当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The 5'UTR in human adenoviruses: leader diversity in late gene expression.

The 5'UTR in human adenoviruses: leader diversity in late gene expression.

Abstract：

:Human adenoviruses (HAdVs) shut down host cellular cap-dependent mRNA translation while initiating the translation of viral late mRNAs in a cap-independent manner. HAdV 5' untranslated regions (5'UTRs) are crucial for cap-independent initiation, and influence mRNA localization and stability. However, HAdV translational regulation remains relatively uncharacterized. The HAdV tripartite leader (TPL), composed of three introns (TPL 1-3), is critical to the translation of HAdV late mRNA. Herein, we annotated and analyzed 72 HAdV genotypes for the HAdV TPL and another previously described leader, the i-leader. Using HAdV species D, type 37 (HAdV-D37), we show by reverse transcription PCR and Sanger sequencing that mRNAs of the HAdV-D37 E3 transcription unit are spliced to the TPL. We also identified a polycistronic mRNA for RID-α and RID-β. Analysis of the i-leader revealed a potential open reading frame within the leader sequence and the termination of this potential protein in TPL3. A potential new leader embedded within the E3 region was also detected and tentatively named the j-leader. These results suggest an underappreciated complexity of post-transcriptional regulation, and the importance of HAdV 5'UTRs for precisely coordinated viral protein expression along the path from genotype to phenotype.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ramke M,Lee JY,Dyer DW,Seto D,Rajaiya J,Chodosh J

doi

10.1038/s41598-017-00747-y

subject

Has Abstract

pub_date

2017-04-04 00:00:00

pages

618

issue

1

issn

2045-2322

pii

10.1038/s41598-017-00747-y

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Southwest Greenland shelf glaciation during MIS 4 more extensive than during the Last Glacial Maximum.

    abstract：:Although geological and modelling evidence indicate that the last glacial inception in North America was in NE Canada, little is known about the glacial response of the nearby western Greenland Ice Sheet (GIS) during the glacial advance of marine oxygen isotope stage 4 (MIS4). Our multi-proxy study of a marine sedimen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51983-3

    authors： Seidenkrantz MS,Kuijpers A,Olsen J,Pearce C,Lindblom S,Ploug J,Przybyło P,Snowball I

    更新日期：2019-10-30 00:00:00

  • Frequent occurrence of Mungbean yellow mosaic India virus in tomato leaf curl disease affected tomato in Oman.

    abstract：:Next generation sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lycopersicum) plants with leaf curl symptoms identified a number of monopartite begomoviruses, including Tomato yellow leaf curl virus (TYLCV), and a betasatellite (Tomato leaf curl betasatellite [ToLCB]). Both TY...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53106-4

    authors： Shahid MS,Shafiq M,Ilyas M,Raza A,Al-Sadrani MN,Al-Sadi AM,Briddon RW

    更新日期：2019-11-12 00:00:00

  • Seven gene deletions in seven days: Fast generation of Escherichia coli strains tolerant to acetate and osmotic stress.

    abstract：:Generation of multiple genomic alterations is currently a time consuming process. Here, a method was established that enables highly efficient and simultaneous deletion of multiple genes in Escherichia coli. A temperature sensitive plasmid containing arabinose inducible lambda Red recombineering genes and a rhamnose i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17874

    authors： Jensen SI,Lennen RM,Herrgård MJ,Nielsen AT

    更新日期：2015-12-08 00:00:00

  • Effects of patch contrast and arrangement on benefits of clonal integration in a rhizomatous clonal plant.

    abstract：:The availabilities of light and soil water resources usually spatially co-vary in natural habitats, and the spatial pattern of such co-variation may affect the benefits of physiological integration between connected ramets of clonal plants. In a greenhouse experiment, we grew connected or disconnected ramet pairs [con...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35459

    authors： Wang YJ,Shi XP,Wu XJ,Meng XF,Wang PC,Zhou ZX,Luo FL,Yu FH

    更新日期：2016-10-19 00:00:00

  • Assessing effects from four years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle, 2013-2017.

    abstract：:The objective was to measure the association between badger culling and bovine tuberculosis (TB) incidents in cattle herds in three areas of England between 2013-2017 (Gloucestershire and Somerset) and 2015-2017 (Dorset). Farming industry-selected licensed culling areas were matched to comparison areas. A TB incident ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49957-6

    authors： Downs SH,Prosser A,Ashton A,Ashfield S,Brunton LA,Brouwer A,Upton P,Robertson A,Donnelly CA,Parry JE

    更新日期：2019-10-11 00:00:00

  • Experimental demonstration of plasmon enhanced energy transfer rate in NaYF4:Yb(3+),Er(3+) upconversion nanoparticles.

    abstract：:Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18894

    authors： Lu D,Mao C,Cho SK,Ahn S,Park W

    更新日期：2016-01-07 00:00:00

  • Kup-mediated Cs+ uptake and Kdp-driven K+ uptake coordinate to promote cell growth during excess Cs+ conditions in Escherichia coli.

