Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

abstract：:When the proximal and distal elements of wire-frame cubes are conflated, observers perceive illusory structures that no longer behave veridically. These phenomena suggest that what we normally see depends on visual associations generated by experience. The necessity of such learning may explain why the mammalian visua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purves D,Andrews TJ

更新日期：1997-06-10 00:00:00

abstract：:The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as noncoding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with AGRs encoding important transcriptional and translational properties d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Napolitano MG,Landon M,Gregg CJ,Lajoie MJ,Govindarajan L,Mosberg JA,Kuznetsov G,Goodman DB,Vargas-Rodriguez O,Isaacs FJ,Söll D,Church GM

更新日期：2016-09-20 00:00:00

abstract：:Chemokine homologs are encoded by many large DNA viruses, suggesting that they contribute to control of host leukocyte transmigration and trafficking during viral infection. Murine cytomegalovirus carries a CC (beta) chemokine homolog gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saederup N,Lin YC,Dairaghi DJ,Schall TJ,Mocarski ES

更新日期：1999-09-14 00:00:00

abstract：:Using a high-resolution isoelectric focusing system, we have been able to separate the products of the individual "nonallelic+ mouse hemoglobin alpha-chain genes. The hemoglobins of mice of inbred strains that make two structurally different, but electrophoretically identical, alpha chains resolve into two bands on is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney JB 3rd,Copland GT,Skow LC,Russell ES

更新日期：1979-02-01 00:00:00

abstract：:Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly mediated through protein-protein interactions as well as reversible phosphorylation of proteins. To facilitate the study of regulated protein-protein interactions in cells and living animals, we optimized firefly luciferase protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luker KE,Smith MC,Luker GD,Gammon ST,Piwnica-Worms H,Piwnica-Worms D

更新日期：2004-08-17 00:00:00

abstract：:Archaea of the phylum Thaumarchaeota are among the most abundant prokaryotes on Earth and are widely distributed in marine, terrestrial, and geothermal environments. All studied Thaumarchaeota couple the oxidation of ammonia at extremely low concentrations with carbon fixation. As the predominant nitrifiers in the oce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Könneke M,Schubert DM,Brown PC,Hügler M,Standfest S,Schwander T,Schada von Borzyskowski L,Erb TJ,Stahl DA,Berg IA

更新日期：2014-06-03 00:00:00

abstract：:Isolated yeast mitochondria, which synthesize identifiable polypeptides identical to those made in vivo, have been used in an invitro system to study cytoplasmic control of mitochondrial protein synthesis. It has been found that protein synthesis in isolated mitochondria is dependent on an endogenous pool of cytoplasm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poyton RO,Kavanagh J

更新日期：1976-11-01 00:00:00

abstract：:Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes). These vesicles have now been purified more than 37-fold based on their content of newly internalized epidermal growth factor. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickson RB,Beguinot L,Hanover JA,Richert ND,Willingham MC,Pastan I

更新日期：1983-09-01 00:00:00

abstract：:Pneumococcal peptidoglycan amidase (N-acetylmuramoyl-L-alanine amidase, EC 3.5.1.28) and phage CPL1 lysozyme degrade a common substrate (choline-containing pneumococcal cell walls); the former hydrolyzes the bond between muramic acid and alanine, whereas the latter breaks down the linkage between muramic acid and gluc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz E,López R,García JL

更新日期：1990-10-01 00:00:00

abstract：:A library of amphiphilic Janus dendrimers including two that are fluorescent and one glycodendrimer presenting lactose were used to construct giant dendrimersomes and glycodendrimersomes. Coassembly with the components of bacterial membrane vesicles by a dehydration-rehydration process generated giant cell-like hybrid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Q,Yadavalli SS,Zhang S,Sherman SE,Fiorin E,da Silva L,Wilson DA,Hammer DA,André S,Gabius HJ,Klein ML,Goulian M,Percec V

更新日期：2016-03-01 00:00:00

abstract：:Maternal microchimerism (MMc) has been associated with development of allospecific transplant tolerance, antitumor immunity, and cross-generational reproductive fitness, but its mode of action is unknown. We found in a murine model that MMc caused exposure to the noninherited maternal antigens in all offspring, but in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bracamonte-Baran W,Florentin J,Zhou Y,Jankowska-Gan E,Haynes WJ,Zhong W,Brennan TV,Dutta P,Claas FH,van Rood JJ,Burlingham WJ

更新日期：2017-01-31 00:00:00

abstract：:A short interspersed nuclear element, Mg-SINE, was isolated and characterized from the genome of the rice blast fungus, Magnaporthe grisea. Mg-SINE was isolated as an insertion element within Pot2, an inverted-repeat transposon from M. grisea and shows typical features of a mammalian SINE. Mg-SINE is present as a 0.47...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo P,Leong SA,Chattoo BB

更新日期：1995-11-21 00:00:00

abstract：:Coacervation is a common phenomenon in natural polymers and has been applied to synthetic materials systems for coatings, adhesives, and encapsulants. Single-component coacervates are formed when block polyampholytes exhibit self-coacervation, phase separating into a dense liquid coacervate phase rich in the polyampho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielsen SPO,McCarty J,Shea JE,Delaney KT,Fredrickson GH

更新日期：2019-04-23 00:00:00

abstract：:In Saccharomyces cerevisiae cells harboring a GAL1 promoter-linked beta-galactosidase gene, the simultaneous expression of Escherichia coli DNA topoisomerase I and inactivation of yeast DNA topoisomerases I and II reduces the cellular level of beta-galactosidase to an undetectable level. Analysis of intracellular mRNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gartenberg MR,Wang JC

