Abstract:
PURPOSE OF REVIEW:Simple limbal epithelial transplant (SLET) is a technique for addressing limbal stem cell deficiency. Limbal tissue from a donor eye, typically the patient's fellow healthy eye, is transplanted onto an amniotic membrane attached to the surface of the diseased eye. SLET was developed to address limitations of other techniques, specifically the technical difficulty of ex-vivo expansion of cells required in some techniques and the larger amount of valuable limbal tissue harvested in techniques not relying on ex-vivo expansion. We described how the provision of this procedure adds to the armamentarium of techniques available to treat some of the many thousands of uniocular corneal blind around the world. RECENT FINDINGS:A total of 125 patients from a recent series from our centre and 68 from a multicentre study provide evidence for efficacy mainly in cases of unilateral corneal burn. Results were comparable to other stem cell techniques described in other papers. Numerous small case reports describe the use of SLET in other contexts including ocular surface squamous neoplasia and pterygium excision. SUMMARY:SLET offers a cheaper and perhaps safer alternative to other techniques. Further evaluation of clinical success against its most similar analogues of conjunctival limbal autograft and cultivated limbal autograft is required.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Sangwan VS,Sharp JAHdoi
10.1097/ICU.0000000000000377subject
Has Abstractpub_date
2017-07-01 00:00:00pages
382-386issue
4eissn
1040-8738issn
1531-7021journal_volume
28pub_type
杂志文章,评审abstract::Macular translocation is a term used to describe any surgical procedure that involves the deliberate detachment of the retina with subsequent repositioning of the macula to a new location relative to the underlying retinal pigment epithelium. By moving the fovea away from abnormal pigment epithelium and/or choroid and...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200006000-00001
更新日期:2000-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Although lens surgery for high myopia has a long History, it has been extremely controversial. Colin's study of 1999 indicated a much higher than expected rate of retinal detachment. The purpose of this review is to reassess the place of refractive lens exchange in high myopia in the light of more rec...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200502000-00009
更新日期:2005-02-01 00:00:00
abstract::Early and late age-related macular degeneration (AMD) have a high prevalence in elderly patients but may be differentiated by medical or environmental factors, eg, hypertension, geographic area, or antioxidant agents. Because nuclear sclerotic cataract is associated with AMD both aging changes may share a common patho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199506000-00009
更新日期:1995-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Plaque brachytherapy remains the dominant globe-sparing therapy of uveal melanoma. This report highlights recent advances, which have expanded plaque brachytherapy's uses as well as improved the surgical technique. RECENT FINDINGS:Plaque brachytherapy is effective for tumors that may previously have ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000468
更新日期:2018-05-01 00:00:00
abstract::Vascular occlusions of the retina and choroid can cause severe visual loss. These occlusions can occur as a result of systemic disease or after surgery. In most cases, the retinal appearance provides evidence of ischemia as the cause of visual loss. On occasion, however, clinical examination shows no objective signs o...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章
doi:10.1097/00055735-199912000-00002
更新日期:1999-12-01 00:00:00
abstract::A review of the ocular manifestations of pediatric disease is in some ways a review of pediatrics itself. A paper this size cannot hope to be comprehensive in scope or encyclopedic in detail. Instead, we have chosen to touch on recent developments in pediatrics that we feel may be of particular interest to the ophthal...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199812000-00020
更新日期:1998-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors. RECENT FINDINGS:Endoresection has been uti...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000561
更新日期:2019-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The art and science of facial rejuvenation is an ever-evolving field of medicine, as evidenced by the continual development of new surgical and nonsurgical treatment modalities. Over the past 10 years, the use of botulinum toxin and dermal fillers for aesthetic purposes has risen sharply. Herein, we d...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32833ce7bc
更新日期:2010-09-01 00:00:00
abstract::Antiphospholipid syndrome includes elevation of either the lupus anticoagulant titer or the anticardiolipin antibody titer on two occasions, separated by 6 weeks in a patient with an episode of thrombosis. The eye is involved frequently in patients with antiphospholipid syndrome. Patients with retinal vascular disease...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200006000-00011
更新日期:2000-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the risks, benefits and value of genetic testing for ocular genetic disease. RECENT FINDINGS:Testing for ocular genetics diseases is becoming more available and successful gene therapy is being reported. Clinicians must prepare for this trend by considering diagnostic genetic testing for t...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000083
更新日期:2014-09-01 00:00:00
abstract::A seven-stage approach to the management of the paretic eyelid complex has been described. These stages include supportive care, planning and execution of general facial reanimation, lower eyelid and canthal resuspension or support, passive upper eyelid animation, dynamic lid animation, and soft tissue repositioning. ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199908000-00004
更新日期:1999-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review how to critically appraise a research article pertaining to changes in health-related quality of life (HRQoL) related to interventions for age-related macular degeneration (AMD). RECENT FINDINGS:We searched PubMed using a strategy that combined the text-words, "macular degeneration" and "qu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000124082.88389.cf
更新日期:2004-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Optical coherence tomography (OCT) aids in the diagnosis and long-term monitoring of various ocular diseases, including glaucoma. Initially, the retinal nerve fiber layer was the only OCT structural parameter used in glaucoma. Subsequent research has resulted in more retinal and optic nerve head param...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000231