    abstract：:The physiological effects of caesium (Cs) on living cells are poorly understood. Here, we examined the physiological role of Cs+ on the activity of the potassium transporters in E. coli. In the absence of potassium (K+), Kup-mediated Cs+ uptake partially supported cell growth, however, at a much lower rate than with s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02164-7

    authors： Tanudjaja E,Hoshi N,Su YH,Hamamoto S,Uozumi N

    更新日期：2017-05-18 00:00:00

  • Temporal variability of diazotroph community composition in the upwelling region off NW Iberia.

    abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39586-4

    authors： Moreira-Coello V,Mouriño-Carballido B,Marañón E,Fernández-Carrera A,Bode A,Sintes E,Zehr JP,Turk-Kubo K,Varela MM

    更新日期：2019-03-06 00:00:00

  • Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

    abstract：:Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35909-z

    authors： Bang CH,Yoon JW,Lee HJ,Lee JY,Park YM,Lee SJ,Lee JH

    更新日期：2018-12-14 00:00:00

  • Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin.

    abstract：:Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15901-9

    authors： Wang AS,Ong PF,Chojnowski A,Clavel C,Dreesen O

    更新日期：2017-11-15 00:00:00

  • Long-term surgical outcomes of primary retropupillary iris claw intraocular lens implantation for the treatment of intraocular lens dislocation.

    abstract：:We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete intraocular lens (IOL) dislocation. In this single-center retrospective case series, we reviewed the medical records of patients who underwent R-IOL implantation surgery w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80292-3

    authors： Choi EY,Lee CH,Kang HG,Han JY,Byeon SH,Kim SS,Koh HJ,Kim M

    更新日期：2021-01-12 00:00:00

  • Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches.

    abstract：:The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56747-7

    authors： Witwinowski J,Moutiez M,Coupet M,Correia I,Belin P,Ruzzini A,Saulnier C,Caraty L,Favry E,Seguin J,Lautru S,Lequin O,Gondry M,Pernodet JL,Darbon E

    更新日期：2019-12-27 00:00:00

  • SGA as a Risk Factor for Cerebral Palsy in Moderate to Late Preterm Infants: a System Review and Meta-analysis.

    abstract：:Small for gestational age (SGA) is an established risk factor for cerebral palsy (CP) in term infants. However, there is conflicting data on the association between SGA and CP in moderate to late preterm infants. The aim of the article was to explore the relationship between SGA and CP in the moderate to late preterm ...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/srep38853

    authors： Zhao M,Dai H,Deng Y,Zhao L

    更新日期：2016-12-13 00:00:00

  • Self-Heating and Failure in Scalable Graphene Devices.

    abstract：:Self-heating induced failure of graphene devices synthesized from both chemical vapor deposition (CVD) and epitaxial means is compared using a combination of infrared thermography and Raman imaging. Despite a larger thermal resistance, CVD devices dissipate >3x the amount of power before failure than their epitaxial c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26457

    authors： Beechem TE,Shaffer RA,Nogan J,Ohta T,Hamilton AB,McDonald AE,Howell SW

    更新日期：2016-06-09 00:00:00

  • Two genomes of highly polyphagous lepidopteran pests (Spodoptera frugiperda, Noctuidae) with different host-plant ranges.

    abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10461-4

    authors： Gouin A,Bretaudeau A,Nam K,Gimenez S,Aury JM,Duvic B,Hilliou F,Durand N,Montagné N,Darboux I,Kuwar S,Chertemps T,Siaussat D,Bretschneider A,Moné Y,Ahn SJ,Hänniger S,Grenet AG,Neunemann D,Maumus F,Luyten I,Labadi

    更新日期：2017-09-25 00:00:00

  • Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells.

    abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43838

    authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

    更新日期：2017-03-08 00:00:00

  • 11C-methionine-PET for differentiating recurrent brain tumor from radiation necrosis: radiomics approach with random forest classifier.

    abstract：:Differentiating recurrent brain tumor from radiation necrosis is often difficult. This study aims to investigate the efficacy of 11C-methionine (MET)-PET radiomics for distinguishing recurrent brain tumor from radiation necrosis, as compared with conventional tumor-to-normal cortex (T/N) ratio evaluation. We enrolled ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-019-52279-2

    authors： Hotta M,Minamimoto R,Miwa K

    更新日期：2019-10-30 00:00:00

  • A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China.

    abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41598-020-67754-4

    authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

    更新日期：2020-07-03 00:00:00

  • Carbon: nitrogen stoichiometry following afforestation: a global synthesis.

    abstract：:Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the results of 53 studies, we examined temporal and spatial variation in C: N ratios and in N-C scaling relationships of both the organic and the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19117

    authors： Xu X,Li D,Cheng X,Ruan H,Luo Y

    更新日期：2016-01-08 00:00:00

  • Formation and stability of complex metallic phases including quasicrystals explored through combinatorial methods.

