Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitus.

Abstract:

OBJECTIVES:To compare 12 weeks of exercise training at two intensities on oxidative stress, antioxidants and inflammatory biomarkers in patients with type 2 diabetes (T2D). DESIGN:Randomized trial. METHODS:Thirty-six participants with T2D were randomized to complete either 12 weeks of treadmill based high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT), followed by 40 weeks of home-based training at the same intensities. Plasma inflammation, oxidative stress and antioxidant biomarkers (total F2-isoprostanes, protein carbonyls, total antioxidant capacity, glutathione peroxidase activity, interleukin-10, interleukin-6, interleukin-8 and TNF-α) were measured at baseline, 12-weeks and 1-year. RESULTS:There were no significant changes (p>0.05) in oxidative stress and inflammation biomarkers from baseline to 12-weeks in either intervention. A decrease in total antioxidant capacity in the MICT group from baseline to 1-year by 0.05mmol/L (p=0.05) was observed. There was a significant difference (p<0.05) when groups were separated by sex with females in the MICT group having a 22.1% (p<0.05) decrease in protein carbonyls from baseline to 1-year. CONCLUSIONS:HIIT and MICT had no acute effect on oxidative stress and inflammatory biomarkers in patients with T2D.

journal_name

J Sci Med Sport

authors

Mallard AR,Hollekim-Strand SM,Coombes JS,Ingul CB

doi

10.1016/j.jsams.2017.03.014

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

893-898

issue

10

eissn

1440-2440

issn

1878-1861

pii

S1440-2440(17)30345-6

journal_volume

20

pub_type

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