Abstract:
OBJECTIVES:To compare 12 weeks of exercise training at two intensities on oxidative stress, antioxidants and inflammatory biomarkers in patients with type 2 diabetes (T2D). DESIGN:Randomized trial. METHODS:Thirty-six participants with T2D were randomized to complete either 12 weeks of treadmill based high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT), followed by 40 weeks of home-based training at the same intensities. Plasma inflammation, oxidative stress and antioxidant biomarkers (total F2-isoprostanes, protein carbonyls, total antioxidant capacity, glutathione peroxidase activity, interleukin-10, interleukin-6, interleukin-8 and TNF-α) were measured at baseline, 12-weeks and 1-year. RESULTS:There were no significant changes (p>0.05) in oxidative stress and inflammation biomarkers from baseline to 12-weeks in either intervention. A decrease in total antioxidant capacity in the MICT group from baseline to 1-year by 0.05mmol/L (p=0.05) was observed. There was a significant difference (p<0.05) when groups were separated by sex with females in the MICT group having a 22.1% (p<0.05) decrease in protein carbonyls from baseline to 1-year. CONCLUSIONS:HIIT and MICT had no acute effect on oxidative stress and inflammatory biomarkers in patients with T2D.
journal_name
J Sci Med Sportjournal_title
Journal of science and medicine in sportauthors
Mallard AR,Hollekim-Strand SM,Coombes JS,Ingul CBdoi
10.1016/j.jsams.2017.03.014subject
Has Abstractpub_date
2017-10-01 00:00:00pages
893-898issue
10eissn
1440-2440issn
1878-1861pii
S1440-2440(17)30345-6journal_volume
20pub_type
杂志文章,随机对照试验abstract::This study investigated the amount of physical activity that occurs during normal working hours, highlighting the occupational differences in physical activity by occupational category. Data were collected by means of a self-administered questionnaire (Tecumseh Occupational Physical Activity Questionnaire [TOQ]), whic...
journal_title:Journal of science and medicine in sport
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abstract::Historically, research into possible causes of exercise-induced fatigue has been found to span numerous scientific disciplines, including medicine, psychology, physiology, neurophysiology, biochemistry, biomechanics, and physics. In order to better understand the mechanisms responsible for fatigue, these disciplines h...
journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章
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journal_title:Journal of science and medicine in sport
pub_type: 临床试验,杂志文章
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
pub_type: 临床试验,杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章
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journal_title:Journal of science and medicine in sport
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journal_title:Journal of science and medicine in sport
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00