更新日期：1992-12-01 00:00:00

abstract：:We examined the ability of macrophages and B cells to function as antigen-presenting cells (APCs) for murine TH1 and TH2 cloned T helper cell lines. Antigen presented by concanavalin A-elicited peritoneal macrophages or resting splenic B cells stimulated antigen-dependent proliferation of both T helper subsets. Parafo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver CT,Hawrylowicz CM,Unanue ER

更新日期：1988-11-01 00:00:00

abstract：:Macrophage foam cells are integral in the development of atherosclerotic lesions. Gene expression analysis of lesional macrophage foam cells is complicated by the cellular heterogeneity of atherosclerotic plaque and the presence of lesions of various degrees of severity. To overcome these limitations, we tested the ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trogan E,Choudhury RP,Dansky HM,Rong JX,Breslow JL,Fisher EA

更新日期：2002-02-19 00:00:00

abstract：:Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hood L,Lackland H,Eichman K,Kindt TJ,Braun DG,Krause RM

更新日期：1969-07-01 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells (CaM kinase Gr) is a neuronal calmodulin-dependent protein kinase whose purification and partial cloning from rat brain has been described. A combination of the polymerase chain reaction and cDNA library screening was used to determine the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohmstede CA,Bland MM,Merrill BM,Sahyoun N

更新日期：1991-07-01 00:00:00

abstract：:The mouse sperm receptor, a glycoprotein called ZP3, is synthesized and secreted by growing oocytes. It is present in more than a billion copies in the unfertilized egg's extracellular coat, or zona pellucida. We have cloned and characterized a region of the mouse (CD-1) genome that spans 10 kilobases of the ZP3 locus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinloch RA,Roller RJ,Fimiani CM,Wassarman DA,Wassarman PM

更新日期：1988-09-01 00:00:00

abstract：:Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal telencephalic projection neurons. The genetic mechanisms that control development of these neurons suggest that most of them are derived from the basal telencephalon where Lhx8, a LIM-homeobox gene, is expressed. Here we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Marín O,Hermesz E,Powell A,Flames N,Palkovits M,Rubenstein JL,Westphal H

更新日期：2003-07-22 00:00:00

abstract：:Cancer patients and tumor-bearing mice possess serum antibodies that recognize antigens expressed by cancer cells at the time of diagnosis. After diagnosis, cancers progress to more aggressive stages, most often by acquiring new genetic changes that can give rise to new proteins, some of which are antigenic. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spiotto MT,Reth MA,Schreiber H

更新日期：2003-04-29 00:00:00

abstract：:The development of protein subunit vaccines to combat some of the world's deadliest pathogens such as a malaria parasite, Plasmodium falciparum, is stalled, due in part to the inability to induce and sustain high-titer antibody responses. Here, we show the induction of persistent, high-titer antibody responses to reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Przysiecki C,Flanagan E,Bello-Irizarry SN,Ionescu R,Muratova O,Dobrescu G,Lambert L,Keister D,Rippeon Y,Long CA,Shi L,Caulfield M,Shaw A,Saul A,Shiver J,Miller LH

更新日期：2006-11-28 00:00:00

abstract：:Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17), a major class of inherited dementing disorders whose gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Murrell JR,Goedert M,Farlow MR,Klug A,Ghetti B

更新日期：1998-06-23 00:00:00

abstract：:RS67333 is a partial serotonin subtype 4 receptor (5-HT4R) agonist that has been widely studied for its procognitive effect. More recently, it has been shown that its ability to promote the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-β peptide leads to the secretion of the neurotrophic protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lecoutey C,Hedou D,Freret T,Giannoni P,Gaven F,Since M,Bouet V,Ballandonne C,Corvaisier S,Malzert Fréon A,Mignani S,Cresteil T,Boulouard M,Claeysen S,Rochais C,Dallemagne P

更新日期：2014-09-09 00:00:00

abstract：:To test the hypothesis that the pubertal increase in luteinizing hormone-releasing hormone (LHRH) release is withheld by a dominant inhibitory neuronal system, the role of gamma-aminobutyric acid (GABA), a known inhibitory neurotransmitter, in the control of LHRH release was examined in conscious female monkeys at the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsushima D,Hei DL,Terasawa E

更新日期：1994-01-04 00:00:00

abstract：:One-electron oxidation of zinc tetraphenylbacteriochlorin and its metal-free base yielded stable cation radicals. Electron spin resonance hyperfine splittings were assigned by selective deuterations. These results indicate that the protons of the saturated rings of the bacteriochlorins carry large spin densities, in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fajer J,Borg DC,Forman A,Felton RH,Dolphin D,Vegh L

更新日期：1974-03-01 00:00:00

abstract：:This paper investigates quantitatively the characteristics of the local folding code. The overlapping four-residue fragments which make up the amino acid sequences of 114 proteins are divided into classes on the basis of the physical properties of their constituent amino acids. The distribution of structural types ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：1993-01-15 00:00:00

abstract：:CR1 is a short interspersed repetitive DNA element originally identified in the domestic chicken (Gallus gallus). However, unlike virtually all other such sequences described to date, CR1 is not confined to one or a few closely related species. It is probably a ubiquitous component of the avian genome, having been det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZQ,Ritzel RG,Lin CC,Hodgetts RB

更新日期：1991-07-01 00:00:00

abstract：:Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous mechanism that generates transcriptomic diversity. This process is particularly important for proper neuronal function; however, little is known about how RNA editing is dynamically regulated between the many functionally distinct ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sapiro AL,Shmueli A,Henry GL,Li Q,Shalit T,Yaron O,Paas Y,Billy Li J,Shohat-Ophir G

更新日期：2019-02-05 00:00:00

abstract：:Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Huang MT,Chang RL,Newmark HL,Lehr RE,Yagi H,Sayer JM,Jerina DM,Conney AH

更新日期：1982-09-01 00:00:00