Abstract：
:There is not a clear consensus regarding the optimal treatment of locally advanced pancreatic disease. There is a potential role for neoadjuvant therapy to treat micrometastatic disease with chemotherapy, as well as for the treatment of local disease with radiotherapy. We evaluated the safety and efficacy of induction chemotherapy with oxaliplatin and gemcitabine followed by a high weekly dose of gemcitabine concurrent to radiation therapy in patients with borderline resectable and unresectable locally advanced pancreatic cancer. In our study, 41 patients with pancreatic cancer were evaluated. In all cases an accurate pre-treatment staging was performed. Patients with evidence of metastatic disease were excluded, and thus a total of 34 patients were consequently enrolled. Of these, twenty-seven patients (80%) had locally advanced unresectable tumours, seven patients (20%) had borderline resectable disease. This protocol treatment represents a well-tolerated promising approach. Fifteen patients (55.5%) underwent surgical radical resection. With a median follow-up of 20 months, the median PFS and OS were 20 months and 19.2 months, respectively. The median OS for borderline resectable patients was 21.5 months compared with 14 months for unresectable patients (p = 0.3). Continued optimization in multimodality therapy and an accurate patient selection remain crucial points for the appropriate treatment of these patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fiore M,Ramella S,Valeri S,Caputo D,Floreno B,Trecca P,Trodella LE,Trodella L,D'Angelillo RM,Coppola Rdoi
10.1038/srep45845subject
Has Abstractpub_date
2017-04-05 00:00:00pages
45845issn
2045-2322pii
srep45845journal_volume
7pub_type
杂志文章abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73242-6
更新日期：2020-10-01 00:00:00
abstract：:Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35570-6
更新日期：2018-11-30 00:00:00
abstract：:The availability and spatial distribution of food resources affect animal behavior and survival. Black howler monkeys (Alouatta pigra) have a foraging strategy to balance their nutrient intake that involves mixing their consumption of leaves and fruits. The spatial aggregation of food items should impact this strategy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55932-y
更新日期：2019-12-19 00:00:00
abstract：:Studies indicate that the gut microbiota (GM) can significantly influence both local and systemic host physiologic processes. With rising concern for optimization of experimental reproducibility and translatability, it is essential to consider the GM in study design. However, GM profiles can vary between rodent produc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28448-0
更新日期：2018-07-04 00:00:00
abstract：:The real time detection of quantitative oxygen release from the cathode is performed by in-situ Gas Chromatography as a tool to not only determine the amount of oxygen release from a lithium-ion cell but also to address the safety concerns. This in-situ gas chromatography technique monitoring the gas evolution during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23394
更新日期：2016-03-22 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep44499. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46959
更新日期：2018-03-19 00:00:00
abstract：:Recovery of nutrients and energy from municipal wastewater has attracted much attention in recent years; however, its efficiency is significantly limited by the low-strength properties of municipal wastewater. Herein, we report a pilot-scale forward osmosis (FO) system using a spiral-wound membrane module to concentra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21653
更新日期：2016-02-22 00:00:00
abstract：:We experimentally investigate a discharging flux of granular particles through a sieve plate subject to vertical vibrations. The mean mass flux shows a non-monotonic relation with the vibration strength. High-speed photography reveals that two stages, the free flight of the particles' bulk over the plate and the adhes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09880
更新日期：2015-06-09 00:00:00
abstract：:Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08842-w
更新日期：2017-08-15 00:00:00
abstract：:Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time their magnitudes are correlated. These conductance amplitude correlat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38405-6
更新日期：2019-02-08 00:00:00
abstract：:Radiation weighting factor wR for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54081-6
更新日期：2019-11-27 00:00:00
abstract：:Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07966-3
更新日期：2017-08-22 00:00:00
abstract：:Rice paddies are a major source of anthropogenic nitrous oxide (N2O) emissions, especially under alternate wetting-drying irrigation and high N input. Increasing photosynthate allocation to the grain in rice (Oryza sativa L.) has been identified as an effective strategy of genetic and agronomic innovation for yield en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29333
更新日期：2016-07-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44746-7
更新日期：2019-06-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31638
更新日期：2016-08-17 00:00:00
abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03204
更新日期：2013-11-13 00:00:00
abstract：:Long-read sequencing technologies such as Pacific Biosciences and Oxford Nanopore MinION are capable of producing long sequencing reads with average fragment lengths of over 10,000 base-pairs and maximum lengths reaching 100,000 base- pairs. Compared with short reads, the assemblies obtained from long-read sequencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03996-z
更新日期：2017-06-21 00:00:00
abstract：:There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06903
更新日期：2014-11-11 00:00:00
abstract：:Levels of neutral poly-/perfluoroalkyl substances (nPFASs) in air and snow collected from Ny-Ålesund were measured and their air-snow exchange was determined to investigate whether they could re-volatilize into the atmosphere driven by means of air-snow exchange. The total concentration of 12 neutral PFASs ranged from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08912
更新日期：2015-03-09 00:00:00
abstract：:In the presence of a lateral periodic potential modulation, two-dimensional electrons may exhibit interesting phenomena, such as a graphene-like energy-momentum dispersion, Bloch oscillations, or the Hofstadter butterfly band structure. To create a sufficiently strong potential modulation using conventional semiconduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20967
更新日期：2016-02-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22545-w
更新日期：2018-03-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27969
更新日期：2016-06-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-55524-w
更新日期：2019-12-18 00:00:00
abstract：:In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are enriched or rRNA molecules are depleted. Targeted depletion of rRNA is particularly useful...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48692-2
更新日期：2019-08-22 00:00:00
abstract：:A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01876
更新日期：2013-01-01 00:00:00
abstract：:The effect of initial evenness on the temporal trajectory of synthetic communities in comprehensive, low-volume microcosm studies remains unknown. We used flow cytometric fingerprinting and 16S rRNA gene amplicon sequencing to assess the impact of time on community structure in one hundred synthetic ecosystems of fixe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18668-1
更新日期：2018-01-10 00:00:00
abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29803
更新日期：2016-07-13 00:00:00
abstract：:The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) within the small intestinal Peyer's patches is essential to establish host infection, and for the disease to efficiently spread to the brain. Factors that influence the early accumulation of prions in Peye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42900-9
更新日期：2019-04-30 00:00:00
abstract：:Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51556-4
更新日期：2019-10-22 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-73944-x
更新日期：2020-10-09 00:00:00
