z,Wong BJ

    更新日期:2016-03-10 00:00:00

  • A prediction model of outcome of SARS-CoV-2 pneumonia based on laboratory findings.

    abstract::The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in thousands of deaths in the world. Information about prediction model of prognosis of SARS-CoV-2 infection is scarce. We used machine learning for processing laboratory findings of 110 patients with SARS-CoV-2 pneumonia (including 51 non-s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71114-7

    authors: Wu G,Zhou S,Wang Y,Lv W,Wang S,Wang T,Li X

    更新日期:2020-08-20 00:00:00

  • Efficient Optical Energy Harvesting in Self-Accelerating Beams.

    abstract::We report the experimental observation of energetically confined self-accelerating optical beams propagating along various convex trajectories. We show that, under an appropriate transverse compression of their spatial spectra, these self-accelerating beams can exhibit a dramatic enhancement of their peak intensity an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13197

    authors: Bongiovanni D,Hu Y,Wetzel B,Robles RA,Mendoza González G,Marti-Panameño EA,Chen Z,Morandotti R

    更新日期:2015-08-24 00:00:00

  • Chemical and structural stability of lithium-ion battery electrode materials under electron beam.

    abstract::The investigation of chemical and structural dynamics in battery materials is essential to elucidation of structure-property relationships for rational design of advanced battery materials. Spatially resolved techniques, such as scanning/transmission electron microscopy (S/TEM), are widely applied to address this chal...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05694

    authors: Lin F,Markus IM,Doeff MM,Xin HL

    更新日期:2014-07-16 00:00:00

  • Biofilm may not be Necessary for the Epidemic Spread of Acinetobacter baumannii.

    abstract::Biofilm is recognized as a contributing factor to the capacity of Acinetobacter baumannii to persist and prosper in medical settings, but it is still unknown whether biofilms contribute to the spread of A. baumannii. In this study, the biofilm formation of 114 clinical A. baumannii isolates and 32 non-baumannii Acinet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32066

    authors: Hu Y,He L,Tao X,Meng F,Zhang J

    更新日期:2016-08-25 00:00:00

  • Improved collective influence of finding most influential nodes based on disjoint-set reinsertion.

    abstract::Identifying vital nodes in complex networks is a critical problem in the field of network theory. To this end, the Collective. Influence (CI) algorithm has been introduced and shows high efficiency and scalability in searching for the influential nodes in. the optimal percolation model. However, the crucial part of th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32874-5

    authors: Zhu F

    更新日期:2018-09-28 00:00:00

  • Evaluation of the cause of unexplained radiocaesium contamination of brown rice in Fukushima in 2013 using autoradiography and gamma-ray spectrometry.

    abstract::The Great East Japan Earthquake on 11 March 2011, caused the release of radioactive materials from the Fukushima Daiichi Nuclear Power Plant (FDNPP), contaminating eastern Japan, particularly in part of Fukushima Prefecture. In 2012 and 2014, the radiocaesium concentration in brown rice did not exceed regulatory level...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20386

    authors: Matsunami H,Murakami T,Fujiwara H,Shinano T

    更新日期:2016-02-04 00:00:00

  • Uncovering representations of sleep-associated hippocampal ensemble spike activity.

    abstract::Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32193

    authors: Chen Z,Grosmark AD,Penagos H,Wilson MA

    更新日期:2016-08-30 00:00:00

  • Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome.

    abstract::Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. However, aberrant mPFC ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50024-3

    authors: Icenhour A,Tapper S,Bednarska O,Witt ST,Tisell A,Lundberg P,Elsenbruch S,Walter S

    更新日期:2019-09-19 00:00:00

  • Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

    abstract::Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08267-5

    authors: Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen T

    更新日期:2017-08-15 00:00:00