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To review new developments in the medical and surgical treatment options for benign essential blepharospasm (BEB). RECENT FINDINGS:Botulinum toxin injections remain the mainstay treatment for BEB with several formulations currently commercially available. Reports in the medical literature support pho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000500
更新日期:2018-09-01 00:00:00
abstract::Several different laser types are available on the market for the practitioner to use in refractive surgery. Each laser type has certain parameters that the surgeon must understand to obtain the best refractive outcomes. Studies published in peer-reviewed literature between February 2002 and March 2003 show that refra...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200308000-00008
更新日期:2003-08-01 00:00:00
abstract::The status of the cornea is crucial to a good outcome with cataract extraction. Preexisting corneal disease must be managed appropriately to get the high quality results that we have come to expect with modern day cataract surgery. It is now more common to perform cataract surgery on patients who have had previous cor...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199802000-00008
更新日期:1998-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The most important recent advance in the treatment of neovascular age-related macular degeneration (AMD) is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents that preserve and improve visual acuity by arresting choroidal neovascular growth and reducing vascular p...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832d25b3
更新日期:2009-05-01 00:00:00
abstract::The surgical management of Graves ophthalmopathy includes treatment of globe malposition (exophthalmos), strabismus, and eyelid abnormalities. The various techniques used continue to be refined and are detailed in this review. ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199910000-00012
更新日期:1999-10-01 00:00:00
abstract::Clonidine hydrochloride, apraclonidine hydrochloride, and brimonidine tartrate constitute the three topical alpha agonists that are used in the treatment of elevated intraocular pressure. All the alpha agonists have prejunctional (alpha 2) as well as postjunctional (alpha 1) effects. Within the past year, questions ha...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199804000-00006
更新日期:1998-04-01 00:00:00
abstract::Recent advances in the field of infectious conjunctivitis and keratitis include new diagnostic methods, the identification of new pathogens, and novel therapeutic agents. Tandem confocal microscopy has been used to diagnose Acanthamoeba keratitis, and polymerase chain reaction has proven to be a rapid and sensitive te...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199708000-00002
更新日期:1997-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the ocular and systemic associations of floppy eyelid syndrome (FES) as well as provide an up-to-date review on the pathogenesis and treatment strategies. RECENT FINDINGS:Virtually all patients with FES have obstructive sleep apnea (OSA). However, a significantly lower proportion of pati...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000617
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the concept and measurement of health literacy, with a focus on the care of patients with glaucoma. RECENT FINDINGS:Nearly one-fourth of adults in the USA lack the skills needed to fully comprehend and act on verbal or written information in the healthcare environment. This prob...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32835c8b0e
更新日期:2013-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Myelin oligodendrocyte glycoprotein (MOG)-IgG-associated optic neuritis has been established as a new entity of optic neuropathy. We will review recent advances in pathophysiology, diagnosis, and clinical manifestations of MOG-IgG-associated optic neuritis to better understand its distinctive characte...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000520
更新日期:2018-11-01 00:00:00
abstract::Using a liberal definition of corneal irregularity, modern videokeratoscopy may define approximately 40% of normal corneas with a toric refractive error as possessing primary irregular astigmatism. The causes of secondary forms of irregular astigmatism include corneal surgery, trauma, dystrophies, and infections. Inte...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200008000-00007
更新日期:2000-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The successful treatment of canalicular obstructions continues to represent a therapeutic challenge. Conjuctivodacryocystorhinostomy with a Lester Jones bypass tube is the standard treatment in these situations. Although a high rate of anatomic success can be achieved with this procedure, a relatively...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32832ec3e0
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:A process is ongoing to produce a definition of glaucomatous optic neuropathy (GON) using quantitative, objective data from structural and functional tests. At present, a common practice is to define GON by subjective features said to be 'characteristic' as judged by those experienced in glaucoma care...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000644
更新日期:2020-03-01 00:00:00
abstract::Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Sever...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199508000-00002
更新日期:1995-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Meibomian gland dysfunction (MGD) is understood to be a highly prevalent, chronic progressive disease and the leading cause of dry eye. All available published peer-reviewed results of the novel vectored thermal pulsation therapy for patients with MGD are investigated. RECENT FINDINGS:The PubMed and ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000165
更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Neonatal corneal opacification (NCO) describes the loss of corneal transparency at or soon after (<4 weeks) birth. Historically, the literature is strewn with terminology that has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan for, accurate genotype-pheno...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328356893d
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis. RECENT FINDINGS:Several important laboratory and clinical studies have established the safety and success of corneal cross-linking...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000146
更新日期:2015-05-01 00:00:00