    abstract：:Aluminum-based quasicrystals typically form across narrow composition ranges within binary to quaternary alloys, which makes their fabrication and characterization challenging. Here, we use combinatorial approaches together with fast characterization techniques to study a wide compositional range including known quasi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43666-w

    authors： Wolf W,Kube SA,Sohn S,Xie Y,Cha JJ,Scanley BE,Kiminami CS,Bolfarini C,Botta WJ,Schroers J

    更新日期：2019-05-09 00:00:00

  • Evaluation of vascular pain in patients with colorectal cancer receiving peripheral venous chemotherapy with or without oxaliplatin.

    abstract：:Oxaliplatin is a key chemotherapy drug in patients with colorectal cancer. Administration of oxaliplatin via a peripheral vein often causes vascular pain. However, no studies have evaluated vascular pain in patients with colorectal cancer in relation to peripheral venous administration of chemotherapy with or without ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-37966-w

    authors： Matsuoka T,Yoshida Y,Aisu N,Yamada T,Mogi A,Komono A,Sakamoto R,Kojima D,Yoshimatsu G,Kiyomi F,Kodama S,Hasegawa S

    更新日期：2019-02-12 00:00:00

  • Albino T-DNA tomato mutant reveals a key function of 1-deoxy-D-xylulose-5-phosphate synthase (DXS1) in plant development and survival.

    abstract：:Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45333

    authors： García-Alcázar M,Giménez E,Pineda B,Capel C,García-Sogo B,Sánchez S,Yuste-Lisbona FJ,Angosto T,Capel J,Moreno V,Lozano R

    更新日期：2017-03-28 00:00:00

  • Global inorganic nitrogen dry deposition inferred from ground- and space-based measurements.

    abstract：:Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO2 satellite measurements from the Ozone Monitoring Instrument (OMI) and groun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19810

    authors： Jia Y,Yu G,Gao Y,He N,Wang Q,Jiao C,Zuo Y

    更新日期：2016-01-27 00:00:00

  • Radiological characterization of gilthead seabream (Sparus aurata) fat by X-ray micro-computed tomography.

    abstract：:In fish, the fat content contributes to promoting the nutritional and organoleptic characteristics of the flesh, which is crucial for consumer acceptance. Methods to predict the fat in fish are important in nutritional and physiological research, where body content is traditionally determined by dissection followed by...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67435-2

    authors： Ceballos-Francisco D,García-Carrillo N,Cuesta A,Esteban MÁ

    更新日期：2020-06-29 00:00:00

  • Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology.

    abstract：:Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrogates at r(2) ≥ 0.8)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30509

    authors： Coetzee SG,Pierce S,Brundin P,Brundin L,Hazelett DJ,Coetzee GA

    更新日期：2016-07-27 00:00:00

  • GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3'-oxime inhibit microRNA maturation in mouse embryonic stem cells.

    abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08666

    authors： Wu Y,Liu F,Liu Y,Liu X,Ai Z,Guo Z,Zhang Y

    更新日期：2015-03-02 00:00:00

  • Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study.

    abstract：:Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38259-y

    authors： Pletsch-Borba L,Grafetstätter M,Hüsing A,González Maldonado S,Kloss M,Groß ML,Johnson T,Sookthai D,Bugert P,Kaaks R,Kühn T

    更新日期：2019-02-28 00:00:00

  • A new primitive Neornithischian dinosaur from the Jurassic of Patagonia with gut contents.

    abstract：:We describe a new species of an ornithischian dinosaur, Isaberrysaura mollensis gen. et sp. nov. The specimen, consisting in an almost complete skull and incomplete postcranium was collected from the marine-deltaic deposits of the Los Molles Formation (Toarcian-Bajocian), being the first reported dinosaur for this uni...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42778

    authors： Salgado L,Canudo JI,Garrido AC,Moreno-Azanza M,Martínez LC,Coria RA,Gasca JM

    更新日期：2017-02-16 00:00:00

  • Bacillus amyloliquefaciens SQR9 induces dendritic cell maturation and enhances the immune response against inactivated avian influenza virus.

    abstract：:The objective of this study was to evaluate the stimulatory effects of Bacillus amyloliquefaciens SQR9 on dendritic cells (DCs) and to verify its ability to enhance the immune response by modulating DC maturation. The results demonstrated that B. amyloliquefaciens SQR9 can adhere to the nasal epithelium and be taken u...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21363

    authors： Huang L,Qin T,Yin Y,Gao X,Lin J,Yang Q,Yu Q

    更新日期：2016-02-19 00:00:00

  • The morphogen Decapentaplegic employs a two-tier mechanism to activate target retinal determining genes during ectopic eye formation in Drosophila.

    abstract：:Understanding the role of morphogen in activating its target genes, otherwise epigenetically repressed, during change in cell fate specification is a very fascinating yet relatively unexplored domain. Our in vivo loss-of-function genetic analyses reveal that specifically during ectopic eye formation, the morphogen Dec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27270

    authors： Aggarwal P,Gera J,Mandal L,Mandal S

    更新日期：2016-06-07 00:00:00